Thrsp (thyroid hormone responsive) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Thrsp (thyroid hormone responsive) Rattus norvegicus
Analyze
Symbol: Thrsp
Name: thyroid hormone responsive
RGD ID: 3859
Description: Predicted to enable molecular function inhibitor activity and protein homodimerization activity. Involved in regulation of lipid biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Orthologous to human THRSP (thyroid hormone responsive); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lipogenic protein S14; Lpgp; S14; spot 14 protein; SPOT14; thyroid hormone responsive protein; Thyroid hormone responsive protein (spot14); thyroid hormone responsive SPOT14 homolog; thyroid hormone responsive SPOT14 homolog (Rattus); thyroid hormone-inducible hepatic protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,134,640 - 161,138,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1161,133,453 - 161,139,827 (-)EnsemblGRCr8
mRatBN7.21151,723,415 - 151,727,740 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,723,086 - 151,728,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1159,711,451 - 159,715,792 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,891,619 - 166,895,960 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01159,765,126 - 159,769,467 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,381,251 - 162,385,575 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,381,253 - 162,385,575 (-)Ensemblrn6Rnor6.0
Rnor_5.01168,587,724 - 168,592,048 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41154,647,339 - 154,651,663 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1149,823,345 - 149,827,669 (-)NCBICelera
RGSC_v3.11154,725,746 - 154,730,069 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+/-)-Aegeline  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,2-dichloroethane  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
Bardoxolone methyl  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cantharidin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clemizole  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clothianidin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
daidzein  (EXP)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diethyl maleate  (EXP)
diquat  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
Ethylenethiourea  (ISO)
fenofibrate  (ISO)
finasteride  (EXP)
fipronil  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP)
glycidol  (EXP,ISO)
graphite  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
Mitotane  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorobutyric acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP,ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
resveratrol  (EXP)
ritodrine  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulconazole  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
theophylline  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
XL147  (ISO)
yohimbine  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO,ISS)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis. Aipoalani DL, etal., Endocrinology. 2010 May;151(5):2071-7. doi: 10.1210/en.2009-1058. Epub 2010 Mar 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Thyroid hormone and dietary carbohydrate interact to regulate rat liver S14 gene transcription and chromatin structure. Jump DB, etal., J Biol Chem 1990 Feb 25;265(6):3474-8.
5. Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thyroid hormone responsive protein genes). Lee AK, etal., Mol Cell Biochem 2002 Feb;231(1-2):163-71.
6. Characterization of a thyroid hormone-responsive gene from rat. Liaw CW and Towle HC, J Biol Chem 1984 Jun 10;259(11):7253-60.
7. Identification of functional cis-acting elements within the rat liver S14 promoter. MacDougald OA and Jump DB, Biochem J 1991 Dec 15;280 ( Pt 3):761-7.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932   PMID:12960053   PMID:15490139   PMID:15890771   PMID:18219437   PMID:20952656   PMID:23012479   PMID:25416956  


Genomics

Comparative Map Data
Thrsp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,134,640 - 161,138,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1161,133,453 - 161,139,827 (-)EnsemblGRCr8
mRatBN7.21151,723,415 - 151,727,740 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,723,086 - 151,728,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1159,711,451 - 159,715,792 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,891,619 - 166,895,960 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01159,765,126 - 159,769,467 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,381,251 - 162,385,575 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,381,253 - 162,385,575 (-)Ensemblrn6Rnor6.0
Rnor_5.01168,587,724 - 168,592,048 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41154,647,339 - 154,651,663 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1149,823,345 - 149,827,669 (-)NCBICelera
RGSC_v3.11154,725,746 - 154,730,069 (-)NCBI
Cytogenetic Map1q32NCBI
THRSP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381178,063,861 - 78,068,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1178,063,861 - 78,068,351 (+)Ensemblhg38GRCh38
GRCh371177,774,907 - 77,779,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,452,555 - 77,457,045 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341177,452,554 - 77,457,044NCBI
Celera1175,083,371 - 75,087,862 (+)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1174,073,273 - 74,077,767 (+)NCBIHuRef
CHM1_11177,658,098 - 77,662,594 (+)NCBICHM1_1
T2T-CHM13v2.01177,997,088 - 78,001,580 (+)NCBIT2T-CHM13v2.0
Thrsp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,062,140 - 97,066,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,062,145 - 97,066,937 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38797,412,933 - 97,417,550 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,412,938 - 97,417,730 (-)Ensemblmm10GRCm38
MGSCv377104,561,467 - 104,566,020 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36797,288,149 - 97,292,702 (-)NCBIMGSCv36mm8
Celera797,723,964 - 97,728,458 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.49NCBI
Thrsp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541413,879,095 - 13,883,378 (-)NCBIChiLan1.0ChiLan1.0
THRSP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2978,996,033 - 78,997,431 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,039,905 - 80,041,303 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01173,123,030 - 73,128,461 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,747,532 - 76,751,718 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,747,547 - 76,747,987 (+)EnsemblpanPan2panpan1.1
THRSP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12120,759,291 - 20,761,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2120,761,109 - 20,761,558 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2120,653,623 - 20,656,058 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02120,962,317 - 20,964,752 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2120,964,135 - 20,964,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12120,737,129 - 20,739,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02120,953,229 - 20,955,664 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02120,878,006 - 20,880,441 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Thrsp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494765,013,973 - 65,025,358 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,622,004 - 6,624,961 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,622,007 - 6,624,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRSP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl912,479,907 - 12,488,557 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1912,479,913 - 12,484,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2913,814,645 - 13,819,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THRSP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,269,174 - 69,274,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,269,746 - 69,270,198 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604356,472,709 - 56,477,534 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thrsp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248631,062,047 - 1,069,959 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248631,062,047 - 1,069,969 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Thrsp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1295,730,845 - 95,735,297 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Thrsp
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:132
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000016540
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Arb38  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01162,387,857 - 162,388,769NCBIRnor6.0
Cytogenetic Map1q32UniSTS
RH135409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21151,723,626 - 151,723,838 (+)MAPPERmRatBN7.2
Rnor_6.01162,381,463 - 162,381,674NCBIRnor6.0
Rnor_5.01168,587,936 - 168,588,147UniSTSRnor5.0
RGSC_v3.41154,647,551 - 154,647,762UniSTSRGSC3.4
Celera1149,823,557 - 149,823,768UniSTS
RH 3.4 Map11166.0UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 36 140 71 70 39 42 39 6 247 111 11 113 74 72 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016540   ⟹   ENSRNOP00000016540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1161,133,453 - 161,139,827 (-)Ensembl
mRatBN7.2 Ensembl1151,723,086 - 151,728,075 (-)Ensembl
Rnor_6.0 Ensembl1162,381,253 - 162,385,575 (-)Ensembl
RefSeq Acc Id: NM_012703   ⟹   NP_036835
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,134,640 - 161,138,964 (-)NCBI
mRatBN7.21151,723,415 - 151,727,740 (-)NCBI
Rnor_6.01162,381,251 - 162,385,575 (-)NCBI
Rnor_5.01168,587,724 - 168,592,048 (-)NCBI
RGSC_v3.41154,647,339 - 154,651,663 (-)RGD
Celera1149,823,345 - 149,827,669 (-)RGD
Sequence:
RefSeq Acc Id: NP_036835   ⟸   NM_012703
- UniProtKB: Q63536 (UniProtKB/Swiss-Prot),   P04143 (UniProtKB/Swiss-Prot),   Q5HZE3 (UniProtKB/TrEMBL),   A6I696 (UniProtKB/TrEMBL),   F7FEP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016540   ⟸   ENSRNOT00000016540

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04143-F1-model_v2 AlphaFold P04143 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690205
Promoter ID:EPDNEW_R730
Type:multiple initiation site
Name:Thrsp_1
Description:thyroid hormone responsive
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,385,586 - 162,385,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3859 AgrOrtholog
BioCyc Gene G2FUF-58447 BioCyc
Ensembl Genes ENSRNOG00000012404 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016540 ENTREZGENE
Gene3D-CATH 6.10.140.1610 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7308757 IMAGE-MGC_LOAD
InterPro Lipogen_MT_Stabilize_sf UniProtKB/Swiss-Prot
  Spot_14 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105418 IMAGE-MGC_LOAD
NCBI Gene 25357 ENTREZGENE
PANTHER PTHR14315 UniProtKB/Swiss-Prot
  THYROID HORMONE-INDUCIBLE HEPATIC PROTEIN UniProtKB/Swiss-Prot
Pfam Spot_14 UniProtKB/Swiss-Prot
PhenoGen Thrsp PhenoGen
RatGTEx ENSRNOG00000012404 RatGTEx
TIGR TC204408
UniProt A6I693_RAT UniProtKB/TrEMBL
  A6I694_RAT UniProtKB/TrEMBL
  A6I695_RAT UniProtKB/TrEMBL
  A6I696 ENTREZGENE, UniProtKB/TrEMBL
  F7FEP1 ENTREZGENE, UniProtKB/TrEMBL
  P04143 ENTREZGENE
  Q5HZE3 ENTREZGENE
  Q63536 ENTREZGENE
  THRSP_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63536 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-28 Thrsp  thyroid hormone responsive  Thrsp  thyroid hormone responsive protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Thrsp  thyroid hormone responsive SPOT14 homolog (Rattus)      Symbol and Name updated 629477 APPROVED
2003-03-07 Thrsp  thyroid hormone responsive SPOT14 homolog (Rattus)  Lpgp  Lipogenic protein S14  Data merged from RGD:3016 628472 PROVISIONAL
2002-06-10 Thrsp  Thyroid hormone responsive protein (spot14)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Lpgp  Lipogenic protein S14      Symbol and Name status set to approved 70586 APPROVED