Sorl1 (sortilin related receptor 1) - Rat Genome Database

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Gene: Sorl1 (sortilin related receptor 1) Rattus norvegicus
Analyze
Symbol: Sorl1
Name: sortilin related receptor 1
RGD ID: 619914
Description: Predicted to enable several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and low-density lipoprotein particle binding activity. Involved in cell migration. Located in multivesicular body and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LDLR relative with 11 ligand-binding repeats; LOC102547257; LOC300652; low-density lipoprotein receptor relative with 11 ligand-binding repeats; Lr11; RGD619914; similar to sortilin-related receptor, LDLR class A repeats-containing; SorLA; sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats-containing; sortilin-related receptor, LDLR class A repeats-containing; sortilin-related receptor-like; sorting protein-related receptor containing LDLR class A repeats
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8851,238,713 - 51,401,458 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl851,238,722 - 51,401,446 (-)EnsemblGRCr8
mRatBN7.2842,341,704 - 42,504,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl842,341,704 - 42,504,513 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx847,834,567 - 47,997,513 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0846,113,233 - 46,276,184 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,980,818 - 44,143,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0846,228,077 - 46,287,171 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0844,702,383 - 44,872,500 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4844,962,730 - 45,101,843 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera841,934,828 - 42,097,222 (-)NCBICelera
RGSC_v3.1844,971,645 - 45,214,890 (-)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitriptyline  (EXP)
amitrole  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
quercitrin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (IEA,ISO)
cell migration  (IMP)
diet induced thermogenesis  (IEA,ISO)
endocytosis  (IEA)
endosome to plasma membrane protein transport  (IEA,ISO)
insulin receptor recycling  (IEA,ISO)
lysosomal protein catabolic process  (IEA,ISO,ISS)
negative regulation of amyloid precursor protein catabolic process  (IEA,ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of cytokine-mediated signaling pathway  (IEA,ISO,ISS)
negative regulation of neurofibrillary tangle assembly  (IEA,ISO)
negative regulation of neurogenesis  (IEA,ISO)
negative regulation of protein-containing complex assembly  (IEA,ISO)
negative regulation of triglyceride catabolic process  (IEA,ISO)
neuropeptide signaling pathway  (IEA,ISO)
positive regulation of adipose tissue development  (IEA,ISO)
positive regulation of early endosome to recycling endosome transport  (IEA,ISO)
positive regulation of endocytic recycling  (IEA,ISO)
positive regulation of ER to Golgi vesicle-mediated transport  (IEA,ISO)
positive regulation of glial cell-derived neurotrophic factor production  (IEA,ISO)
positive regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein exit from endoplasmic reticulum  (IEA,ISO)
positive regulation of protein localization to early endosome  (IEA,ISO)
post-Golgi vesicle-mediated transport  (IBA,IEA,ISO)
protein localization to Golgi apparatus  (IEA,ISO)
protein retention in Golgi apparatus  (IBA,IEA,ISO)
protein targeting  (IEA,ISO)
protein targeting to lysosome  (IBA,IEA,ISO)
protein transport  (IEA)
receptor-mediated endocytosis  (IEA,ISO)
regulation of smooth muscle cell migration  (IEA,ISO)
retrograde transport, endosome to Golgi  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Differential expression of LR11 during proliferation and differentiation of cultured neuroblastoma cells. Hirayama S, etal., Biochem Biophys Res Commun. 2000 Aug 28;275(2):365-73.
3. Expression of LR11, a mosaic LDL receptor family member, is markedly increased in atherosclerotic lesions. Kanaki T, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2687-95.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. Offe K, etal., J Neurosci. 2006 Feb 1;26(5):1596-603.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Uptake of lipoproteins for axonal growth of sympathetic neurons. Posse De Chaves EI, etal., J Biol Chem. 2000 Jun 30;275(26):19883-90.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Scherzer CR, etal., Arch Neurol. 2004 Aug;61(8):1200-5.
12. Enhanced expression of the LDL receptor family member LR11 increases migration of smooth muscle cells in vitro. Zhu Y, etal., Circulation. 2002 Apr 16;105(15):1830-6.
Additional References at PubMed
PMID:11082041   PMID:11294867   PMID:14764453   PMID:15632090   PMID:16174740   PMID:16407538   PMID:17326667   PMID:17855360   PMID:18362153   PMID:19036982   PMID:19047013   PMID:19056867  
PMID:21385844   PMID:21989385   PMID:21994944   PMID:22621900   PMID:22986780   PMID:23376485   PMID:24001769   PMID:24523320   PMID:26584636   PMID:27322061   PMID:31904090  


Genomics

Comparative Map Data
Sorl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8851,238,713 - 51,401,458 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl851,238,722 - 51,401,446 (-)EnsemblGRCr8
mRatBN7.2842,341,704 - 42,504,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl842,341,704 - 42,504,513 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx847,834,567 - 47,997,513 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0846,113,233 - 46,276,184 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,980,818 - 44,143,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0846,228,077 - 46,287,171 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0844,702,383 - 44,872,500 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4844,962,730 - 45,101,843 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera841,934,828 - 42,097,222 (-)NCBICelera
RGSC_v3.1844,971,645 - 45,214,890 (-)NCBI
Cytogenetic Map8q22NCBI
SORL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811121,452,314 - 121,633,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11121,452,314 - 121,633,763 (+)Ensemblhg38GRCh38
GRCh3711121,323,023 - 121,504,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611120,828,130 - 121,005,621 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411120,828,129 - 121,005,610NCBI
Celera11118,482,367 - 118,662,804 (+)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11117,266,146 - 117,448,320 (+)NCBIHuRef
CHM1_111121,210,607 - 121,392,157 (+)NCBICHM1_1
T2T-CHM13v2.011121,478,500 - 121,660,113 (+)NCBIT2T-CHM13v2.0
Sorl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,876,005 - 42,035,593 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,876,016 - 42,035,593 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38941,964,709 - 42,124,297 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,964,720 - 42,124,297 (-)Ensemblmm10GRCm38
MGSCv37941,776,572 - 41,932,372 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36941,719,598 - 41,875,108 (-)NCBIMGSCv36mm8
Celera939,209,765 - 39,348,584 (-)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map923.55NCBI
Sorl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541222,421,984 - 22,576,179 (+)Ensembl
ChiLan1.0NW_00495541222,421,984 - 22,576,179 (+)NCBIChiLan1.0ChiLan1.0
SORL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29122,164,892 - 122,345,259 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111123,269,279 - 123,449,639 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011116,297,014 - 116,477,399 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111120,222,491 - 120,402,432 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11120,222,491 - 120,402,432 (+)EnsemblpanPan2panpan1.1
SORL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1512,493,750 - 12,650,530 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl512,431,377 - 12,650,784 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha512,548,775 - 12,705,458 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0512,443,942 - 12,600,792 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl512,448,034 - 12,600,792 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1512,550,420 - 12,707,102 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0512,486,757 - 12,643,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0512,525,262 - 12,682,112 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sorl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947103,270,998 - 103,431,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365426,192,407 - 6,352,424 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365426,192,407 - 6,352,835 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl948,435,345 - 48,653,655 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1948,435,350 - 48,653,670 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2953,829,728 - 53,907,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SORL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11112,877,052 - 113,062,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,877,151 - 113,058,050 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604313,044,662 - 13,224,435 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sorl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248803,583,838 - 3,749,930 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248803,579,783 - 3,749,958 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sorl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1836,555,463 - 36,715,316 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sorl1
1449 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:481
Count of miRNA genes:251
Interacting mature miRNAs:317
Transcripts:ENSRNOT00000059974
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625851589833Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
BM385009  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0844,797,788 - 44,797,978UniSTSRnor5.0
RGSC_v3.4845,027,322 - 45,027,512UniSTSRGSC3.4
Celera842,022,439 - 42,022,629UniSTS
RH 3.4 Map8406.7UniSTS
Cytogenetic Map8q22UniSTS
RH133899  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2842,345,620 - 42,346,958 (+)MAPPERmRatBN7.2
Rnor_6.0846,231,995 - 46,233,332NCBIRnor6.0
Rnor_5.0844,706,301 - 44,707,638UniSTSRnor5.0
RGSC_v3.4844,962,908 - 44,964,246UniSTSRGSC3.4
Celera841,938,745 - 41,940,082UniSTS
RH 3.4 Map8404.3UniSTS
Cytogenetic Map8q22UniSTS
BF401246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2842,387,137 - 42,387,318 (+)MAPPERmRatBN7.2
Rnor_6.0846,281,440 - 46,281,620NCBIRnor6.0
Rnor_5.0844,755,746 - 44,755,926UniSTSRnor5.0
RGSC_v3.4845,003,699 - 45,003,879UniSTSRGSC3.4
Celera841,980,225 - 41,980,405UniSTS
RH 3.4 Map8406.9UniSTS
Cytogenetic Map8q22UniSTS
RH137847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2842,341,769 - 42,341,933 (+)MAPPERmRatBN7.2
Rnor_6.0846,228,143 - 46,228,306NCBIRnor6.0
Rnor_5.0844,702,449 - 44,702,612UniSTSRnor5.0
RGSC_v3.4844,958,644 - 44,958,807UniSTSRGSC3.4
Celera841,934,894 - 41,935,057UniSTS
RH 3.4 Map8404.2UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 51 67 138 95 11 49 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000095508   ⟹   ENSRNOP00000089955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl851,238,722 - 51,401,446 (-)Ensembl
mRatBN7.2 Ensembl842,341,704 - 42,504,513 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096310   ⟹   ENSRNOP00000081995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl851,238,722 - 51,401,446 (-)Ensembl
mRatBN7.2 Ensembl842,341,704 - 42,504,513 (-)Ensembl
RefSeq Acc Id: NM_053519   ⟹   NP_445971
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,238,722 - 51,401,247 (-)NCBI
mRatBN7.2842,341,704 - 42,504,228 (-)NCBI
Rnor_6.0846,228,077 - 46,287,171 (-)NCBI
Rnor_5.0844,702,383 - 44,872,500 (-)NCBI
Celera841,934,828 - 42,097,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081046   ⟹   XP_038936974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,264,453 - 51,401,458 (-)NCBI
mRatBN7.2842,367,438 - 42,504,435 (-)NCBI
RefSeq Acc Id: XM_063265102   ⟹   XP_063121172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,238,713 - 51,307,238 (-)NCBI
Protein Sequences
Protein RefSeqs NP_445971 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936974 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121172 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA86122 (Get FASTA)   NCBI Sequence Viewer  
  EDL95248 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089955
  ENSRNOP00000089955.1
GenBank Protein P0DSP1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445971   ⟸   NM_053519
- Peptide Label: precursor
- UniProtKB: P0DSP1 (UniProtKB/Swiss-Prot),   A0A8I5ZUZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038936974   ⟸   XM_039081046
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000081995   ⟸   ENSRNOT00000096310
Ensembl Acc Id: ENSRNOP00000089955   ⟸   ENSRNOT00000095508
RefSeq Acc Id: XP_063121172   ⟸   XM_063265102
- Peptide Label: isoform X2
Protein Domains
EGF-like   Fibronectin type-III   LDL-receptor class A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DSP1-F1-model_v2 AlphaFold P0DSP1 1-2215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619914 AgrOrtholog
BioCyc Gene G2FUF-30786 BioCyc
Ensembl Genes ENSRNOG00000064634 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000095508 ENTREZGENE
  ENSRNOT00000095508.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.70.80 UniProtKB/Swiss-Prot
  2.120.10.30 UniProtKB/Swiss-Prot
  2.130.10.10 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  3.30.60.270 UniProtKB/Swiss-Prot
  4.10.400.10 UniProtKB/Swiss-Prot
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDLR_class-A_CS UniProtKB/Swiss-Prot
  LDLR_classB_rpt UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
  Sortilin_C UniProtKB/Swiss-Prot
  Sortilin_N UniProtKB/Swiss-Prot
  VPS10 UniProtKB/Swiss-Prot
  VPS10-sortilin UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:300652 UniProtKB/Swiss-Prot
NCBI Gene Sorl1 ENTREZGENE
PANTHER SORTILIN RELATED UniProtKB/Swiss-Prot
  SORTILIN-RELATED RECEPTOR UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot
  Ldl_recept_b UniProtKB/Swiss-Prot
  Sortilin-Vps10 UniProtKB/Swiss-Prot
  Sortilin_C UniProtKB/Swiss-Prot
PhenoGen Sorl1 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
PROSITE EGF_2 UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  LDLRB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000064634 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  LDLa UniProtKB/Swiss-Prot
  SM00135 UniProtKB/Swiss-Prot
  VPS10 UniProtKB/Swiss-Prot
Superfamily-SCOP Oligoxyloglucan reducing end-specific cellobiohydrolase UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
  YWTD domain UniProtKB/Swiss-Prot
UniProt A0A8I5ZUZ4 ENTREZGENE, UniProtKB/TrEMBL
  P0DSP1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Sorl1  sortilin related receptor 1  LOC102547257  sortilin-related receptor-like  Data merged from RGD:7639233 737654 PROVISIONAL
2016-06-29 Sorl1  sortilin related receptor 1  Sorl1  sortilin-related receptor, LDLR class A repeats-containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102547257  sortilin-related receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2007-03-27 Sorl1  sortilin-related receptor, LDLR class A repeats-containing  RGD619914  similar to sortilin-related receptor, LDLR class A repeats-containing  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2007-03-27 RGD619914  similar to sortilin-related receptor, LDLR class A repeats-containing  Sorl1_predicted  sortilin-related receptor, L(DLR class) A repeats-containing (predicted)  Data merged from RGD:1310938 737654 APPROVED
2007-02-01 RGD619914  similar to sortilin-related receptor, LDLR class A repeats-containing  Sorl1  sortilin-related receptor, LDLR class A repeats-containing  Symbol and Name updated 1299863 APPROVED
2005-01-20 Sorl1  sortilin-related receptor, LDLR class A repeats-containing      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Sorl1_predicted  sortilin-related receptor, L(DLR class) A repeats-containing (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Sorl1  sortilin-related receptor, LDLR class A repeats-containing      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the LDL receptor family 634106