Ptp4a1 (protein tyrosine phosphatase 4A1) - Rat Genome Database

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Gene: Ptp4a1 (protein tyrosine phosphatase 4A1) Rattus norvegicus
Analyze
Symbol: Ptp4a1
Name: protein tyrosine phosphatase 4A1
RGD ID: 61970
Description: Enables protein tyrosine phosphatase activity. Predicted to be involved in positive regulation of cell migration. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A1 (protein tyrosine phosphatase 4A1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100360241; LOC103693189; MGC93357; PRL-1; protein tyrosine phosphatase 4a1-like; protein tyrosine phosphatase type IVA 1; protein tyrosine phosphatase type IVA, member 1; protein-tyrosine phosphatase 4a1; protein-tyrosine phosphatase of regenerating liver 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ptp4a1-ps5  
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: The loci 103693189 and 29463 are annotated independently on Rnor_6.0 (Annotation Release 105) assembly. [04 Jun 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8940,710,250 - 40,718,176 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl940,710,250 - 40,718,176 (-)EnsemblGRCr8
mRatBN7.2933,214,201 - 33,245,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl933,214,208 - 33,221,964 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx941,706,932 - 41,714,858 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0946,838,082 - 46,846,016 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0945,119,940 - 45,127,874 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0937,223,363 - 37,254,222 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl93,896,337 - 3,899,315 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl937,223,729 - 37,231,291 (-)Ensemblrn6Rnor6.0
Rnor_5.0936,028,286 - 36,059,131 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4929,617,636 - 29,625,197 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera931,034,176 - 31,042,102 (-)NCBICelera
RGSC_v3.1929,618,696 - 29,626,440 (-)NCBI
Cytogenetic Map9q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
aldrin  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phytoestrogen  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
triacsin C  (ISO)
trichloroethene  (EXP)
trovafloxacin  (EXP,ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Diamond RH, etal., Mol Cell Biol 1994 Jun;14(6):3752-62.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8840018   PMID:10679780   PMID:10940933   PMID:12782572   PMID:15489334   PMID:15682487   PMID:16142898   PMID:17032584   PMID:23376485   PMID:34689832   PMID:35255961  


Genomics

Comparative Map Data
Ptp4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8940,710,250 - 40,718,176 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl940,710,250 - 40,718,176 (-)EnsemblGRCr8
mRatBN7.2933,214,201 - 33,245,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl933,214,208 - 33,221,964 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx941,706,932 - 41,714,858 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0946,838,082 - 46,846,016 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0945,119,940 - 45,127,874 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0937,223,363 - 37,254,222 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl93,896,337 - 3,899,315 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl937,223,729 - 37,231,291 (-)Ensemblrn6Rnor6.0
Rnor_5.0936,028,286 - 36,059,131 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4929,617,636 - 29,625,197 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera931,034,176 - 31,042,102 (-)NCBICelera
RGSC_v3.1929,618,696 - 29,626,440 (-)NCBI
Cytogenetic Map9q21NCBI
PTP4A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38663,516,440 - 63,583,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl663,521,746 - 63,583,588 (+)Ensemblhg38GRCh38
GRCh37664,226,345 - 64,293,493 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36664,339,879 - 64,351,448 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34664,340,378 - 64,351,244NCBI
Celera662,442,473 - 62,454,047 (+)NCBICelera
Cytogenetic Map6q12NCBI
HuRef661,461,747 - 61,473,329 (+)NCBIHuRef
CHM1_1664,448,190 - 64,459,766 (+)NCBICHM1_1
T2T-CHM13v2.0664,662,355 - 64,729,529 (+)NCBIT2T-CHM13v2.0
Ptp4a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39130,979,384 - 30,988,838 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl130,979,383 - 30,988,851 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl130,979,383 - 30,988,390 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38130,940,303 - 30,949,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl130,940,302 - 30,949,770 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl130,940,302 - 30,949,309 (-)Ensemblmm10GRCm38
MGSCv37130,997,148 - 31,006,600 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36130,886,135 - 30,894,291 (-)NCBIMGSCv36mm8
Celera130,745,276 - 30,754,732 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map111.47NCBI
Ptp4a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955502322,105 - 329,220 (-)Ensembl
ChiLan1.0NW_004955502322,827 - 329,226 (-)NCBIChiLan1.0ChiLan1.0
PTP4A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2578,439,210 - 78,443,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1673,099,104 - 73,105,570 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0661,257,780 - 61,269,097 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1666,529,894 - 66,541,665 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl666,530,382 - 66,541,672 (+)EnsemblpanPan2panpan1.1
PTP4A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11227,044,470 - 27,053,181 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1227,044,533 - 27,052,314 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1226,953,087 - 26,961,741 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01227,579,933 - 27,588,608 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1227,579,753 - 27,622,432 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11227,084,459 - 27,093,127 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01227,166,923 - 27,175,589 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01227,264,042 - 27,272,715 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptp4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494662,514,567 - 62,524,902 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364761,438,412 - 1,441,142 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364761,435,295 - 1,441,142 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTP4A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl145,170,468 - 45,180,289 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1145,169,913 - 45,180,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2150,511,780 - 50,521,596 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTP4A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11711,215,005 - 11,248,911 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605817,511,518 - 17,545,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptp4a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475321,918,461 - 21,923,873 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475321,918,445 - 21,926,451 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptp4a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14107,700,100 - 107,706,973 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptp4a1
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:135
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000016237
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH128958  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q21UniSTS
RH140279  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q21UniSTS
Ptp4a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X137,875,660 - 137,876,614 (-)MAPPERmRatBN7.2
Rnor_6.0965,085,524 - 65,086,268NCBIRnor6.0
Rnor_6.01372,154,591 - 72,155,544NCBIRnor6.0
Rnor_5.01377,096,527 - 77,097,480UniSTSRnor5.0
Rnor_5.0964,882,122 - 64,882,866UniSTSRnor5.0
RGSC_v3.4X145,027,098 - 145,028,051UniSTSRGSC3.4
RGSC_v3.4956,853,881 - 56,854,858UniSTSRGSC3.4
Celera957,179,170 - 57,180,147UniSTS
CeleraX133,964,534 - 133,965,487UniSTS
Cytogenetic Map9q21UniSTS
Cytogenetic Map13q21UniSTS
Cytogenetic Map9q31UniSTS
Cytogenetic MapXq36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016237   ⟹   ENSRNOP00000016237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl940,710,250 - 40,718,176 (-)Ensembl
mRatBN7.2 Ensembl933,214,208 - 33,221,964 (-)Ensembl
Rnor_6.0 Ensembl937,223,729 - 37,231,291 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079166   ⟹   ENSRNOP00000074101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl93,896,337 - 3,899,315 (+)Ensembl
RefSeq Acc Id: NM_031579   ⟹   NP_113767
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8940,710,250 - 40,718,176 (-)NCBI
mRatBN7.2933,214,201 - 33,222,127 (-)NCBI
Rnor_6.0937,223,363 - 37,231,291 (-)NCBI
Rnor_5.0936,028,286 - 36,059,131 (-)NCBI
RGSC_v3.4929,617,636 - 29,625,197 (-)RGD
Celera931,034,176 - 31,042,102 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266813   ⟹   XP_063122883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8940,710,250 - 40,714,846 (-)NCBI
RefSeq Acc Id: NP_113767   ⟸   NM_031579
- UniProtKB: Q4QRA5 (UniProtKB/Swiss-Prot),   Q8VH48 (UniProtKB/Swiss-Prot),   Q78EG7 (UniProtKB/Swiss-Prot),   A6IN79 (UniProtKB/TrEMBL),   A0A8I5Y1B8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016237   ⟸   ENSRNOT00000016237
Ensembl Acc Id: ENSRNOP00000074101   ⟸   ENSRNOT00000079166
RefSeq Acc Id: XP_063122883   ⟸   XM_063266813
- Peptide Label: isoform X1
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q78EG7-F1-model_v2 AlphaFold Q78EG7 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696586
Promoter ID:EPDNEW_R7111
Type:initiation region
Name:Ptp4a1_1
Description:protein tyrosine phosphatase type IVA, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0937,231,300 - 37,231,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61970 AgrOrtholog
BioCyc Gene G2FUF-27898 BioCyc
Ensembl Genes ENSRNOG00000011771 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000057009 Ensembl
Ensembl Transcript ENSRNOT00000016237 ENTREZGENE
  ENSRNOT00000016237.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124031 IMAGE-MGC_LOAD
  IMAGE:7446277 IMAGE-MGC_LOAD
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTP UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report rno:29463 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114303 IMAGE-MGC_LOAD
  MGC:93357 IMAGE-MGC_LOAD
NCBI Gene 29463 ENTREZGENE
PANTHER TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
Pfam Tc-R-P UniProtKB/Swiss-Prot
PhenoGen Ptp4a1 PhenoGen
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011771 RatGTEx
  ENSRNOG00000057009 RatGTEx
SMART PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
TIGR TC229389
UniProt A0A8I5Y1B8 ENTREZGENE
  A6IN79 ENTREZGENE, UniProtKB/TrEMBL
  Q4QRA5 ENTREZGENE
  Q78EG7 ENTREZGENE
  Q8VH48 ENTREZGENE
  TP4A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4QRA5 UniProtKB/Swiss-Prot
  Q8VH48 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ptp4a1  protein tyrosine phosphatase 4A1  LOC103693189  protein tyrosine phosphatase type IVA 1  Data merged from RGD:9374124 737654 PROVISIONAL
2019-04-03 Ptp4a1  protein tyrosine phosphatase 4A1  Ptp4a1  protein tyrosine phosphatase type IVA, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103693189  protein tyrosine phosphatase type IVA 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-04-12 Ptp4a1  protein tyrosine phosphatase type IVA, member 1  LOC100360241  protein tyrosine phosphatase 4a1-like  Data merged from RGD:2322509 737654 PROVISIONAL
2011-02-22 Ptp4a1  protein tyrosine phosphatase type IVA, member 1  Ptp4a1  protein tyrosine phosphatase 4a1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360241  protein tyrosine phosphatase 4a1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ptp4a1  protein tyrosine phosphatase 4a1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology similarity to other protein tyrosine phosphatases is limited to the active site consensus sequence 61722
gene_process involved in normal cell growth control and may play a role in cellular tumorigenicity 61722