Tmbim6 (transmembrane BAX inhibitor motif containing 6) - Rat Genome Database

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Gene: Tmbim6 (transmembrane BAX inhibitor motif containing 6) Rattus norvegicus
Analyze
Symbol: Tmbim6
Name: transmembrane BAX inhibitor motif containing 6
RGD ID: 3842
Description: Predicted to enable calcium channel activity; endoribonuclease inhibitor activity; and ubiquitin protein ligase binding activity. Involved in lung development and spermatogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Biomarker of invasive ductal carcinoma. Orthologous to human TMBIM6 (transmembrane BAX inhibitor motif containing 6); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ab1-011; Ac1-149; bax inhibitor 1; Bax inhibitor-1; BI-1; Cc1-27; Tegt; testis enhanced gene transcript; testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,405,217 - 132,422,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7132,386,134 - 132,422,492 (+)EnsemblGRCr8
mRatBN7.27130,527,313 - 130,542,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,527,316 - 130,543,633 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7132,332,457 - 132,347,226 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,558,037 - 134,572,806 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,470,553 - 134,485,322 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,039,433 - 141,070,269 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,034,982 - 141,069,989 (+)Ensemblrn6Rnor6.0
Rnor_5.0X115,557,801 - 115,572,802 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47138,139,438 - 138,154,243 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7127,009,876 - 127,024,679 (+)NCBICelera
RGSC_v3.17138,216,492 - 138,230,680 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
azoxystrobin  (EXP,ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (EXP)
carmustine  (ISO)
celastrol  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
clofibrate  (EXP)
corosolic acid  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gallic acid  (ISO)
glafenine  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methylparaben  (ISO)
nickel dichloride  (EXP)
omeprazole  (EXP)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
pyrimidifen  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts. Esseghir S, etal., J Pathol. 2006 Dec;210(4):420-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. Grzmil M, etal., Am J Pathol. 2003 Aug;163(2):543-52.
5. Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis. Harima Y, etal., Int J Radiat Oncol Biol Phys. 2004 Sep 1;60(1):237-48.
6. The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters. Jean JC, etal., Genomics. 1999 Apr 15;57(2):201-8.
7. Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
8. Role of perfusion medium, oxygen and rheology for endoplasmic reticulum stress-induced cell death after hypothermic machine preservation of the liver. Manekeller S, etal., Transpl Int. 2008 Feb;21(2):169-77. Epub 2007 Nov 12.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. A novel, conserved gene of the rat that is developmentally regulated in the testis. Walter L, etal., Mamm Genome 1994 Apr;5(4):216-21.
Additional References at PubMed
PMID:9660918   PMID:12477932   PMID:15304216   PMID:15489334   PMID:16757804   PMID:19328063   PMID:19946888   PMID:21068390   PMID:21075086   PMID:22240901   PMID:26582200   PMID:29169414  
PMID:36747144   PMID:37814860  


Genomics

Comparative Map Data
Tmbim6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,405,217 - 132,422,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7132,386,134 - 132,422,492 (+)EnsemblGRCr8
mRatBN7.27130,527,313 - 130,542,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,527,316 - 130,543,633 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7132,332,457 - 132,347,226 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,558,037 - 134,572,806 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,470,553 - 134,485,322 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,039,433 - 141,070,269 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,034,982 - 141,069,989 (+)Ensemblrn6Rnor6.0
Rnor_5.0X115,557,801 - 115,572,802 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47138,139,438 - 138,154,243 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7127,009,876 - 127,024,679 (+)NCBICelera
RGSC_v3.17138,216,492 - 138,230,680 (+)NCBI
Cytogenetic Map7q36NCBI
TMBIM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,741,557 - 49,764,934 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,707,725 - 49,764,935 (+)Ensemblhg38GRCh38
GRCh371250,135,340 - 50,158,717 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,421,560 - 48,444,984 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341248,432,511 - 48,444,760NCBI
Celera1248,931,228 - 48,954,652 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,166,860 - 47,190,297 (+)NCBIHuRef
CHM1_11250,101,626 - 50,125,066 (+)NCBICHM1_1
T2T-CHM13v2.01249,704,579 - 49,727,957 (+)NCBIT2T-CHM13v2.0
Tmbim6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,290,828 - 99,307,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,290,763 - 99,307,930 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381599,392,947 - 99,410,049 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,392,882 - 99,410,049 (+)Ensemblmm10GRCm38
MGSCv371599,223,378 - 99,240,480 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361599,221,020 - 99,238,074 (+)NCBIMGSCv36mm8
Celera15101,548,094 - 101,565,263 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Tmbim6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547335,275 - 358,503 (+)Ensembl
ChiLan1.0NW_004955547335,344 - 358,503 (+)NCBIChiLan1.0ChiLan1.0
TMBIM6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,420,329 - 44,443,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,417,090 - 44,440,530 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,986,844 - 39,010,307 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,879,951 - 39,902,607 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,879,951 - 39,902,303 (-)EnsemblpanPan2panpan1.1
TMBIM6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,921,606 - 4,944,830 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,921,606 - 4,944,783 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2741,313,127 - 41,336,268 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0274,971,016 - 4,994,198 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,971,043 - 4,993,921 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,936,445 - 4,959,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,926,010 - 4,949,602 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,707,565 - 41,730,952 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmbim6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,716,130 - 65,736,962 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,427,729 - 7,449,078 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,427,926 - 7,448,700 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMBIM6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,674,057 - 15,692,936 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1515,674,028 - 15,692,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMBIM6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,976,689 - 46,001,021 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,976,700 - 46,001,457 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037200,122,797 - 200,147,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmbim6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248162,519,839 - 2,540,766 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmbim6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11272,195,086 - 272,212,542 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmbim6
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:127
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000022838, ENSRNOT00000045927
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
BF389213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,536,121 - 130,536,272 (+)MAPPERmRatBN7.2
Rnor_6.07141,062,795 - 141,062,945NCBIRnor6.0
Rnor_5.0X115,566,720 - 115,566,870UniSTSRnor5.0
RGSC_v3.47138,148,249 - 138,148,399UniSTSRGSC3.4
Celera7127,018,685 - 127,018,835UniSTS
RH 3.4 Map71076.2UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF118564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000084674   ⟹   ENSRNOP00000073494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,406,164 - 132,420,879 (+)Ensembl
mRatBN7.2 Ensembl7130,527,320 - 130,542,184 (+)Ensembl
Rnor_6.0 Ensembl7141,053,876 - 141,068,789 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088176   ⟹   ENSRNOP00000074493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,406,164 - 132,420,444 (+)Ensembl
mRatBN7.2 Ensembl7130,527,583 - 130,541,589 (+)Ensembl
Rnor_6.0 Ensembl7141,054,494 - 141,068,789 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091050   ⟹   ENSRNOP00000069944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,386,134 - 132,422,213 (+)Ensembl
mRatBN7.2 Ensembl7130,534,803 - 130,543,358 (+)Ensembl
Rnor_6.0 Ensembl7141,034,982 - 141,069,989 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105911   ⟹   ENSRNOP00000094489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,406,164 - 132,422,492 (+)Ensembl
mRatBN7.2 Ensembl7130,527,316 - 130,543,633 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106863   ⟹   ENSRNOP00000086064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,406,164 - 132,422,492 (+)Ensembl
mRatBN7.2 Ensembl7130,535,188 - 130,543,633 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111575   ⟹   ENSRNOP00000077478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7130,527,583 - 130,541,573 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169101   ⟹   ENSRNOP00000109048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,406,168 - 132,422,492 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173365   ⟹   ENSRNOP00000112002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,406,164 - 132,420,827 (+)Ensembl
RefSeq Acc Id: NM_019381   ⟹   NP_062254
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,406,170 - 132,420,973 (+)NCBI
mRatBN7.27130,527,313 - 130,542,118 (+)NCBI
Rnor_6.07141,053,876 - 141,068,789 (+)NCBI
Rnor_5.0X115,557,801 - 115,572,802 (+)NCBI
RGSC_v3.47138,139,438 - 138,154,243 (+)RGD
Celera7127,009,876 - 127,024,679 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257323   ⟹   XP_006257385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,405,217 - 132,422,492 (+)NCBI
mRatBN7.27130,527,992 - 130,542,567 (+)NCBI
Rnor_6.07141,053,959 - 141,068,870 (+)NCBI
Rnor_5.0X115,557,801 - 115,572,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078436   ⟹   XP_038934364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,405,241 - 132,422,492 (+)NCBI
mRatBN7.27130,527,463 - 130,542,567 (+)NCBI
RefSeq Acc Id: XM_039078437   ⟹   XP_038934365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,405,241 - 132,422,492 (+)NCBI
mRatBN7.27130,527,463 - 130,542,567 (+)NCBI
RefSeq Acc Id: XM_063263001   ⟹   XP_063119071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,405,241 - 132,422,492 (+)NCBI
RefSeq Acc Id: XM_063263002   ⟹   XP_063119072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,405,241 - 132,422,492 (+)NCBI
RefSeq Acc Id: XM_063263003   ⟹   XP_063119073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,405,217 - 132,422,492 (+)NCBI
RefSeq Acc Id: XM_063263004   ⟹   XP_063119074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,405,241 - 132,422,492 (+)NCBI
RefSeq Acc Id: NP_062254   ⟸   NM_019381
- UniProtKB: Q64712 (UniProtKB/Swiss-Prot),   Q6PDV4 (UniProtKB/Swiss-Prot),   P55062 (UniProtKB/Swiss-Prot),   A6KCF2 (UniProtKB/TrEMBL),   A0A8L2R907 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257385   ⟸   XM_006257323
- Peptide Label: isoform X2
- UniProtKB: Q64712 (UniProtKB/Swiss-Prot),   Q6PDV4 (UniProtKB/Swiss-Prot),   P55062 (UniProtKB/Swiss-Prot),   A6KCF2 (UniProtKB/TrEMBL),   A0A8L2R907 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073494   ⟸   ENSRNOT00000084674
Ensembl Acc Id: ENSRNOP00000069944   ⟸   ENSRNOT00000091050
Ensembl Acc Id: ENSRNOP00000074493   ⟸   ENSRNOT00000088176
RefSeq Acc Id: XP_038934364   ⟸   XM_039078436
- Peptide Label: isoform X2
- UniProtKB: Q64712 (UniProtKB/Swiss-Prot),   P55062 (UniProtKB/Swiss-Prot),   Q6PDV4 (UniProtKB/Swiss-Prot),   A6KCF2 (UniProtKB/TrEMBL),   A0A8L2R907 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934365   ⟸   XM_039078437
- Peptide Label: isoform X2
- UniProtKB: Q64712 (UniProtKB/Swiss-Prot),   P55062 (UniProtKB/Swiss-Prot),   Q6PDV4 (UniProtKB/Swiss-Prot),   A6KCF2 (UniProtKB/TrEMBL),   A0A8L2R907 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094489   ⟸   ENSRNOT00000105911
Ensembl Acc Id: ENSRNOP00000086064   ⟸   ENSRNOT00000106863
Ensembl Acc Id: ENSRNOP00000077478   ⟸   ENSRNOT00000111575
RefSeq Acc Id: XP_063119073   ⟸   XM_063263003
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R907 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119074   ⟸   XM_063263004
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R907 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119072   ⟸   XM_063263002
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R907 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119071   ⟸   XM_063263001
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R907 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112002   ⟸   ENSRNOT00000173365
Ensembl Acc Id: ENSRNOP00000109048   ⟸   ENSRNOT00000169101

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55062-F1-model_v2 AlphaFold P55062 1-237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695642
Promoter ID:EPDNEW_R6167
Type:multiple initiation site
Name:Tmbim6_1
Description:transmembrane BAX inhibitor motif containing 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,053,874 - 141,053,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3842 AgrOrtholog
BioCyc Gene G2FUF-32074 BioCyc
Ensembl Genes ENSRNOG00000055579 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000084674 ENTREZGENE
  ENSRNOT00000105911 ENTREZGENE
  ENSRNOT00000169101 ENTREZGENE
IMAGE_CLONE IMAGE:6888036 IMAGE-MGC_LOAD
InterPro Bax_inhbtr1_CS UniProtKB/Swiss-Prot
  Bax_inhibitor_1-related UniProtKB/Swiss-Prot
KEGG Report rno:24822 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72852 IMAGE-MGC_LOAD
NCBI Gene 24822 ENTREZGENE
PANTHER BAX INHIBITOR 1 UniProtKB/Swiss-Prot
  PTHR23291 UniProtKB/Swiss-Prot
Pfam Bax1-I UniProtKB/Swiss-Prot
PhenoGen Tmbim6 PhenoGen
PROSITE BI1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055579 RatGTEx
UniProt A0A8I6A1G9_RAT UniProtKB/TrEMBL
  A0A8I6AKW8_RAT UniProtKB/TrEMBL
  A0A8L2R907 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UR06_RAT UniProtKB/TrEMBL
  A0ABK0M207_RAT UniProtKB/TrEMBL
  A6KCF2 ENTREZGENE, UniProtKB/TrEMBL
  BI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64712 ENTREZGENE
  Q6PDV4 ENTREZGENE
  Q7TMC1_RAT UniProtKB/TrEMBL
UniProt Secondary Q64712 UniProtKB/Swiss-Prot
  Q6PDV4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tmbim6  transmembrane BAX inhibitor motif containing 6  Tegt  testis enhanced gene transcript  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tegt  Testis enhanced gene transcript      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed postmeiotically in sperm 730005