Unc119 (unc-119 lipid binding chaperone) - Rat Genome Database

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Gene: Unc119 (unc-119 lipid binding chaperone) Rattus norvegicus
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Symbol: Unc119
Name: unc-119 lipid binding chaperone
RGD ID: 3942
Description: Predicted to enable lipid binding activity. Predicted to be involved in several processes, including lipoprotein transport; negative regulation of endocytosis; and positive regulation of protein tyrosine kinase activity. Predicted to be located in cytoplasm. Predicted to be active in intercellular bridge and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: protein unc-119 homolog A; rat retinal gene 4; retinal gene 4; retinal protein 4; RRG4; UNC-119 homolog; UNC-119 homolog (C. elegans); Uncl19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,735,927 - 63,741,404 (+)NCBIGRCr8
mRatBN7.21063,237,862 - 63,243,339 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,237,903 - 63,243,339 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,870,234 - 67,875,633 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,375,583 - 67,380,982 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,846,688 - 62,852,088 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,606,919 - 65,612,324 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,606,898 - 65,612,324 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,026,840 - 66,032,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,285,993 - 64,291,392 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,299,615 - 64,305,015 (-)NCBI
Celera1062,215,606 - 62,221,005 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Unc119Ratcone-rod dystrophy  ISOUNC119 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11006213 more ...
Unc119Ratcone-rod dystrophy 24  ISOUNC119 (Homo sapiens)8554872ClinVar Annotator: match by term: Cone-rod dystrophy 24ClinVarPMID:11006213 more ...
Unc119Ratidiopathic CD4-positive T-lymphocytopenia  ISOUNC119 (Homo sapiens)8554872ClinVar Annotator: match by term: IDIOPATHIC CD4 LYMPHOPENIAClinVarPMID:22184408 more ...
Unc119Ratimmunodeficiency 13  ISOUNC119 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22184408 more ...
Unc119Ratmacular degeneration  ISOUNC119 (Homo sapiens)8554872ClinVar Annotator: match by term: Macular dystrophyClinVarPMID:26992781 and PMID:35947183
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Unc119Ratidiopathic CD4-positive T-lymphocytopenia  ISOUNC119 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Unc119Ratretinitis pigmentosa  ISOUNC119 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11006213
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Unc119Ratcone-rod dystrophy 24  ISOUNC119 (Homo sapiens)7240710 OMIM 
Unc119Ratimmunodeficiency 13  ISOUNC119 (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Unc119Rat(1->4)-beta-D-glucan multiple interactionsISOUnc119 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of UNC119 mRNACTDPMID:36331819
Unc119Rat(S)-nicotine decreases expressionISOUNC119 (Homo sapiens)6480464Nicotine results in decreased expression of UNC119 mRNACTDPMID:16949557
Unc119Rat1,2-dimethylhydrazine increases expressionISOUnc119 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of UNC119 mRNACTDPMID:22206623
Unc119Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOUnc119 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of UNC119 mRNACTDPMID:18796159 and PMID:19465110
Unc119Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of UNC119 mRNACTDPMID:33387578
Unc119Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of UNC119 mRNACTDPMID:34747641
Unc119Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of UNC119 mRNACTDPMID:21346803
Unc119Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of UNC119 mRNACTDPMID:19162173
Unc119Rat4,4'-diaminodiphenylmethane decreases expressionISOUnc119 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of UNC119 mRNACTDPMID:18648102
Unc119Rat4-hydroxyphenyl retinamide decreases expressionISOUnc119 (Mus musculus)6480464Fenretinide results in decreased expression of UNC119 mRNACTDPMID:28973697
Unc119Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of UNC119 mRNACTDPMID:24780913
Unc119Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of UNC119 mRNACTDPMID:30047161
Unc119Ratall-trans-retinoic acid increases expressionISOUNC119 (Homo sapiens)6480464Tretinoin results in increased expression of UNC119 mRNACTDPMID:33167477
Unc119Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of UNC119 mRNACTDPMID:16483693
Unc119Ratbenzo[a]pyrene decreases methylationISOUNC119 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of UNC119 promoterCTDPMID:27901495
Unc119Ratbenzo[a]pyrene increases methylationISOUNC119 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of UNC119 3' UTRCTDPMID:27901495
Unc119Ratbeta-lapachone increases expressionISOUNC119 (Homo sapiens)6480464beta-lapachone results in increased expression of UNC119 mRNACTDPMID:38218311
Unc119Ratbeta-lapachone decreases expressionISOUNC119 (Homo sapiens)6480464beta-lapachone results in decreased expression of UNC119 mRNACTDPMID:38218311
Unc119Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of UNC119 mRNACTDPMID:25181051
Unc119Ratbisphenol A increases expressionISOUnc119 (Mus musculus)6480464bisphenol A results in increased expression of UNC119 mRNACTDPMID:32156529

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Biological Process
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Original Reference(s)
Unc119Ratendocytosis involved_inIEAUniProtKB-KW:KW-02541600115GO_REF:0000043UniProtGO_REF:0000043
Unc119Ratlipoprotein transport involved_inISSUniProtKB:Q134321600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratlipoprotein transport involved_inIBAMGI:1328357 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratlipoprotein transport involved_inISOUnc119 (Mus musculus)1624291 PMID:21642972RGDPMID:21642972
Unc119Ratlipoprotein transport involved_inISOUNC119 (Homo sapiens)1624291 PMID:21642972 and PMID:22085962RGDPMID:21642972 and PMID:22085962
Unc119Ratlipoprotein transport involved_inIEAUniProtKB:Q13432 and ensembl:ENSP000003370401600115GO_REF:0000107EnsemblGO_REF:0000107
Unc119Ratmitotic cytokinesis involved_inIEAUniProtKB:Q13432 and ensembl:ENSP000003370401600115GO_REF:0000107EnsemblGO_REF:0000107
Unc119Ratmitotic cytokinesis involved_inIBAPANTHER:PTN002658567 and UniProtKB:Q134321600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratmitotic cytokinesis involved_inISSUniProtKB:Q134321600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratmitotic cytokinesis involved_inISOUNC119 (Homo sapiens)1624291 PMID:23535298RGDPMID:23535298
Unc119Ratnegative regulation of caveolin-mediated endocytosis involved_inISOUnc119 (Mus musculus)1624291 PMID:19781630RGDPMID:19781630
Unc119Ratnegative regulation of caveolin-mediated endocytosis involved_inIBAMGI:1328357 and PANTHER:PTN0026585671600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratnegative regulation of caveolin-mediated endocytosis involved_inISSUniProtKB:Q9Z2R61600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratnegative regulation of clathrin-dependent endocytosis involved_inISOUnc119 (Mus musculus)1624291 PMID:19781630RGDPMID:19781630
Unc119Ratnegative regulation of clathrin-dependent endocytosis involved_inIBAMGI:1328357 and PANTHER:PTN0026585671600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratnegative regulation of clathrin-dependent endocytosis involved_inISSUniProtKB:Q9Z2R61600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratnervous system development involved_inIBAFB:FBgn0025549 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratpositive regulation of protein tyrosine kinase activity involved_inISOUNC119 (Homo sapiens)1624291 PMID:14757743RGDPMID:14757743
Unc119Ratprotein transport involved_inIEAUniProtKB-KW:KW-06531600115GO_REF:0000043UniProtGO_REF:0000043
Unc119Ratvisual perception involved_inIEAUniProtKB-KW:KW-08441600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Object Symbol
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Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Unc119Ratcentrosome located_inISSUniProtKB:Q134321600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratcentrosome is_active_inIBAPANTHER:PTN002658567 and UniProtKB:Q134321600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratcentrosome located_inIEAUniProtKB-SubCell:SL-00481600115GO_REF:0000044UniProtGO_REF:0000044
Unc119Ratcentrosome located_inISOUNC119 (Homo sapiens)1624291 PMID:22085962 and PMID:23535298RGDPMID:22085962 and PMID:23535298
Unc119Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Unc119Ratintercellular bridge located_inISSUniProtKB:Q134321600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratintercellular bridge is_active_inIBAPANTHER:PTN002658567 and UniProtKB:Q134321600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratintercellular bridge located_inISOUNC119 (Homo sapiens)1624291 PMID:23535298RGDPMID:23535298
Unc119Ratintercellular bridge located_inIEAUniProtKB:Q13432 and ensembl:ENSP000003370401600115GO_REF:0000107EnsemblGO_REF:0000107
Unc119Ratspindle midzone located_inISSUniProtKB:Q134321600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratspindle midzone is_active_inIBAPANTHER:PTN002658567 and UniProtKB:Q134321600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratspindle midzone located_inISOUNC119 (Homo sapiens)1624291 PMID:23535298RGDPMID:23535298
Unc119Ratspindle midzone located_inIEAUniProtKB:Q13432 and ensembl:ENSP000003370401600115GO_REF:0000107EnsemblGO_REF:0000107
Unc119Ratspindle pole located_inISSUniProtKB:Q134321600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratspindle pole is_active_inIBAPANTHER:PTN002658567 and UniProtKB:Q134321600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratspindle pole located_inIEAUniProtKB-SubCell:SL-04481600115GO_REF:0000044UniProtGO_REF:0000044
Unc119Ratspindle pole located_inISOUNC119 (Homo sapiens)1624291 PMID:23535298RGDPMID:23535298
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Molecular Function

  
Object Symbol
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Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Unc119Ratlipid binding enablesISOUNC119 (Homo sapiens)1624291 PMID:21642972 and PMID:22085962RGDPMID:21642972 and PMID:22085962
Unc119Ratlipid binding enablesIBAPANTHER:PTN000310586 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Unc119Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Unc119Ratlipid binding enablesIEAUniProtKB:Q13432 and ensembl:ENSP000003370401600115GO_REF:0000107EnsemblGO_REF:0000107
Unc119Ratlipid binding enablesISSUniProtKB:Q134321600115GO_REF:0000024UniProtGO_REF:0000024
Unc119Ratprotein binding enablesISOUNC119 (Homo sapiens)1624291UniProtKB:A2BDD9 more ...RGDPMID:14757743 more ...
Unc119Ratprotein binding enablesISOUnc119 (Mus musculus)1624291PR:Q7TNH6 more ...RGDPMID:19781630 more ...
Unc119Ratprotein binding enablesIPIUniProtKB:O086978553320PMID:12527357UniProt 


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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning of the cDNA for a novel photoreceptor protein. Higashide T, etal., J Biol Chem 1996 Jan 19;271(3):1797-804.
3. Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain. Kobayashi A, etal., FEBS Lett. 2003 Jan 16;534(1-3):26-32.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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PMID:14757743   PMID:15489334   PMID:19781630   PMID:21642972   PMID:22085962   PMID:23535298  



Unc119
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,735,927 - 63,741,404 (+)NCBIGRCr8
mRatBN7.21063,237,862 - 63,243,339 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,237,903 - 63,243,339 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,870,234 - 67,875,633 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,375,583 - 67,380,982 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,846,688 - 62,852,088 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,606,919 - 65,612,324 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,606,898 - 65,612,324 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,026,840 - 66,032,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,285,993 - 64,291,392 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,299,615 - 64,305,015 (-)NCBI
Celera1062,215,606 - 62,221,005 (+)NCBICelera
Cytogenetic Map10q25NCBI
UNC119
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,546,707 - 28,552,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,546,708 - 28,552,631 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,873,725 - 26,879,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,897,852 - 23,903,770 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,897,852 - 23,903,770NCBI
Celera1723,732,750 - 23,738,671 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,082,548 - 23,088,469 (-)NCBIHuRef
CHM1_11726,935,427 - 26,941,348 (-)NCBICHM1_1
T2T-CHM13v2.01729,489,330 - 29,495,251 (-)NCBIT2T-CHM13v2.0
Unc119
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,234,321 - 78,239,990 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,234,308 - 78,239,990 (+)EnsemblGRCm39 Ensembl
GRCm381178,343,495 - 78,349,164 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,343,482 - 78,349,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,157,024 - 78,162,658 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,159,717 - 78,165,351 (+)NCBIMGSCv36mm8
Celera1187,975,604 - 87,981,238 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Unc119
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,597,839 - 4,603,313 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,597,839 - 4,603,313 (+)NCBIChiLan1.0ChiLan1.0
UNC119
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21935,907,677 - 35,913,612 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,787,803 - 37,793,737 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,223,428 - 28,229,361 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,729,569 - 28,732,229 (+)NCBIpanpan1.1PanPan1.1panPan2
UNC119
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,754,575 - 42,760,337 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,754,887 - 42,760,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,911,236 - 41,917,005 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,573,537 - 43,579,307 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,573,540 - 43,579,444 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,356,587 - 42,362,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,649,035 - 42,654,797 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,726,501 - 42,732,272 (-)NCBIUU_Cfam_GSD_1.0
Unc119
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,894,288 - 41,900,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,772,283 - 4,778,137 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,772,236 - 4,778,149 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC119
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,801,267 - 44,807,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,801,265 - 44,807,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,785,656 - 46,791,681 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UNC119
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,315,900 - 22,321,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660757,804,980 - 7,810,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc119
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,134,162 - 1,141,474 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,134,508 - 1,140,831 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Unc119
13 total Variants

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:78
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000015091
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat

1 to 10 of 79 rows
RH127571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,243,118 - 63,243,301 (+)MAPPERmRatBN7.2
Rnor_6.01065,612,104 - 65,612,286NCBIRnor6.0
Rnor_5.01066,026,872 - 66,027,054UniSTSRnor5.0
RGSC_v3.41064,286,025 - 64,286,207UniSTSRGSC3.4
Celera1062,220,791 - 62,220,973UniSTS
RH 3.4 Map10525.79UniSTS
Cytogenetic Map10q25UniSTS
RH129323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,236,928 - 63,237,147 (+)MAPPERmRatBN7.2
Rnor_6.01065,605,914 - 65,606,132NCBIRnor6.0
Rnor_5.01066,033,026 - 66,033,244UniSTSRnor5.0
RGSC_v3.41064,292,179 - 64,292,397UniSTSRGSC3.4
Celera1062,214,601 - 62,214,819UniSTS
Cytogenetic Map10q25UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000015091   ⟹   ENSRNOP00000015091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,237,903 - 63,243,339 (+)Ensembl
Rnor_6.0 Ensembl1065,606,898 - 65,612,324 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096250   ⟹   ENSRNOP00000097045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,237,903 - 63,242,837 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107663   ⟹   ENSRNOP00000095078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,241,036 - 63,243,339 (+)Ensembl
RefSeq Acc Id: NM_017188   ⟹   NP_058884
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,735,999 - 63,741,398 (+)NCBI
mRatBN7.21063,237,934 - 63,243,333 (+)NCBI
Rnor_6.01065,606,919 - 65,612,318 (+)NCBI
Rnor_5.01066,026,840 - 66,032,239 (-)NCBI
RGSC_v3.41064,285,993 - 64,291,392 (-)RGD
Celera1062,215,606 - 62,221,005 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085739   ⟹   XP_038941667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,736,370 - 63,741,404 (+)NCBI
mRatBN7.21063,239,112 - 63,243,339 (+)NCBI
RefSeq Acc Id: XM_063268810   ⟹   XP_063124880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81063,735,927 - 63,740,527 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_058884 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941667 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124880 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52389 (Get FASTA)   NCBI Sequence Viewer  
  AAH62057 (Get FASTA)   NCBI Sequence Viewer  
  EDM05349 (Get FASTA)   NCBI Sequence Viewer  
  EDM05350 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015091.4
  ENSRNOP00000095078.1
  ENSRNOP00000097045.1
GenBank Protein Q62885 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_058884   ⟸   NM_017188
- UniProtKB: Q62885 (UniProtKB/Swiss-Prot),   A6HH44 (UniProtKB/TrEMBL),   A6HH45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015091   ⟸   ENSRNOT00000015091
RefSeq Acc Id: XP_038941667   ⟸   XM_039085739
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AN70 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097045   ⟸   ENSRNOT00000096250
Ensembl Acc Id: ENSRNOP00000095078   ⟸   ENSRNOT00000107663
Name Modeler Protein Id AA Range Protein Structure
AF-Q62885-F1-model_v2 AlphaFold Q62885 1-240 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697478
Promoter ID:EPDNEW_R8003
Type:initiation region
Name:Unc119_1
Description:unc-119 lipid binding chaperone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01065,606,880 - 65,606,940EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24066 BioCyc
Ensembl Genes ENSRNOG00000011060 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015091.8 UniProtKB/Swiss-Prot
  ENSRNOT00000096250.1 UniProtKB/TrEMBL
  ENSRNOT00000107663.1 UniProtKB/TrEMBL
Gene3D-CATH 2.70.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598983 IMAGE-MGC_LOAD
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDE6D_unc-119_myristoyl-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDED_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29402 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72491 IMAGE-MGC_LOAD
NCBI Gene Unc119 ENTREZGENE
PANTHER PTHR12951:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINAL PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GMP_PDE_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Unc119 PhenoGen
RatGTEx ENSRNOG00000011060 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205025
UniProt A0A8I6AN70 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARX8_RAT UniProtKB/TrEMBL
  A6HH44 ENTREZGENE, UniProtKB/TrEMBL
  A6HH45 ENTREZGENE, UniProtKB/TrEMBL
  Q62885 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-26 Unc119  unc-119 lipid binding chaperone  Unc119  UNC-119 homolog (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Unc119  UNC-119 homolog (C. elegans)  Uncl19    Symbol updated 1299863 APPROVED
2002-06-10 Uncl19  UNC-119 homolog (C. elegans)      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression high expression seen around postnatal day 5 in the rat outer retina when the photoreceptors begin to differentiate 70051