Unc13b (unc-13 homolog B) - Rat Genome Database

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Gene: Unc13b (unc-13 homolog B) Rattus norvegicus
Analyze
Symbol: Unc13b
Name: unc-13 homolog B
RGD ID: 619723
Description: Enables calmodulin binding activity and syntaxin-1 binding activity. Involved in several processes, including positive regulation of inhibitory postsynaptic potential; regulation of secretion by cell; and secretion by cell. Located in cytosol; synaptic membrane; and terminal bouton. Orthologous to human UNC13B (unc-13 homolog B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; allethrin; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Munc13-2; unc-13 homolog B (C. elegans); Unc13h2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,084,809 - 62,299,884 (+)NCBIGRCr8
mRatBN7.2557,288,999 - 57,504,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,289,227 - 57,502,926 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,262,249 - 59,477,176 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,081,066 - 61,295,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,066,236 - 61,280,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,505,449 - 58,714,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,505,500 - 58,715,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,030,715 - 63,240,229 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,551,928 - 59,768,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,716,002 - 59,769,080 (+)NCBI
Celera555,876,984 - 56,089,901 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
graphite  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methoxyacetic acid  (ISO)
Methylazoxymethanol acetate  (EXP)
Monobutylphthalate  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pyrethrins  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential expression of two novel Munc13 proteins in rat brain. Augustin I, etal., Biochem J. 1999 Feb 1;337 ( Pt 3):363-71.
2. Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Betz A, etal., Neuron 2001 Apr;30(1):183-96.
3. Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. Brose N, etal., J Biol Chem 1995 Oct 20;270(42):25273-80.
4. RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Deng L, etal., Neuron. 2011 Jan 27;69(2):317-31. doi: 10.1016/j.neuron.2011.01.005.
5. Structural insights into the calmodulin-Munc13 interaction obtained by cross-linking and mass spectrometry. Dimova K, etal., Biochemistry. 2009 Jun 30;48(25):5908-21. doi: 10.1021/bi900300r.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia. Goldenberg NM and Silverman M, Am J Physiol Cell Physiol. 2009 Oct;297(4):C1053-8. doi: 10.1152/ajpcell.00286.2009. Epub 2009 Jul 29.
9. CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis. Kabachinski G, etal., Mol Biol Cell. 2014 Feb;25(4):508-21. doi: 10.1091/mbc.E12-11-0829. Epub 2013 Dec 19.
10. Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity. Lipstein N, etal., Mol Cell Biol. 2012 Nov;32(22):4628-41. doi: 10.1128/MCB.00933-12. Epub 2012 Sep 10.
11. Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Man KN, etal., Elife. 2015 Nov 17;4. pii: e10635. doi: 10.7554/eLife.10635.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators. Persoon CM, etal., Neuron. 2019 Dec 18;104(6):1065-1080.e12. doi: 10.1016/j.neuron.2019.09.015. Epub 2019 Oct 31.
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9607201   PMID:9697857   PMID:10233166   PMID:11792326   PMID:11832228   PMID:12070347   PMID:15294163   PMID:15988013   PMID:16138900   PMID:16704978   PMID:19558619   PMID:19700493  
PMID:22248876   PMID:22674279   PMID:23197834   PMID:23229896   PMID:23658173   PMID:25374362   PMID:28264913   PMID:31936129  


Genomics

Comparative Map Data
Unc13b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,084,809 - 62,299,884 (+)NCBIGRCr8
mRatBN7.2557,288,999 - 57,504,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,289,227 - 57,502,926 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,262,249 - 59,477,176 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,081,066 - 61,295,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,066,236 - 61,280,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,505,449 - 58,714,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,505,500 - 58,715,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,030,715 - 63,240,229 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,551,928 - 59,768,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,716,002 - 59,769,080 (+)NCBI
Celera555,876,984 - 56,089,901 (+)NCBICelera
Cytogenetic Map5q22NCBI
UNC13B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,162,009 - 35,405,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,161,992 - 35,405,338 (+)EnsemblGRCh38hg38GRCh38
GRCh37935,162,006 - 35,405,332 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,151,989 - 35,395,332 (+)NCBINCBI36Build 36hg18NCBI36
Build 34935,152,058 - 35,395,331NCBI
Celera935,093,995 - 35,337,320 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,117,517 - 35,359,509 (+)NCBIHuRef
CHM1_1935,161,866 - 35,405,103 (+)NCBICHM1_1
T2T-CHM13v2.0935,181,209 - 35,424,479 (+)NCBIT2T-CHM13v2.0
Unc13b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,046,193 - 43,264,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,058,953 - 43,264,871 (+)EnsemblGRCm39 Ensembl
GRCm38443,046,193 - 43,264,873 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,058,953 - 43,264,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv37443,071,856 - 43,277,759 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,080,053 - 43,285,973 (+)NCBIMGSCv36mm8
Celera443,089,000 - 43,293,387 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.0NCBI
UNC13B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,184,307 - 89,431,211 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,190,246 - 89,437,207 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,011,350 - 35,255,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,817,353 - 36,059,895 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,817,353 - 36,059,894 (+)Ensemblpanpan1.1panPan2
UNC13B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,707,968 - 51,941,148 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,708,302 - 51,940,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,276,777 - 50,508,946 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01152,773,675 - 53,006,449 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,773,727 - 53,006,464 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,388,636 - 51,551,200 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,302,640 - 51,534,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,004,520 - 52,236,429 (+)NCBIUU_Cfam_GSD_1.0
Unc13b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,680,023 - 166,822,285 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365243,320,859 - 3,369,865 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC13B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1235,918,747 - 236,158,098 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11235,918,751 - 236,158,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21263,840,380 - 263,877,078 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103219228
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,230,661 - 45,461,934 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,230,659 - 45,461,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,341,062 - 42,574,219 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc13b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624915327,401 - 531,886 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624915327,633 - 530,522 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Unc13b
883 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:36
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000043216, ENSRNOT00000064755, ENSRNOT00000067281
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
AU046617  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0558,526,945 - 58,527,136NCBIRnor6.0
Rnor_5.0563,052,202 - 63,052,393UniSTSRnor5.0
RGSC_v3.4559,573,380 - 59,573,571UniSTSRGSC3.4
Celera555,898,470 - 55,898,661UniSTS
Cytogenetic Map5q22UniSTS
PMC30485P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,498,429 - 57,498,861 (+)MAPPERmRatBN7.2
Rnor_6.0558,709,900 - 58,710,331NCBIRnor6.0
Rnor_5.0563,235,733 - 63,236,164UniSTSRnor5.0
RGSC_v3.4559,764,405 - 59,764,836UniSTSRGSC3.4
Celera556,085,402 - 56,085,833UniSTS
Cytogenetic Map5q22UniSTS
RH130683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,343,780 - 57,343,975 (+)MAPPERmRatBN7.2
Rnor_6.0558,559,867 - 58,560,062NCBIRnor6.0
Rnor_5.0563,085,205 - 63,085,400UniSTSRnor5.0
RGSC_v3.4559,606,097 - 59,606,292UniSTSRGSC3.4
Celera555,931,495 - 55,931,690UniSTS
Cytogenetic Map5q22UniSTS
RH142716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,313,837 - 57,314,019 (+)MAPPERmRatBN7.2
Rnor_6.0558,530,056 - 58,530,237NCBIRnor6.0
Rnor_5.0563,055,313 - 63,055,494UniSTSRnor5.0
RGSC_v3.4559,576,491 - 59,576,672UniSTSRGSC3.4
Celera555,901,581 - 55,901,762UniSTS
Cytogenetic Map5q22UniSTS
RH134618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,331,770 - 57,331,967 (+)MAPPERmRatBN7.2
mRatBN7.2411,449,634 - 11,449,831 (-)MAPPERmRatBN7.2
mRatBN7.2557,331,770 - 57,331,967 (-)MAPPERmRatBN7.2
mRatBN7.2411,449,634 - 11,449,831 (+)MAPPERmRatBN7.2
Rnor_6.0558,548,211 - 58,548,407NCBIRnor6.0
Rnor_6.047,978,966 - 7,979,162NCBIRnor6.0
Rnor_5.0563,073,363 - 63,073,559UniSTSRnor5.0
Rnor_5.047,986,868 - 7,987,064UniSTSRnor5.0
RGSC_v3.4559,594,398 - 59,594,594UniSTSRGSC3.4
RGSC_v3.446,824,971 - 6,825,167UniSTSRGSC3.4
Celera47,061,262 - 7,061,458UniSTS
Celera555,919,497 - 55,919,693UniSTS
Cytogenetic Map5q22UniSTS
AU049544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,372,392 - 57,372,662 (+)MAPPERmRatBN7.2
Rnor_6.0558,586,092 - 58,586,359NCBIRnor6.0
Rnor_5.0563,112,160 - 63,112,427UniSTSRnor5.0
RGSC_v3.4559,635,604 - 59,635,871UniSTSRGSC3.4
Celera555,959,562 - 55,959,833UniSTS
Cytogenetic Map5q22UniSTS
MARC_17336-17337:1021394418:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,498,832 - 57,499,457 (+)MAPPERmRatBN7.2
Rnor_6.0558,710,303 - 58,710,927NCBIRnor6.0
Rnor_5.0563,236,136 - 63,236,760UniSTSRnor5.0
RGSC_v3.4559,764,808 - 59,765,432UniSTSRGSC3.4
Celera556,085,805 - 56,086,429UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF159706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U24071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000043216   ⟹   ENSRNOP00000046751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,289,227 - 57,502,926 (+)Ensembl
Rnor_6.0 Ensembl558,505,500 - 58,715,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064755   ⟹   ENSRNOP00000058802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,289,227 - 57,502,926 (+)Ensembl
Rnor_6.0 Ensembl558,667,885 - 58,714,247 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067281   ⟹   ENSRNOP00000058915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,337,228 - 57,502,926 (+)Ensembl
Rnor_6.0 Ensembl558,636,083 - 58,714,241 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078274   ⟹   ENSRNOP00000073250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,449,853 - 57,502,926 (+)Ensembl
Rnor_6.0 Ensembl558,661,049 - 58,714,396 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112338   ⟹   ENSRNOP00000087301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,289,227 - 57,502,926 (+)Ensembl
RefSeq Acc Id: NM_001042579   ⟹   NP_001036044
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,085,037 - 62,299,884 (+)NCBI
mRatBN7.2557,289,227 - 57,504,110 (+)NCBI
Rnor_6.0558,505,449 - 58,714,396 (+)NCBI
Rnor_5.0563,030,715 - 63,240,229 (+)NCBI
RGSC_v3.4559,551,928 - 59,768,901 (+)RGD
Celera555,876,984 - 56,089,901 (+)RGD
Sequence:
RefSeq Acc Id: NM_022862   ⟹   NP_074053
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,245,629 - 62,299,884 (+)NCBI
mRatBN7.2557,449,853 - 57,504,110 (+)NCBI
Rnor_6.0558,661,049 - 58,714,396 (+)NCBI
Rnor_5.0563,030,715 - 63,240,229 (+)NCBI
RGSC_v3.4559,551,928 - 59,768,901 (+)RGD
Celera556,036,692 - 56,089,901 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110716   ⟹   XP_038966644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,245,859 - 62,299,882 (+)NCBI
mRatBN7.2557,450,086 - 57,502,777 (+)NCBI
RefSeq Acc Id: XM_039110717   ⟹   XP_038966645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,084,815 - 62,299,882 (+)NCBI
mRatBN7.2557,288,999 - 57,503,198 (+)NCBI
RefSeq Acc Id: XM_039110721   ⟹   XP_038966649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,084,815 - 62,299,882 (+)NCBI
mRatBN7.2557,288,999 - 57,502,777 (+)NCBI
RefSeq Acc Id: XM_039110722   ⟹   XP_038966650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,084,815 - 62,299,882 (+)NCBI
mRatBN7.2557,288,999 - 57,502,777 (+)NCBI
RefSeq Acc Id: XM_039110723   ⟹   XP_038966651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,084,815 - 62,299,882 (+)NCBI
mRatBN7.2557,288,999 - 57,502,777 (+)NCBI
RefSeq Acc Id: XM_039110724   ⟹   XP_038966652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,084,815 - 62,299,882 (+)NCBI
mRatBN7.2557,288,999 - 57,502,777 (+)NCBI
RefSeq Acc Id: XM_063288357   ⟹   XP_063144427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,243,806 - 62,299,882 (+)NCBI
RefSeq Acc Id: XM_063288358   ⟹   XP_063144428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,243,806 - 62,299,882 (+)NCBI
RefSeq Acc Id: XM_063288359   ⟹   XP_063144429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,245,859 - 62,299,882 (+)NCBI
RefSeq Acc Id: XM_063288360   ⟹   XP_063144430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,084,809 - 62,299,882 (+)NCBI
RefSeq Acc Id: XM_063288361   ⟹   XP_063144431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,220,092 - 62,299,882 (+)NCBI
RefSeq Acc Id: XM_063288363   ⟹   XP_063144433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,244,831 - 62,299,882 (+)NCBI
RefSeq Acc Id: XM_063288364   ⟹   XP_063144434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,084,815 - 62,299,882 (+)NCBI
RefSeq Acc Id: NP_074053   ⟸   NM_022862
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: NP_001036044   ⟸   NM_001042579
- Peptide Label: isoform u
- UniProtKB: Q9WV40 (UniProtKB/Swiss-Prot),   Q62769 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058915   ⟸   ENSRNOT00000067281
Ensembl Acc Id: ENSRNOP00000046751   ⟸   ENSRNOT00000043216
Ensembl Acc Id: ENSRNOP00000073250   ⟸   ENSRNOT00000078274
Ensembl Acc Id: ENSRNOP00000058802   ⟸   ENSRNOT00000064755
RefSeq Acc Id: XP_038966645   ⟸   XM_039110717
- Peptide Label: isoform X4
- UniProtKB: Q9WV40 (UniProtKB/Swiss-Prot),   Q62769 (UniProtKB/Swiss-Prot),   A6IJ08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966650   ⟸   XM_039110722
- Peptide Label: isoform X6
- UniProtKB: Q9WV40 (UniProtKB/Swiss-Prot),   Q62769 (UniProtKB/Swiss-Prot),   F1LXM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966651   ⟸   XM_039110723
- Peptide Label: isoform X7
- UniProtKB: Q9WV40 (UniProtKB/Swiss-Prot),   Q62769 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038966649   ⟸   XM_039110721
- Peptide Label: isoform X5
- UniProtKB: Q9WV40 (UniProtKB/Swiss-Prot),   Q62769 (UniProtKB/Swiss-Prot),   D3Z9Y2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966652   ⟸   XM_039110724
- Peptide Label: isoform X8
- UniProtKB: Q9WV40 (UniProtKB/Swiss-Prot),   Q62769 (UniProtKB/Swiss-Prot),   A6IJ09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966644   ⟸   XM_039110716
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000087301   ⟸   ENSRNOT00000112338
RefSeq Acc Id: XP_063144430   ⟸   XM_063288360
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063144434   ⟸   XM_063288364
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063144431   ⟸   XM_063288361
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063144428   ⟸   XM_063288358
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K511 (UniProtKB/TrEMBL),   A6IJ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144427   ⟸   XM_063288357
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K511 (UniProtKB/TrEMBL),   A6IJ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144433   ⟸   XM_063288363
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063144429   ⟸   XM_063288359
- Peptide Label: isoform X2
Protein Domains
C2   MHD1   MHD2   Phorbol-ester/DAG-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62769-F1-model_v2 AlphaFold Q62769 1-1622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693670
Promoter ID:EPDNEW_R4195
Type:single initiation site
Name:Unc13b_1
Description:unc-13 homolog B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0558,505,484 - 58,505,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619723 AgrOrtholog
BioCyc Gene G2FUF-41522 BioCyc
Ensembl Genes ENSRNOG00000008237 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043216.6 UniProtKB/TrEMBL
  ENSRNOT00000064755.4 UniProtKB/TrEMBL
  ENSRNOT00000067281.5 UniProtKB/TrEMBL
  ENSRNOT00000078274.2 UniProtKB/TrEMBL
  ENSRNOT00000112338.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.357.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.1100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAPS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Munc13_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Munc13_dom-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Unc-13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Unc-13_C2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64830 UniProtKB/Swiss-Prot
NCBI Gene 64830 ENTREZGENE
PANTHER PROTEIN UNC-13 HOMOLOG B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Unc13b PhenoGen
PRINTS C2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MHD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008237 RatGTEx
SMART DUF1041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K511 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGA8_RAT UniProtKB/TrEMBL
  A6IJ08 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ09 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ10 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9Y2 ENTREZGENE, UniProtKB/TrEMBL
  F1LTC1_RAT UniProtKB/TrEMBL
  F1LXM4 ENTREZGENE, UniProtKB/TrEMBL
  Q62769 ENTREZGENE
  Q9WV40 ENTREZGENE
  UN13B_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9WV40 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Unc13b  unc-13 homolog B  Unc13b  unc-13 homolog B (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Unc13b  unc-13 homolog B (C. elegans)  Unc13h2  Munc13-2 protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Unc13h2  Munc13-2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL