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Gene: Slk (STE20-like kinase) Rattus norvegicus

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Symbol:

Slk

Name:

STE20-like kinase

RGD ID:

3780

Description:

Enables histone kinase activity. Involved in cellular response to tumor necrosis factor; cellular response to type II interferon; and positive regulation of apoptotic process. Predicted to be located in cell leading edge and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human SLK (STE20 like kinase); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

serine/threonine kinase 2; SK2; STE20-like kinase (yeast); STE20-like serine/threonine-protein kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase; Stk2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLK (STE20 like kinase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Slk (STE20-like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slk (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLK (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLK (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slk (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLK (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLK (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slk (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slk (STE20 like kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NBR1 (NBR1 autophagy cargo receptor)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLK (STE20 like kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slk (STE20-like kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slka (STE20-like kinase a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	slkb (STE20-like kinase b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	gck-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gck-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Slik	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slk	Alliance	DIOPT (OrthoFinder\|PANTHER)

Candidate Gene For:

Rf1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	256,415,013 - 256,470,942 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	256,415,013 - 256,467,829 (+)	Ensembl				GRCr8
mRatBN7.2	1	246,473,712 - 246,529,643 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	246,473,712 - 246,526,530 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	254,600,599 - 254,653,647 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	261,294,743 - 261,346,991 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	253,942,727 - 253,996,162 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	267,359,761 - 267,415,735 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	267,359,830 - 267,412,810 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	274,792,996 - 274,848,925 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	252,954,514 - 253,007,330 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	242,240,482 - 242,293,210 (+)	NCBI		Celera
RGSC_v3.1	1	253,219,115 - 253,271,839 (+)	NCBI
Cytogenetic Map	1	q54	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Reperfusion Injury (IEP)

substance-related disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (EXP)

choline (ISO)

cisplatin (ISO)

clorgyline (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furfural (ISO)

genistein (ISO)

glyphosate (EXP)

heparin (EXP)

heptanal (ISO)

hexanal (ISO)

hypochlorous acid (ISO)

imidacloprid (EXP)

ivermectin (ISO)

L-methionine (ISO)

lipopolysaccharide (EXP)

methamphetamine (ISO)

methapyrilene (EXP)

N-nitrosodiethylamine (EXP,ISO)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

nonanal (ISO)

octanal (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

pentachlorophenol (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

propanal (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

ranitidine (EXP)

resveratrol (ISO)

rotenone (ISO)

sodium arsenate (ISO)

sodium chloride (ISO)

sodium fluoride (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thiabendazole (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene (EXP)

topotecan (EXP)

Tributyltin oxide (ISO)

Triptolide (EXP)

troglitazone (ISO)

tungsten (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

cellular response to tumor necrosis factor (IEP)

cellular response to type II interferon (IDA)

chromatin remodeling (IEA)

cytoplasmic microtubule organization (IEA,ISO)

intracellular signal transduction (IBA)

positive regulation of apoptotic process (IMP)

protein autophosphorylation (IDA,ISO)

protein phosphorylation (IDA)

regulation of apoptotic process (IBA,IEA,ISO)

regulation of cell migration (IBA,IEA,ISO,ISS)

regulation of focal adhesion assembly (IEA,ISO,ISS)

Cellular Component

cell leading edge (IEA,ISO,ISS)

cytoplasm (IBA,IEA,ISO)

perinuclear region of cytoplasm (IEA,ISO,ISS)

Molecular Function

ATP binding (IEA)

histone kinase activity (IDA)

identical protein binding (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (IPI,ISO)

protein homodimerization activity (IEA,ISO,ISS)

protein kinase activity (IDA,IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA,ISO,ISS)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Renal expression and activity of the germinal center kinase SK2.	Cybulsky AV, etal., Am J Physiol Renal Physiol. 2004 Jan;286(1):F16-25. Epub 2003 Sep 9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.	Guilluy C, etal., Circ Res. 2008 May 23;102(10):1265-74. Epub 2008 Apr 17.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10.	Novel putative protein kinase clones from a rat large granular lymphocyte tumor cell line.	Yue CC Mol Immunol 1991 Apr-May;28(4-5):399-408.
11.	Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.	Yun HJ, etal., EMBO J. 2011 May 13;30(12):2465-76. doi: 10.1038/emboj.2011.152.

Additional References at PubMed

PMID:8889548	PMID:15060005	PMID:16316999	PMID:18239682	PMID:18287541	PMID:19056867	PMID:19199708	PMID:22203681	PMID:23128389	PMID:25468996	PMID:25882817	PMID:26094769
PMID:26818812	PMID:29054447

Genomics

Comparative Map Data

Slk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	256,415,013 - 256,470,942 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	256,415,013 - 256,467,829 (+)	Ensembl				GRCr8
mRatBN7.2	1	246,473,712 - 246,529,643 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	246,473,712 - 246,526,530 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	254,600,599 - 254,653,647 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	261,294,743 - 261,346,991 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	253,942,727 - 253,996,162 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	267,359,761 - 267,415,735 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	267,359,830 - 267,412,810 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	274,792,996 - 274,848,925 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	252,954,514 - 253,007,330 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	242,240,482 - 242,293,210 (+)	NCBI		Celera
RGSC_v3.1	1	253,219,115 - 253,271,839 (+)	NCBI
Cytogenetic Map	1	q54	NCBI

SLK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	103,967,140 - 104,029,233 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	103,966,916 - 104,029,242 (+)	Ensembl			hg38	GRCh38
GRCh37	10	105,726,898 - 105,788,991 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	105,717,460 - 105,777,332 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	105,717,459 - 105,777,332	NCBI
Celera	10	99,468,053 - 99,527,925 (+)	NCBI		Celera
Cytogenetic Map	10	q24.33-q25.1	NCBI
HuRef	10	99,381,490 - 99,418,394 (+)	NCBI		HuRef
CHM1_1	10	106,011,167 - 106,071,021 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	104,854,380 - 104,916,616 (+)	NCBI		T2T-CHM13v2.0

Slk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	47,568,458 - 47,633,685 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	47,568,117 - 47,633,685 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	47,580,019 - 47,645,246 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	47,579,678 - 47,645,246 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	47,654,509 - 47,719,736 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	47,633,330 - 47,695,766 (+)	NCBI		MGSCv36	mm8
Celera	19	48,341,076 - 48,407,067 (+)	NCBI		Celera
Cytogenetic Map	19	C3- D1	NCBI
cM Map	19	39.77	NCBI

Slk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	6,617,698 - 6,685,220 (-)	Ensembl
ChiLan1.0	NW_004955485	6,617,698 - 6,685,220 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	115,853,459 - 115,915,621 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	115,858,777 - 115,920,954 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	100,566,801 - 100,628,955 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	104,027,041 - 104,088,671 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	104,027,041 - 104,088,671 (+)	Ensembl			panPan2	panpan1.1

SLK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	16,286,827 - 16,347,766 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	16,286,688 - 16,346,368 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	16,457,421 - 16,520,635 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	16,762,662 - 16,825,933 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	16,762,934 - 16,825,927 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	16,311,382 - 16,374,596 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	16,339,611 - 16,402,786 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	16,478,364 - 16,541,544 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	30,531,161 - 30,590,073 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	2,137,798 - 2,193,192 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	2,134,374 - 2,193,302 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	114,899,147 - 114,955,070 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	114,898,963 - 114,957,494 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	124,814,716 - 124,872,784 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	97,016,085 - 97,077,133 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	97,016,184 - 97,077,138 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	58,133,521 - 58,194,531 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624831	3,076,856 - 3,142,289 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624831	3,076,548 - 3,144,107 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slk
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	47,112,793 - 47,168,943 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slk
554 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	27
Count of miRNA genes:	24
Interacting mature miRNAs:	24
Transcripts:	ENSRNOT00000015495
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	248619887	269633915	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	5e-06	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	247133834	270518180	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
1598839	Rf56	Renal function QTL 56			renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	255849111	270518180	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat

Markers in Region

RH143160

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	246,501,414 - 246,501,634 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	267,387,507 - 267,387,726	NCBI	Rnor6.0
Rnor_5.0	1	274,820,697 - 274,820,916	UniSTS	Rnor5.0
RGSC_v3.4	1	252,982,215 - 252,982,434	UniSTS	RGSC3.4
Celera	1	242,268,057 - 242,268,276	UniSTS
RH 3.4 Map	1	1625.3	UniSTS
Cytogenetic Map	1	q54	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019349	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC096331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI136919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK227996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015495 ⟹ ENSRNOP00000015496

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	256,415,013 - 256,467,829 (+)	Ensembl
mRatBN7.2 Ensembl	1	246,473,712 - 246,526,530 (+)	Ensembl
Rnor_6.0 Ensembl	1	267,359,830 - 267,412,810 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119890 ⟹ ENSRNOP00000087678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	256,415,013 - 256,467,829 (+)	Ensembl
mRatBN7.2 Ensembl	1	246,473,712 - 246,526,530 (+)	Ensembl

RefSeq Acc Id:

NM_019349 ⟹ NP_062222

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	256,415,013 - 256,467,829 (+)	NCBI
mRatBN7.2	1	246,473,712 - 246,526,530 (+)	NCBI
Rnor_6.0	1	267,359,807 - 267,412,622 (+)	NCBI
Rnor_5.0	1	274,792,996 - 274,848,925 (+)	NCBI
RGSC_v3.4	1	252,954,514 - 253,007,330 (+)	RGD
Celera	1	242,240,482 - 242,293,210 (+)	RGD

Sequence:

show sequence

GCGCGCCCCCCTCCGGGGCCGGAGCCCTGTCGGCGCCCCGCCTTCTCCGGGGAGCGCCCGGCGG
GAGCGGCCCGGACCCCGGGCTCGCGCGGGAGACGACGCGCCACAAACTTTGCCTTTTATTGTTC
CTAGCCCTTTAAGTGCAAGGGGCTCTGTTGGGCTGGAAAAATGTCCTTCTTCAATTTCCGTAAG
ATCTTCAAGTTGGGGAGCGAGAAGAAGAAGAAACAGTACGAACACGTGAAGAGAGACCTGAACC
CCGAGGAGTTTTGGGAGATTATCGGAGAGCTGGGCGACGGAGCCTTTGGGAAAGTGTATAAGGC
CCAGAATAAGGAGACCAATGTTTTAGCTGCTGCAAAGGTGATTGACACCAAATCTGAAGAAGAA
CTTGAAGATTATATGGTTGAGATTGACATATTAGCATCTTGTGATCACCCAAACATAGTCAAGC
TTCTAGATGCCTTCTATTATGAGAACAATCTTTGGATCCTCATTGAATTTTGTGCAGGGGGAGC
AGTAGATGCCGTGATGCTTGAACTTGAGAGACCATTAACTGAGTCCCAAATTCAAGTAGTTTGC
AAGCAGACATTAGAGGCGTTGAATTACCTACATGACAATAAAATCATCCACAGAGATCTAAAAG
CTGGCAATATTCTCTTTACCTTAGATGGAGACATTAAATTAGCGGATTTTGGAGTGTCAGCTAA
GAATACCAGGACAATTCAAAGGAGGGATTCATTTATTGGCACACCGTATTGGATGGCTCCTGAA
GTCGTCATGTGTGAGACATCGAAGGACAGACCCTATGACTACAAAGCGGACGTTTGGTCCCTGG
GAATCACTTTAATAGAAATGGCTGAGATAGAGCCGCCTCATCATGAGCTAAACCCAATGCGAGT
GCTGCTGAAAATAGCAAAGTCGGAGCCCCCCACACTAGCACAGCCATCCAGATGGTCTTCAAAT
TTTAAGGACTTTCTAAAGAAATGCTTGGAAAAGAATGTGGATGCGCGGTGGACCACATCCCAGC
TGTTACAGCATCCCTTTGTTACCGTTGATTCCAACAAACCAGTCCGAGAATTGATTGCTGAGGC
GAAGGCTGAAGTAACAGAAGAAGTTGAAGATGGCAAAGAGGAAGATGACGATGATGAGACAGAG
AGTGCTCTGCCAATACCTGCGAATAAACGCGCCTCCTCTGACCTCAGCATTGCCAGCTCTGAGG
AAGATAAGCTTTCACAAAATGCTTGTATTTTGGAATCTGTGTCAGAAAGAACAGAACACAATAC
TTCTGGGGATAAATTTAGCAACAAAGTTCTTAGTGAGAAGCCTACTCCTGAGGGACCTGAGAAG
ACTGTGGATGTGGATGGGCCTGCAAATGATGTTAACTTAGAAACTGTGGCTGAACCAAATGACC
AAGCGGTAGGATTCCATGAGAATGGGAGAGAGAAGAAAAGACCCCAACTGGAAAGTCAACCAGA
TACAGAAGACCAACAAACTGTGGATGTTAATTTAGTCGGTGAAGGAAATGACAGCAATATAGTA
ATTTTAGAAACAAACACTGATTGTCTGAAACCAGAGGAAGACAGAAATGAAGAAAACCAAGAGA
TAATTGAGAATAAACTTACACAATCTGAAGAAATTAAAGATATACATATTCAAACAATGGACTT
AGTTTCTCAAGAAACTGGAGAAAAAGAGGCAGATTTTCAGGCAATTGACAATGAAGTTGGGTTT
ACAAAGGAAGAAACCCAAGAGAAATTGGGAAAAGATGATAAAACTCACAAAGTTGTGATCAGTG
ATATAACCAGTGAGGTGGGAACAGACGAGCCTCCAGGTGATACCCAGAAGTCTGCTGAGCAGAG
CCAGGATGCAGAGGGTGGGGCTGGGGAAGAAGCCCCGGAGCCTGCCCAGACACTAACAGAGAAG
GCCACTGAGGGCCCTGAGGCTCATGGTGCTGAGGAAGAGCCTCGTAGTGGAGAGAGAGTAGAGG
ATAAGCAGCTAGAGCAGCAGTCTGCAGTGTGTGAAGGTGAGGGACAGGTAACCAGCACTTCAGA
GAGCACACGGGCAACCACGGAGGAACCAGAGACTGACGAAGTTGACCAAGTCAGCGAGTCAAAT
AGCATTGAGGAACTAGAGAGACTTGGAGTTACTGGTGCTGAGGAACAGGCTCTAGGGAGCAAAG
GGGAGGCTGCTACGGAGCTAGATTTGGAGAGAGAAGAAAATGCACAGGAACTGCCAGTTAAAGC
AGAGCCCCAAGCTCCTGCAGCATCGCAGGCCAGCGAACCTCCCCCTGTCTTAATACCCAGTATT
AATATTCATTCGGAAAACACAGAAAATAAAGGAGAAATGGGTGCTTTGCCAAAACCTGAAACCA
TACTGCCACCAGAGCCTGAAAATGGAAAGGGAAATGACACGGACTCAGGGACTGGGTCCACTGT
GGAGAACAGCAGCAGTGACCTGAACTTGTCCATCTCTAGCTTCCTGAGCAAAACCAAGGACAGT
GGCTCGGTGTCTCTGCAGGAGACAAGAAGACAGAAGAAAACATTGAAGAAAACACGTAAATTTA
TTGTTGATGGAGTAGAAGTGAGTGTGACAACATCAAAGATAGTTACAGACAGCGACTCTAAAAC
CGAGGAATTGAGGTTTCTCAGGCGTCAGGAACTTCGAGAGCTAAGGCTTCTCCAGAAGGAAGAG
CAGAAAGCCCAGCAGCAGCTCAACGGGAAATTGCAGCAGCAGCGCGAGCAGATCTTCAGGCGCT
TTGAGCAGGAGATGCTGAGTAAGAAGCGACAATATGACCAAGAAATTGAGAATCTAGAGAAGCA
GCAGAAACAGACAATTGAACGACTAGAACAAGAACACACAAACCGCCTGAGAGACGAAGCTAAG
CGCATCAAAGGAGAGCAGGAGAAGGAGCTGTCCAAATTCCAGAATATGCTAAGAAACCGAAAGA
AGGAGGAACAAGAATTTGTTCAGAAGCAACAGCAAGAGTTAGACGGCGCTCTGAAAAAGATCAT
CCAGCAGCAGAAGGCAGAGTTGGCCAATATTGAGAGAGAGTGCTTGAATAACAAGCAGCAGCTC
CTGAGAGCCCGAGAAGCTGCAATTTGGGAGCTTGAAGAACGACATTTACAAGAAAAGCACCAGC
TGCTTAAACAGCAACTTAAAGATCAGTATTTCATACAGAGACATCAGCTGCTTAAACGCCATGA
GAAGGAAACAGAACAAATGCAGCGTTACAATCAACGACTTATTGAAGAATTGAAGAACAGACAG
ACTCAGGAACGAGCTAGACTGCCCAAGATTCAGAGAAGTGAAGCCAAGACACGAATGGCCATGT
TTAAAAAAAGTTTGAGGATTAACTCAACAGCTACACCAGACCAGGACCGTGAAAAAATTAAACA
GTTTGCTGCACAGGAAGAAAAGAGACAGAAAAATGAGAGAATGGCTCAGCATCAAAAACATGAG
AGTCAGATGCGGGACCTTCAGTTGCAGTGTGAAGCCAACGTCCGAGAGCTGCACCAGCTGCAGA
ATGAAAAATGCCACCTGTTGGTTGAACATGAGACTCAGAAACTGAAGGAGTTAGATGAGGAGCA
CAGCCAAGAGCTCAAGGAGTGGAGAGAGAAGCTGAGGCCCAGGAAGAAGACACTGGAGGAAGAG
TTTGCCAGGAAACTTCAGGAACAGGAAGTGTTCTTTAAAATGACCGGGGAGTCCGAATGCCTCA
ACCCCTCAGCGCAGAGCCGGATCTCCAAATTCTACCCTATTCCCACCTTACATTCCACTGGGTC
ATAGCGGCAGCAGTGTCCTC

hide sequence

RefSeq Acc Id:

XM_006231558 ⟹ XP_006231620

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	256,415,139 - 256,470,942 (+)	NCBI
mRatBN7.2	1	246,473,842 - 246,529,643 (+)	NCBI
Rnor_6.0	1	267,359,761 - 267,415,735 (+)	NCBI
Rnor_5.0	1	274,792,996 - 274,848,925 (+)	NCBI

Sequence:

show sequence

CGAGGTGCCCACCGCGCCGCTTGGCCCGTCCCGGCTCGCAGCGGCCGCGCGCCCCCCTCCGGGG
CCGGAGCCCTGTCGGCGCCCCGCCTTCTCCGGGGAGCGCCCGGCGGGAGCGGCCCGGACCCCGG
GCTCGCGCGGGAGACGACGCGCCACAAACTTTGCCTTTTATTGTTCCTAGCCCTTTAAGTGCAA
GGGGCTCTGTTGGGCTGGAAAAATGTCCTTCTTCAATTTCCGTAAGATCTTCAAGTTGGGGAGC
GAGAAGAAGAAGAAACAGTACGAACACGTGAAGAGAGACCTGAACCCCGAGGAGTTTTGGGAGA
TTATCGGAGAGCTGGGCGACGGAGCCTTTGGGAAAGTGTATAAGGCCCAGAATAAGGAGACCAA
TGTTTTAGCTGCTGCAAAGGTGATTGACACCAAATCTGAAGAAGAACTTGAAGATTATATGGTT
GAGATTGACATATTAGCATCTTGTGATCACCCAAACATAGTCAAGCTTCTAGATGCCTTCTATT
ATGAGAACAATCTTTGGATCCTCATTGAATTTTGTGCAGGGGGAGCAGTAGATGCCGTGATGCT
TGAACTTGAGAGACCATTAACTGAGTCCCAAATTCAAGTAGTTTGCAAGCAGACATTAGAGGCG
TTGAATTACCTACATGACAATAAAATCATCCACAGAGATCTAAAAGCTGGCAATATTCTCTTTA
CCTTAGATGGAGACATTAAATTAGCGGATTTTGGAGTGTCAGCTAAGAATACCAGGACAATTCA
AAGGAGGGATTCATTTATTGGCACACCGTATTGGATGGCTCCTGAAGTCGTCATGTGTGAGACA
TCGAAGGACAGACCCTATGACTACAAAGCGGACGTTTGGTCCCTGGGAATCACTTTAATAGAAA
TGGCTGAGATAGAGCCGCCTCATCATGAGCTAAACCCAATGCGAGTGCTGCTGAAAATAGCAAA
GTCGGAGCCCCCCACACTAGCACAGCCATCCAGATGGTCTTCAAATTTTAAGGACTTTCTAAAG
AAATGCTTGGAAAAGAATGTGGATGCGCGGTGGACCACATCCCAGCTGTTACAGCATCCCTTTG
TTACCGTTGATTCCAACAAACCAGTCCGAGAATTGATTGCTGAGGCGAAGGCTGAAGTAACAGA
AGAAGTTGAAGATGGCAAAGAGGAAGATGACGATGATGAGACAGAGAGTGCTCTGCCAATACCT
GCGAATAAACGCGCCTCCTCTGACCTCAGCATTGCCAGCTCTGAGGAAGATAAGCTTTCACAAA
ATGCTTGTATTTTGGAATCTGTGTCAGAAAGAACAGAACACAATACTTCTGGGGATAAATTTAG
CAACAAAGTTCTTAGTGAGAAGCCTACTCCTGAGGGACCTGAGAAGGCTGTGGATGTGGATGGG
CCTGCAAATGATGTTAACTTAGAAACTGTGGCTGAACCAAATGACCAAGCGGTAGGATTCCATG
AGAATGGGAGAGAGAAGAAAAGACCCAAACTGGAAAGTCAACCAGATACAGAAGACCAACAAAC
TGTGGATGTTAATTTAGTCGGTGAAGGAAATGACAGCAATATAGTAATTTTAGAAACAAACACT
GATTGTCTGAAACCAGAGGAAGACAGAAATGAAGAAAACCAAGAGATAATTGAGAATAAACTTA
CACAATCTGAAGAAATTAAAGATATACATATTCAAACAATGGACTTAGTTTCTCAAGAAACTGG
AGAAAAAGAGGCAGATTTTCAGGCAATTGACAATGAAGTTGGGTTTACAAAGGAAGAAACCCAA
GAGAAATTGGGAAAAGATGATAAAACTCAAAAAGTTGTGATCAGTGATATAAGCAGTGAGGTGG
GAACAGACGAGGCTCCAGGTGATACCCAGAAGGCTGCTGAGCAGAGCCAGGATGCAGAGGGTGG
GGCTGGGGAAGAAGCCCCGGAGCCTGCCCAGACACTAACAGAGAAGGCCACTGAGGGCCCTGAG
GCTCATGGTGCTGAGGAAGAGCCTCGTAGTGGAGAGAGAGTAGAGGATAAGCAGCTAGAGCAGC
AGTCTGCAGTGTGTGAAGGTGAGGGACAGGTAACCAGCACTTCAGAGAGCACACGGGCAACCAC
GGAGGAACCAGAGACTGACGAAGTTGACCAAGTCAGCGAGTCAAATAGCATTGAGGAACTAGAG
AGACTTGGAGTTACTGGTGCTGAGGAACAGGCTCTAGGGAGCAAAGGGGAGGCTGCTACGGAGG
TAGATTTGGAGAGAGAAGAAAATGCACAGGAACTGCCAATTAAAGCAGAGCCCCAAGCTCCTGC
AGCATCGCAGCCCAGTGAACCTCCCCCTGTCTTAATACCCAGTATTAATATTCATTCGGAAAAC
ACAGAAAATAAAGGAGAAATGGGTGCTTTGCCAAAACCTGAAACCATACTGCCACCAGAGCCTG
AAAATGGAAAGGGAAATGACACGGACTCAGGGACTGGGTCCACTGTGGAGAACAGCAGCAGTGA
CCTGAACTTGTCCATCTCTAGCTTCCTGAGCAAAACCAAGGACAGTGGCTCGGTGTCTCTGCAG
GAGACAAGAAGACAGAAGAAAACATTGAAGAAAACACGTAAATTTATTGTTGATGGAGTAGAAG
TGAGTGTGACAACATCAAAGATAGTTACAGACAGCGACTCTAAAACCGAGGAATTGCGGTTTCT
CAGGCGTCAGGAACTTCGAGAGCTAAGGCTTCTCCAGAAGGAAGAGCAGAAAGCCCAGCAGCAG
CTCAACGGGAAATTGCAGCAGCAGCGCGAGCAGATCTTCAGGCGCTTTGAGCAGGAGATGCTGA
GTAAGAAGCGACAATATGACCAAGAAATTGAGAATCTAGAGAAGCAGCAGAAACAGACAATTGA
ACGACTAGAACAAGAACACACAAACCGCCTGAGAGACGAAGCTAAGCGCATCAAAGGAGAGCAG
GAGAAGGAGCTGTCCAAGTTCCAGAATATGCTAAGAAACCGAAAGAAGGAGGTTATAAATGAAG
TGGAGAAAGCACCCAAAGAGCTGAGAAAAGAGCTCATGAAGCGCAGGAAAGAGGAGCTTGCACA
GAGCCAGCATGCTCAGGAACAAGAATTTGTTCAGAAGCAACAGCAAGAGTTAGACGGCGCTCTG
AAAAAGATCATCCAGCAGCAGAAGGCAGAGTTGGCCAATATTGAGAGAGAGTGCTTGAATAACA
AGCAGCAGCTCCTGAGAGCCCGAGAAGCTGCAATTTGGGAGCTTGAAGAACGACATTTACAAGA
AAAGCACCAGCTGCTTAAACAGCAACTTAAAGATCAGTATTTCATACAGAGACATCAGCTGCTT
AAACGCCACGAGAAGGAAACAGAACAAATGCAGCGTTACAATCAACGACTTATTGAAGAATTGA
AGAACAGACAGACTCAGGAACGAGCTAGACTGCCCAAGATTCAGAGAAGTGAAGCCAAGACACG
AATGGCCATGTTTAAAAAAAGTTTGAGGATTAACTCAACAGCTACACCAGACCAGGACCGTGAA
AAAATTAAACAGTTTGCTGCACAGGAAGAAAAGAGACAGAAAAATGAGAGAATGGCTCAGCATC
AAAAACACGAGAGTCAGATGCGGGACCTTCAGTTGCAGTGTGAAGCCAACGTCCGAGAGCTGCA
CCAGCTGCAGAATGAAAAATGCCACCTGTTGGTTGAACATGAGACTCAGAAACTGAAGGAGTTA
GATGAGGAGCACAGCCAAGAGCTCAAGGAGTGGAGAGAGAAGCTGAGGCCCAGGAAGAAGACAC
TGGAGGAAGAGTTTGCCAGGAAACTTCAGGAACAGGAAGTGTTCTTTAAAATGACCGGGGAGTC
CGAATGCCTCAACCCCTCAGCGCAGAGCCGGATCTCCAAATTCTACCCTATTCCCACCTTACAT
TCCACTGGGTCATAGCGGCAGCAGTGTCCTCATCTGGATTTGCCTTCTGAGTGCATCGTTGTGT
TCTCTCCCACGCGTGTGACTACAAAGACAATCGCCTGCTTCATCTTGGTTTTTAGAATTTCTTT
CTTGGATTTTATTGTTAAACAAAGATGAAGAGCAAACGAACTAAGATAGATGCTAGGCCACGCT
GCAGCGTAGATCTGCAGGGAATCCCTAAGGTGATTCTGTGTATCAACCTTAGATACTGTATTCT
TTAACACTCTTAGTGAAAACTGCCAGAGACATAATGTTTAAAGTTATTTGGAAAACATATCTGT
TACATCACTAAGTATTAAAAAATATTGTTTTATCTGATTTCTCAATGATGCTAAATTCTATAGA
TAGGATTCTGCTGTAGAATTGGAATAATTTTCTTTGGTAAACCAACTCTTAATTTAAAAAAGCC
ATGAGTTACAGAAATACATTATTGATCGAGTACATAGATATATTTTTATCACTAAACAGAATCA
AAATCTTTTAAAAGAGAAAAGTTATTTCAGTAATTTGTCACAAACATTAGCCTGTGTGGGTAGG
AGCTAATTATTAAGGTGCTAATTTTATTAAGATAGTGCCTAAAACACTAAATTTTAAACATATG
TAAATGGGGTTTTCCTTTTGGTCAACAGGAACAAAGTACCCTTCTCACTGAGCATCACTTCTCA
ATAGAAACTTACATCCTAAAACAAAGGAAAGATGGAAGGATTGGCTTTAAAATGTGAGTCGACT
GAGCCTGCATCTCAGCGAGTTCTGTCCGTCACTGGGAGCTCAGATGGCATTGTGCCACAGTCAC
AGCTGCAGTTCTGAGGCTGGTCTTAGGGGACATGTTTGTCCACAAAGGACATTCATATGCGTTC
ATATCAGGCAAACACACACCCAAAGTGACCCTGGGTCGTTCCCAGTGAGGTTAGTCAAGAGCAT
TGTGGTTTTAGTTTGTCTCTGTTTAAATTAACTGCTTTGAGTAGGAAAAGTCTGAAGTCTTTAT
CATGTGGTAGCTGGTCATGTGACTGTTGAGGAAATGCTCACGCTTAATTCCTTTAGAAGTTCAG
AGTCTCAGCCCCATGTCAGGTCAACAGTGTTATAAACAGCGCCTTTGTGAACGCTGCTCACTGC
CTGCCATTGGCAACCTGTTCTCTTCTAAGAGTGCTGGGTACCAAATTGTTACCAGTGTTTATAT
TTCAAGGTCGGTGAAAAGTAGAAGTCTCAGTGTAATGTGGGAACAGCAGTCCACGTAAGAAACT
GTAGATGTCTGTAGTACTTTCTTGCAGTTCATTTGAAACTTTGGATGCTGAGCTTTATCTGGTT
TAGATGGTTAAAAAATGCATGTGTAATTTTAATTTTATAATTATTTTGACAAGCATAATTTTTC
TGGACAACCTTGTAGGTGGTAGCCTTAACTTTTAGCCAACTTTGTTTTTTTTTTATATAAATAT
ATATATACATATTATATATATAATGTATGGTTGTAAATTCATACACTTATCACATGAATATGTT
ACTATATACAGAACTCTTAATGCTTTATTTTCAGATGCTGGGTTGAAACTGTTTGAAAGCCTTT
AAATATATATCTTTATAAAGTAATATTTAGGATGATGATGGAAATTGTTTATATTGTTATGATA
AAAGATGGTATTATGTTGCCCAGTGTGTTTAATGAGTTATTTGAGGAGGAGAGGGGAGGCAGGC
TCTCAGACCACTTTCTCCTTTAAGTTTTACAGATCAGCTCCCCAGTCAGTGGGTTTTCTTTCCG
TTGCATTCAGGTAATCCAGACATGATTTGATCTGAGCGTCTCCCCTTCCTGTTCTTGACATTCA
GAGTATTGTATCTGGGAGGGAGGGCAAAGGGTGTCTCCCTGAAGCCTGCCCTCTAGAGTCCCTG
CTCCTGCTTGGAGTTTTCTTTCAAACATGGCGGCTGCCTTCCTGTGTGTGCAGGGACTGTTAGT
GGAGCACACTCATCTCAGCACTTCAGGTTATGTGTAGGACGTGTTTGTAACAGAACATGCTGTT
TCCAAGCAAACTTGCCTACTCCTTCTAAGGCCTTACCCCAAGTAGATAATGGTGATTGTTCTCT
CCTGCATGAAGTACAAGTGGGGAGGGGCCGAGGGGCAGAGGCATCCGTTCATACGGTGAGTCTG
TTCCTGTTTAGGTCGCTTGGTTGCTGTGGCAGAATGTGCCATGCAGAGCATAAAGGGAATTGTC
AACAGTCACCTCCCCAGTCCCTGCATGCTGTGGACACGCCTCACCCCTCCCCACCTCTGCAGGT
CCAGCTCCTAGAGCTCGTACAGGGTTTCCTCCCTAACCCTGTCGAGGCTCAGGCCGTGGGCTGC
TCCATCAGCTGTTGTATTAGGTGGAGTCGTATCCAGCTCTTCCTTACCTTTTCTGCGTGTGAGG
AGGAAGTTGGGAGTGTTTCTAGGTTGCTGACGATACTGGAAGCTTCTCCCATGTTAGGACACAG
TGAGTGAGGACAGCAGGAGCAGAACCAGAGCTACCTCTAAGCAGTGTTTCCTCAAGCACGCGCT
CTCAGGTCAGGAGACCCTCGCGGAGGCTCTCTGATTTCTTGAGCATCAGCAAGTCTCAGAAGTG
ATTGTTTTTGTATTCTTCCCGCTCCCTCACACCTTCATACTTTCCCCATCCTACACTGTGCTTA
TTAAATGACAAAGACTCTTCTAAGAAGCCAAATTTGGCCAAATTAATAGCTAGAAACATTGCAG
AATAGAACACCTAGAGCTGCTGTGGAAGAAGGGGCCTCAGCTCTCTGACCCTTCTGGTCCTCCC
TGGAGACGGCCATGCAGGATGCGGGGTGCTGATTTTTAATGCTTCTCGTAAGACAGGCCACAGT
CGATGCCTCTGCTGTCCTGTTCTTTGGCTGACATGGTTTTAATAATGCTTTAAAATTTCTGCTA
CAAAGCTTGGAGTAAAGTGTTTTACCAGTTTCAAATGTTGGCTGCAGCTTAAAAAATGTGATTC
TTTGCAGTATAATAAGTTCACAAGCTAAGTTTTCAAAGAGAATTTTGTTTCACAGTGTGCTTCT
TGTCTATTTGGGATCAGAAACATGCCTTTTCAATCATGGGATTGTTAAACAATAAAATTATTTC
TTAATCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_062222	(Get FASTA)	NCBI Sequence Viewer
	XP_006231620	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94382	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015496
	ENSRNOP00000087678
GenBank Protein	O08815	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062222 ⟸ NM_019349

- UniProtKB:

A6JHQ9 (UniProtKB/TrEMBL), G3V7I8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKV
IDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLT
ESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG
TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLA
QPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKE
EDDDDETESALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEHNTSGDKFSNKVLSEK
PTPEGPEKTVDVDGPANDVNLETVAEPNDQAVGFHENGREKKRPQLESQPDTEDQQTVDVNLVG
EGNDSNIVILETNTDCLKPEEDRNEENQEIIENKLTQSEEIKDIHIQTMDLVSQETGEKEADFQ
AIDNEVGFTKEETQEKLGKDDKTHKVVISDITSEVGTDEPPGDTQKSAEQSQDAEGGAGEEAPE
PAQTLTEKATEGPEAHGAEEEPRSGERVEDKQLEQQSAVCEGEGQVTSTSESTRATTEEPETDE
VDQVSESNSIEELERLGVTGAEEQALGSKGEAATELDLEREENAQELPVKAEPQAPAASQASEP
PPVLIPSINIHSENTENKGEMGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISS
FLSKTKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRE
LRLLQKEEQKAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHT
NRLRDEAKRIKGEQEKELSKFQNMLRNRKKEEQEFVQKQQQELDGALKKIIQQQKAELANIERE
CLNNKQQLLRAREAAIWELEERHLQEKHQLLKQQLKDQYFIQRHQLLKRHEKETEQMQRYNQRL
IEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNER
MAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRP
RKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS

hide sequence

RefSeq Acc Id:	XP_006231620 ⟸ XM_006231558
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A6A2 (UniProtKB/TrEMBL), A6JHQ8 (UniProtKB/TrEMBL), A6JHQ9 (UniProtKB/TrEMBL), G3V7I8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKV IDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLT ESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLA QPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKE EDDDDETESALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEHNTSGDKFSNKVLSEK PTPEGPEKAVDVDGPANDVNLETVAEPNDQAVGFHENGREKKRPKLESQPDTEDQQTVDVNLVG EGNDSNIVILETNTDCLKPEEDRNEENQEIIENKLTQSEEIKDIHIQTMDLVSQETGEKEADFQ AIDNEVGFTKEETQEKLGKDDKTQKVVISDISSEVGTDEAPGDTQKAAEQSQDAEGGAGEEAPE PAQTLTEKATEGPEAHGAEEEPRSGERVEDKQLEQQSAVCEGEGQVTSTSESTRATTEEPETDE VDQVSESNSIEELERLGVTGAEEQALGSKGEAATEVDLEREENAQELPIKAEPQAPAASQPSEP PPVLIPSINIHSENTENKGEMGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISS FLSKTKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRE LRLLQKEEQKAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHT NRLRDEAKRIKGEQEKELSKFQNMLRNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQ EFVQKQQQELDGALKKIIQQQKAELANIERECLNNKQQLLRAREAAIWELEERHLQEKHQLLKQ QLKDQYFIQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKS LRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKC HLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSA QSRISKFYPIPTLHSTGS hide sequence

Ensembl Acc Id:

ENSRNOP00000015496 ⟸ ENSRNOT00000015495

Ensembl Acc Id:

ENSRNOP00000087678 ⟸ ENSRNOT00000119890

Protein Domains

Protein kinase UVR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08815-F1-model_v2	AlphaFold	O08815	1-1206	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3780	AgrOrtholog
BioCyc Gene	G2FUF-55470	BioCyc
Ensembl Genes	ENSRNOG00000011339	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000015495	ENTREZGENE
	ENSRNOT00000119890	ENTREZGENE
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	PKK	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
	STE20_Ser/Thr_Kinases	UniProtKB/Swiss-Prot
	UVR_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:54308	UniProtKB/Swiss-Prot
NCBI Gene	54308	ENTREZGENE
PANTHER	NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE	UniProtKB/Swiss-Prot
	PROTEIN KINASE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
	PKK	UniProtKB/Swiss-Prot
PhenoGen	Slk	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
	UVR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011339	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
TIGR	TC228737
UniProt	A0A8I6A6A2	ENTREZGENE, UniProtKB/TrEMBL
	A6JHQ8	ENTREZGENE, UniProtKB/TrEMBL
	A6JHQ9	ENTREZGENE, UniProtKB/TrEMBL
	G3V7I8	ENTREZGENE, UniProtKB/TrEMBL
	O08815	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Slk	STE20-like kinase	Slk	STE20-like kinase (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-15	Slk	STE20-like kinase (yeast)	Slk	serine/threonine kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Slk	serine/threonine kinase 2	Stk2		Symbol and Name updated	1299863	APPROVED
2002-06-10	Stk2	Serine/threonine kinase 2			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_product	putative protein kinase	634167

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD