Gal (galanin and GMAP prepropeptide) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gal (galanin and GMAP prepropeptide) Rattus norvegicus
Analyze
Symbol: Gal
Name: galanin and GMAP prepropeptide
RGD ID: 61954
Description: Predicted to enable galanin receptor activity; galanin receptor binding activity; and neuropeptide hormone activity. Involved in several processes, including behavioral response to ethanol; drinking behavior; and response to estrogen. Located in secretory granule. Biomarker of brain ischemia; hypertension; mononeuropathy; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 8 and opiate dependence. Orthologous to human GAL (galanin and GMAP prepropeptide); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: galanin; galanin peptides; galanin prepropeptide; galanin/GMAP prepropeptide; Galn
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,079,709 - 210,084,572 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,079,702 - 210,084,229 (-)EnsemblGRCr8
mRatBN7.21200,650,439 - 200,655,302 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,650,439 - 200,654,959 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1209,023,646 - 209,028,521 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,112,399 - 216,117,262 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,786,607 - 208,791,470 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,653,059 - 218,657,922 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,652,917 - 218,657,925 (-)Ensemblrn6Rnor6.0
Rnor_5.01225,520,966 - 225,525,829 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41205,936,352 - 205,941,215 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1198,205,890 - 198,210,753 (-)NCBICelera
RGSC_v3.11206,089,804 - 206,094,668 (-)NCBI
Cytogenetic Map1q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-palmitoylglycerol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-methylhistamine  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bromochloroacetic acid  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carrageenan  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
corticosterone  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (EXP)
DDT  (EXP)
desipramine  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ferulic acid  (EXP)
flavonoids  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Meclizine  (ISO)
megestrol  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
Methazolamide  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naloxone  (EXP)
naringin  (EXP)
nickel atom  (EXP,ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotine  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paraquat  (EXP)
pentanal  (ISO)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Phenoxybenzamine  (EXP)
phenylmercury acetate  (ISO)
phosalone  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propanal  (ISO)
raloxifene  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-allylcysteine  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sulindac  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
thioglycolic acid  (EXP)
tributylstannane  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
Urolithin A  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Large reduction in the number of galanin-immunoreactive cells in pancreatic islets of diabetic rats. Adeghate E and Ponery AS, J Neuroendocrinol. 2001 Aug;13(8):706-10.
2. Evidence for a paracrine role of endogenous adrenomedullary galanin in the regulation of glucocorticoid secretion in the rat adrenal gland. Andreis PG, etal., Int J Mol Med. 2007 Mar;19(3):511-5.
3. Disturbed release of gastrointestinal peptides in anorexia nervosa and in obesity. Baranowska B, etal., Diabetes Obes Metab. 2000 Apr;2(2):99-103.
4. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B, etal., PLoS One. 2013 Sep 25;8(9):e75359. doi: 10.1371/journal.pone.0075359. eCollection 2013.
5. Enteric neuropeptides in streptozotocin-diabetic rats; effects of insulin and aldose reductase inhibition. Belai A, etal., J Auton Nerv Syst. 1996 May 6;58(3):163-9.
6. Circulating acylated and total ghrelin and galanin in children with insulin-treated type 1 diabetes: relationship to insulin therapy, metabolic control and pubertal development. Celi F, etal., Clin Endocrinol (Oxf). 2005 Aug;63(2):139-45.
7. Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: relationship with circulating triglycerides. Chang GQ, etal., Alcohol Clin Exp Res. 2007 Feb;31(2):249-59. doi: 10.1111/j.1530-0277.2006.00312.x.
8. Hypothalamic peptides controlling alcohol intake: differential effects on microstructure of drinking bouts. Chen YW, etal., Alcohol. 2014 Nov;48(7):657-64. doi: 10.1016/j.alcohol.2014.08.005. Epub 2014 Aug 20.
9. Effects of fluoxetine administration on regional galanin expression in obese Zucker rat hypothalamus. Churruca I, etal., Nutr Neurosci. 2004 Jun;7(3):171-5.
10. Decreases in the expression of CGRP and galanin mRNA in central and peripheral neurons related to the control of blood pressure following experimental hypertension in rats. Coelho EF, etal., Brain Res Bull. 2004 Jul 30;64(1):59-66.
11. Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat. De Michele M, etal., Regul Pept. 2006 Mar 15;134(1):38-45. Epub 2006 Feb 3.
12. Tissue-specific reduction of galanin content in the pancreas in alloxan diabetes in the mouse. Dunning BE and Ahren B, Acta Physiol Scand. 1993 Oct;149(2):215-9.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy. Gu XL, etal., Behav Brain Res. 2007 May 16;179(2):331-5. Epub 2007 Feb 25.
16. Colocalization of galanin and prolactin within secretory granules of anterior pituitary cells in estrogen-treated Fischer 344 rats. Hyde JF, etal., Endocrinology. 1991 Jul;129(1):270-6.
17. Tissue-specific expression of the rat galanin gene. Kaplan LM, etal., Proc Natl Acad Sci U S A 1988 Feb;85(4):1065-9.
18. Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice. Kinney JW, etal., Learn Mem 2002 Jul-Aug;9(4):178-90.
19. Expression of galanin in hypothalamic magnocellular neurones of lactating rats: co-existence with vasopressin and oxytocin. Landry M, etal., J Endocrinol. 1997 Dec;155(3):467-81.
20. Positive correlation of galanin with glucose in type 2 diabetes. Legakis I, etal., Diabetes Care. 2005 Mar;28(3):759-60.
21. Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. Leibowitz SF, etal., Physiol Behav. 2003 Jun;79(1):103-11. doi: 10.1016/s0031-9384(03)00110-0.
22. Increased galanin expression in the celiac ganglion of BB diabetic rats. Mei Q, etal., Neuropeptides. 2006 Feb;40(1):1-10.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats. Millón C, etal., Addict Biol. 2019 Jan;24(1):76-87. doi: 10.1111/adb.12582. Epub 2017 Dec 6.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
28. Galanin in adjuvant arthritis in the rat. Qinyang W, etal., J Rheumatol 2004 Feb;31(2):302-7.
29. GOA pipeline RGD automated data pipeline
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Sahu A Endocrinology. 1998 Nov;139(11):4739-42.
32. Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. Schauble N, etal., J Nutr. 2005 Jun;135(6):1387-92.
33. Expression of preprogalanin mRNA following acute and chronic restraint stress in brains of normotensive and hypertensive rats. Sweerts BW, etal., Brain Res Mol Brain Res. 1999 May 21;69(1):113-23.
34. The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats. Sárközy M, etal., Cardiovasc Diabetol. 2015 Jun 28;14:85. doi: 10.1186/s12933-015-0248-6.
35. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. Effects of galanin on proliferation and apoptosis of immature rat thymocytes. Trejter M, etal., Int J Mol Med 2002 Aug;10(2):183-6.
37. Isolation and characterization of a complementary DNA (galanin) clone from estrogen-induced pituitary tumor messenger RNA. Vrontakis ME, etal., J Biol Chem 1987 Dec 15;262(35):16755-8.
38. The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress. Zhao X, etal., Neuroscience. 2013 Aug 29;246:82-93. doi: 10.1016/j.neuroscience.2013.04.046. Epub 2013 Apr 30.
Additional References at PubMed
PMID:8837218   PMID:9402244   PMID:11712539   PMID:11782668   PMID:11826038   PMID:12147214   PMID:12409220   PMID:12435417   PMID:12468105   PMID:12533397   PMID:12533601   PMID:12634483  
PMID:12814355   PMID:12933672   PMID:12955388   PMID:14581121   PMID:14623054   PMID:14988032   PMID:15342143   PMID:15752542   PMID:15790727   PMID:15829223   PMID:15882902   PMID:15944005  
PMID:15944017   PMID:15944019   PMID:15944023   PMID:16143396   PMID:16611841   PMID:16996684   PMID:17263797   PMID:17287581   PMID:17331599   PMID:17693056   PMID:17850457   PMID:17982695  
PMID:18097766   PMID:18208479   PMID:19006184   PMID:19158406   PMID:19248773   PMID:19500224   PMID:19531380   PMID:19598284   PMID:20051236   PMID:20692550   PMID:20850488   PMID:21569622  
PMID:21763401   PMID:21800306   PMID:21894515   PMID:21958458   PMID:21958860   PMID:21975846   PMID:22079346   PMID:22197078   PMID:22306246   PMID:22329353   PMID:22624057   PMID:22725682  
PMID:23415787   PMID:23687905   PMID:23731834   PMID:23747305   PMID:24517231   PMID:24602615   PMID:25197671   PMID:25445608   PMID:25545502   PMID:25639936   PMID:25691535   PMID:25917569  
PMID:25952775   PMID:26565961   PMID:26928087   PMID:27300187   PMID:27907151   PMID:27923581   PMID:28062253   PMID:28196718   PMID:28365702   PMID:28378856   PMID:29127424   PMID:33044017  
PMID:33212101   PMID:34497682  


Genomics

Comparative Map Data
Gal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,079,709 - 210,084,572 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,079,702 - 210,084,229 (-)EnsemblGRCr8
mRatBN7.21200,650,439 - 200,655,302 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,650,439 - 200,654,959 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1209,023,646 - 209,028,521 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,112,399 - 216,117,262 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,786,607 - 208,791,470 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,653,059 - 218,657,922 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,652,917 - 218,657,925 (-)Ensemblrn6Rnor6.0
Rnor_5.01225,520,966 - 225,525,829 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41205,936,352 - 205,941,215 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1198,205,890 - 198,210,753 (-)NCBICelera
RGSC_v3.11206,089,804 - 206,094,668 (-)NCBI
Cytogenetic Map1q42NCBI
GAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,684,544 - 68,691,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,683,020 - 68,691,205 (+)Ensemblhg38GRCh38
GRCh371168,452,012 - 68,458,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361168,208,559 - 68,215,219 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341168,208,610 - 68,215,219NCBI
Celera1165,788,525 - 65,795,257 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,788,371 - 64,795,031 (+)NCBIHuRef
CHM1_11168,335,752 - 68,342,412 (+)NCBICHM1_1
T2T-CHM13v2.01168,690,664 - 68,697,295 (+)NCBIT2T-CHM13v2.0
Gal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,459,915 - 3,464,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,459,915 - 3,464,544 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38193,409,915 - 3,414,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,409,915 - 3,414,544 (-)Ensemblmm10GRCm38
MGSCv37193,409,917 - 3,414,457 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36193,409,917 - 3,414,457 (-)NCBIMGSCv36mm8
Celera193,279,401 - 3,283,920 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.16NCBI
Gal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,202,946 - 17,207,948 (-)Ensembl
ChiLan1.0NW_00495542217,202,770 - 17,207,948 (-)NCBIChiLan1.0ChiLan1.0
GAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2969,636,630 - 69,646,600 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,679,823 - 70,689,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,770,758 - 63,777,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11167,075,104 - 67,081,696 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1167,075,547 - 67,081,696 (+)EnsemblpanPan2panpan1.1
GAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,240,437 - 49,246,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,240,437 - 49,246,950 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1847,849,939 - 47,855,743 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01850,155,635 - 50,161,742 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,155,635 - 50,161,523 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,376,255 - 49,382,059 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,950,015 - 48,955,820 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01849,743,208 - 49,749,012 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,120,761 - 5,125,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,563,270 - 1,566,158 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,563,270 - 1,567,618 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,351,113 - 4,356,647 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.124,351,113 - 4,357,167 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,931,347 - 2,937,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115,849,947 - 5,857,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15,849,952 - 5,857,072 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038103,132,895 - 103,140,180 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,204,508 - 18,210,416 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476718,195,288 - 18,210,634 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gal
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v124,247,678 - 4,252,378 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gal
72 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:95
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000020425
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH137044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,650,520 - 200,651,979 (+)MAPPERmRatBN7.2
Rnor_6.01218,653,141 - 218,654,599NCBIRnor6.0
Rnor_5.01225,521,048 - 225,522,506UniSTSRnor5.0
RGSC_v3.41205,936,434 - 205,937,892UniSTSRGSC3.4
Celera1198,205,972 - 198,207,430UniSTS
RH 3.4 Map11561.1UniSTS
Cytogenetic Map1q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 57 152 66 65 34 27 34 6 222 115 10 131 52 80 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020425   ⟹   ENSRNOP00000020425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,079,702 - 210,084,229 (-)Ensembl
mRatBN7.2 Ensembl1200,650,439 - 200,654,959 (-)Ensembl
Rnor_6.0 Ensembl1218,652,917 - 218,657,925 (-)Ensembl
RefSeq Acc Id: NM_033237   ⟹   NP_150240
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,079,709 - 210,084,572 (-)NCBI
mRatBN7.21200,650,439 - 200,655,302 (-)NCBI
Rnor_6.01218,653,059 - 218,657,922 (-)NCBI
Rnor_5.01225,520,966 - 225,525,829 (-)NCBI
RGSC_v3.41205,936,352 - 205,941,215 (-)RGD
Celera1198,205,890 - 198,210,753 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_150240 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41186 (Get FASTA)   NCBI Sequence Viewer  
  AAA41187 (Get FASTA)   NCBI Sequence Viewer  
  AAB94490 (Get FASTA)   NCBI Sequence Viewer  
  EDM12290 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020425
  ENSRNOP00000020425.3
GenBank Protein P10683 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_150240   ⟸   NM_033237
- Peptide Label: preproprotein
- UniProtKB: P10683 (UniProtKB/Swiss-Prot),   A6HYK9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020425   ⟸   ENSRNOT00000020425
Protein Domains
GALANIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10683-F1-model_v2 AlphaFold P10683 1-124 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690597
Promoter ID:EPDNEW_R1121
Type:single initiation site
Name:Gal_1
Description:galanin and GMAP prepropeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01218,657,933 - 218,657,993EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61954 AgrOrtholog
BioCyc Gene G2FUF-56815 BioCyc
Ensembl Genes ENSRNOG00000015156 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020425 ENTREZGENE
  ENSRNOT00000020425.6 UniProtKB/Swiss-Prot
InterPro Galanin UniProtKB/Swiss-Prot
  Galanin_pre UniProtKB/Swiss-Prot
  GMAP UniProtKB/Swiss-Prot
KEGG Report rno:29141 UniProtKB/Swiss-Prot
NCBI Gene Gal ENTREZGENE
PANTHER GALANIN PEPTIDES UniProtKB/Swiss-Prot
  PTHR16839 UniProtKB/Swiss-Prot
Pfam Galanin UniProtKB/Swiss-Prot
  GMAP UniProtKB/Swiss-Prot
PhenoGen Gal PhenoGen
PRINTS GALANIN UniProtKB/Swiss-Prot
PROSITE GALANIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015156 RatGTEx
SMART Galanin UniProtKB/Swiss-Prot
TIGR TC206781
UniProt A6HYK9 ENTREZGENE, UniProtKB/TrEMBL
  GALA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Gal  galanin and GMAP prepropeptide  Gal  galanin/GMAP prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-07 Gal  galanin/GMAP prepropeptide  Gal  galanin prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Gal  galanin prepropeptide  Gal  galanin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gal  galanin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference