Gpam (glycerol-3-phosphate acyltransferase, mitochondrial) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gpam (glycerol-3-phosphate acyltransferase, mitochondrial) Rattus norvegicus
Analyze
Symbol: Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
RGD ID: 61847
Description: Enables glycerol-3-phosphate O-acyltransferase activity. Involved in several processes, including cellular response to insulin stimulus; glycerolipid biosynthetic process; and positive regulation of triglyceride biosynthetic process. Located in mitochondrial outer membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease; nephrotic syndrome; and obesity. Orthologous to human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT; GPAT-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81264,111,599 - 264,176,112 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1264,113,813 - 264,175,911 (-)EnsemblGRCr8
mRatBN7.21254,106,323 - 254,170,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,106,331 - 254,142,639 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1262,315,818 - 262,376,481 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01269,021,904 - 269,082,569 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01261,664,129 - 261,730,618 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01275,843,823 - 275,906,880 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1275,846,819 - 275,906,686 (-)Ensemblrn6Rnor6.0
Rnor_5.01283,246,186 - 283,309,245 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41261,370,264 - 261,431,434 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1249,818,009 - 249,877,839 (-)NCBICelera
RGSC_v3.11261,581,308 - 261,642,479 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acadesine  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromuconazole  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entacapone  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fentin chloride  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glycidol  (EXP)
GW 6471  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nordihydroguaiaretic acid  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oxycodone  (EXP)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
propamocarb  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
sodium arsenite  (ISO)
steviol  (ISO)
sucrose  (ISO)
sulfluramid  (ISO)
sunitinib  (ISO)
tectoridin  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of chronic exposure to cadmium on prostate lipids and morphology. Alvarez SM, etal., Biometals. 2007 Oct;20(5):727-41. Epub 2006 Oct 26.
2. Acute effects of insulin on the activity of mitochondrial GPAT1 in primary adipocytes. Bronnikov GE, etal., Biochem Biophys Res Commun. 2008 Feb 29;367(1):201-7. Epub 2007 Dec 31.
3. Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols. Cattaneo ER, etal., PLoS One. 2012;7(8):e42986. doi: 10.1371/journal.pone.0042986. Epub 2012 Aug 8.
4. Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein. Ganesh Bhat B, etal., Biochim Biophys Acta 1999 Aug 18;1439(3):415-23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Increased mitochondrial glycerol-3-phosphate acyltransferase protein and enzyme activity in rat epididymal fat upon cessation of wheel running. Kump DS, etal., Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E480-9. Epub 2005 Oct 18.
8. Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Lee Y, etal., Diabetes. 1997 Mar;46(3):408-13.
9. Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes. Lewin TM, etal., Am J Physiol Endocrinol Metab. 2005 May;288(5):E835-44. Epub 2004 Dec 14.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Casein kinase II stimulates rat liver mitochondrial glycerophosphate acyltransferase activity. Onorato TM and Haldar D, Biochem Biophys Res Commun 2002 Sep 6;296(5):1091-6.
13. Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting. Palou M, etal., Pflugers Arch. 2008 Aug;456(5):825-36. Epub 2008 May 21.
14. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. Park H, etal., J Biol Chem 2002 Sep 6;277(36):32571-7.
15. Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV). Pellon-Maison M, etal., Biochim Biophys Acta. 2007 Jul;1771(7):830-8. Epub 2007 Apr 10.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A. Rodriguez-Calvo R, etal., Hepatology. 2009 Jan;49(1):106-15.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
24. Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Zhou Y, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F662-71. Epub 2008 Jul 9.
Additional References at PubMed
PMID:10924502   PMID:12417724   PMID:12865426   PMID:14651853   PMID:15152008   PMID:15708364   PMID:15778226   PMID:15878874   PMID:16054099   PMID:16431156   PMID:16935266   PMID:18021946  
PMID:18238778   PMID:18339309   PMID:18522808   PMID:18614015   PMID:18971390   PMID:19193813   PMID:19682972  


Genomics

Comparative Map Data
Gpam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81264,111,599 - 264,176,112 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1264,113,813 - 264,175,911 (-)EnsemblGRCr8
mRatBN7.21254,106,323 - 254,170,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,106,331 - 254,142,639 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1262,315,818 - 262,376,481 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01269,021,904 - 269,082,569 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01261,664,129 - 261,730,618 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01275,843,823 - 275,906,880 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1275,846,819 - 275,906,686 (-)Ensemblrn6Rnor6.0
Rnor_5.01283,246,186 - 283,309,245 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41261,370,264 - 261,431,434 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1249,818,009 - 249,877,839 (-)NCBICelera
RGSC_v3.11261,581,308 - 261,642,479 (-)NCBI
Cytogenetic Map1q55NCBI
GPAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810112,149,865 - 112,227,677 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10112,149,865 - 112,215,416 (-)Ensemblhg38GRCh38
GRCh3710113,909,623 - 113,943,523 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610113,899,612 - 113,933,508 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410113,899,611 - 113,933,508NCBI
Celera10107,637,183 - 107,671,081 (-)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10107,537,900 - 107,571,823 (-)NCBIHuRef
CHM1_110114,191,437 - 114,225,332 (-)NCBICHM1_1
T2T-CHM13v2.010113,040,886 - 113,118,691 (-)NCBIT2T-CHM13v2.0
Gpam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,056,067 - 55,115,666 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1955,055,700 - 55,115,670 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381955,067,635 - 55,127,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,067,268 - 55,127,238 (-)Ensemblmm10GRCm38
MGSCv371955,144,224 - 55,173,937 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361955,122,984 - 55,152,703 (-)NCBIMGSCv36mm8
Celera1957,260,690 - 57,290,402 (-)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1950.81NCBI
Gpam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543117,291,270 - 17,363,714 (-)Ensembl
ChiLan1.0NW_00495543117,291,890 - 17,363,611 (-)NCBIChiLan1.0ChiLan1.0
GPAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28124,031,551 - 124,065,468 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110124,036,887 - 124,070,804 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010108,747,370 - 108,781,270 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110112,186,744 - 112,246,549 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,186,744 - 112,246,549 (-)EnsemblpanPan2panpan1.1
GPAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12823,261,673 - 23,323,985 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2823,258,428 - 23,298,017 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2823,413,452 - 23,450,047 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02823,793,834 - 23,830,470 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2823,793,834 - 23,830,650 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12823,351,250 - 23,387,551 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02823,362,221 - 23,398,810 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02823,557,678 - 23,594,318 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721322,737,594 - 22,806,520 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364862,754,751 - 2,823,665 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364862,754,753 - 2,823,600 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14122,538,491 - 122,579,436 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114122,538,600 - 122,582,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214133,473,315 - 133,545,241 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,049,954 - 105,083,750 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9105,049,711 - 105,113,374 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604866,253,108 - 66,316,689 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473734,198,518 - 34,265,192 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473734,198,773 - 34,268,815 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpam
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1261,062,870 - 61,096,196 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:99
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000047903
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1263946994269633915Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000047903   ⟹   ENSRNOP00000050050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1275,846,966 - 275,876,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083215   ⟹   ENSRNOP00000069320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,114,742 - 264,175,911 (-)Ensembl
mRatBN7.2 Ensembl1254,106,331 - 254,142,442 (-)Ensembl
Rnor_6.0 Ensembl1275,846,819 - 275,882,444 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092170   ⟹   ENSRNOP00000072382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,114,742 - 264,144,553 (-)Ensembl
mRatBN7.2 Ensembl1254,109,466 - 254,142,639 (-)Ensembl
Rnor_6.0 Ensembl1275,847,064 - 275,906,686 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142012   ⟹   ENSRNOP00000103828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,113,813 - 264,175,911 (-)Ensembl
RefSeq Acc Id: NM_017274   ⟹   NP_058970
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,114,840 - 264,175,911 (-)NCBI
mRatBN7.21254,109,564 - 254,170,561 (-)NCBI
Rnor_6.01275,847,064 - 275,906,686 (-)NCBI
Rnor_5.01283,246,186 - 283,309,245 (-)NCBI
RGSC_v3.41261,370,264 - 261,431,434 (-)RGD
Celera1249,818,009 - 249,877,839 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231625   ⟹   XP_006231687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,111,599 - 264,148,578 (-)NCBI
mRatBN7.21254,109,482 - 254,143,111 (-)NCBI
Rnor_6.01275,843,823 - 275,878,536 (-)NCBI
Rnor_5.01283,246,186 - 283,309,245 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231626   ⟹   XP_006231688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,111,599 - 264,176,111 (-)NCBI
mRatBN7.21254,109,482 - 254,170,755 (-)NCBI
Rnor_6.01275,843,823 - 275,906,880 (-)NCBI
Rnor_5.01283,246,186 - 283,309,245 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063287765   ⟹   XP_063143835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,111,599 - 264,176,112 (-)NCBI
RefSeq Acc Id: NP_058970   ⟸   NM_017274
- UniProtKB: P97565 (UniProtKB/Swiss-Prot),   O35349 (UniProtKB/Swiss-Prot),   P97566 (UniProtKB/Swiss-Prot),   P97564 (UniProtKB/Swiss-Prot),   A0A0G2K2U7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231688   ⟸   XM_006231626
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2U7 (UniProtKB/TrEMBL),   A0A0G2JV22 (UniProtKB/TrEMBL),   A6JHY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231687   ⟸   XM_006231625
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2U7 (UniProtKB/TrEMBL),   A0A0G2JV22 (UniProtKB/TrEMBL),   A6JHY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072382   ⟸   ENSRNOT00000092170
Ensembl Acc Id: ENSRNOP00000050050   ⟸   ENSRNOT00000047903
Ensembl Acc Id: ENSRNOP00000069320   ⟸   ENSRNOT00000083215
RefSeq Acc Id: XP_063143835   ⟸   XM_063287765
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K2U7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103828   ⟸   ENSRNOT00000142012
Protein Domains
Phospholipid/glycerol acyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97564-F1-model_v2 AlphaFold P97564 1-828 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690999
Promoter ID:EPDNEW_R1520
Type:single initiation site
Name:Gpam_2
Description:glycerol-3-phosphate acyltransferase, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1521  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01275,882,460 - 275,882,520EPDNEW
RGD ID:13690996
Promoter ID:EPDNEW_R1521
Type:initiation region
Name:Gpam_1
Description:glycerol-3-phosphate acyltransferase, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1520  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01275,906,779 - 275,906,839EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61847 AgrOrtholog
BioCyc Gene G2FUF-55350 BioCyc
BioCyc Pathway PWY-5667 [CDP-diacylglycerol biosynthesis I] BioCyc
  PWY-7411 [phosphatidate biosynthesis (yeast)] BioCyc
  PWY-8053 [anandamide biosynthesis II] BioCyc
  TRIGLSYN-PWY [diacylglycerol and triacylglycerol biosynthesis] BioCyc
BioCyc Pathway Image PWY-5667 BioCyc
  PWY-7411 BioCyc
  PWY-8053 BioCyc
  TRIGLSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000015124 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000083215 ENTREZGENE
  ENSRNOT00000142012 ENTREZGENE
InterPro GPAT/DHAPAT UniProtKB/Swiss-Prot
  GPAT/DHAPAT_LPLAT UniProtKB/Swiss-Prot
  GPAT_C UniProtKB/Swiss-Prot
  GPAT_PlsB UniProtKB/Swiss-Prot
  Plipid/glycerol_acylTrfase UniProtKB/Swiss-Prot
KEGG Report rno:29653 UniProtKB/Swiss-Prot
NCBI Gene 29653 ENTREZGENE
PANTHER GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR12563 UniProtKB/Swiss-Prot
Pfam Acyltransferase UniProtKB/Swiss-Prot
  GPAT_C UniProtKB/Swiss-Prot
PhenoGen Gpam PhenoGen
PIRSF GPAT UniProtKB/Swiss-Prot
  GPAT_DHAPAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015124 RatGTEx
SMART PlsC UniProtKB/Swiss-Prot
Superfamily-SCOP Glycerol-3-phosphate (1)-acyltransferase UniProtKB/Swiss-Prot
TIGR TC235444
UniProt A0A0G2JV22 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K2U7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LG87_RAT UniProtKB/TrEMBL
  A6JHY2 ENTREZGENE, UniProtKB/TrEMBL
  GPAT1_RAT UniProtKB/Swiss-Prot
  O35349 ENTREZGENE
  P97564 ENTREZGENE
  P97565 ENTREZGENE
  P97566 ENTREZGENE
UniProt Secondary O35349 UniProtKB/Swiss-Prot
  P97565 UniProtKB/Swiss-Prot
  P97566 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gpam  glycerol-3-phosphate acyltransferase, mitochondrial    glycerol-3-phosphate acyltransferase, mitochondrial   Name updated 1299863 APPROVED
2002-06-10 Gpam  glycerol-3-phosphate acyltransferase, mitochondrial       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation acyltransferase activity is activated by phosphorylation by casein kinase II 633001
gene_regulation expression is regulated in liver and adipose tissue by AMP-activated protein kinase in response to exercise 631891