Cd200r1 (CD200 receptor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cd200r1 (CD200 receptor 1) Rattus norvegicus
Analyze
Symbol: Cd200r1
Name: CD200 receptor 1
RGD ID: 61837
Description: Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including negative regulation of interleukin-6 production; negative regulation of mononuclear cell migration; and negative regulation of neuroinflammatory response. Located in cell surface. Orthologous to human CD200R1 (CD200 receptor 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; Mox2r; OX102 antigen; OX2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,392,943 - 69,427,213 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1169,392,975 - 69,427,128 (-)EnsemblGRCr8
mRatBN7.21155,886,937 - 55,921,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,887,717 - 55,921,285 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1164,701,896 - 64,734,611 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,363,755 - 57,396,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,434,097 - 56,466,769 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,848,161 - 60,882,470 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,848,131 - 60,882,379 (-)Ensemblrn6Rnor6.0
Rnor_5.01164,962,558 - 64,994,987 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41157,427,237 - 57,459,716 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1155,452,759 - 55,484,520 (-)NCBICelera
RGSC_v3.11157,484,825 - 57,517,305 (-)NCBI
Cytogenetic Map11q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. Meuth SG, etal., J Neuroimmunol. 2008 Feb;194(1-2):62-9. doi: 10.1016/j.jneuroim.2007.11.013.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Wright GJ, etal., Immunity 2000 Aug;13(2):233-42.
8. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Wright GJ, etal., Immunology. 2001 Feb;102(2):173-9.
Additional References at PubMed
PMID:15274657   PMID:19151626   PMID:21471232   PMID:22053982   PMID:22342946   PMID:23382219   PMID:25569356   PMID:30006626   PMID:30032349   PMID:31078691   PMID:32394288   PMID:32473633  
PMID:32664639   PMID:36565856   PMID:36591265   PMID:37971567   PMID:38237226  


Genomics

Comparative Map Data
Cd200r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,392,943 - 69,427,213 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1169,392,975 - 69,427,128 (-)EnsemblGRCr8
mRatBN7.21155,886,937 - 55,921,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,887,717 - 55,921,285 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1164,701,896 - 64,734,611 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,363,755 - 57,396,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,434,097 - 56,466,769 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,848,161 - 60,882,470 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,848,131 - 60,882,379 (-)Ensemblrn6Rnor6.0
Rnor_5.01164,962,558 - 64,994,987 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41157,427,237 - 57,459,716 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1155,452,759 - 55,484,520 (-)NCBICelera
RGSC_v3.11157,484,825 - 57,517,305 (-)NCBI
Cytogenetic Map11q21NCBI
CD200R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383112,921,205 - 112,975,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3112,921,205 - 112,975,103 (-)Ensemblhg38GRCh38
GRCh373112,640,052 - 112,693,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363114,124,222 - 114,176,627 (-)NCBIBuild 36Build 36hg18NCBI36
Celera3111,049,870 - 111,102,275 (-)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3110,025,071 - 110,077,471 (-)NCBIHuRef
CHM1_13112,605,064 - 112,657,469 (-)NCBICHM1_1
T2T-CHM13v2.03115,642,153 - 115,696,046 (-)NCBIT2T-CHM13v2.0
Cd200r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391644,586,141 - 44,615,341 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1644,586,099 - 44,615,341 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381644,765,736 - 44,794,977 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1644,765,736 - 44,794,978 (+)Ensemblmm10GRCm38
MGSCv371644,765,849 - 44,795,090 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361644,685,124 - 44,714,310 (+)NCBIMGSCv36mm8
Celera1645,131,563 - 45,160,813 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1629.08NCBI
Cd200r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542713,143,695 - 13,148,743 (-)NCBIChiLan1.0ChiLan1.0
LOC487977
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13317,332,986 - 17,357,301 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3317,436,279 - 17,460,591 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03317,577,294 - 17,601,611 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.13317,381,692 - 17,406,001 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03317,429,158 - 17,453,448 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,978,760 - 18,003,078 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CD200R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12267,862,368 - 67,902,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2267,862,783 - 67,901,872 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604198,576,511 - 98,618,733 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd200r1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1429,639,810 - 29,681,350 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd200r1
305 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:66
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000002799
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 92 59 6 352 191 11 130 78 90 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000002799   ⟹   ENSRNOP00000002799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1169,392,975 - 69,427,128 (-)Ensembl
mRatBN7.2 Ensembl1155,887,717 - 55,921,285 (-)Ensembl
Rnor_6.0 Ensembl1160,848,131 - 60,882,379 (-)Ensembl
RefSeq Acc Id: NM_023953   ⟹   NP_076443
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,975 - 69,427,128 (-)NCBI
mRatBN7.21155,886,969 - 55,921,130 (-)NCBI
Rnor_6.01160,849,447 - 60,882,153 (-)NCBI
Rnor_5.01164,962,558 - 64,994,987 (-)NCBI
RGSC_v3.41157,427,237 - 57,459,716 (-)RGD
Celera1155,452,759 - 55,484,520 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248347   ⟹   XP_006248409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,212 (-)NCBI
mRatBN7.21155,886,937 - 55,921,217 (-)NCBI
Rnor_6.01160,848,161 - 60,882,470 (-)NCBI
Rnor_5.01164,962,558 - 64,994,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768743   ⟹   XP_008766965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,212 (-)NCBI
mRatBN7.21155,886,937 - 55,921,217 (-)NCBI
Rnor_6.01160,848,161 - 60,882,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088611   ⟹   XP_038944539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,211 (-)NCBI
mRatBN7.21155,886,937 - 55,921,215 (-)NCBI
RefSeq Acc Id: XM_039088612   ⟹   XP_038944540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,213 (-)NCBI
mRatBN7.21155,886,937 - 55,921,217 (-)NCBI
RefSeq Acc Id: NP_076443   ⟸   NM_023953
- Peptide Label: precursor
- UniProtKB: Q6PS97 (UniProtKB/Swiss-Prot),   Q9ES58 (UniProtKB/Swiss-Prot),   A6IQZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248409   ⟸   XM_006248347
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008766965   ⟸   XM_008768743
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000002799   ⟸   ENSRNOT00000002799
RefSeq Acc Id: XP_038944540   ⟸   XM_039088612
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038944539   ⟸   XM_039088611
- Peptide Label: isoform X2
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES58-F1-model_v2 AlphaFold Q9ES58 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698146
Promoter ID:EPDNEW_R8670
Type:initiation region
Name:Cd200r1_1
Description:CD200 receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,882,342 - 60,882,402EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61837 AgrOrtholog
BioCyc Gene G2FUF-21358 BioCyc
Ensembl Genes ENSRNOG00000039048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002799 ENTREZGENE
  ENSRNOT00000002799.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro CD200R UniProtKB/Swiss-Prot
  CD80_C2-set UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
KEGG Report rno:64357 UniProtKB/Swiss-Prot
NCBI Gene 64357 ENTREZGENE
PANTHER CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1 UniProtKB/Swiss-Prot
  PTHR21462 UniProtKB/Swiss-Prot
Pfam C2-set_2 UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PhenoGen Cd200r1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000039048 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A6IQZ7 ENTREZGENE, UniProtKB/TrEMBL
  MO2R1_RAT UniProtKB/Swiss-Prot
  Q6PS97 ENTREZGENE
  Q9ES58 ENTREZGENE
UniProt Secondary Q6PS97 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Cd200r1  CD200 receptor 1  Mox2r  antigen identified by monoclonal antibody MRC OX-2 receptor   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mox2r  antigen identified by monoclonal antibody MRC OX-2 receptor       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function receptor for OX2 61663
gene_physical_interaction interacts with OX2 61663
gene_regulation phosphorylated on tyrosine residues 61663