Tub (TUB bipartite transcription factor) - Rat Genome Database

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Pathways
Gene: Tub (TUB bipartite transcription factor) Rattus norvegicus
Analyze
Symbol: Tub
Name: TUB bipartite transcription factor
RGD ID: 3918
Description: Predicted to enable G protein-coupled receptor binding activity and intraciliary transport particle A binding activity. Involved in response to cocaine and response to hormone. Located in nucleus and plasma membrane. Orthologous to human TUB (TUB bipartite transcription factor); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Tubby (mouse) homolog; tubby bipartite transcription factor; tubby homolog (mouse); tubby protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81172,386,772 - 172,465,791 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1172,382,197 - 172,465,790 (+)EnsemblGRCr8
mRatBN7.21163,008,198 - 163,030,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,951,931 - 163,026,812 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,350,257 - 171,368,453 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,536,314 - 178,554,516 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,209,520 - 171,227,526 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01173,550,929 - 173,629,550 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1173,607,101 - 173,625,550 (+)Ensemblrn6Rnor6.0
Rnor_5.01180,541,359 - 180,618,745 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1160,923,600 - 160,933,169 (+)NCBICelera
RH 3.4 Map11355.4RGD
Cytogenetic Map1q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IBA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (ISO)
extracellular region  (IEA,ISO)
nucleus  (IDA,IEA,ISO)
plasma membrane  (IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Catabolic action of insulin in rat arcuate nucleus is not enhanced by exogenous "tub" expression. Figlewicz DP, etal., Am J Physiol Endocrinol Metab 2004 Jun;286(6):E1004-10. Epub 2004 Jan 28.
2. Cocaine potentiates multiple 5-HT2A receptor signaling pathways and is associated with decreased phosphorylation of 5-HT2A receptors in vivo. Franklin JM and Carrasco GA, J Mol Neurosci. 2015 Mar;55(3):770-7. doi: 10.1007/s12031-014-0419-z. Epub 2014 Sep 12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Kleyn PW, etal., Cell. 1996 Apr 19;85(2):281-90.
5. Thyroid hormone regulates the obesity gene tub. Koritschoner NP, etal., EMBO Rep 2001 Jun;2(6):499-504.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Norman RA, etal., Diabetes. 1996 Sep;45(9):1229-32.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia. Soetedjo L, etal., Biol Open. 2013 May 23;2(7):686-94. doi: 10.1242/bio.20134747. Print 2013 Jul 15.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10629044   PMID:11925566   PMID:19695251   PMID:19837063   PMID:19887065   PMID:20889716   PMID:20978472   PMID:21052544   PMID:23351594   PMID:24316073   PMID:25931508   PMID:28154160  


Genomics

Comparative Map Data
Tub
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81172,386,772 - 172,465,791 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1172,382,197 - 172,465,790 (+)EnsemblGRCr8
mRatBN7.21163,008,198 - 163,030,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,951,931 - 163,026,812 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,350,257 - 171,368,453 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,536,314 - 178,554,516 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,209,520 - 171,227,526 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01173,550,929 - 173,629,550 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1173,607,101 - 173,625,550 (+)Ensemblrn6Rnor6.0
Rnor_5.01180,541,359 - 180,618,745 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1160,923,600 - 160,933,169 (+)NCBICelera
RH 3.4 Map11355.4RGD
Cytogenetic Map1q33NCBI
TUB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38118,019,245 - 8,106,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl118,019,244 - 8,106,243 (+)Ensemblhg38GRCh38
GRCh37118,060,180 - 8,127,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36118,016,756 - 8,084,228 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34118,059,484 - 8,084,228NCBI
Celera118,175,909 - 8,243,289 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef117,726,921 - 7,794,103 (+)NCBIHuRef
CHM1_1118,059,163 - 8,126,615 (+)NCBICHM1_1
T2T-CHM13v2.0118,098,417 - 8,185,410 (+)NCBIT2T-CHM13v2.0
Tub
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397108,610,087 - 108,633,666 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7108,549,545 - 108,633,667 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387109,010,880 - 109,034,459 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7108,950,338 - 109,034,460 (+)Ensemblmm10GRCm38
MGSCv377116,154,394 - 116,177,973 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367108,802,057 - 108,825,636 (+)NCBIMGSCv36mm8
Celera7108,987,319 - 109,010,903 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.21NCBI
Tub
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541423,898,345 - 23,917,952 (+)Ensembl
ChiLan1.0NW_00495541423,832,741 - 23,919,697 (+)NCBIChiLan1.0ChiLan1.0
TUB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2910,442,367 - 10,529,803 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11110,404,530 - 10,491,857 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,135,981 - 8,223,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1117,882,680 - 7,969,434 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl117,882,680 - 7,969,434 (+)EnsemblpanPan2panpan1.1
TUB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12131,566,095 - 31,629,545 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2131,566,130 - 31,625,101 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2131,169,705 - 31,198,274 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02132,474,471 - 32,503,096 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2132,418,336 - 32,502,574 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12131,744,431 - 31,773,004 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02131,854,131 - 31,938,931 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02132,204,165 - 32,232,719 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tub
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494753,796,392 - 53,860,166 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365289,834,954 - 9,855,080 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365289,829,889 - 9,912,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl91,183,822 - 1,206,274 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.191,183,821 - 1,260,209 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.291,493,594 - 1,516,072 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TUB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1156,699,044 - 56,764,162 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl156,699,408 - 56,783,126 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038154,416,365 - 154,510,473 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tub
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624766268,778 - 293,356 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624766206,082 - 293,922 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tub
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1292,452,223 - 92,530,707 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tub
270 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:79
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000074636
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1qUniSTS
tub  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21163,025,770 - 163,025,861 (+)MAPPERmRatBN7.2
Rnor_6.01173,624,368 - 173,624,458NCBIRnor6.0
Rnor_5.01180,614,827 - 180,614,917UniSTSRnor5.0
Celera1160,932,128 - 160,932,218UniSTS
Cytogenetic Map1qUniSTS
RH94759  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21163,026,118 - 163,026,775 (+)MAPPERmRatBN7.2
Rnor_6.01173,624,716 - 173,625,372NCBIRnor6.0
Rnor_5.01180,615,175 - 180,615,831UniSTSRnor5.0
Celera1160,932,476 - 160,933,132UniSTS
RH 3.4 Map11355.4UniSTS
Cytogenetic Map1qUniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 10 66 159 73 72 41 83 41 6 298 180 9 138 56 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074636   ⟹   ENSRNOP00000064486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1172,443,342 - 172,461,645 (+)Ensembl
mRatBN7.2 Ensembl1163,008,510 - 163,026,812 (+)Ensembl
Rnor_6.0 Ensembl1173,607,101 - 173,625,550 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096784   ⟹   ENSRNOP00000083866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,952,194 - 163,026,812 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107491   ⟹   ENSRNOP00000097726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1172,386,724 - 172,465,790 (+)Ensembl
mRatBN7.2 Ensembl1162,951,931 - 163,026,812 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122264   ⟹   ENSRNOP00000104333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1172,387,188 - 172,465,790 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130742   ⟹   ENSRNOP00000101142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1172,382,197 - 172,465,790 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139306   ⟹   ENSRNOP00000111371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1172,430,102 - 172,465,790 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145222   ⟹   ENSRNOP00000109367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1172,387,068 - 172,465,790 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154031   ⟹   ENSRNOP00000102379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1172,387,068 - 172,465,790 (+)Ensembl
RefSeq Acc Id: NM_013077   ⟹   NP_037209
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,443,342 - 172,461,645 (+)NCBI
mRatBN7.21163,008,510 - 163,026,812 (+)NCBI
Rnor_6.01173,607,119 - 173,625,409 (+)NCBI
Rnor_5.01180,541,359 - 180,618,745 (+)NCBI
Celera1160,923,600 - 160,933,169 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282067   ⟹   XP_063138137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,386,772 - 172,465,791 (+)NCBI
RefSeq Acc Id: XM_063282071   ⟹   XP_063138141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,387,158 - 172,465,791 (+)NCBI
RefSeq Acc Id: XM_063282072   ⟹   XP_063138142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,439,974 - 172,465,791 (+)NCBI
RefSeq Acc Id: NP_037209   ⟸   NM_013077
- UniProtKB: Q9Z1A2 (UniProtKB/Swiss-Prot),   O88808 (UniProtKB/Swiss-Prot),   A6I7V5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064486   ⟸   ENSRNOT00000074636
Ensembl Acc Id: ENSRNOP00000097726   ⟸   ENSRNOT00000107491
Ensembl Acc Id: ENSRNOP00000083866   ⟸   ENSRNOT00000096784
RefSeq Acc Id: XP_063138137   ⟸   XM_063282067
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZXW6 (UniProtKB/TrEMBL),   A0A8I6GM69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138141   ⟸   XM_063282071
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138142   ⟸   XM_063282072
- Peptide Label: isoform X3
- UniProtKB: A6I7V5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101142   ⟸   ENSRNOT00000130742
Ensembl Acc Id: ENSRNOP00000102379   ⟸   ENSRNOT00000154031
Ensembl Acc Id: ENSRNOP00000104333   ⟸   ENSRNOT00000122264
Ensembl Acc Id: ENSRNOP00000111371   ⟸   ENSRNOT00000139306
Ensembl Acc Id: ENSRNOP00000109367   ⟸   ENSRNOT00000145222
Protein Domains
Tubby C-terminal   Tubby N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88808-F1-model_v2 AlphaFold O88808 1-505 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3918 AgrOrtholog
BioCyc Gene G2FUF-57881 BioCyc
Ensembl Genes ENSRNOG00000046566 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074636 ENTREZGENE
  ENSRNOT00000074636.3 UniProtKB/Swiss-Prot
  ENSRNOT00000107491 ENTREZGENE
  ENSRNOT00000122264 ENTREZGENE
  ENSRNOT00000130742 ENTREZGENE
Gene3D-CATH Tubby Protein, Chain A UniProtKB/Swiss-Prot
InterPro Tubby-like_C UniProtKB/Swiss-Prot
  Tubby_C UniProtKB/Swiss-Prot
  Tubby_C_CS UniProtKB/Swiss-Prot
  Tubby_N UniProtKB/Swiss-Prot
KEGG Report rno:25609 UniProtKB/Swiss-Prot
NCBI Gene 25609 ENTREZGENE
PANTHER TUBBY PROTEIN HOMOLOG UniProtKB/Swiss-Prot
  TUBBY-RELATED UniProtKB/Swiss-Prot
Pfam Tub UniProtKB/Swiss-Prot
  Tub_N UniProtKB/Swiss-Prot
PhenoGen Tub PhenoGen
PRINTS SUPERTUBBY UniProtKB/Swiss-Prot
  TUBBYPROTEIN UniProtKB/Swiss-Prot
PROSITE TUB_1 UniProtKB/Swiss-Prot
  TUB_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046566 RatGTEx
Superfamily-SCOP SSF54518 UniProtKB/Swiss-Prot
TIGR TC202677
UniProt A0A8I5ZXW6 ENTREZGENE
  A0A8I6GM69 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LCZ2_RAT UniProtKB/TrEMBL
  A0ABK0LL98_RAT UniProtKB/TrEMBL
  A0ABK0LMW3_RAT UniProtKB/TrEMBL
  A0ABK0LTD9_RAT UniProtKB/TrEMBL
  A0ABK0LY26_RAT UniProtKB/TrEMBL
  A6I7V5 ENTREZGENE, UniProtKB/TrEMBL
  O88808 ENTREZGENE
  Q9Z1A2 ENTREZGENE
  TUB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9Z1A2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Tub  TUB bipartite transcription factor  Tub  tubby bipartite transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-09-17 Tub  tubby bipartite transcription factor  Tub  tubby homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tub  tubby homolog (mouse)    Tubby (mouse) homolog  Name updated 629478 APPROVED
2002-06-10 Tub  Tubby (mouse) homolog      Symbol and Name status set to approved 70586 APPROVED