Ecel1 (endothelin converting enzyme-like 1) - Rat Genome Database

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Gene: Ecel1 (endothelin converting enzyme-like 1) Rattus norvegicus
Analyze
Symbol: Ecel1
Name: endothelin converting enzyme-like 1
RGD ID: 61806
Description: Predicted to enable metalloendopeptidase activity. Involved in intracellular signal transduction and neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; allethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: damage-induced neuronal endopeptidase; Dine; endothelin-converting enzyme-like 1; metallopeptidase; xce protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,267,417 - 95,276,508 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl995,264,618 - 95,274,575 (-)EnsemblGRCr8
mRatBN7.2987,819,516 - 87,829,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,816,718 - 87,826,675 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx996,243,845 - 96,251,002 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,379,495 - 101,386,656 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,747,775 - 99,754,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,238,568 - 94,252,484 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,239,006 - 94,250,809 (-)Ensemblrn6Rnor6.0
Rnor_5.0993,963,712 - 93,976,988 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4985,933,894 - 85,946,083 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera985,228,139 - 85,240,370 (-)NCBICelera
RGSC_v3.1986,117,313 - 86,129,502 (-)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Damage-induced neuronal endopeptidase (DINE/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury. Kato R, etal., J Neurosci 2002 Nov 1;22(21):9410-8.
4. Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Kiryu-Seo S, etal., Proc Natl Acad Sci U S A 2000 Apr 11;97(8):4345-50.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family. Schweizer A, etal., J Biol Chem 1999 Jul 16;274(29):20450-6.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS. Valdenaire O, etal., Brain Res Mol Brain Res 1999 Feb 5;64(2):211-21.
Additional References at PubMed
PMID:16675137   PMID:18192274  


Genomics

Comparative Map Data
Ecel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,267,417 - 95,276,508 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl995,264,618 - 95,274,575 (-)EnsemblGRCr8
mRatBN7.2987,819,516 - 87,829,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,816,718 - 87,826,675 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx996,243,845 - 96,251,002 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,379,495 - 101,386,656 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,747,775 - 99,754,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,238,568 - 94,252,484 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,239,006 - 94,250,809 (-)Ensemblrn6Rnor6.0
Rnor_5.0993,963,712 - 93,976,988 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4985,933,894 - 85,946,083 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera985,228,139 - 85,240,370 (-)NCBICelera
RGSC_v3.1986,117,313 - 86,129,502 (-)NCBI
Cytogenetic Map9q35NCBI
ECEL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,479,827 - 232,487,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,479,825 - 232,489,045 (-)Ensemblhg38GRCh38
GRCh372233,344,537 - 233,352,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,052,781 - 233,060,776 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342233,170,041 - 233,178,036NCBI
Celera2227,108,836 - 227,116,836 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2225,195,323 - 225,202,264 (-)NCBIHuRef
CHM1_12233,350,656 - 233,358,651 (-)NCBICHM1_1
T2T-CHM13v2.02232,966,632 - 232,974,639 (-)NCBIT2T-CHM13v2.0
Ecel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,070,596 - 87,084,867 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,075,377 - 87,084,243 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38187,142,874 - 87,157,085 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,147,655 - 87,156,521 (-)Ensemblmm10GRCm38
MGSCv37189,044,230 - 89,051,602 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36188,978,826 - 88,986,198 (-)NCBIMGSCv36mm8
Celera190,119,625 - 90,126,994 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map144.06NCBI
LOC100993088
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213135,085,211 - 135,093,234 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B135,100,176 - 135,108,199 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B119,711,355 - 119,719,378 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B238,630,404 - 238,637,319 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B238,630,731 - 238,637,233 (-)EnsemblpanPan2panpan1.1
ECEL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,120,200 - 44,128,049 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2544,120,196 - 44,128,046 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2544,614,760 - 44,622,531 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02544,377,692 - 44,385,491 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2544,377,688 - 44,385,476 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12544,303,629 - 44,311,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02544,148,892 - 44,156,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02544,303,963 - 44,311,740 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ecel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303186,331,252 - 186,339,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365254,600,246 - 4,608,508 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365254,599,840 - 4,608,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ECEL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,988,657 - 132,997,825 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115132,988,705 - 132,997,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215146,882,398 - 146,890,247 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ECEL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110118,500,297 - 118,507,775 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10118,500,233 - 118,507,238 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604080,994,284 - 81,002,318 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ecel1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14159,274,753 - 159,282,127 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ecel1
71 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:786
Count of miRNA genes:295
Interacting mature miRNAs:363
Transcripts:ENSRNOT00000026387
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
RH144119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,819,761 - 87,819,927 (+)MAPPERmRatBN7.2
Rnor_6.0994,243,896 - 94,244,061NCBIRnor6.0
Rnor_5.0993,969,040 - 93,969,205UniSTSRnor5.0
RGSC_v3.4985,939,222 - 85,939,387UniSTSRGSC3.4
Celera985,233,457 - 85,233,622UniSTS
Cytogenetic Map9q35UniSTS
AW527169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,825,854 - 87,826,006 (+)MAPPERmRatBN7.2
Rnor_6.0994,249,989 - 94,250,140NCBIRnor6.0
Rnor_5.0993,975,133 - 93,975,284UniSTSRnor5.0
RGSC_v3.4985,945,263 - 85,945,414UniSTSRGSC3.4
Celera985,239,550 - 85,239,701UniSTS
Cytogenetic Map9q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 29 152 53 52 21 26 21 6 168 81 8 130 42 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026387   ⟹   ENSRNOP00000026388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,264,618 - 95,274,575 (-)Ensembl
mRatBN7.2 Ensembl987,816,718 - 87,826,675 (-)Ensembl
Rnor_6.0 Ensembl994,239,006 - 94,250,809 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095466   ⟹   ENSRNOP00000095212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,264,618 - 95,274,575 (-)Ensembl
mRatBN7.2 Ensembl987,816,718 - 87,826,675 (-)Ensembl
RefSeq Acc Id: NM_021776   ⟹   NP_068544
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,267,417 - 95,274,572 (-)NCBI
mRatBN7.2987,819,517 - 87,826,672 (-)NCBI
Rnor_6.0994,238,568 - 94,250,809 (-)NCBI
Rnor_5.0993,963,712 - 93,976,988 (-)NCBI
RGSC_v3.4985,933,894 - 85,946,083 (-)RGD
Celera985,228,139 - 85,240,370 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596615   ⟹   XP_017452104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,267,417 - 95,275,637 (-)NCBI
mRatBN7.2987,819,516 - 87,827,726 (-)NCBI
Rnor_6.0994,243,651 - 94,251,847 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063267665   ⟹   XP_063123735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,267,417 - 95,275,638 (-)NCBI
RefSeq Acc Id: XM_063267666   ⟹   XP_063123736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,267,417 - 95,276,508 (-)NCBI
RefSeq Acc Id: XM_063267667   ⟹   XP_063123737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,267,417 - 95,275,418 (-)NCBI
RefSeq Acc Id: NP_068544   ⟸   NM_021776
- UniProtKB: Q9Z192 (UniProtKB/Swiss-Prot),   Q9JHL3 (UniProtKB/Swiss-Prot),   D4AD32 (UniProtKB/TrEMBL),   A6JWK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452104   ⟸   XM_017596615
- Peptide Label: isoform X2
- UniProtKB: Q9Z192 (UniProtKB/Swiss-Prot),   Q9JHL3 (UniProtKB/Swiss-Prot),   D4AD32 (UniProtKB/TrEMBL),   A6JWK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026388   ⟸   ENSRNOT00000026387
Ensembl Acc Id: ENSRNOP00000095212   ⟸   ENSRNOT00000095466
RefSeq Acc Id: XP_063123736   ⟸   XM_063267666
- Peptide Label: isoform X1
- UniProtKB: Q9Z192 (UniProtKB/Swiss-Prot),   Q9JHL3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123735   ⟸   XM_063267665
- Peptide Label: isoform X1
- UniProtKB: Q9Z192 (UniProtKB/Swiss-Prot),   Q9JHL3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123737   ⟸   XM_063267667
- Peptide Label: isoform X1
- UniProtKB: Q9Z192 (UniProtKB/Swiss-Prot),   Q9JHL3 (UniProtKB/Swiss-Prot)
Protein Domains
Peptidase M13   Peptidase M13 C-terminal   Peptidase M13 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHL3-F1-model_v2 AlphaFold Q9JHL3 1-775 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61806 AgrOrtholog
BioCyc Gene G2FUF-26852 BioCyc
Ensembl Genes ENSRNOG00000019447 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000095466 ENTREZGENE
Gene3D-CATH 1.10.1380.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Peptidase_M13 UniProtKB/Swiss-Prot
  Peptidase_M13_C UniProtKB/Swiss-Prot
  Peptidase_M13_dom_2 UniProtKB/Swiss-Prot
  Peptidase_M13_N UniProtKB/Swiss-Prot
KEGG Report rno:60417 UniProtKB/Swiss-Prot
NCBI Gene 60417 ENTREZGENE
PANTHER PTHR11733 UniProtKB/Swiss-Prot
  PTHR11733:SF195 UniProtKB/Swiss-Prot
Pfam Peptidase_M13 UniProtKB/Swiss-Prot
  Peptidase_M13_N UniProtKB/Swiss-Prot
PhenoGen Ecel1 PhenoGen
PRINTS NEPRILYSIN UniProtKB/Swiss-Prot
PROSITE NEPRILYSIN UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019447 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
TIGR TC231293
UniProt A0A8I6AM70_RAT UniProtKB/TrEMBL
  A6JWK8 ENTREZGENE, UniProtKB/TrEMBL
  D4AD32 ENTREZGENE, UniProtKB/TrEMBL
  ECEL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z192 ENTREZGENE
UniProt Secondary Q9Z192 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ecel1  endothelin converting enzyme-like 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed specifically in neurons of the central nervous system (CNS) and peripheral nervous system 628377
gene_function membrane-bound metallopeptidase 628377
gene_process may mediate neuropeptide processing 628377
gene_process enhances the expression and the activity of antioxidant enzymes such as Cu/Zn-superoxide dismutase (SOD), Mn-SOD, and glutathione peroxidase under oxidative stress 628377
gene_product membrane-bound metallopeptidase  
gene_regulation mRNA expression was enhanced by leukemia inhibitory factor (LIF) but not by other growth factors and cytokines 628377
gene_regulation mRNA expression is increased by nerve growth factor (NGF) deprivation, and by leukemia inhibitory factor (LIF) but not by other growth factors and cytokines; mRNA is increased in the dorsal root ganglion (DRG) neurons by sciatic nerve injury 628377