Psmc3 (proteasome 26S subunit, ATPase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Psmc3 (proteasome 26S subunit, ATPase 3) Rattus norvegicus
Analyze
Symbol: Psmc3
Name: proteasome 26S subunit, ATPase 3
RGD ID: 61905
Description: Predicted to enable identical protein binding activity and proteasome-activating activity. Predicted to be involved in host-mediated perturbation of viral transcription; positive regulation of transcription by RNA polymerase II; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within blastocyst development. Located in perinuclear region of cytoplasm. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; 26S proteasome regulatory subunit 6A; proteasome (prosome, macropain) 26S subunit, ATPase 3; proteasome 26S subunit ATPase 3; spermatogenic cell/sperm-associated TAT-binding protein homolog SATA; TAT-binding protein 1; TBP-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,487,643 - 97,493,025 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,487,632 - 97,499,176 (+)EnsemblGRCr8
mRatBN7.2377,031,825 - 77,037,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,031,825 - 77,043,358 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,510,318 - 80,515,699 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,109,333 - 89,114,714 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,960,503 - 86,965,883 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,876,938 - 79,882,319 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,876,938 - 79,882,319 (+)Ensemblrn6Rnor6.0
Rnor_5.0386,585,691 - 86,591,072 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,413,567 - 75,418,948 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,240,531 - 76,245,912 (+)NCBICelera
RGSC_v3.1375,309,938 - 75,315,317 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
picrotoxin  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. Ghee M, etal., J Neurochem. 2000 Nov;75(5):2221-4.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing. Makino Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):1049-54.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A protein associated with the manchette during rat spermiogenesis is encoded by a gene of the TBP-1-like subfamily with highly conserved ATPase and protease domains. Rivkin E, etal., Mol Reprod Dev 1997 Sep;48(1):77-89.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses. Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.
13. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
Additional References at PubMed
PMID:2194290   PMID:8419915   PMID:9688553   PMID:10657252   PMID:10945464   PMID:16857966   PMID:17323924   PMID:19182904   PMID:19517565   PMID:19853614   PMID:19946888   PMID:21630459  
PMID:22078707   PMID:22871113   PMID:25416956   PMID:30053369   PMID:35352799  


Genomics

Comparative Map Data
Psmc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,487,643 - 97,493,025 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,487,632 - 97,499,176 (+)EnsemblGRCr8
mRatBN7.2377,031,825 - 77,037,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,031,825 - 77,043,358 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,510,318 - 80,515,699 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,109,333 - 89,114,714 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,960,503 - 86,965,883 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,876,938 - 79,882,319 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,876,938 - 79,882,319 (+)Ensemblrn6Rnor6.0
Rnor_5.0386,585,691 - 86,591,072 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,413,567 - 75,418,948 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,240,531 - 76,245,912 (+)NCBICelera
RGSC_v3.1375,309,938 - 75,315,317 (+)NCBI
Cytogenetic Map3q24NCBI
PSMC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,418,775 - 47,426,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,418,765 - 47,426,488 (-)Ensemblhg38GRCh38
GRCh371147,440,326 - 47,447,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,396,896 - 47,404,600 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341147,396,895 - 47,404,565NCBI
Celera1147,582,015 - 47,589,718 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,139,662 - 47,147,028 (-)NCBIHuRef
CHM1_11147,439,552 - 47,447,251 (-)NCBICHM1_1
T2T-CHM13v2.01147,577,679 - 47,585,336 (-)NCBIT2T-CHM13v2.0
Psmc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,884,361 - 90,889,783 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,884,354 - 90,896,714 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,054,016 - 91,059,438 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,054,009 - 91,066,369 (+)Ensemblmm10GRCm38
MGSCv37290,894,173 - 90,899,595 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36290,854,921 - 90,860,267 (+)NCBIMGSCv36mm8
Celera292,438,480 - 92,443,912 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Psmc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422837,573 - 845,341 (+)Ensembl
ChiLan1.0NW_004955422837,934 - 843,161 (+)NCBIChiLan1.0ChiLan1.0
PSMC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,621,734 - 49,629,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,641,522 - 49,649,232 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,366,986 - 47,374,677 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,920,295 - 47,927,654 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,920,295 - 47,927,654 (-)EnsemblpanPan2panpan1.1
PSMC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,212,083 - 42,218,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,942,640 - 40,949,498 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01842,867,799 - 42,874,682 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,867,947 - 42,874,677 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,354,412 - 42,361,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,909,294 - 41,916,243 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,638,826 - 42,645,702 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psmc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,699,233 - 19,705,397 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,810,864 - 1,823,077 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,810,883 - 1,817,040 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,166,306 - 15,193,047 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1215,185,482 - 15,191,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,392,149 - 16,397,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,881,844 - 17,896,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038115,190,816 - 115,198,248 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,362,132 - 1,372,083 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247671,361,970 - 1,367,282 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Psmc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1565,222,466 - 65,227,836 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psmc3
35 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:98
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000015757
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015757   ⟹   ENSRNOP00000015757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,487,632 - 97,493,024 (+)Ensembl
mRatBN7.2 Ensembl377,031,825 - 77,037,206 (+)Ensembl
Rnor_6.0 Ensembl379,876,938 - 79,882,319 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103724   ⟹   ENSRNOP00000082627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,487,632 - 97,499,176 (+)Ensembl
mRatBN7.2 Ensembl377,031,825 - 77,043,358 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104701   ⟹   ENSRNOP00000088016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,487,632 - 97,493,024 (+)Ensembl
mRatBN7.2 Ensembl377,031,825 - 77,037,206 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133770   ⟹   ENSRNOP00000106409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,487,632 - 97,499,176 (+)Ensembl
RefSeq Acc Id: NM_031595   ⟹   NP_113783
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,487,643 - 97,493,024 (+)NCBI
mRatBN7.2377,031,825 - 77,037,206 (+)NCBI
Rnor_6.0379,876,938 - 79,882,319 (+)NCBI
Rnor_5.0386,585,691 - 86,591,072 (+)NCBI
RGSC_v3.4375,413,567 - 75,418,948 (+)RGD
Celera376,240,531 - 76,245,912 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104795   ⟹   XP_038960723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,489,599 - 97,493,025 (+)NCBI
mRatBN7.2377,033,781 - 77,037,207 (+)NCBI
RefSeq Acc Id: NP_113783   ⟸   NM_031595
- UniProtKB: Q63569 (UniProtKB/Swiss-Prot),   P97638 (UniProtKB/Swiss-Prot),   Q6P6U2 (UniProtKB/TrEMBL),   A6HNA2 (UniProtKB/TrEMBL),   F7EY30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015757   ⟸   ENSRNOT00000015757
RefSeq Acc Id: XP_038960723   ⟸   XM_039104795
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000088016   ⟸   ENSRNOT00000104701
Ensembl Acc Id: ENSRNOP00000082627   ⟸   ENSRNOT00000103724
Ensembl Acc Id: ENSRNOP00000106409   ⟸   ENSRNOT00000133770
Protein Domains
AAA+ ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63569-F1-model_v2 AlphaFold Q63569 1-439 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692204
Promoter ID:EPDNEW_R2729
Type:initiation region
Name:Psmc3_1
Description:proteasome 26S subunit, ATPase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0379,876,987 - 79,877,047EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61905 AgrOrtholog
BioCyc Gene G2FUF-48753 BioCyc
Ensembl Genes ENSRNOG00000011414 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015757 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5620971 IMAGE-MGC_LOAD
InterPro 26S_Proteasome_ATPase UniProtKB/Swiss-Prot
  AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
KEGG Report rno:29677 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72399 IMAGE-MGC_LOAD
NCBI Gene 29677 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
PhenoGen Psmc3 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011414 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZUG8_RAT UniProtKB/TrEMBL
  A0A8I6A723_RAT UniProtKB/TrEMBL
  A0ABK0LZJ3_RAT UniProtKB/TrEMBL
  A6HNA1_RAT UniProtKB/TrEMBL
  A6HNA2 ENTREZGENE, UniProtKB/TrEMBL
  A6HNA3_RAT UniProtKB/TrEMBL
  F7EY30 ENTREZGENE, UniProtKB/TrEMBL
  P97638 ENTREZGENE
  PRS6A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P6U2 ENTREZGENE
UniProt Secondary P97638 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Psmc3  proteasome 26S subunit, ATPase 3  Psmc3  proteasome (prosome, macropain) 26S subunit, ATPase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psmc3  proteasome (prosome, macropain) 26S subunit, ATPase 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference