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Gene: Sv2c (synaptic vesicle glycoprotein 2c) Rattus norvegicus

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Symbol:

Sv2c

Name:

synaptic vesicle glycoprotein 2c

RGD ID:

619718

Description:

Predicted to enable transmembrane transporter activity. Involved in negative regulation of excitatory postsynaptic potential. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human SV2C (synaptic vesicle glycoprotein 2C); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

synaptic vesicle protein 2C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SV2C (synaptic vesicle glycoprotein 2C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sv2c (synaptic vesicle glycoprotein 2c)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sv2c (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SV2C (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SV2C (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sv2c (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SV2C (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SV2C (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sv2c (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sv2c (synaptic vesicle glycoprotein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SV2C (synaptic vesicle glycoprotein 2C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sv2c (synaptic vesicle glycoprotein 2c)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sv2ca (synaptic vesicle glycoprotein 2Ca)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3168	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sv2c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sv2c	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	28,967,631 - 29,163,168 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	28,964,582 - 29,163,168 (-)	Ensembl				GRCr8
mRatBN7.2	2	27,232,933 - 27,428,479 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	27,232,933 - 27,428,477 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	34,272,667 - 34,465,181 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	32,372,766 - 32,565,287 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	27,188,759 - 27,389,783 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	26,495,757 - 26,707,691 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	26,501,833 - 26,699,333 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	45,631,737 - 45,828,663 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	26,326,862 - 26,555,019 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	23,293,289 - 23,483,743 (-)	NCBI		Celera
RGSC_v3.1	2	26,247,230 - 26,475,388 (-)	NCBI
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

spinal muscular atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

Botulinum toxin type A (ISO)

Butylbenzyl phthalate (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

genistein (ISO)

lead diacetate (EXP,ISO)

mercury dibromide (ISO)

methamphetamine (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

panobinostat (ISO)

PCB138 (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

silicon dioxide (EXP)

sodium arsenite (ISO)

sodium chloride (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemical synaptic transmission (IEA)

negative regulation of excitatory postsynaptic potential (IMP)

neurotransmitter transport (IEA)

regulation of synaptic vesicle exocytosis (IBA,ISO)

transmembrane transport (IEA)

Cellular Component

cytoplasmic vesicle (IEA)

dopaminergic synapse (ISO)

membrane (IEA)

nucleoplasm (ISO)

synaptic vesicle (IDA,IEA,ISO)

synaptic vesicle membrane (EXP,IBA,IDA,IEA)

Molecular Function

protein binding (IPI,ISO)

transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cell-extracellular matrix signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.	Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles.	Janz R, etal., J Neurosci 1998 Nov 15;18(22):9269-81.
4.	The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.	Mahrhold S, etal., FEBS Lett. 2006 Apr 3;580(8):2011-4. Epub 2006 Mar 7.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	SV2A and SV2C contain a unique synaptotagmin-binding site.	Schivell AE, etal., Mol Cell Neurosci. 2005 May;29(1):56-64. doi: 10.1016/j.mcn.2004.12.011.
12.	Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.	Strotmeier J, etal., FEBS Lett. 2014 Apr 2;588(7):1087-93. doi: 10.1016/j.febslet.2014.02.034. Epub 2014 Feb 25.
13.	Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy.	Tejero R, etal., Hum Mol Genet. 2016 Aug 29. pii: ddw297.

Additional References at PubMed

PMID:10625067	PMID:12687700	PMID:16306227	PMID:16543415

Genomics

Comparative Map Data

Sv2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	28,967,631 - 29,163,168 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	28,964,582 - 29,163,168 (-)	Ensembl				GRCr8
mRatBN7.2	2	27,232,933 - 27,428,479 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	27,232,933 - 27,428,477 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	34,272,667 - 34,465,181 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	32,372,766 - 32,565,287 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	27,188,759 - 27,389,783 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	26,495,757 - 26,707,691 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	26,501,833 - 26,699,333 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	45,631,737 - 45,828,663 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	26,326,862 - 26,555,019 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	23,293,289 - 23,483,743 (-)	NCBI		Celera
RGSC_v3.1	2	26,247,230 - 26,475,388 (-)	NCBI
Cytogenetic Map	2	q12	NCBI

SV2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	75,847,464 - 76,353,939 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	76,083,383 - 76,353,939 (+)	Ensembl			hg38	GRCh38
GRCh37	5	75,379,208 - 75,649,764 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	75,415,061 - 75,657,172 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	75,526,658 - 75,661,645	NCBI
Celera	5	71,320,469 - 71,515,084 (+)	NCBI		Celera
Cytogenetic Map	5	q13.3	NCBI
HuRef	5	70,632,037 - 70,829,092 (+)	NCBI		HuRef
CHM1_1	5	74,860,605 - 75,054,059 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	76,328,570 - 76,835,704 (+)	NCBI		T2T-CHM13v2.0

Sv2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	96,091,102 - 96,270,837 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	96,091,102 - 96,269,085 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	95,959,443 - 96,132,577 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	95,954,594 - 96,132,577 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	96,729,398 - 96,902,532 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	97,060,142 - 97,233,276 (-)	NCBI		MGSCv36	mm8
Celera	13	99,577,609 - 99,753,046 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	50.47	NCBI

Sv2c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	24,496,434 - 24,683,179 (-)	Ensembl
ChiLan1.0	NW_004955425	24,489,304 - 24,682,555 (-)	NCBI	ChiLan1.0	ChiLan1.0

SV2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	38,969,968 - 39,223,327 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	37,123,598 - 37,376,956 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	38,969,056 - 39,222,300 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	39,566,207 - 39,836,653 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	39,566,207 - 39,836,852 (-)	Ensembl			panPan2	panpan1.1

SV2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	30,232,892 - 30,440,046 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	30,232,710 - 30,440,327 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	31,469,780 - 31,678,170 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	30,156,170 - 30,363,724 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	30,156,894 - 30,363,969 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	30,087,278 - 30,241,695 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	30,066,666 - 30,270,719 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	30,437,678 - 30,645,896 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sv2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	190,039,748 - 190,265,745 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	590,978 - 765,741 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936549	592,975 - 819,252 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SV2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	84,996,716 - 85,236,130 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	84,996,697 - 85,235,827 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	86,622,023 - 86,679,582 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SV2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	70,358,164 - 70,601,764 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	70,358,236 - 70,601,242 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666049	19,160,261 - 19,408,353 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sv2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624869	669,391 - 831,138 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624869	611,873 - 838,014 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sv2c
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	200,443,211 - 200,572,834 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sv2c
2264 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	42
Interacting mature miRNAs:	44
Transcripts:	ENSRNOT00000024459
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	42977529	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
9590080	Insglur4	Insulin/glucose ratio QTL 4	28.7	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	2	6152767	51152767	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
731166	Mamtr2	Mammary tumor resistance QTL 2		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	54623581	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	44538110	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	5736325	50736325	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

BE108455

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	27,423,442 - 27,423,604 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	26,694,240 - 26,694,401	NCBI	Rnor6.0
Rnor_5.0	2	45,823,627 - 45,823,788	UniSTS	Rnor5.0
RGSC_v3.4	2	26,549,983 - 26,550,144	UniSTS	RGSC3.4
Celera	2	23,478,693 - 23,478,854	UniSTS
RH 3.4 Map	2	13.3	UniSTS
Cytogenetic Map	2	q12	UniSTS

RH139477

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	27,429,858 - 27,430,064 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	26,700,656 - 26,700,861	NCBI	Rnor6.0
Rnor_5.0	2	45,830,043 - 45,830,248	UniSTS	Rnor5.0
RGSC_v3.4	2	26,556,399 - 26,556,604	UniSTS	RGSC3.4
Celera	2	23,485,123 - 23,485,328	UniSTS
RH 3.4 Map	2	13.3	UniSTS
Cytogenetic Map	2	q12	UniSTS

AI179314

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	29,033,186 - 29,033,342 (+)	Marker Load Pipeline
mRatBN7.2	2	27,298,492 - 27,298,648 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	26,568,693 - 26,568,848	NCBI	Rnor6.0
Rnor_5.0	2	45,698,340 - 45,698,495	UniSTS	Rnor5.0
RGSC_v3.4	2	26,424,057 - 26,424,212	UniSTS	RGSC3.4
Celera	2	23,354,862 - 23,355,017	UniSTS
RH 3.4 Map	2	13.3	UniSTS
Cytogenetic Map	2	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	9	66	136	49	48	17	26	17	6	201	122	9	115	40	92	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF060174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CQ819367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024459 ⟹ ENSRNOP00000024459

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	28,967,631 - 29,163,168 (-)	Ensembl
mRatBN7.2 Ensembl	2	27,232,933 - 27,428,477 (-)	Ensembl
Rnor_6.0 Ensembl	2	26,501,833 - 26,699,333 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132654 ⟹ ENSRNOP00000111912

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	28,989,650 - 29,163,168 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135436 ⟹ ENSRNOP00000098715

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	28,964,582 - 29,163,168 (-)	Ensembl

RefSeq Acc Id:

NM_031593 ⟹ NP_113781

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	28,967,631 - 29,163,168 (-)	NCBI
mRatBN7.2	2	27,232,933 - 27,428,479 (-)	NCBI
Rnor_6.0	2	26,502,115 - 26,699,276 (-)	NCBI
Rnor_5.0	2	45,631,737 - 45,828,663 (-)	NCBI
RGSC_v3.4	2	26,326,862 - 26,555,019 (-)	RGD
Celera	2	23,293,289 - 23,483,743 (-)	RGD

Sequence:

show sequence

GCGCGCTGCAGGAAGAGTGGCAGACCGAAGCGGCCTCGGGCTGCAAACGGAGGGGCGCTCGCGC
GGCGACGGCTGCAGGGCTGACACCGCTCAGGGCAGGGGGGTCCCAGGCGGCTGGAACGCTCTAT
TCTGAACTGTGAGTGGATGATGCTGTTGCAGCCAAGCTGCTGAACACACTCCGTGGACTCTTCC
CTGCTGTGCCTTGCCCATCGGCCGAGATAAAATGGAAGACTCCTACAAGGATAGGACTTCACTG
ATGAAGGGCGCCAAGGACATTGCCAAAGAGGTGAAGAAGCAAACAGTGAAGAAGGTGAACCAGG
CAGTGGACCGGGCCCAGGATGAATACACCCAGCGGTCCTACAGTCGATTCCAGGATGAAGATGA
TGATGATGACTACTACCCACCTGGAGAAACCTACAGTGGGGAGGCCAATGATGATGAAGGCTCA
AGTGAAGCCACTGAGGGTCACGATGAAGAAGACGAGATCTATGAAGGGGAATACCAGGGCATCC
CCAGCACGAACCAAGGGAAGGACAGCATAGTGTCTGTAGGACAACCCAAAGGAGATGAGTACAA
GGACCGCAGAGAGCTGGAGTCAGAGAGGAGGGCTGATGAGGAGGAGCTCGCCCAGCAGTATGAG
CTGATAATCCAAGAGTGTGGCCATGGCCGTTTCCAGTGGGCCCTTTTCTTCGTCCTGGGCATGG
CTCTCATGGCAGACGGCGTGGAGGTGTTTGTGGTGGGCTTTGTGTTACCCAGTGCAGAGACAGA
CCTATGCATACCGAATTCAGGATCTGGATGGCTAGGCAGCATAGTGTACCTCGGGATGATGGTG
GGGGCGTTCTTCTGGGGAGGACTGGCAGACAAAGTGGGAAGGAAGCAGTCTCTTCTGATTTGCA
TGTCCGTCAACGGATTCTTTGCCTTCCTTTCTTCATTTGTCCAAGGTTACGGCTTCTTTCTCCT
CTGTCGTTTGCTTTCAGGATTCGGGATTGGAGGCGCCATTCCCACTGTGTTCTCCTACTTTGCT
GAAGTCCTGGCCCGGGAGAAGCGCGGTGAGCACCTCAGTTGGCTCTGCATGTTCTGGATGATTG
GCGGTATCTATGCTTCAGCCATGGCCTGGGCCATCATCCCCCACTATGGGTGGAGCTTCAGCAT
GGGCTCAGCCTACCAGTTCCACAGCTGGCGCGTCTTCGTCATCGTCTGTGCCCTCCCGTGCGTC
TCCTCGGTGGTGGCCCTCACCTTCATGCCCGAAAGCCCTCGGTTCTTGCTGGAGGTAGGAAAAC
ATGATGAAGCCTGGATGATTCTGAAGCTAATTCATGATACCAACATGAGAGCCCGGGGCCAGCC
AGAGAAGGTCTTCACGGTAAATAAAATCAAGACTCCCAAGCAAATAGATGAGCTGATTGAGATT
GAGAGCGACACAGGAACCTGGTACCGGAGGTGTTTTGTTCGGATCCGCACAGAACTGTACGGAA
TTTGGTTGACTTTTATGAGATGCTTCAACTACCCGGTCAGGGAAAACACCATAAAGCTTACGAT
TGTTTGGTTCACCCTGTCCTTTGGGTACTATGGACTGTCCGTTTGGTTCCCAGATGTCATTAAA
CACCTCCAGTCTGACGAGTACGCCCTGCTGACTCGGAATGTGCAGAAGGATAAATATGCAAACT
TTAGCATTAACTTCACCATGGAAAACCAGGTCCACACCGGAATGGAATATGACAATGGCAGGTT
CCTCGGAGTCAAATTCAAATCGGTAACCTTCAAGGATTCAGTGTTTAAGTCCTGCACCTTTGAC
GATGTGACCTCAGTCAACACCTACTTCAAGAACTGCACGTTTATTGATACCCTTTTTGAGAACA
CAGATTTTGAGCCCTATAAATTCATAGACAGCGAGTTTCAAAACTGCTCGTTTCTTCACAATAA
GACGGGATGTCAGATTACTTTTGACGACGACTACAGTGCCTACTGGATTTACTTTGTCAACTTT
CTCGGGACATTGGCAGTGTTACCAGGAAATATCGTGTCTGCTCTCCTGATGGACAGGATCGGGC
GCTTAACGATGCTAGGTGGCTCCATGGTGCTCTCGGGGATCAGCTGCTTCTTCCTGTGGTTTGG
CACCAGCGAATCCATGATGATAGGCATGCTGTGCTTGTACAACGGACTGACCATCTCAGCGTGG
AACTCTCTTGATGTAGTCACGGTGGAACTATACCCCACAGACCGGAGAGCAACGGGCTTTGGCT
TCTTGAACGCACTCTGTAAAGCAGCGGCCGTCCTGGGAAACTTAATATTCGGCTCCTTGGTCAG
CATCACCAAAGCAATCCCTATCCTGCTGGCTTCCACCGTGCTCGTGTGTGGAGGACTCGTGGGG
CTGCGCCTGCCCGACACAAGAACCCAGGTTCTGATGTGACAAAAGCCATTCTCTTCTCTCACCA
TGGGTCAGCCCTATTGCCTGACTCAAGGCTTCAGAGTTTTTATGTATAGAAAGGTGGCCAAGTA
TCAGAACTCAAACTTTTGCTGTGACGTAAATGTAGCTGTGTATTGTCCCCGCCAGTGTGATTTG
CAGGGTCCTCCCCCTCCCCCGCGCCTTGTTATCTTTTCCTAATTGTGATGTTCCTGCTTCCG

hide sequence

Protein Sequences


Protein RefSeqs	NP_113781	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC78628	(Get FASTA)	NCBI Sequence Viewer
	CAG34351	(Get FASTA)	NCBI Sequence Viewer
	EDM10107	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024459
	ENSRNOP00000024459.3
GenBank Protein	Q9Z2I6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113781 ⟸ NM_031593

- UniProtKB:

Q9Z2I6 (UniProtKB/Swiss-Prot), A6I4Z9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEDSYKDRTSLMKGAKDIAKEVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEDDDDDYYPPGET
YSGEANDDEGSSEATEGHDEEDEIYEGEYQGIPSTNQGKDSIVSVGQPKGDEYKDRRELESERR
ADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGW
LGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIG
GAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWR
VFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIK
TPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWFTLSFGYY
GLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTF
KDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDD
YSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGML
CLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLA
STVLVCGGLVGLRLPDTRTQVLM

hide sequence

Ensembl Acc Id:

ENSRNOP00000024459 ⟸ ENSRNOT00000024459

Ensembl Acc Id:

ENSRNOP00000111912 ⟸ ENSRNOT00000132654

Ensembl Acc Id:

ENSRNOP00000098715 ⟸ ENSRNOT00000135436

Protein Domains

Major facilitator superfamily (MFS) profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9Z2I6-F1-model_v2	AlphaFold	Q9Z2I6	1-727	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619718	AgrOrtholog
BioCyc Gene	G2FUF-54786	BioCyc
Ensembl Genes	ENSRNOG00000018094	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000024459	ENTREZGENE
	ENSRNOT00000024459.7	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot
	E3 ubiquitin-protein ligase SopA	UniProtKB/Swiss-Prot
InterPro	LD_SV2	UniProtKB/Swiss-Prot
	MFS	UniProtKB/Swiss-Prot
	MFS_dom	UniProtKB/Swiss-Prot
	MFS_sugar_transport-like	UniProtKB/Swiss-Prot
	MFS_trans_sf	UniProtKB/Swiss-Prot
	Sugar_transporter_CS	UniProtKB/Swiss-Prot
	SV2	UniProtKB/Swiss-Prot
KEGG Report	rno:29643	UniProtKB/Swiss-Prot
NCBI Gene	29643	ENTREZGENE
PANTHER	SYNAPTIC VESICLE GLYCOPROTEIN 2	UniProtKB/Swiss-Prot
	SYNAPTIC VESICLE GLYCOPROTEIN 2C	UniProtKB/Swiss-Prot
Pfam	LD_SV2	UniProtKB/Swiss-Prot
	MFS_1	UniProtKB/Swiss-Prot
	Sugar_tr	UniProtKB/Swiss-Prot
PhenoGen	Sv2c	PhenoGen
PROSITE	MFS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000018094	RatGTEx
Superfamily-SCOP	Pentapeptide repeat-like	UniProtKB/Swiss-Prot
	SSF103473	UniProtKB/Swiss-Prot
UniProt	A0ABK0KWS6_RAT	UniProtKB/TrEMBL
	A0ABK0LZF2_RAT	UniProtKB/TrEMBL
	A6I4Z9	ENTREZGENE, UniProtKB/TrEMBL
	Q9Z2I6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Sv2c	synaptic vesicle glycoprotein 2c		synaptic vesicle protein 2C	Name updated	1299863	APPROVED
2002-08-07	Sv2c	synaptic vesicle protein 2C			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in synaptic vesicles	634114
gene_function	vesicular transporter of a charged molecule	634114

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)