Kcnk10 (potassium two pore domain channel subfamily K member 10) - Rat Genome Database

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Gene: Kcnk10 (potassium two pore domain channel subfamily K member 10) Rattus norvegicus
Analyze
Symbol: Kcnk10
Name: potassium two pore domain channel subfamily K member 10
RGD ID: 619732
Description: Enables potassium channel activity. Involved in memory. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of brain ischemia. Orthologous to human KCNK10 (potassium two pore domain channel subfamily K member 10); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: outward rectifying potassium channel protein TREK-2; potassium channel subfamily K member 10; potassium channel TREK-2; potassium channel, subfamily K, member 10; potassium channel, two pore domain subfamily K, member 10; TREK-2 K(+) channel subunit; TREK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,419,778 - 123,555,820 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6123,423,950 - 123,555,614 (-)EnsemblGRCr8
mRatBN7.26117,690,052 - 117,826,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,694,222 - 117,825,695 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6117,844,163 - 117,973,353 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06118,140,969 - 118,270,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,475,841 - 117,605,022 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,417,079 - 122,549,532 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,419,046 - 122,545,899 (-)Ensemblrn6Rnor6.0
Rnor_5.06131,631,562 - 131,760,720 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46122,600,156 - 122,729,583 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,256,086 - 115,384,773 (-)NCBICelera
RGSC_v3.16122,603,902 - 122,733,330 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
brain ischemia  (IEP)
Deafness  (IEP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family. Bang H, etal., J Biol Chem 2000 Jun 9;275(23):17412-9.
2. Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus. Cui YL, etal., Neuroscience. 2007 Oct 26;149(2):421-33. Epub 2007 Jul 17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes. Gnatenco C, etal., Brain Res 2002 Mar 22;931(1):56-67.
5. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. Gu W, etal., J Physiol 2002 Mar 15;539(Pt 3):657-68.
6. Characterization of four types of background potassium channels in rat cerebellar granule neurons. Han J, etal., J Physiol 2002 Jul 15;542(Pt 2):431-44.
7. Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia. Li ZB, etal., Biochem Biophys Res Commun. 2005 Feb 25;327(4):1163-9.
8. The inhibitor of volume-regulated anion channels DCPIB activates TREK potassium channels in cultured astrocytes. Minieri L, etal., Br J Pharmacol. 2013 Mar;168(5):1240-54. doi: 10.1111/bph.12011.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. [mRNA expression alteration of two-pore potassium channels in the brain of beta-amyloid peptide25-35-induced memory impaired rats]. Pan YP, etal., Yao Xue Xue Bao. 2003 Oct;38(10):721-4.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15677687   PMID:16672694   PMID:17540699   PMID:18845607   PMID:19244246   PMID:19429069   PMID:19439530   PMID:19640481   PMID:21306568   PMID:23219908   PMID:24453337   PMID:25501330  
PMID:25886567   PMID:27609046   PMID:29980241   PMID:34461754   PMID:35907583  


Genomics

Comparative Map Data
Kcnk10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,419,778 - 123,555,820 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6123,423,950 - 123,555,614 (-)EnsemblGRCr8
mRatBN7.26117,690,052 - 117,826,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,694,222 - 117,825,695 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6117,844,163 - 117,973,353 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06118,140,969 - 118,270,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,475,841 - 117,605,022 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,417,079 - 122,549,532 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,419,046 - 122,545,899 (-)Ensemblrn6Rnor6.0
Rnor_5.06131,631,562 - 131,760,720 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46122,600,156 - 122,729,583 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,256,086 - 115,384,773 (-)NCBICelera
RGSC_v3.16122,603,902 - 122,733,330 (-)NCBI
Cytogenetic Map6q32NCBI
KCNK10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381488,180,108 - 88,326,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1488,180,103 - 88,326,907 (-)Ensemblhg38GRCh38
GRCh371488,646,452 - 88,793,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361487,720,993 - 87,863,004 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341487,720,999 - 87,863,004NCBI
Celera1468,692,135 - 68,838,993 (-)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1468,816,576 - 68,963,621 (-)NCBIHuRef
CHM1_11488,584,550 - 88,731,289 (-)NCBICHM1_1
T2T-CHM13v2.01482,400,736 - 82,547,879 (-)NCBIT2T-CHM13v2.0
Kcnk10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,395,691 - 98,544,472 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,395,696 - 98,544,569 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381298,429,432 - 98,578,213 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,429,437 - 98,578,310 (-)Ensemblmm10GRCm38
MGSCv371299,672,204 - 99,816,150 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361298,835,044 - 98,978,990 (-)NCBIMGSCv36mm8
Celera1299,659,474 - 99,802,888 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.86NCBI
Kcnk10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543810,873,131 - 10,999,441 (-)Ensembl
ChiLan1.0NW_00495543810,867,695 - 10,996,005 (-)NCBIChiLan1.0ChiLan1.0
KCNK10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21589,318,727 - 89,465,402 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11488,535,233 - 88,681,901 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01468,792,290 - 68,938,947 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11488,152,288 - 88,298,811 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1488,157,714 - 88,235,878 (-)EnsemblpanPan2panpan1.1
KCNK10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,484,385 - 59,612,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,484,328 - 59,612,750 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha859,058,106 - 59,190,884 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0859,748,550 - 59,882,007 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,753,288 - 59,882,355 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,426,150 - 59,559,090 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,472,627 - 59,606,367 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0859,806,721 - 59,940,310 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnk10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,240,409 - 16,371,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648815,698,143 - 15,827,661 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648815,698,137 - 15,773,582 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7110,121,263 - 110,271,481 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17110,117,087 - 110,271,877 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,613,778 - 116,770,316 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12465,835,010 - 65,989,030 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2465,835,650 - 65,987,964 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605353,194,967 - 53,339,806 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473413,990,495 - 14,156,674 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473414,062,218 - 14,161,869 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnk10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17111,599,636 - 111,730,004 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnk10
895 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:655
Count of miRNA genes:282
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000005175
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 6 30 157 48 44 16 51 16 3 219 106 10 138 75 92 28 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005175   ⟹   ENSRNOP00000005175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,423,950 - 123,552,184 (-)Ensembl
mRatBN7.2 Ensembl6117,694,222 - 117,822,463 (-)Ensembl
Rnor_6.0 Ensembl6122,419,046 - 122,545,899 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100878   ⟹   ENSRNOP00000093775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,423,950 - 123,527,591 (-)Ensembl
mRatBN7.2 Ensembl6117,694,222 - 117,825,695 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102643   ⟹   ENSRNOP00000094177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,446,303 - 123,552,184 (-)Ensembl
mRatBN7.2 Ensembl6117,716,575 - 117,822,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111719   ⟹   ENSRNOP00000092512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,423,950 - 123,552,833 (-)Ensembl
mRatBN7.2 Ensembl6117,694,222 - 117,823,319 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141601   ⟹   ENSRNOP00000107366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,423,950 - 123,555,614 (-)Ensembl
RefSeq Acc Id: NM_023096   ⟹   NP_075584
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,423,950 - 123,552,184 (-)NCBI
mRatBN7.26117,694,222 - 117,822,463 (-)NCBI
Rnor_6.06122,419,046 - 122,545,899 (-)NCBI
Rnor_5.06131,631,562 - 131,760,720 (-)NCBI
RGSC_v3.46122,600,156 - 122,729,583 (-)RGD
Celera6115,256,086 - 115,384,773 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764847   ⟹   XP_008763069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,419,778 - 123,555,228 (-)NCBI
mRatBN7.26117,690,052 - 117,824,000 (-)NCBI
Rnor_6.06122,417,079 - 122,547,492 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594351   ⟹   XP_017449840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,419,778 - 123,555,820 (-)NCBI
mRatBN7.26117,690,052 - 117,826,120 (-)NCBI
Rnor_6.06122,417,079 - 122,549,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112918   ⟹   XP_038968846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,425,507 - 123,552,344 (-)NCBI
mRatBN7.26117,695,775 - 117,822,610 (-)NCBI
RefSeq Acc Id: XM_063262460   ⟹   XP_063118530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,425,508 - 123,555,228 (-)NCBI
RefSeq Acc Id: NP_075584   ⟸   NM_023096
- UniProtKB: Q548D8 (UniProtKB/Swiss-Prot),   Q9JIS4 (UniProtKB/Swiss-Prot),   A6JEE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763069   ⟸   XM_008764847
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449840   ⟸   XM_017594351
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AXI0 (UniProtKB/TrEMBL),   A6JEE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005175   ⟸   ENSRNOT00000005175
RefSeq Acc Id: XP_038968846   ⟸   XM_039112918
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000092512   ⟸   ENSRNOT00000111719
Ensembl Acc Id: ENSRNOP00000093775   ⟸   ENSRNOT00000100878
Ensembl Acc Id: ENSRNOP00000094177   ⟸   ENSRNOT00000102643
RefSeq Acc Id: XP_063118530   ⟸   XM_063262460
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000107366   ⟸   ENSRNOT00000141601
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIS4-F1-model_v2 AlphaFold Q9JIS4 1-538 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619732 AgrOrtholog
BioCyc Gene G2FUF-36541 BioCyc
Ensembl Genes ENSRNOG00000003813 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005175 ENTREZGENE
  ENSRNOT00000005175.5 UniProtKB/Swiss-Prot
  ENSRNOT00000111719 ENTREZGENE
  ENSRNOT00000141601 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
InterPro 2pore_dom_K_chnl UniProtKB/Swiss-Prot
  2pore_dom_K_chnl_TREK UniProtKB/Swiss-Prot
  K_chnl_dom UniProtKB/Swiss-Prot
KEGG Report rno:65272 UniProtKB/Swiss-Prot
NCBI Gene 65272 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 10 UniProtKB/Swiss-Prot
  PTHR11003 UniProtKB/Swiss-Prot
Pfam Ion_trans_2 UniProtKB/Swiss-Prot
PhenoGen Kcnk10 PhenoGen
PRINTS 2POREKCHANEL UniProtKB/Swiss-Prot
  TREKCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003813 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A8I6AHS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AXI0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL17_RAT UniProtKB/TrEMBL
  A0ABK0LQG5_RAT UniProtKB/TrEMBL
  A6JEE2 ENTREZGENE, UniProtKB/TrEMBL
  A6JEE3 ENTREZGENE, UniProtKB/TrEMBL
  KCNKA_RAT UniProtKB/Swiss-Prot
  Q548D8 ENTREZGENE
  Q9JIS4 ENTREZGENE
UniProt Secondary Q548D8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnk10  potassium two pore domain channel subfamily K member 10  Kcnk10  potassium channel, two pore domain subfamily K, member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk10  potassium channel, two pore domain subfamily K, member 10  Kcnk10  potassium channel, subfamily K, member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnk10  potassium channel, subfamily K, member 10    potassium channel TREK-2  Name updated 1299863 APPROVED
2002-08-07 Kcnk10  potassium channel TREK-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in cerebellum, spleen, and testis 633171