Uba1y (ubiquitin-activating enzyme, Chr Y) - Rat Genome Database

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Gene: Uba1y (ubiquitin-activating enzyme, Chr Y) Rattus norvegicus
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Symbol: Uba1y
Name: ubiquitin-activating enzyme, Chr Y
RGD ID: 3925
Description: Predicted to enable ubiquitin activating enzyme activity. Involved in spermatogenesis. Predicted to be active in cytoplasm and nucleus; PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ube1y; Ube1y1; Ubiquitin enzyme 1 on Y; ubiquitin-activating enzyme E1, Chr Y 1; ubiquitin-like modifier-activating enzyme 1 Y
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8Y481,352 - 504,038 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblY483,578 - 504,038 (+)EnsemblGRCr8
mRatBN7.2Y457,617 - 480,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblY459,843 - 480,216 (+)EnsemblmRatBN7.2
Rnor_6.0Y422,819 - 445,477 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblY422,855 - 445,477 (+)Ensemblrn6Rnor6.0
Cytogenetic MapYq11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of a spermatogenesis-related gene Ube1 in rat testis. DU Y, etal., Sheng Li Xue Bao. 2008 Jun 25;60(3):382-90.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Defective ubiquitination of cerebral proteins in Alzheimer's disease. Lopez Salon M, etal., J Neurosci Res 2000 Oct 15;62(2):302-10.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Control of ubiquitination of proteins in rat tissues by ubiquitin conjugating enzymes and isopeptidases. Rajapurohitam V, etal., Am J Physiol Endocrinol Metab 2002 Apr;282(4):E739-45.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7714913   PMID:20333173  


Genomics

Comparative Map Data
Uba1y
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8Y481,352 - 504,038 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblY483,578 - 504,038 (+)EnsemblGRCr8
mRatBN7.2Y457,617 - 480,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblY459,843 - 480,216 (+)EnsemblmRatBN7.2
Rnor_6.0Y422,819 - 445,477 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblY422,855 - 445,477 (+)Ensemblrn6Rnor6.0
Cytogenetic MapYq11NCBI
Uba1y
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39Y818,612 - 843,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblY818,649 - 844,224 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38Y818,612 - 843,684 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblY818,649 - 844,224 (+)Ensemblmm10GRCm38
MGSCv37Y155,156 - 180,667 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36Y155,156 - 180,667 (+)NCBIMGSCv36mm8
CeleraY3,653,902 - 3,679,412 (+)NCBICelera
Cytogenetic MapYpterNCBI

Variants

.
Variants in Uba1y
46 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 5 22 25 24 13 7 13 5 47 18 14 9 38 11

Sequence


Ensembl Acc Id: ENSRNOT00000092178   ⟹   ENSRNOP00000074531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblY422,855 - 445,477 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098508   ⟹   ENSRNOP00000085953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblY459,843 - 480,216 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142933   ⟹   ENSRNOP00000101223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblY483,578 - 504,038 (+)Ensembl
RefSeq Acc Id: NM_001408738   ⟹   NP_001395667
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8Y481,352 - 504,038 (+)NCBI
mRatBN7.2Y457,617 - 480,306 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395667 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52172 (Get FASTA)   NCBI Sequence Viewer  
  ABS18281 (Get FASTA)   NCBI Sequence Viewer  
  ACX55122 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000101223
  ENSRNOP00000101223.1
Ensembl Acc Id: ENSRNOP00000074531   ⟸   ENSRNOT00000092178
Ensembl Acc Id: ENSRNOP00000085953   ⟸   ENSRNOT00000098508
RefSeq Acc Id: NP_001395667   ⟸   NM_001408738
- UniProtKB: A7LAC4 (UniProtKB/TrEMBL),   A0A8I6A544 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101223   ⟸   ENSRNOT00000142933
Protein Domains
Ubiquitin-activating enzyme E1 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8A5-F1-model_v2 AlphaFold A0A0G2K8A5 1-1057 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3925 AgrOrtholog
BioCyc Gene G2FUF-592 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000052326 Ensembl
  ENSRNOG00000063279 Ensembl
  ENSRNOG00000083862 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000142933 ENTREZGENE
  ENSRNOT00000142933.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2660 UniProtKB/TrEMBL
  2.40.30.180 UniProtKB/TrEMBL
  3.10.290.60 UniProtKB/TrEMBL
  3.50.50.80 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2 UniProtKB/TrEMBL
InterPro E1_4HB UniProtKB/TrEMBL
  E1_FCCH UniProtKB/TrEMBL
  E1_FCCH_sf UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/TrEMBL
  Ub-activating_enz_E1_C UniProtKB/TrEMBL
  Ub-E1_IAD_1 UniProtKB/TrEMBL
  UBA_E1_C_sf UniProtKB/TrEMBL
  UBA_E1_SCCH UniProtKB/TrEMBL
  Ubi_acti_E1_SCCH UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/TrEMBL
  UBQ-activ_enz_E1 UniProtKB/TrEMBL
  UBQ-activ_enz_E1_CS UniProtKB/TrEMBL
  UBQ-activ_enz_E1_Cys_AS UniProtKB/TrEMBL
  UBQ/SUMO-activ_enz_E1-like UniProtKB/TrEMBL
NCBI Gene 25225 ENTREZGENE
PANTHER PTHR10953 UniProtKB/TrEMBL
  UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1 Y UniProtKB/TrEMBL
Pfam E1_4HB UniProtKB/TrEMBL
  E1_FCCH UniProtKB/TrEMBL
  E1_UFD UniProtKB/TrEMBL
  ThiF UniProtKB/TrEMBL
  UBA_e1_thiolCys UniProtKB/TrEMBL
PhenoGen Uba1y PhenoGen
PRINTS UBIQUITINACT UniProtKB/TrEMBL
PROSITE UBIQUITIN_ACTIVAT_1 UniProtKB/TrEMBL
  UBIQUITIN_ACTIVAT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052326 RatGTEx
  ENSRNOG00000063279 RatGTEx
  ENSRNOG00000083862 RatGTEx
SMART UBA_e1_C UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/TrEMBL
UniProt A0A8I6A544 ENTREZGENE
  A0ABK0LD70_RAT UniProtKB/TrEMBL
  A7LAC4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-06 Uba1y  ubiquitin-activating enzyme, Chr Y  Ube1y1  ubiquitin-activating enzyme E1, Chr Y 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ube1y1  ubiquitin-activating enzyme E1, Chr Y 1    ubiquitin-activating enzyme E1, Chr Y 1   Name updated 1299863 APPROVED
2003-04-09 Ube1y1  ubiquitin-activating enzyme E1, Chr Y 1   Ube1y  Ubiquitin enzyme 1 on Y  Symbol and Name updated 629477 APPROVED
2002-06-10 Ube1y  Ubiquitin enzyme 1 on Y      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activation of ubiquitin involved in an ATP-hydrolyzing reaction that initially results in formation of a ubiquitin adenylate intermediate bound to the enzyme 724779