Fhl2 (four and a half LIM domains 2) - Rat Genome Database

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Gene: Fhl2 (four and a half LIM domains 2) Rattus norvegicus
Analyze
Symbol: Fhl2
Name: four and a half LIM domains 2
RGD ID: 61963
Description: Predicted to enable bHLH transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of calcineurin-NFAT signaling cascade. Located in M band and Z disc. Orthologous to human FHL2 (four and a half LIM domains 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FHL-2; four and a half LIM domains protein 2; LIM domain protein DRAL; skeletal muscle LIM-protein 3; SLIM 3; SLIM-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8952,881,091 - 52,954,540 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl952,880,998 - 52,923,326 (-)EnsemblGRCr8
mRatBN7.2945,388,979 - 45,462,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,388,981 - 45,431,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx953,883,965 - 53,913,129 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,006,764 - 59,035,926 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,287,269 - 57,316,406 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0949,920,611 - 49,994,906 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,920,854 - 49,950,093 (-)Ensemblrn6Rnor6.0
Rnor_5.0949,591,185 - 49,664,022 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4942,319,997 - 42,349,055 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera943,107,290 - 43,136,314 (-)NCBICelera
RGSC_v3.1942,321,410 - 42,350,469 (-)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
estrone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (EXP)
hexestrol  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mestranol  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
cytoplasm  (IEA)
focal adhesion  (IEA,ISO)
M band  (IDA)
nucleus  (IBA,IEA,ISO)
Z disc  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. FHL2 binds calcineurin and represses pathological cardiac growth. Hojayev B, etal., Mol Cell Biol. 2012 Oct;32(19):4025-34. doi: 10.1128/MCB.05948-11. Epub 2012 Jul 30.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis. Scholl FA, etal., J Cell Biol. 2000 Oct 30;151(3):495-506.
9. FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1. Sun J, etal., Circ Res. 2006 Sep 1;99(5):468-76. Epub 2006 Aug 3.
10. Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. Tanahashi H and Tabira T, Hum Mol Genet 2000 Sep 22;9(15):2281-9.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10906324   PMID:11813260   PMID:12151099   PMID:12432079   PMID:15509787   PMID:15692560   PMID:16311053   PMID:17975004   PMID:18255255   PMID:18586895   PMID:21423176   PMID:22159597  
PMID:25103794   PMID:26316108   PMID:29771425   PMID:34342639   PMID:35176204   PMID:35352799  


Genomics

Comparative Map Data
Fhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8952,881,091 - 52,954,540 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl952,880,998 - 52,923,326 (-)EnsemblGRCr8
mRatBN7.2945,388,979 - 45,462,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,388,981 - 45,431,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx953,883,965 - 53,913,129 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,006,764 - 59,035,926 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,287,269 - 57,316,406 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0949,920,611 - 49,994,906 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,920,854 - 49,950,093 (-)Ensemblrn6Rnor6.0
Rnor_5.0949,591,185 - 49,664,022 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4942,319,997 - 42,349,055 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera943,107,290 - 43,136,314 (-)NCBICelera
RGSC_v3.1942,321,410 - 42,350,469 (-)NCBI
Cytogenetic Map9q22NCBI
FHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382105,357,712 - 105,438,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2105,357,712 - 105,438,585 (-)Ensemblhg38GRCh38
GRCh372105,974,169 - 106,054,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,343,715 - 105,421,392 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342105,435,802 - 105,513,478NCBI
Celera2100,177,732 - 100,255,816 (-)NCBICelera
Cytogenetic Map2q12.2NCBI
HuRef299,745,771 - 99,823,720 (-)NCBIHuRef
CHM1_12105,981,590 - 106,059,537 (-)NCBICHM1_1
T2T-CHM13v2.02105,818,881 - 105,899,699 (-)NCBIT2T-CHM13v2.0
Fhl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,162,233 - 43,237,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl143,162,234 - 43,236,144 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38143,123,071 - 43,198,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,123,074 - 43,196,984 (-)Ensemblmm10GRCm38
MGSCv37143,179,919 - 43,220,806 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36143,067,623 - 43,108,396 (-)NCBIMGSCv36mm8
Celera143,461,506 - 43,502,542 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map122.33NCBI
Fhl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547010,240,117 - 10,286,289 (-)Ensembl
ChiLan1.0NW_00495547010,240,117 - 10,286,117 (-)NCBIChiLan1.0ChiLan1.0
FHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21222,318,702 - 22,357,262 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A22,321,474 - 22,360,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A96,391,513 - 96,469,267 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A106,446,368 - 106,524,555 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A106,446,368 - 106,484,895 (-)EnsemblpanPan2panpan1.1
FHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11037,997,912 - 38,065,633 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1037,997,942 - 38,065,330 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1037,924,199 - 37,991,867 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01038,854,939 - 38,922,615 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1038,854,978 - 38,923,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11038,579,623 - 38,647,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01038,859,021 - 38,926,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01039,050,777 - 39,118,466 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629287,195,507 - 87,233,273 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936764613,193 - 656,224 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936764613,863 - 656,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl349,363,555 - 49,467,527 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1349,389,900 - 49,448,459 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2351,610,541 - 51,729,225 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1148,992,881 - 9,069,432 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl148,990,861 - 9,069,227 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041176,712,666 - 176,789,126 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247499,453,088 - 9,483,009 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247499,453,081 - 9,507,050 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fhl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14119,267,275 - 119,309,518 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fhl2
585 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:45
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000023014
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
BE114833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2945,390,407 - 45,390,582 (+)MAPPERmRatBN7.2
Rnor_6.0949,922,041 - 49,922,215NCBIRnor6.0
Rnor_5.0949,592,615 - 49,592,789UniSTSRnor5.0
RGSC_v3.4942,320,985 - 42,321,159UniSTSRGSC3.4
Celera943,108,278 - 43,108,452UniSTS
RH 3.4 Map9399.9UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023014   ⟹   ENSRNOP00000023014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl952,880,998 - 52,923,326 (-)Ensembl
mRatBN7.2 Ensembl945,389,172 - 45,431,171 (-)Ensembl
Rnor_6.0 Ensembl949,920,854 - 49,950,093 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101412   ⟹   ENSRNOP00000088694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl952,881,091 - 52,923,326 (-)Ensembl
mRatBN7.2 Ensembl945,389,239 - 45,431,192 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114387   ⟹   ENSRNOP00000084804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl952,881,091 - 52,920,530 (-)Ensembl
mRatBN7.2 Ensembl945,388,981 - 45,419,109 (-)Ensembl
RefSeq Acc Id: NM_001412599   ⟹   NP_001399528
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8952,881,091 - 52,923,326 (-)NCBI
mRatBN7.2945,388,979 - 45,431,212 (-)NCBI
RefSeq Acc Id: NM_031677   ⟹   NP_113865
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8952,881,091 - 52,954,540 (-)NCBI
mRatBN7.2945,388,979 - 45,462,421 (-)NCBI
Rnor_6.0949,921,053 - 49,950,071 (-)NCBI
Rnor_5.0949,591,185 - 49,664,022 (-)NCBI
RGSC_v3.4942,319,997 - 42,349,055 (-)RGD
Celera943,107,290 - 43,136,314 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084158   ⟹   XP_038940086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8952,881,091 - 52,911,057 (-)NCBI
mRatBN7.2945,388,979 - 45,418,825 (-)NCBI
RefSeq Acc Id: NP_113865   ⟸   NM_031677
- UniProtKB: O35115 (UniProtKB/Swiss-Prot),   A6INR3 (UniProtKB/TrEMBL),   A0A8I6A8C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023014   ⟸   ENSRNOT00000023014
RefSeq Acc Id: XP_038940086   ⟸   XM_039084158
- Peptide Label: isoform X1
- UniProtKB: O35115 (UniProtKB/Swiss-Prot),   A6INR3 (UniProtKB/TrEMBL),   A0A8I6A8C5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084804   ⟸   ENSRNOT00000114387
Ensembl Acc Id: ENSRNOP00000088694   ⟸   ENSRNOT00000101412
RefSeq Acc Id: NP_001399528   ⟸   NM_001412599
- UniProtKB: O35115 (UniProtKB/Swiss-Prot),   A6INR3 (UniProtKB/TrEMBL),   A0A8I6A8C5 (UniProtKB/TrEMBL)
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35115-F1-model_v2 AlphaFold O35115 1-279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61963 AgrOrtholog
BioCyc Gene G2FUF-27672 BioCyc
Ensembl Genes ENSRNOG00000016866 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023014.4 UniProtKB/Swiss-Prot
  ENSRNOT00000101412 ENTREZGENE
  ENSRNOT00000114387 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
InterPro LIM_FHL1/2/3/5_N UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report rno:63839 UniProtKB/Swiss-Prot
NCBI Gene 63839 ENTREZGENE
PANTHER FOUR AND A HALF LIM DOMAINS PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR24205 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  LIM_FHL2-3_N UniProtKB/Swiss-Prot
PhenoGen Fhl2 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016866 RatGTEx
SMART LIM UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
TIGR TC229306
UniProt A0A8I6A8C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GC70_RAT UniProtKB/TrEMBL
  A6INR3 ENTREZGENE, UniProtKB/TrEMBL
  FHL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fhl2  four and a half LIM domains 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains four LIM domains and an N-terminal half LIM domain 61586
gene_function is an adaptor protein that links PS2 to an intracellular signaling 61586