Nr1h3 (nuclear receptor subfamily 1, group H, member 3) - Rat Genome Database

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Gene: Nr1h3 (nuclear receptor subfamily 1, group H, member 3) Rattus norvegicus
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Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
RGD ID: 61909
Description: Enables nuclear retinoid X receptor binding activity and sequence-specific DNA binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; insulin receptor signaling pathway; and response to cholesterol. Located in nucleolus. Used to study metabolic dysfunction and alcohol associated liver disease. Biomarker of metabolic dysfunction and alcohol associated liver disease and obesity. Human ortholog(s) of this gene implicated in cerebral infarction; cerebrovascular disease; myocardial infarction; and obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; hepatitis C pathway; INTERACTS WITH (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: liver X receptor alpha; LXRalpha; nuclear orphan receptor LXR-alpha; nuclear receptor subfamily 1 group H member 3; oxysterols receptor LXR-alpha; RLD-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,614,616 - 97,632,053 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,614,616 - 97,624,532 (-)EnsemblGRCr8
mRatBN7.2377,158,808 - 77,168,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,158,808 - 77,168,722 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,637,176 - 80,645,771 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,236,183 - 89,244,778 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,087,220 - 87,095,813 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,004,130 - 80,014,197 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,004,130 - 80,012,750 (-)Ensemblrn6Rnor6.0
Rnor_5.0386,712,883 - 86,722,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,542,211 - 75,550,793 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,367,211 - 76,375,760 (-)NCBICelera
RGSC_v3.1375,438,551 - 75,447,172 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pinoresinol  (ISO)
(+)-schisandrin B  (EXP)
(-)-acanthoic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(22R)-22-hydroxycholesterol  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(S)-nicotine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
24(S),25-epoxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3beta-hydroxycholest-5-en-26-oic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
Adiponectin  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allicin  (ISO)
allopurinol  (EXP,ISO)
alpha-Spinasterol  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
androstane  (ISO)
angiotensin II  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin  (ISO)
atrazine  (ISO)
baicalin  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bosentan  (ISO)
bucladesine  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (EXP)
chrysin  (ISO)
ciglitazone  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
D-glucose  (EXP,ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (EXP)
doxorubicin  (ISO)
elemental selenium  (EXP)
emodin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fumonisin B1  (ISO)
gemfibrozil  (EXP,ISO)
genistein  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
GW 3965  (EXP,ISO)
GW 501516  (ISO)
hexadecanoic acid  (EXP,ISO)
hydralazine  (ISO)
Ile(5)-angiotensin II (1-7)  (ISO)
ketoconazole  (EXP,ISO)
kuwanone G  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lansoprazole  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
loliolide  (ISO)
losartan  (EXP)
lycopene  (ISO)
magnesium atom  (EXP)
melatonin  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
mevastatin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naringenin  (ISO)
nefazodone  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP,ISO)
oxaliplatin  (EXP)
oxidised LDL  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paxilline  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirfenidone  (EXP)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platycodin D  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
prostaglandin J2  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
SB 203580  (ISO)
selenium atom  (EXP)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium cholate  (ISO)
streptozocin  (EXP)
sucrose  (EXP)
tacrolimus (anhydrous)  (ISO)
temozolomide  (ISO)
teniposide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetramethylpyrazine  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroid hormone  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vitexin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic cell clearance  (IEA,ISO)
bile acid metabolic process  (ISO)
cell differentiation  (IBA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to starvation  (IEP)
cholesterol homeostasis  (IBA,IEA,ISO,ISS)
digestive tract development  (IEP)
DNA-templated transcription  (IEA)
hormone-mediated signaling pathway  (IEA,ISO)
insulin receptor signaling pathway  (IEP)
intracellular receptor signaling pathway  (IBA,IEA)
lipid homeostasis  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
liver development  (IEP)
mRNA transcription by RNA polymerase II  (IEA,ISO)
negative regulation of cholesterol storage  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of inflammatory response  (IBA,IEA,ISO)
negative regulation of lipid transport  (IEA,ISO)
negative regulation of macrophage activation  (IEA,ISO)
negative regulation of pancreatic juice secretion  (IEA,ISO)
negative regulation of pinocytosis  (IEA,ISO)
negative regulation of proteolysis  (IEA,ISO)
negative regulation of response to endoplasmic reticulum stress  (IEA,ISO,ISS)
negative regulation of secretion of lysosomal enzymes  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
nuclear receptor-mediated steroid hormone signaling pathway  (IEA)
phosphatidylcholine acyl-chain remodeling  (IEA,ISO,ISS)
positive regulation of cholesterol efflux  (IBA,IEA,ISO,ISS)
positive regulation of cholesterol transport  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO)
positive regulation of toll-like receptor 4 signaling pathway  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,ISS)
positive regulation of triglyceride biosynthetic process  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fatty acid metabolic process  (IMP)
regulation of lipid storage  (IBA)
regulation of transcription by RNA polymerase II  (IEA)
response to cholesterol  (IEP)
response to nutrient levels  (IEP)
response to progesterone  (IEA,ISO)
spleen development  (IEP)
sterol homeostasis  (IEA,ISO)
thymus development  (IEP)
triglyceride homeostasis  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
nucleolus  (IDA)
nucleus  (IBA,IEA,ISO)
receptor complex  (IEA,ISO)
RNA polymerase II transcription regulator complex  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. ABCA1 expression in carotid atherosclerotic plaques. Albrecht C, etal., Stroke. 2004 Dec;35(12):2801-6. doi: 10.1161/01.STR.0000147036.07307.93. Epub 2004 Nov 4.
3. Effects of allicin on human Simpson-Golabi-Behmel syndrome cells in mediating browning phenotype. Ali U, etal., Front Endocrinol (Lausanne). 2023 Mar 1;14:1141303. doi: 10.3389/fendo.2023.1141303. eCollection 2023.
4. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Apfel R, etal., Mol Cell Biol 1994 Oct;14(10):7025-35.
5. Simultaneous activation of the liver X receptors (LXRalpha and LXRbeta) drives murine collagen-induced arthritis disease pathology. Asquith DL, etal., Ann Rheum Dis. 2011 Dec;70(12):2225-8. Epub 2011 Aug 22.
6. Importance of blood cellular genomic profile in coronary heart disease. Baba MI, etal., J Biomed Sci. 2006 Jan;13(1):17-26. doi: 10.1007/s11373-005-9041-y. Epub 2005 Oct 28.
7. The critical role of ABCG1 and PPARγ/LXRα signaling in TLR4 mediates inflammatory responses and lipid accumulation in vascular smooth muscle cells. Cao X, etal., Cell Tissue Res. 2017 Apr;368(1):145-157. doi: 10.1007/s00441-016-2518-3. Epub 2016 Nov 2.
8. Elevated expression of liver X receptor alpha (LXRα) in myocardium of streptozotocin-induced diabetic rats. Cheng Y, etal., Inflammation. 2011 Dec;34(6):698-706. doi: 10.1007/s10753-010-9281-5.
9. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Chiang JY, etal., Gene 2001 Jan 10;262(1-2):257-65.
10. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
11. Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. Dahlman I, etal., Pharmacogenet Genomics. 2006 Dec;16(12):881-9.
12. Functional genomics of blood cellular LXR-alpha gene in human coronary heart disease. Dave VP, etal., J Mol Cell Cardiol. 2009 Apr;46(4):536-44. doi: 10.1016/j.yjmcc.2008.12.020. Epub 2009 Jan 13.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort. Grbić E, etal., Gene. 2022 Oct 5;840:146764. doi: 10.1016/j.gene.2022.146764. Epub 2022 Jul 27.
17. Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction. Hammer SS, etal., Diabetologia. 2021 Jul;64(7):1674-1689. doi: 10.1007/s00125-021-05431-5. Epub 2021 Mar 26.
18. Liver X receptor-alpha gene expression is positively regulated by thyroid hormone. Hashimoto K, etal., Endocrinology. 2007 Oct;148(10):4667-75. doi: 10.1210/en.2007-0150. Epub 2007 Jul 12.
19. Anti-atherosclerotic potential of baicalin mediated by promoting cholesterol efflux from macrophages via the PPARγ-LXRα-ABCA1/ABCG1 pathway. He XW, etal., Biomed Pharmacother. 2016 Oct;83:257-264. doi: 10.1016/j.biopha.2016.06.046. Epub 2016 Jul 4.
20. Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells. Helleboid-Chapman A, etal., Cell Res. 2006 Jul;16(7):661-70.
21. Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower saponins in rats with metabolic hypertension by inhibiting the activation of the renin-angiotensin-aldosterone system through complement 3. Huang Q, etal., BMC Complement Med Ther. 2023 Jan 18;23(1):13. doi: 10.1186/s12906-022-03828-2.
22. In Vivo and In Vitro Analysis in Coronary Artery Disease Related to Type 2 Diabetes. Infante T, etal., Front Endocrinol (Lausanne). 2017 Aug 21;8:209. doi: 10.3389/fendo.2017.00209. eCollection 2017.
23. Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia. Jianhua L, etal., Open Med (Wars). 2016 Aug 13;11(1):292-296. doi: 10.1515/med-2016-0057. eCollection 2016.
24. Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Korach-André M, etal., Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):403-8. doi: 10.1073/pnas.1017884108. Epub 2010 Dec 20.
25. Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha. Lai P, etal., Pharm Biol. 2020 Dec;58(1):760-770. doi: 10.1080/13880209.2020.1798471.
26. Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages. Lee TS, etal., J Cell Biochem. 2010 Sep 1;111(1):104-10. doi: 10.1002/jcb.22667.
27. Angiotensin-(1-7) upregulates expression of adenosine triphosphate-binding cassette transporter A1 and adenosine triphosphate-binding cassette transporter G1 through the Mas receptor through the liver X receptor alpha signalling pathway in THP-1 macrophages treated with angiotensin-II. Liang B, etal., Clin Exp Pharmacol Physiol. 2014 Dec;41(12):1023-30. doi: 10.1111/1440-1681.12312.
28. Adiponectin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in RAW 264.7 macrophages. Liang B, etal., Int J Clin Exp Pathol. 2015 Jan 1;8(1):450-7. eCollection 2015.
29. Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage. Liu T, etal., Inflamm Res. 2014 Oct;63(10):841-50. doi: 10.1007/s00011-014-0758-9. Epub 2014 Jul 27.
30. Quercetin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in THP-1 macrophages. Lu Y and Jia YP, Eur Rev Med Pharmacol Sci. 2016 Sep;20(18):3945-3952.
31. The pharmacodynamic effects of sirolimus and sirolimus-calcineurin inhibitor combinations on macrophage scavenger and nuclear hormone receptors. Mathis AS, etal., J Pharm Sci. 2007 Jan;96(1):209-22. doi: 10.1002/jps.20751.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Lycopene regulation of cholesterol synthesis and efflux in human macrophages. Palozza P, etal., J Nutr Biochem. 2011 Oct;22(10):971-8. doi: 10.1016/j.jnutbio.2010.08.010. Epub 2011 Jan 3.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. Ritonavir increases CD36, ABCA1 and CYP27 expression in THP-1 macrophages. Pou J, etal., Exp Biol Med (Maywood). 2008 Dec;233(12):1572-82. doi: 10.3181/0805-RM-144. Epub 2008 Oct 10.
37. Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. Qiu G and Hill JS, J Lipid Res. 2007 Oct;48(10):2112-22. doi: 10.1194/jlr.M600510-JLR200. Epub 2007 Jul 20.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Grapefruit Flavonoid Naringenin Regulates the Expression of LXRα in THP-1 Macrophages by Modulating AMP-Activated Protein Kinase. Saenz J, etal., Mol Pharm. 2018 May 7;15(5):1735-1745. doi: 10.1021/acs.molpharmaceut.7b00797. Epub 2018 Apr 19.
42. Expression of liver X receptor alpha in rat fetal tissues at different developmental stages. Sakamoto A, etal., J Histochem Cytochem. 2007 Jun;55(6):641-9. doi: 10.1369/jhc.6A7120.2007. Epub 2007 Mar 6.
43. mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease. Soumian S, etal., J Clin Pathol. 2005 Dec;58(12):1255-60. doi: 10.1136/jcp.2005.026161.
44. Genetic variation in liver X receptor alpha and risk of ischemic vascular disease in the general population. Stender S, etal., Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2990-6. doi: 10.1161/ATVBAHA.111.223867. Epub 2011 Sep 8.
45. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
46. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
47. Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. Tobin KA, etal., J Biol Chem 2002 Mar 22;277(12):10691-7.
48. Chrysin inhibits foam cell formation through promoting cholesterol efflux from RAW264.7 macrophages. Wang S, etal., Pharm Biol. 2015;53(10):1481-7. doi: 10.3109/13880209.2014.986688. Epub 2015 Apr 10.
49. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
50. Expression of the LXRalpha protein in human atherosclerotic lesions. Watanabe Y, etal., Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):622-7. Epub 2004 Dec 29.
51. Expression of liver X receptors in pregnancies complicated by preeclampsia. Weedon-Fekjær MS, etal., Placenta. 2010 Sep;31(9):818-24. doi: 10.1016/j.placenta.2010.06.015. Epub 2010 Jul 22.
52. Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. Whitney KD, etal., J Biol Chem. 2001 Nov 23;276(47):43509-15. doi: 10.1074/jbc.M106155200. Epub 2001 Aug 23.
53. Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE-/- mice. Yu X, etal., Lipids Health Dis. 2023 Apr 15;22(1):51. doi: 10.1186/s12944-023-01810-6.
54. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD. Zhang Y, etal., J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
55. LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats. Zhao YP, etal., Hepatobiliary Pancreat Dis Int. 2015 Aug;14(4):386-93.
Additional References at PubMed
PMID:9013544   PMID:11090130   PMID:12054605   PMID:12815040   PMID:12917410   PMID:14739254   PMID:15266058   PMID:15319426   PMID:15637161   PMID:16141411   PMID:16325781   PMID:16354191  
PMID:16825483   PMID:16834571   PMID:16941710   PMID:17054913   PMID:17107947   PMID:17186944   PMID:17296605   PMID:17362639   PMID:17369526   PMID:17526932   PMID:17657314   PMID:17693624  
PMID:17766241   PMID:18055760   PMID:18079124   PMID:18443233   PMID:18511497   PMID:18806227   PMID:18989661   PMID:19119143   PMID:19228891   PMID:19229075   PMID:19351492   PMID:19366697  
PMID:19481530   PMID:19628791   PMID:19646905   PMID:19716432   PMID:19782030   PMID:19878707   PMID:20005944   PMID:20080977   PMID:20108769   PMID:20219900   PMID:20837115   PMID:20887359  
PMID:21187453   PMID:21763752   PMID:21906525   PMID:21986124   PMID:22415588   PMID:22634718   PMID:22836489   PMID:23433337   PMID:23633563   PMID:23639777   PMID:23674092   PMID:23835330  
PMID:24231105   PMID:24321552   PMID:25091941   PMID:25186103   PMID:25661920   PMID:27352290   PMID:27382175   PMID:27383786   PMID:29207101   PMID:30471864   PMID:35597151   PMID:36155419  


Genomics

Comparative Map Data
Nr1h3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,614,616 - 97,632,053 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,614,616 - 97,624,532 (-)EnsemblGRCr8
mRatBN7.2377,158,808 - 77,168,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,158,808 - 77,168,722 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,637,176 - 80,645,771 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,236,183 - 89,244,778 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,087,220 - 87,095,813 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,004,130 - 80,014,197 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,004,130 - 80,012,750 (-)Ensemblrn6Rnor6.0
Rnor_5.0386,712,883 - 86,722,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,542,211 - 75,550,793 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,367,211 - 76,375,760 (-)NCBICelera
RGSC_v3.1375,438,551 - 75,447,172 (-)NCBI
Cytogenetic Map3q24NCBI
NR1H3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,248,300 - 47,269,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,248,300 - 47,269,070 (+)Ensemblhg38GRCh38
GRCh371147,269,851 - 47,290,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,237,309 - 47,246,972 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341147,237,308 - 47,246,972NCBI
Celera1147,409,676 - 47,429,619 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,968,831 - 46,989,561 (+)NCBIHuRef
CHM1_11147,268,541 - 47,289,773 (+)NCBICHM1_1
T2T-CHM13v2.01147,405,058 - 47,425,803 (+)NCBIT2T-CHM13v2.0
Nr1h3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,014,406 - 91,033,189 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,014,406 - 91,033,179 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,184,061 - 91,202,829 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,184,061 - 91,202,834 (-)Ensemblmm10GRCm38
MGSCv37291,024,218 - 91,035,273 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36290,984,949 - 90,995,955 (-)NCBIMGSCv36mm8
Celera292,568,901 - 92,580,220 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.52NCBI
Nr1h3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422940,310 - 949,049 (-)Ensembl
ChiLan1.0NW_004955422940,310 - 954,170 (-)NCBIChiLan1.0ChiLan1.0
NR1H3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,449,743 - 49,469,835 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,469,538 - 49,489,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,195,122 - 47,215,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,748,452 - 47,768,672 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,748,353 - 47,768,672 (+)EnsemblpanPan2panpan1.1
NR1H3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,333,173 - 42,346,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,333,202 - 42,341,236 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1841,061,865 - 41,074,852 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01842,987,642 - 43,000,646 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,986,620 - 43,000,608 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,473,538 - 42,486,527 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,029,130 - 42,042,123 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,758,228 - 42,771,525 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr1h3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,826,023 - 19,835,848 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,937,667 - 1,946,669 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,937,665 - 1,946,680 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1H3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,315,282 - 15,334,820 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1215,315,283 - 15,336,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,539,892 - 16,560,353 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR1H3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,041,495 - 18,061,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,041,830 - 18,051,501 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038115,344,981 - 115,364,565 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr1h3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,459,601 - 1,467,795 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247671,459,601 - 1,473,224 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nr1h3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1565,350,155 - 65,360,751 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr1h3
143 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:55
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000018154
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
STS-U22662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,158,984 - 77,159,214 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,307 - 80,004,536NCBIRnor6.0
Rnor_5.0386,713,060 - 86,713,289UniSTSRnor5.0
RGSC_v3.4375,542,357 - 75,542,586UniSTSRGSC3.4
Celera376,367,357 - 76,367,586UniSTS
Cytogenetic Map3q24UniSTS
AI548269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,158,931 - 77,159,087 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,254 - 80,004,409NCBIRnor6.0
Rnor_5.0386,713,007 - 86,713,162UniSTSRnor5.0
RGSC_v3.4375,542,304 - 75,542,459UniSTSRGSC3.4
Celera376,367,304 - 76,367,459UniSTS
Cytogenetic Map3q24UniSTS
PMC33205P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8397,615,010 - 97,615,246 (+)Marker Load Pipeline
mRatBN7.2377,159,202 - 77,159,438 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,525 - 80,004,760NCBIRnor6.0
Rnor_5.0386,713,278 - 86,713,513UniSTSRnor5.0
RGSC_v3.4375,542,575 - 75,542,810UniSTSRGSC3.4
Celera376,367,575 - 76,367,810UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 89 59 6 353 189 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC072499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000018154   ⟹   ENSRNOP00000018154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,614,654 - 97,623,236 (-)Ensembl
mRatBN7.2 Ensembl377,158,808 - 77,167,426 (-)Ensembl
Rnor_6.0 Ensembl380,004,130 - 80,012,750 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102389   ⟹   ENSRNOP00000090383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,614,616 - 97,623,236 (-)Ensembl
mRatBN7.2 Ensembl377,158,808 - 77,167,426 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103975   ⟹   ENSRNOP00000088605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,614,617 - 97,624,532 (-)Ensembl
mRatBN7.2 Ensembl377,158,809 - 77,168,722 (-)Ensembl
RefSeq Acc Id: NM_031627   ⟹   NP_113815
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,647 - 97,623,229 (-)NCBI
mRatBN7.2377,158,839 - 77,167,419 (-)NCBI
Rnor_6.0380,004,161 - 80,012,743 (-)NCBI
Rnor_5.0386,712,883 - 86,722,950 (-)NCBI
RGSC_v3.4375,542,211 - 75,550,793 (-)RGD
Celera376,367,211 - 76,375,760 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234533   ⟹   XP_006234595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,628 (-)NCBI
mRatBN7.2377,158,808 - 77,168,813 (-)NCBI
Rnor_6.0380,004,130 - 80,014,074 (-)NCBI
Rnor_5.0386,712,883 - 86,722,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234534   ⟹   XP_006234596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,649 (-)NCBI
mRatBN7.2377,158,808 - 77,168,815 (-)NCBI
Rnor_6.0380,004,130 - 80,014,142 (-)NCBI
Rnor_5.0386,712,883 - 86,722,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234535   ⟹   XP_006234597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,844 (-)NCBI
mRatBN7.2377,158,808 - 77,168,648 (-)NCBI
Rnor_6.0380,004,130 - 80,013,978 (-)NCBI
Rnor_5.0386,712,883 - 86,722,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234537   ⟹   XP_006234599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,708 (-)NCBI
mRatBN7.2377,158,808 - 77,168,907 (-)NCBI
Rnor_6.0380,004,130 - 80,014,197 (-)NCBI
Rnor_5.0386,712,883 - 86,722,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105751   ⟹   XP_038961679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,711 (-)NCBI
mRatBN7.2377,158,808 - 77,168,905 (-)NCBI
RefSeq Acc Id: XM_039105752   ⟹   XP_038961680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,633 (-)NCBI
mRatBN7.2377,158,808 - 77,168,285 (-)NCBI
RefSeq Acc Id: XM_039105753   ⟹   XP_038961681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,615 (-)NCBI
mRatBN7.2377,158,808 - 77,168,814 (-)NCBI
RefSeq Acc Id: XM_063284426   ⟹   XP_063140496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,632,053 (-)NCBI
RefSeq Acc Id: XM_063284428   ⟹   XP_063140498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,656 (-)NCBI
RefSeq Acc Id: XM_063284429   ⟹   XP_063140499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,614,616 - 97,624,640 (-)NCBI
RefSeq Acc Id: NP_113815   ⟸   NM_031627
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot),   Q5I035 (UniProtKB/TrEMBL),   A6HNB4 (UniProtKB/TrEMBL),   A6HNB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234599   ⟸   XM_006234537
- Peptide Label: isoform X2
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006234596   ⟸   XM_006234534
- Peptide Label: isoform X1
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot),   Q5I035 (UniProtKB/TrEMBL),   A6HNB4 (UniProtKB/TrEMBL),   A6HNB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234595   ⟸   XM_006234533
- Peptide Label: isoform X1
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot),   Q5I035 (UniProtKB/TrEMBL),   A6HNB4 (UniProtKB/TrEMBL),   A6HNB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234597   ⟸   XM_006234535
- Peptide Label: isoform X1
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot),   Q5I035 (UniProtKB/TrEMBL),   A6HNB4 (UniProtKB/TrEMBL),   A6HNB3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018154   ⟸   ENSRNOT00000018154
RefSeq Acc Id: XP_038961679   ⟸   XM_039105751
- Peptide Label: isoform X1
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot),   Q5I035 (UniProtKB/TrEMBL),   A6HNB4 (UniProtKB/TrEMBL),   A6HNB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961681   ⟸   XM_039105753
- Peptide Label: isoform X2
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038961680   ⟸   XM_039105752
- Peptide Label: isoform X1
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot),   Q5I035 (UniProtKB/TrEMBL),   A6HNB4 (UniProtKB/TrEMBL),   A6HNB3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088605   ⟸   ENSRNOT00000103975
Ensembl Acc Id: ENSRNOP00000090383   ⟸   ENSRNOT00000102389
RefSeq Acc Id: XP_063140496   ⟸   XM_063284426
- Peptide Label: isoform X1
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot),   A6HNB3 (UniProtKB/TrEMBL),   A6HNB4 (UniProtKB/TrEMBL),   Q5I035 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140498   ⟸   XM_063284428
- Peptide Label: isoform X2
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140499   ⟸   XM_063284429
- Peptide Label: isoform X2
- UniProtKB: Q62685 (UniProtKB/Swiss-Prot)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62685-F1-model_v2 AlphaFold Q62685 1-445 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61909 AgrOrtholog
BioCyc Gene G2FUF-48746 BioCyc
Ensembl Genes ENSRNOG00000013172 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018154 ENTREZGENE
  ENSRNOT00000103975 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096798 IMAGE-MGC_LOAD
  IMAGE:7314121 IMAGE-MGC_LOAD
InterPro Liver_X_rcpt UniProtKB/Swiss-Prot
  NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR1 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
MGC_CLONE MGC:105398 IMAGE-MGC_LOAD
  MGC:91628 IMAGE-MGC_LOAD
NCBI Gene 58852 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  OXYSTEROLS RECEPTOR LXR-ALPHA UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr1h3 PhenoGen
PRINTS LIVERXRECPTR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013172 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC232336
UniProt A0A8I6ACE5_RAT UniProtKB/TrEMBL
  A0A8I6GGE2_RAT UniProtKB/TrEMBL
  A0ABZ3NNB5_RAT UniProtKB/TrEMBL
  A6HNB2_RAT UniProtKB/TrEMBL
  A6HNB3 ENTREZGENE, UniProtKB/TrEMBL
  A6HNB4 ENTREZGENE, UniProtKB/TrEMBL
  NR1H3_RAT UniProtKB/Swiss-Prot
  Q5I035 ENTREZGENE
  Q62685 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr1h3  nuclear receptor subfamily 1, group H, member 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, kidney and intestines 61675
gene_expression expressed in liver, kidney and intestines 68195
gene_expression expressed in adipose tissue and adrenal gland 625467
gene_function binds to DR4 and DR5 motifs as a heterodimer with retinoid X receptor 61675
gene_function binds to DR4 and DR5 motifs as a heterodimer with retinoid X receptor 68195
gene_function nuclear receptor which is activated by binding with oxysterols 61675
gene_function nuclear receptor which is activated by binding with oxysterols 68195
gene_process plays a role in insulin regulation of cholesterol homeostasis and fatty acid metabolism in hetatocytes 625467
gene_regulation mRNA increased by insulin in a time- and dose-dependent manner 625467
gene_regulation mRNA increases during fasting but decreases after refeeding 625467