Svs4 (seminal vesicle secretory protein 4) - Rat Genome Database

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Gene: Svs4 (seminal vesicle secretory protein 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Svs4
Name: seminal vesicle secretory protein 4
RGD ID: 3791
Description: Enables identical protein binding activity. Located in extracellular space. Part of protein-containing complex; INTERACTS WITH 1,2-dimethylhydrazine; 3,7-dihydropurine-6-thione; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADP; androgen-dependent protein; LOC100909594; LOC103691965; RNSVSP4U; seminal vesicle protein 2; Seminal vesicle protein 4; Seminal vesicle protein-4; seminal vesicle secretory protein 4-like; seminal vesicle secretory protein IV; Svp4; SVS IV; SVS protein S; SVSIV1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: Svs4 appears to be a redundant annotation with LOC103691965 on Rnor_6.0 (Annot. Release 105). The location where Svs4 is annotated on Rnor_6.0 is not conserved in mouse syntenic region. Annotation of Svs4 at location where LOC103691965 is currently annotated on Rnor_6.0 would be supported by mouse synteny and annotation on Rn_Celera. BLAST analysis of Svs4 NM_012662.3 against reference assembly shows high sequence identity with Svs4 (100% identity for each exon with genome) and LOC103691965 (100% identity for each exon with genome). 2-sequence BLAST analysis of Svs4 underlying component on Rnor_6.0 AABR07054533.1 and LOC103691965 underlying component AC132741.4 shows high sequence identity (100% coverage, 99% identity) across ~50 kb length of AABR07054533.1. [16 Mar 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,367,643 - 173,369,878 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,367,643 - 173,369,878 (-)EnsemblGRCr8
mRatBN7.23152,948,264 - 152,950,499 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,948,264 - 152,950,499 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,758,103 - 156,760,338 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,257,040 - 165,259,275 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,002,291 - 163,004,526 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03159,095,825 - 159,098,060 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,095,876 - 159,096,671 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl3160,660,749 - 160,661,544 (+)Ensemblrn6Rnor6.0
Rnor_5.03166,849,398 - 166,851,630 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,212,244 - 155,214,477 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,593,129 - 151,595,362 (-)NCBICelera
RGSC_v3.13155,118,330 - 155,119,126 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Structural properties of the protein SV-IV. Caporale C, etal., Eur J Biochem. 2004 Jan;271(2):263-71.
2. Protein SV-IV promotes nitric oxide production not associated with apoptosis in murine macrophages. Esposito C, etal., Eur J Cell Biol 2002 Apr;81(4):185-96.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Seminal vesicle secretion IV gene: allelic difference due to a series of 20-base-pair direct tandem repeats within an intron. Harris SE, etal., Proc Natl Acad Sci U S A 1983 Nov;80(21):6460-4.
5. Use of a cloned double stranded cDNA coding for a major androgen dependent protein in rat seminal vesicle secretion: the effect of testosterone in gene expression. Mansson PE, etal., Nucleic Acids Res 1981 Feb 25;9(4):935-46.
6. Divergent protein coding regions in otherwise closely related androgen-regulated mRNAs. McDonald CJ, etal., EMBO J 1984 Nov;3(11):2517-21.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The self-association of protein SV-IV and its possible functional implications. Stiuso P, etal., Eur J Biochem. 1999 Dec;266(3):1029-35.
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:6304626   PMID:7007263   PMID:17458892   PMID:18215165   PMID:18243331   PMID:18616464   PMID:19851073  


Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:34
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000018456
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
D3Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83173,372,028 - 173,372,152 (+)Marker Load Pipeline
mRatBN7.23152,952,649 - 152,952,773 (-)MAPPERmRatBN7.2
Rnor_6.03159,093,551 - 159,093,674NCBIRnor6.0
Rnor_6.03160,658,424 - 160,658,547NCBIRnor6.0
Rnor_5.03166,853,781 - 166,853,904UniSTSRnor5.0
Rnor_5.03165,301,136 - 165,301,259UniSTSRnor5.0
RGSC_v3.43155,209,951 - 155,212,132RGDRGSC3.4
RGSC_v3.43155,209,970 - 155,210,093UniSTSRGSC3.4
Celera3151,597,513 - 151,597,636UniSTS
RGSC_v3.13155,116,005 - 155,116,129RGD
RH 3.4 Map31423.2RGD
RH 3.4 Map31423.2UniSTS
RH 2.0 Map3978.6RGD
SHRSP x BN Map380.1699RGD
Cytogenetic Map3q42UniSTS
BF416756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23152,949,614 - 152,949,713 (-)MAPPERmRatBN7.2
Rnor_6.03160,661,484 - 160,661,582NCBIRnor6.0
Rnor_6.03159,096,611 - 159,096,709NCBIRnor6.0
Rnor_5.03166,850,746 - 166,850,844UniSTSRnor5.0
Rnor_5.03165,304,196 - 165,304,294UniSTSRnor5.0
RGSC_v3.43155,213,030 - 155,213,128UniSTSRGSC3.4
Celera3151,594,478 - 151,594,576UniSTS
RH 3.4 Map31422.9UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

ectoderm
mesenchyme
nervous system
renal system
reproductive system
sensory system
visual system
1 7 1 7 2 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000018456   ⟹   ENSRNOP00000018456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3160,660,749 - 160,661,544 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074363   ⟹   ENSRNOP00000064062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3159,095,876 - 159,096,671 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106198   ⟹   ENSRNOP00000097434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,367,643 - 173,369,878 (-)Ensembl
mRatBN7.2 Ensembl3152,948,264 - 152,950,499 (-)Ensembl
RefSeq Acc Id: NM_012662   ⟹   NP_036794
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,367,643 - 173,369,878 (-)NCBI
mRatBN7.23152,948,264 - 152,950,499 (-)NCBI
Rnor_6.03159,095,825 - 159,098,060 (+)NCBI
Rnor_5.03166,849,398 - 166,851,630 (-)NCBI
RGSC_v3.43155,212,244 - 155,214,477 (+)RGD
Celera3151,593,129 - 151,595,362 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036794 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40684 (Get FASTA)   NCBI Sequence Viewer  
  AAA42193 (Get FASTA)   NCBI Sequence Viewer  
  AAA42194 (Get FASTA)   NCBI Sequence Viewer  
  CAA25584 (Get FASTA)   NCBI Sequence Viewer  
  CAA25730 (Get FASTA)   NCBI Sequence Viewer  
  EDL96539 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000097434
GenBank Protein P02783 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036794   ⟸   NM_012662
- Peptide Label: precursor
- UniProtKB: Q64713 (UniProtKB/Swiss-Prot),   P02783 (UniProtKB/Swiss-Prot),   A0A0G2JSZ2 (UniProtKB/TrEMBL),   A6JX70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064062   ⟸   ENSRNOT00000074363
Ensembl Acc Id: ENSRNOP00000018456   ⟸   ENSRNOT00000018456
Ensembl Acc Id: ENSRNOP00000097434   ⟸   ENSRNOT00000106198

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02783-F1-model_v2 AlphaFold P02783 1-112 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6853628
Promoter ID:EP14079
Type:single initiation site
Name:RN_SVS4
Description:Seminal vesicle secretory protein IV, SVP2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 59; Rat seminal vesicle proteins.
Experiment Methods:Nuclease protection; Primer extension
Regulation:seminal vesicle; (induced by or strongly expressed in) androgen
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.43155,212,273 - 155,212,333EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3791 AgrOrtholog
BioCyc Gene G2FUF-46873 BioCyc
Ensembl Genes ENSRNOG00000013796 Ensembl
  ENSRNOG00000046558 Ensembl
  ENSRNOG00000068526 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000106198 ENTREZGENE
InterPro Svs4/5/6 UniProtKB/Swiss-Prot
KEGG Report rno:24802 UniProtKB/Swiss-Prot
NCBI Gene 24802 ENTREZGENE
PANTHER PTHR17498 UniProtKB/Swiss-Prot
  SEMINAL VESICLE SECRETORY PROTEIN 4 UniProtKB/Swiss-Prot
Pfam Svs_4_5_6 UniProtKB/Swiss-Prot
PhenoGen Svs4 PhenoGen
RatGTEx ENSRNOG00000013796 RatGTEx
  ENSRNOG00000046558 RatGTEx
  ENSRNOG00000068526 RatGTEx
TIGR TC216716
UniProt A0A0G2JSZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6JX70 ENTREZGENE, UniProtKB/TrEMBL
  P02783 ENTREZGENE
  Q64713 ENTREZGENE
  SVS4_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64713 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Svs4  seminal vesicle secretory protein 4  LOC103691965  seminal vesicle secretory protein 4  Data merged from RGD:9305048 737654 PROVISIONAL
2015-07-29 Svs4  seminal vesicle secretory protein 4  LOC100909594  seminal vesicle secretory protein 4-like  Data merged from RGD:6502519 737654 PROVISIONAL
2014-08-25 LOC103691965  seminal vesicle secretory protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100909594  seminal vesicle secretory protein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-15 Svs4  seminal vesicle secretory protein 4  Svp4  seminal vesicle protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Svp4  seminal vesicle protein 4  Svs4  Seminal vesicle protein-4  Symbol and Name updated 629477 APPROVED
2002-06-10 Svs4  Seminal vesicle protein-4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the seminal vesicle epithelium 634196
gene_process upregulates the expression of inducible nitric oxide synthase (iNOS) 634196
gene_process possibly involved in determining the NO concentration in the female genital tract mucosa via controlling the iNOS gene expression in local macrophages 634196