Cdkl3 (cyclin-dependent kinase-like 3) - Rat Genome Database

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Pathways
Gene: Cdkl3 (cyclin-dependent kinase-like 3) Rattus norvegicus
Analyze
Symbol: Cdkl3
Name: cyclin-dependent kinase-like 3
RGD ID: 619874
Description: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within dendrite extension; negative regulation of axon extension; and positive regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Orthologous to human CDKL3 (cyclin dependent kinase like 3); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,4-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103693326; LOC103694901; Nkiatre; Nkiatreb; serine/threonine kinase NKIATRE; serine/threonine kinase NKIATRE beta; serine/threonine protein kinase NKIATRE; uncharacterized LOC103693326
RGD Orthologs
Human
Mouse
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,755,413 - 36,850,197 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,764,377 - 36,878,660 (+)EnsemblGRCr8
mRatBN7.21036,263,212 - 36,349,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,266,977 - 36,349,268 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1040,961,446 - 40,985,530 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,451,416 - 40,475,500 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,955,138 - 35,979,222 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,458,397 - 37,510,345 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,458,452 - 37,493,491 (+)Ensemblrn6Rnor6.0
Rnor_5.01037,227,962 - 37,315,393 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,527,865 - 37,552,851 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,621,986 - 35,646,386 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA,IEA)
nucleus  (IBA,IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NKIATRE is a novel conserved cdc2-related kinase. Haq R, etal., Genomics 2001 Jan 15;71(2):131-41.
3. Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis. Liu Z, etal., Neurobiol Dis. 2010 Sep;39(3):242-51. doi: 10.1016/j.nbd.2010.03.015. Epub 2010 Mar 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:15057822  


Genomics

Comparative Map Data
Cdkl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,755,413 - 36,850,197 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,764,377 - 36,878,660 (+)EnsemblGRCr8
mRatBN7.21036,263,212 - 36,349,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,266,977 - 36,349,268 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1040,961,446 - 40,985,530 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,451,416 - 40,475,500 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,955,138 - 35,979,222 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,458,397 - 37,510,345 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,458,452 - 37,493,491 (+)Ensemblrn6Rnor6.0
Rnor_5.01037,227,962 - 37,315,393 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,527,865 - 37,552,851 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,621,986 - 35,646,386 (+)NCBICelera
Cytogenetic Map10q22NCBI
CDKL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,283,345 - 134,371,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,286,350 - 134,371,047 (-)Ensemblhg38GRCh38
GRCh375133,634,115 - 133,706,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,671,591 - 133,730,113 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345133,671,590 - 133,730,113NCBI
Celera5129,757,884 - 129,826,544 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,818,996 - 128,887,557 (-)NCBIHuRef
CHM1_15133,066,750 - 133,135,396 (-)NCBICHM1_1
T2T-CHM13v2.05134,806,646 - 134,895,410 (-)NCBIT2T-CHM13v2.0
Cdkl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,891,694 - 51,980,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,895,048 - 51,980,611 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381152,000,842 - 52,089,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,004,221 - 52,089,784 (+)Ensemblmm10GRCm38
MGSCv371151,817,723 - 51,898,169 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361151,847,745 - 51,881,588 (+)NCBIMGSCv36mm8
Celera1156,572,516 - 56,652,949 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.85NCBI
Cdkl3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1934,594,027 - 34,677,927 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdkl3
663 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000059040
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH132769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,267,163 - 36,267,366 (+)MAPPERmRatBN7.2
Rnor_6.01037,458,677 - 37,458,879NCBIRnor6.0
Rnor_5.01037,231,787 - 37,231,989UniSTSRnor5.0
RGSC_v3.41037,528,052 - 37,528,254UniSTSRGSC3.4
Celera1035,622,173 - 35,622,375UniSTS
RH 3.4 Map10390.5UniSTS
Cytogenetic Map10q22UniSTS
RH133033  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,302,574 - 36,302,768 (+)MAPPERmRatBN7.2
Rnor_6.01037,494,122 - 37,494,315NCBIRnor6.0
Rnor_5.01037,268,701 - 37,268,894UniSTSRnor5.0
RGSC_v3.41037,564,834 - 37,565,027UniSTSRGSC3.4
Celera1035,657,659 - 35,657,852UniSTS
RH 3.4 Map10387.2UniSTS
Cytogenetic Map10q22UniSTS
AU049026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,280,983 - 36,281,214 (+)MAPPERmRatBN7.2
Rnor_6.01037,472,495 - 37,472,725NCBIRnor6.0
Rnor_5.01037,245,886 - 37,246,117NCBIRnor5.0
RGSC_v3.41037,541,870 - 37,542,100UniSTSRGSC3.4
Celera1035,635,961 - 35,636,191UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 13 103 226 108 111 63 102 63 6 450 243 11 199 115 132 48 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_597993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07024291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01063836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01063837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01063838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW523244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI296078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000079411   ⟹   ENSRNOP00000072310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,764,377 - 36,802,965 (+)Ensembl
mRatBN7.2 Ensembl1036,266,977 - 36,302,432 (+)Ensembl
Rnor_6.0 Ensembl1037,458,452 - 37,493,491 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079985   ⟹   ENSRNOP00000071286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,767,885 - 36,878,660 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085895   ⟹   ENSRNOP00000073449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,767,776 - 36,850,197 (+)Ensembl
mRatBN7.2 Ensembl1036,266,977 - 36,349,268 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087152   ⟹   ENSRNOP00000068841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,764,377 - 36,805,038 (+)Ensembl
mRatBN7.2 Ensembl1036,266,977 - 36,304,109 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098640   ⟹   ENSRNOP00000091215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,764,377 - 36,845,502 (+)Ensembl
mRatBN7.2 Ensembl1036,266,977 - 36,344,571 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099737   ⟹   ENSRNOP00000084767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,767,800 - 36,803,851 (+)Ensembl
mRatBN7.2 Ensembl1036,266,984 - 36,302,946 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102740   ⟹   ENSRNOP00000082633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,767,883 - 36,811,912 (+)Ensembl
mRatBN7.2 Ensembl1036,266,977 - 36,310,602 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113693   ⟹   ENSRNOP00000096533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,764,377 - 36,810,088 (+)Ensembl
mRatBN7.2 Ensembl1036,266,977 - 36,310,602 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120278   ⟹   ENSRNOP00000094552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,764,377 - 36,798,569 (+)Ensembl
mRatBN7.2 Ensembl1036,266,977 - 36,296,776 (+)Ensembl
RefSeq Acc Id: NM_021772   ⟹   NP_068540
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,908 - 36,792,231 (+)NCBI
mRatBN7.21036,266,977 - 36,291,302 (+)NCBI
Rnor_6.01037,458,490 - 37,482,849 (+)NCBI
Rnor_5.01037,227,962 - 37,315,393 (+)NCBI
RGSC_v3.41037,527,865 - 37,552,851 (+)RGD
Celera1035,621,986 - 35,646,386 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773883   ⟹   XP_008772105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,889 - 36,311,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773884   ⟹   XP_008772106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,891 - 36,311,827 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773885   ⟹   XP_008772107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,888 - 36,311,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773886   ⟹   XP_008772108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,889 - 36,311,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773889   ⟹   XP_008772111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,803,875 (+)NCBI
mRatBN7.21036,266,892 - 36,301,301 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602529   ⟹   XP_017458018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,850,197 (+)NCBI
mRatBN7.21036,266,891 - 36,349,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602531   ⟹   XP_017458020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,783,505 - 36,833,314 (+)NCBI
mRatBN7.21036,282,568 - 36,312,568 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086735   ⟹   XP_038942663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,426 - 36,833,314 (+)NCBI
mRatBN7.21036,263,525 - 36,311,829 (+)NCBI
RefSeq Acc Id: XM_039086737   ⟹   XP_038942665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,679 - 36,833,314 (+)NCBI
mRatBN7.21036,263,742 - 36,311,829 (+)NCBI
RefSeq Acc Id: XM_039086738   ⟹   XP_038942666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,755,413 - 36,833,314 (+)NCBI
mRatBN7.21036,263,212 - 36,311,829 (+)NCBI
RefSeq Acc Id: XM_039086739   ⟹   XP_038942667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,795,881 (+)NCBI
mRatBN7.21036,266,884 - 36,295,034 (+)NCBI
RefSeq Acc Id: XM_063269754   ⟹   XP_063125824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,679 - 36,833,314 (+)NCBI
RefSeq Acc Id: XM_063269756   ⟹   XP_063125826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269757   ⟹   XP_063125827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,848,400 (+)NCBI
RefSeq Acc Id: XM_063269758   ⟹   XP_063125828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269759   ⟹   XP_063125829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,292 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269760   ⟹   XP_063125830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,755,413 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269762   ⟹   XP_063125832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,292 - 36,848,400 (+)NCBI
RefSeq Acc Id: XM_063269763   ⟹   XP_063125833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,799,663 (+)NCBI
RefSeq Acc Id: XR_005489935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,797,376 (+)NCBI
mRatBN7.21036,266,890 - 36,296,453 (+)NCBI
RefSeq Acc Id: XR_005489936
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,795,881 (+)NCBI
mRatBN7.21036,266,885 - 36,294,922 (+)NCBI
RefSeq Acc Id: XR_010055232
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,820 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055233
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,755,413 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055234
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,683 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055235
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,426 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055236
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,797,376 (+)NCBI
RefSeq Acc Id: XR_597993
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,850,197 (+)NCBI
mRatBN7.21036,266,893 - 36,349,268 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_068540 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772105 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772106 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772107 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772108 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772111 (Get FASTA)   NCBI Sequence Viewer  
  XP_017458018 (Get FASTA)   NCBI Sequence Viewer  
  XP_017458020 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942663 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942665 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942666 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942667 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125824 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125826 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125827 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125828 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125829 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125830 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125832 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125833 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF34870 (Get FASTA)   NCBI Sequence Viewer  
  AAF34871 (Get FASTA)   NCBI Sequence Viewer  
  EDM04342 (Get FASTA)   NCBI Sequence Viewer  
  EDM04343 (Get FASTA)   NCBI Sequence Viewer  
  EDM04344 (Get FASTA)   NCBI Sequence Viewer  
  EDM04345 (Get FASTA)   NCBI Sequence Viewer  
  EDM04346 (Get FASTA)   NCBI Sequence Viewer  
  EDM04347 (Get FASTA)   NCBI Sequence Viewer  
  EDM04348 (Get FASTA)   NCBI Sequence Viewer  
  EDM04349 (Get FASTA)   NCBI Sequence Viewer  
  EDM04350 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072310
  ENSRNOP00000073449
  ENSRNOP00000073449.2
  ENSRNOP00000082633
  ENSRNOP00000084767
  ENSRNOP00000091215
  ENSRNOP00000094552
GenBank Protein Q9JM01 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068540   ⟸   NM_021772
- UniProtKB: A6HE95 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072310   ⟸   ENSRNOT00000079411
RefSeq Acc Id: XP_038942666   ⟸   XM_039086738
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942663   ⟸   XM_039086735
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942665   ⟸   XM_039086737
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942667   ⟸   XM_039086739
- Peptide Label: isoform X11
RefSeq Acc Id: XP_008772107   ⟸   XM_008773885
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772105   ⟸   XM_008773883
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772108   ⟸   XM_008773886
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017458018   ⟸   XM_017602529
- Peptide Label: isoform X2
- UniProtKB: A6HE87 (UniProtKB/TrEMBL),   A0A0G2K5J4 (UniProtKB/TrEMBL),   A6HE88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772106   ⟸   XM_008773884
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772111   ⟸   XM_008773889
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GKT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017458020   ⟸   XM_017602531
- Peptide Label: isoform X10
- Sequence:
Ensembl Acc Id: ENSRNOP00000073449   ⟸   ENSRNOT00000085895
Ensembl Acc Id: ENSRNOP00000084767   ⟸   ENSRNOT00000099737
Ensembl Acc Id: ENSRNOP00000091215   ⟸   ENSRNOT00000098640
Ensembl Acc Id: ENSRNOP00000096533   ⟸   ENSRNOT00000113693
Ensembl Acc Id: ENSRNOP00000094552   ⟸   ENSRNOT00000120278
Ensembl Acc Id: ENSRNOP00000068841   ⟸   ENSRNOT00000087152
Ensembl Acc Id: ENSRNOP00000082633   ⟸   ENSRNOT00000102740
RefSeq Acc Id: XP_063125830   ⟸   XM_063269760
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZYS3 (UniProtKB/TrEMBL),   A0A8I6GKT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125832   ⟸   XM_063269762
- Peptide Label: isoform X8
- UniProtKB: Q9JM02 (UniProtKB/Swiss-Prot),   Q9JM01 (UniProtKB/Swiss-Prot),   A6HE90 (UniProtKB/TrEMBL),   A0A8L2R015 (UniProtKB/TrEMBL),   A6HE93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125829   ⟸   XM_063269759
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZYS3 (UniProtKB/TrEMBL),   A0A8I6GKT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125824   ⟸   XM_063269754
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125826   ⟸   XM_063269756
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K2N2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125827   ⟸   XM_063269757
- Peptide Label: isoform X6
- UniProtKB: A0A8L2R015 (UniProtKB/TrEMBL),   A6HE93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125828   ⟸   XM_063269758
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZYS3 (UniProtKB/TrEMBL),   A0A8I6GKT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125833   ⟸   XM_063269763
- Peptide Label: isoform X9
- UniProtKB: A0A8I6GKT9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000071286   ⟸   ENSRNOT00000079985
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM01-F1-model_v2 AlphaFold Q9JM01 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697167
Promoter ID:EPDNEW_R7692
Type:multiple initiation site
Name:Cdkl3_1
Description:cyclin-dependent kinase-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01037,458,470 - 37,458,530EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619874 AgrOrtholog
BioCyc Gene G2FUF-25178 BioCyc
Ensembl Genes ENSRNOG00000059485 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079411 ENTREZGENE
  ENSRNOT00000085895 ENTREZGENE
  ENSRNOT00000085895.2 UniProtKB/Swiss-Prot
  ENSRNOT00000098640 ENTREZGENE
  ENSRNOT00000099737 ENTREZGENE
  ENSRNOT00000102740 ENTREZGENE
  ENSRNOT00000120278 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CDK UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:60396 UniProtKB/Swiss-Prot
NCBI Gene 60396 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot
  CYCLIN-DEPENDENT KINASE-LIKE 3 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Cdkl3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000059485 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2K2N2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5J4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYS3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQU1_RAT UniProtKB/TrEMBL
  A0A8I6GKT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R015 ENTREZGENE, UniProtKB/TrEMBL
  A6HE87 ENTREZGENE, UniProtKB/TrEMBL
  A6HE88 ENTREZGENE, UniProtKB/TrEMBL
  A6HE90 ENTREZGENE, UniProtKB/TrEMBL
  A6HE93 ENTREZGENE, UniProtKB/TrEMBL
  A6HE95 ENTREZGENE, UniProtKB/TrEMBL
  CDKL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JM02 ENTREZGENE
UniProt Secondary Q9JM02 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cdkl3  cyclin-dependent kinase-like 3  LOC103693326  uncharacterized LOC103693326  Data merged from RGD:9397746 737654 PROVISIONAL
2015-02-13 Cdkl3  cyclin-dependent kinase-like 3  LOC103694901  cyclin-dependent kinase-like 3  Data merged from RGD:9243578 737654 APPROVED
2014-08-25 LOC103693326  uncharacterized LOC103693326      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-08-25 LOC103694901  cyclin-dependent kinase-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cdkl3  cyclin-dependent kinase-like 3  Nkiatreb  serine/threonine kinase NKIATRE beta  Symbol and Name updated 1299863 APPROVED
2002-08-07 Nkiatreb  serine/threonine kinase NKIATRE beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a cyclin-binding domain 633468
gene_protein contains two isoforms, of which one has a nuclear localization signal 633468