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Gene: Hacl1 (2-hydroxyacyl-CoA lyase 1) Rattus norvegicus

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Symbol:

Hacl1

Name:

2-hydroxyacyl-CoA lyase 1

RGD ID:

619849

Description:

Enables carbon-carbon lyase activity and thiamine pyrophosphate binding activity. Involved in fatty acid alpha-oxidation and methyl-branched fatty acid metabolic process. Located in peroxisome. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1); PARTICIPATES IN phytanic acid degradation pathway; Refsum disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2-HPCL; 2-hydroxyphytanoyl-CoA lyase; 2-hydroxyphytanoyl-Coenzyme A lyase; Hpcl2; Phyh2; phytanoyl-CoA 2-hydroxylase 2; phytanoyl-Coenzyme A 2-hydroxylase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HACL1 (2-hydroxyacyl-CoA lyase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Hacl1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hacl1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HACL1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC608697 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hacl1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HACL1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HACL1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hacl1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Hacl1 (2-hydroxyacyl-CoA lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Hacl1 (2-hydroxyacyl-CoA lyase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HACL1 (2-hydroxyacyl-CoA lyase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hacl1 (2-hydroxyacyl-CoA lyase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11208	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	B0334.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PXP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hacl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hacl1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	6,831,293 - 6,869,410 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	6,833,268 - 6,869,410 (-)	Ensembl				GRCr8
mRatBN7.2	16	6,826,881 - 6,863,027 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	6,824,906 - 6,863,027 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	6,830,764 - 6,867,047 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	7,975,662 - 8,011,946 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	6,838,214 - 6,874,501 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	7,720,047 - 7,758,119 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	7,714,465 - 7,758,189 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	7,646,580 - 7,682,704 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	7,073,038 - 7,108,830 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	8,335,334 - 8,371,457 (+)	NCBI		Celera
RGSC_v3.1	16	7,073,036 - 7,108,828 (-)	NCBI
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

congenital myasthenic syndrome 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrabromodibenzodioxine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aconitine (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

Aroclor 1254 (EXP)

arsenous acid (ISO)

atazanavir sulfate (ISO)

benzene (EXP)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bromuconazole (EXP)

buspirone (EXP)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

carmustine (EXP)

chenodeoxycholic acid (ISO)

cholesterol (ISO)

chromium trinitrate (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (EXP)

clofibric acid (EXP)

cobalt dichloride (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

deoxycholic acid (ISO)

diarsenic trioxide (ISO)

dibenzofurans (ISO)

dicrotophos (ISO)

dioxygen (ISO)

diquat (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

glafenine (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

ivermectin (ISO)

methapyrilene (EXP)

methotrexate (EXP)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP,ISO)

nickel atom (ISO)

nimesulide (EXP)

okadaic acid (ISO)

oxycodone (EXP)

paclitaxel (EXP)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (EXP,ISO)

potassium chromate (ISO)

quercetin (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

Tesaglitazar (EXP)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP)

thioacetamide (EXP)

tioguanine (EXP)

triphenyl phosphate (EXP)

troglitazone (EXP,ISO)

trovafloxacin (EXP,ISO)

tungsten (ISO)

valproic acid (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carboxylic acid catabolic process (IEA)

fatty acid alpha-oxidation (IBA,IDA,IEA,ISO)

fatty acid metabolic process (IEA,ISO)

lipid metabolic process (IEA,ISO)

methyl-branched fatty acid metabolic process (IDA,IEA,ISO)

phytanic acid metabolic process (IEA,ISO,ISS)

protein targeting to peroxisome (IEA,ISO,ISS)

Cellular Component

peroxisome (IBA,IDA,IEA,ISO)

Molecular Function

2-hydroxyacyl-CoA lyase activity (IEA,ISO)

2-hydroxyphytanoyl-CoA lyase activity (IEA)

ATP binding (IEA,ISO)

carbon-carbon lyase activity (IDA,IEA,ISO)

catalytic activity (IEA)

identical protein binding (IEA,ISO,ISS)

lyase activity (IEA,ISO)

magnesium ion binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

thiamine pyrophosphate binding (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phytanic acid degradation pathway (ISO)

Refsum disease pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids.	Foulon V, etal., Proc Natl Acad Sci U S A 1999 Aug 31;96(18):10039-44.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11171065	PMID:14561759	PMID:15644336	PMID:16189514	PMID:20178365	PMID:21708296	PMID:25416956	PMID:28289220	PMID:28629946

Genomics

Comparative Map Data

Hacl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	6,831,293 - 6,869,410 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	6,833,268 - 6,869,410 (-)	Ensembl				GRCr8
mRatBN7.2	16	6,826,881 - 6,863,027 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	6,824,906 - 6,863,027 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	6,830,764 - 6,867,047 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	7,975,662 - 8,011,946 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	6,838,214 - 6,874,501 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	7,720,047 - 7,758,119 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	7,714,465 - 7,758,189 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	7,646,580 - 7,682,704 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	7,073,038 - 7,108,830 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	8,335,334 - 8,371,457 (+)	NCBI		Celera
RGSC_v3.1	16	7,073,036 - 7,108,828 (-)	NCBI
Cytogenetic Map	16	p16	NCBI

HACL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	15,560,699 - 15,601,569 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	15,560,582 - 15,601,883 (-)	Ensembl			hg38	GRCh38
GRCh37	3	15,602,206 - 15,643,076 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	15,577,243 - 15,618,134 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	3	15,540,467 - 15,581,279 (-)	NCBI		Celera
Cytogenetic Map	3	p25.1	NCBI
HuRef	3	15,537,616 - 15,578,260 (-)	NCBI		HuRef
CHM1_1	3	15,553,051 - 15,593,804 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	15,563,097 - 15,603,888 (-)	NCBI		T2T-CHM13v2.0

Hacl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	31,329,183 - 31,364,201 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	31,320,687 - 31,363,243 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	31,607,226 - 31,640,965 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	31,598,730 - 31,641,286 (-)	Ensembl			mm10	GRCm38
MGSCv37	14	32,420,412 - 32,454,151 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	30,436,235 - 30,469,970 (-)	NCBI		MGSCv36	mm8
Celera	14	27,864,878 - 27,898,614 (-)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	19.23	NCBI

Hacl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	2,053,640 - 2,096,432 (-)	Ensembl
ChiLan1.0	NW_004955430	2,055,774 - 2,096,260 (-)	NCBI	ChiLan1.0	ChiLan1.0

HACL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	15,546,138 - 15,586,459 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	15,550,904 - 15,591,223 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	15,486,897 - 15,526,552 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	15,823,979 - 15,863,982 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	15,823,979 - 15,863,982 (-)	Ensembl			panPan2	panpan1.1

LOC608697
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	27,069,676 - 27,188,247 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	27,043,917 - 27,162,593 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	27,572,135 - 27,700,471 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	23	27,271,635 - 27,389,865 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	27,333,444 - 27,451,635 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	27,581,893 - 27,700,406 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hacl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	169,684,583 - 169,717,508 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	2,823,123 - 2,856,077 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	2,823,183 - 2,856,077 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HACL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	2,766,514 - 2,840,902 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	2,786,007 - 2,840,882 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	2,714,442 - 2,737,983 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HACL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	60,360,380 - 60,433,528 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	60,322,722 - 60,433,647 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	33,390,238 - 33,465,437 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hacl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624822	5,079,634 - 5,145,503 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624822	5,078,925 - 5,189,253 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hacl1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	7,330,052 - 7,368,192 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Hacl1
385 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	19
Count of miRNA genes:	16
Interacting mature miRNAs:	19
Transcripts:	ENSRNOT00000026588
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	4234212	16278352	Rat
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	387123	45387123	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33425095	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39568015	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4234212	53708481	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	4744222	49744222	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4234212	16278352	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	1	26734272	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26734272	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	4354822	49354822	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	387123	45387123	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4234212	49757901	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	66955197	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	16061395	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39568015	Rat
631524	Bp75	Blood pressure QTL 75		0.05	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	117710	8157035	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	839086	66195506	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3386790	49757901	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3386790	26128267	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	839086	66195506	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	839086	66195506	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26734272	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4234333	17730812	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	839086	52786090	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	839086	66195506	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	3301683	48301683	Rat

Markers in Region

D10Mgh3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	10	96,099,749 - 96,099,902 (+)	Marker Load Pipeline
mRatBN7.2	10	95,600,334 - 95,600,487 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	98,939,209 - 98,939,361	NCBI	Rnor6.0
Rnor_5.0	10	98,640,137 - 98,640,289	UniSTS	Rnor5.0
RGSC_v3.4	10	100,090,302 - 100,090,454	UniSTS	RGSC3.4
RGSC_v3.4	10	100,090,301 - 100,090,454	RGD	RGSC3.4
Celera	10	94,250,177 - 94,250,329	UniSTS
RGSC_v3.1	10	100,104,671 - 100,104,824	RGD
RH 3.4 Map	10	1080.69	UniSTS
RH 3.4 Map	10	1080.69	RGD
RH 2.0 Map	10	1218.6	RGD
SHRSP x BN Map	10	77.15	RGD
FHH x ACI Map	10	81.3499	RGD
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	89	59	6	353	189	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010058324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ245707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ517469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026588 ⟹ ENSRNOP00000026588

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	6,833,268 - 6,869,410 (-)	Ensembl
mRatBN7.2 Ensembl	16	6,824,906 - 6,863,015 (-)	Ensembl
Rnor_6.0 Ensembl	16	7,714,465 - 7,758,189 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098301 ⟹ ENSRNOP00000090429

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	6,833,268 - 6,869,410 (-)	Ensembl
mRatBN7.2 Ensembl	16	6,824,906 - 6,863,015 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102645 ⟹ ENSRNOP00000090650

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,849,713 - 6,863,027 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108746 ⟹ ENSRNOP00000082285

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	6,834,147 - 6,869,410 (-)	Ensembl
mRatBN7.2 Ensembl	16	6,827,012 - 6,863,027 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111010 ⟹ ENSRNOP00000085929

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	6,834,623 - 6,869,410 (-)	Ensembl
mRatBN7.2 Ensembl	16	6,852,297 - 6,863,027 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117524 ⟹ ENSRNOP00000091949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	6,833,268 - 6,869,410 (-)	Ensembl
mRatBN7.2 Ensembl	16	6,824,906 - 6,863,015 (-)	Ensembl

RefSeq Acc Id:

NM_053493 ⟹ NP_445945

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	6,833,268 - 6,869,410 (-)	NCBI
mRatBN7.2	16	6,826,881 - 6,863,027 (-)	NCBI
Rnor_6.0	16	7,720,047 - 7,758,119 (-)	NCBI
Rnor_5.0	16	7,646,580 - 7,682,704 (-)	NCBI
RGSC_v3.4	16	7,073,038 - 7,108,830 (-)	RGD
Celera	16	8,335,334 - 8,371,457 (+)	RGD

Sequence:

show sequence

TCAGAAGCGGGTGTCACCAACAGCAAACGTGCGACCAACTCTTCGGCTAGTGAATCTCTAAGCC
GCGAAGAGTGCTTTGAAGTAGCTTTAGGTGGAAGATGTCAGAAAGTAACTCGGCAGAGGGTAGC
GACAGAAGCGAGGAGCAGGTGTCTGGTGCTAAAGTCATCGCCCAGGCCCTAAAAACGCAAGATG
TGGAGTACATGTTCGGTGTCGTAGGCATCCCCGTGACCGAAATCGCCCTTGCTGCCCAGGAACT
GGGCATCAAGTACATTGGGATGAGGAATGAGCAAGCGGCTTGTTACGCTGCCTCTGCGGTTGGA
TACCTAACGGGCAGGCCAGGAGTATGCCTCGTTGTTTCTGGTCCCGGCCTCATCCACGCCTTGG
GCGGCATGGCGAATGCAAACATGAACTGTTGGCCCTTGATTGTGATTGGTGGTTCTTCTGAAAG
GAATCAAGAAGCAATGGGAGCCTTCCAGGAGTTTCCTCAGGTTGAAGCTTGCAGATTATATTCC
AAGTTCTCTGCCCGGCCAAGCAGCATTCAGCACATTCCTTTTGTTATTGAAAAGGCAGTGAGGA
GCAGTATCTACGGTCGCCCGGGAGCGTGTTACATTGATGTTCCTGCAGACCTTGTGACCCTCCA
GGAGAGCACGACTTCTATAAAGTACAAGGAATGCTGCATGCCACCTCCACTTAGCCTGGCAGAA
ACCTCTGCTGTGCGTGCGGCAGCCTCTGTTCTTAGGAGCGCCAAGCAGCCCCTGCTCATCATCG
GGAAAGGCGCTGCTTATTCCCATGCAGAGGACAGCATCCGGAAGCTGGTGGAGCTGTGCAATCT
GCCATTTTTACCTACTCCCATGGGGAAGGGTGTCGTCCCTGACAACCACCCAAACTGTGTGGGT
GCGGCCAGATCCAGGGCTTTGCAGTTTGCTGATGTGATTGTGTTATTTGGTGCAAGACTCAACT
GGATATTACATTTTGGACTGCCGCCAAGGTACCAGGCAGACGTGAAGTTTATTCAGATTGATAT
CTGTGCAGAAGAACTGGGGAATAATGTAAGGCCTTCGGTGACTTTGCTAGGAGATGTAAATGCT
GTTTCTAAACAGCTTTTAGAACAGTTTGTTAAAAATCCATGGCAGTACCCCACAGACAGCAAAT
GGTGGGAGACTCTGAGGGAGAAAAGGAAGAACAATGAAGCCGTATCCAAGGAATTAGCTTCCAA
AAAATCCCTCCCTATGAATTATTACACAGTGTTCTACCATGTTCAAGAACAGTTGCCCAGGAAC
TGTTTCATAGTGAGCGAAGGAGCAAACACCATGGACATTGGACGGACTGTGCTTCAGAACTACC
TTCCTCGTCACCGGCTGGATGCCGGTTCCTTTGGAACAATGGGAGTTGGTTTGGGATTTGCCAT
TGCAGCTGCTGTGGTGGCTAAGGAGAGAAGCCCTGGGCAGCGGGTCATCTGTGTGGAAGGAGAC
AGTGCCTTTGGATTTTCCGGCATGGAAGTGGAAACCATCTGCAGGTACAACTTGCCAATCATAA
TCTTGGTAGTGAACAATAATGGAATTTACCAAGGTTTTGATGCTGACACCTGGGGGAAAATATT
AAATTTTCAAGGAACTGCTACAACAATCCCTCCAATGTGTCTGCTTCCAAACTCACACTACGAG
CAGGTCATGACTGCATTTGGAGGCAAAGGGTATTTTGTACAAACGCCAGAAGAGCTCCAAGACT
CGCTGAGGCAGGCTCTGAAAGACACAAGTAAACCGTGTCTTATCAACATCATGATTGAACCACA
AAGTACTCGGAAGGCCCAGGATTTTCACTGGCTCACCCGTTCCAACATATGAATAAACTACTTG
GCGTTTTTTGAGGCATTTTCTCTTTCCTACAAGGTAGAATTACCTTTTCATAGCAAAATTACCA
CAATGCTAACATTGTATTTAAAAATACACTTTAAATTGTCTTTTATAGTAAAGAAATTGATTAA
AGCTGTCATTATTTGTTAAAA

hide sequence

RefSeq Acc Id:

XM_063275790 ⟹ XP_063131860

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	6,833,268 - 6,869,362 (-)	NCBI

RefSeq Acc Id:

XM_063275791 ⟹ XP_063131861

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	6,833,465 - 6,869,362 (-)	NCBI

RefSeq Acc Id:

XM_063275792 ⟹ XP_063131862

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	6,831,293 - 6,869,362 (-)	NCBI

RefSeq Acc Id:

XR_010058324

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	6,831,293 - 6,869,362 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_445945	(Get FASTA)	NCBI Sequence Viewer
	XP_063131860	(Get FASTA)	NCBI Sequence Viewer
	XP_063131861	(Get FASTA)	NCBI Sequence Viewer
	XP_063131862	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78697	(Get FASTA)	NCBI Sequence Viewer
	CAC01252	(Get FASTA)	NCBI Sequence Viewer
	CAD56981	(Get FASTA)	NCBI Sequence Viewer
	EDL88941	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026588
	ENSRNOP00000026588.2
	ENSRNOP00000082285
	ENSRNOP00000085929
GenBank Protein	Q8CHM7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445945 ⟸ NM_053493

- UniProtKB:

Q8CHM7 (UniProtKB/Swiss-Prot), A6KFY4 (UniProtKB/TrEMBL), A0A8I6ACR4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSESNSAEGSDRSEEQVSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQ
AACYAASAVGYLTGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEF
PQVEACRLYSKFSARPSSIQHIPFVIEKAVRSSIYGRPGACYIDVPADLVTLQESTTSIKYKEC
CMPPPLSLAETSAVRAAASVLRSAKQPLLIIGKGAAYSHAEDSIRKLVELCNLPFLPTPMGKGV
VPDNHPNCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEELGNNVRP
SVTLLGDVNAVSKQLLEQFVKNPWQYPTDSKWWETLREKRKNNEAVSKELASKKSLPMNYYTVF
YHVQEQLPRNCFIVSEGANTMDIGRTVLQNYLPRHRLDAGSFGTMGVGLGFAIAAAVVAKERSP
GQRVICVEGDSAFGFSGMEVETICRYNLPIIILVVNNNGIYQGFDADTWGKILNFQGTATTIPP
MCLLPNSHYEQVMTAFGGKGYFVQTPEELQDSLRQALKDTSKPCLINIMIEPQSTRKAQDFHWL
TRSNI

hide sequence

Ensembl Acc Id:

ENSRNOP00000026588 ⟸ ENSRNOT00000026588

Ensembl Acc Id:

ENSRNOP00000085929 ⟸ ENSRNOT00000111010

Ensembl Acc Id:

ENSRNOP00000090650 ⟸ ENSRNOT00000102645

Ensembl Acc Id:

ENSRNOP00000091949 ⟸ ENSRNOT00000117524

Ensembl Acc Id:

ENSRNOP00000082285 ⟸ ENSRNOT00000108746

Ensembl Acc Id:

ENSRNOP00000090429 ⟸ ENSRNOT00000098301

RefSeq Acc Id:	XP_063131862 ⟸ XM_063275792
- Peptide Label:	isoform X3
- UniProtKB:	Q8CHM7 (UniProtKB/Swiss-Prot), A6KFY4 (UniProtKB/TrEMBL), A0A8I6ACR4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063131860 ⟸ XM_063275790
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G9A1 (UniProtKB/TrEMBL), A0A8I6ACR4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063131861 ⟸ XM_063275791
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6ACR4 (UniProtKB/TrEMBL)

Protein Domains

Thiamine pyrophosphate enzyme central Thiamine pyrophosphate enzyme N-terminal TPP- Thiamine pyrophosphate enzyme TPP-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8CHM7-F1-model_v2	AlphaFold	Q8CHM7	1-581	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699935

Promoter ID:

EPDNEW_R10458

Type:

multiple initiation site

Name:

Hacl1_1

Description:

2-hydroxyacyl-CoA lyase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	7,758,117 - 7,758,177	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619849	AgrOrtholog
BioCyc Gene	G2FUF-12137	BioCyc
BioCyc Pathway	PWY66-387 [3-methyl-branched fatty acid alpha-oxidation]	BioCyc
	PWY66-388 [ceramide degradation by alpha-oxidation]	BioCyc
BioCyc Pathway Image	PWY66-387	BioCyc
	PWY66-388	BioCyc
Ensembl Genes	ENSRNOG00000019630	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000026588	ENTREZGENE
	ENSRNOT00000026588.4	UniProtKB/Swiss-Prot
	ENSRNOT00000108746	ENTREZGENE
	ENSRNOT00000111010	ENTREZGENE
Gene3D-CATH	3.40.50.970	UniProtKB/Swiss-Prot
	TPP-binding domain	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7110355	IMAGE-MGC_LOAD
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/Swiss-Prot
	HACL1-like	UniProtKB/Swiss-Prot
	THDP-binding	UniProtKB/Swiss-Prot
	Thiamin_PyroP_enz_cen_dom	UniProtKB/Swiss-Prot
	Thiamin_PyroP_enz_TPP-bd_dom	UniProtKB/Swiss-Prot
	TPP_enzyme-bd_C	UniProtKB/Swiss-Prot
KEGG Report	rno:85255	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93083	IMAGE-MGC_LOAD
NCBI Gene	85255	ENTREZGENE
PANTHER	2-HYDROXYACYL-COA LYASE 1	UniProtKB/Swiss-Prot
	PTHR43710	UniProtKB/Swiss-Prot
Pfam	TPP_enzyme_C	UniProtKB/Swiss-Prot
	TPP_enzyme_M	UniProtKB/Swiss-Prot
	TPP_enzyme_N	UniProtKB/Swiss-Prot
PhenoGen	Hacl1	PhenoGen
RatGTEx	ENSRNOG00000019630	RatGTEx
Superfamily-SCOP	SSF52467	UniProtKB/Swiss-Prot
	SSF52518	UniProtKB/Swiss-Prot
UniProt	A0A8I6A4D4_RAT	UniProtKB/TrEMBL
	A0A8I6ACR4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G9A1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GIV8_RAT	UniProtKB/TrEMBL
	A6KFY4	ENTREZGENE, UniProtKB/TrEMBL
	HACL1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-22	Hacl1	2-hydroxyacyl-CoA lyase 1	Phyh2	phytanoyl-CoA 2-hydroxylase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Phyh2	phytanoyl-CoA 2-hydroxylase 2		phytanoyl-Coenzyme A 2-hydroxylase 2	Symbol and Name updated	1299863	APPROVED
2006-03-27	Phyh2	phytanoyl-Coenzyme A 2-hydroxylase 2	Hpcl2	2-hydroxyphytanoyl-Coenzyme A lyase	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2005-01-20	Hpcl2	2-hydroxyphytanoyl-Coenzyme A lyase		2-hydroxyphytanoyl-CoA lyase	Name updated	1299863	APPROVED
2002-08-07	Hpcl2	2-hydroxyphytanoyl-CoA lyase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIA

Imported Annotations - SMPDB

BioCyc Pathways

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