Sqle (squalene epoxidase) - Rat Genome Database

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Gene: Sqle (squalene epoxidase) Rattus norvegicus
Analyze
Symbol: Sqle
Name: squalene epoxidase
RGD ID: 3755
Description: Enables squalene monooxygenase activity. Involved in cholesterol metabolic process and response to biphenyl. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SQLE (squalene epoxidase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: SE; squalene monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8792,758,175 - 92,773,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl792,757,409 - 92,773,050 (+)EnsemblGRCr8
mRatBN7.2790,867,973 - 90,883,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx792,758,583 - 92,773,453 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0794,959,761 - 94,974,631 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0794,787,067 - 94,801,940 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,609,929 - 99,624,803 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,609,191 - 99,624,732 (+)Ensemblrn6Rnor6.0
Rnor_5.07100,197,094 - 100,211,968 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4796,096,897 - 96,111,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera787,631,412 - 87,646,286 (+)NCBICelera
RGSC_v3.1796,130,995 - 96,146,001 (+)NCBI
Cytogenetic Map7q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acrylamide  (EXP,ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
antimony(0)  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
corosolic acid  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
Febrifugine  (ISO)
fenofibrate  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP,ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flusilazole  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lead(II) chloride  (ISO)
leflunomide  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
loperamide  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylparaben  (ISO)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naled  (ISO)
neomycin  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phytosterols  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanil  (ISO)
propiconazole  (EXP,ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topiramate  (EXP)
triadimefon  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. Abe I, etal., J Nat Prod. 2001 Aug;64(8):1010-4.
2. Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse. Clarke GA, etal., Gut. 2004 Jan;53(1):136-42.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model. Kim S, etal., Gene. 2004 Sep 29;340(1):99-109.
7. Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Marmugi A, etal., Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
8. Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts. Matzno S, etal., J Lipid Res. 1997 Aug;38(8):1639-48.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase. Nagai M, etal., Biochem Biophys Res Commun 2002 Jul 5;295(1):74-80.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Purification and partial characterization of squalene epoxidase from rat liver microsomes. Ono T, etal., Biochim Biophys Acta. 1982 Dec 6;709(1):84-90.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Molecular cloning and expression of rat squalene epoxidase. Sakakibara J, etal., J Biol Chem 1995 Jan 6;270(1):17-20.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:12454003   PMID:12477932   PMID:17112472   PMID:29765154   PMID:30626872  


Genomics

Comparative Map Data
Sqle
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8792,758,175 - 92,773,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl792,757,409 - 92,773,050 (+)EnsemblGRCr8
mRatBN7.2790,867,973 - 90,883,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx792,758,583 - 92,773,453 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0794,959,761 - 94,974,631 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0794,787,067 - 94,801,940 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,609,929 - 99,624,803 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,609,191 - 99,624,732 (+)Ensemblrn6Rnor6.0
Rnor_5.07100,197,094 - 100,211,968 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4796,096,897 - 96,111,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera787,631,412 - 87,646,286 (+)NCBICelera
RGSC_v3.1796,130,995 - 96,146,001 (+)NCBI
Cytogenetic Map7q33NCBI
SQLE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388124,998,505 - 125,022,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8124,998,467 - 125,022,287 (+)Ensemblhg38GRCh38
GRCh378126,010,747 - 126,034,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368126,079,901 - 126,103,707 (+)NCBIBuild 36Build 36hg18NCBI36
Build 348126,080,612 - 126,103,706NCBI
Celera8122,199,057 - 122,223,195 (+)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8121,334,165 - 121,358,312 (+)NCBIHuRef
CHM1_18126,050,996 - 126,075,149 (+)NCBICHM1_1
T2T-CHM13v2.08126,131,528 - 126,156,104 (+)NCBIT2T-CHM13v2.0
Sqle
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391559,186,941 - 59,203,042 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1559,186,926 - 59,203,041 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381559,315,092 - 59,331,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1559,315,077 - 59,331,192 (+)Ensemblmm10GRCm38
MGSCv371559,146,647 - 59,162,748 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361559,144,773 - 59,160,874 (+)NCBIMGSCv36mm8
Celera1560,845,733 - 60,861,834 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1525.16NCBI
Sqle
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955461122,528 - 143,064 (+)Ensembl
ChiLan1.0NW_004955461121,886 - 143,389 (+)NCBIChiLan1.0ChiLan1.0
SQLE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27142,421,180 - 142,445,046 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18117,932,264 - 117,956,167 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08121,684,269 - 121,708,131 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18124,435,668 - 124,459,441 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8124,435,668 - 124,459,441 (+)EnsemblpanPan2panpan1.1
SQLE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11322,994,010 - 23,018,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1322,993,862 - 23,017,978 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1322,958,181 - 22,982,327 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01323,335,721 - 23,359,940 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1323,334,422 - 23,359,939 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11323,056,318 - 23,080,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01323,165,695 - 23,189,887 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01323,408,709 - 23,432,884 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sqle
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530315,300,693 - 15,326,293 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647022,725,888 - 22,752,500 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647022,726,793 - 22,752,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SQLE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl414,669,791 - 14,700,126 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1414,669,789 - 14,700,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2415,248,863 - 15,279,281 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SQLE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18119,586,639 - 119,610,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8119,586,659 - 119,611,142 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603920,569,199 - 20,595,508 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sqle
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473530,226,465 - 30,246,294 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473530,225,307 - 30,246,202 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sqle
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11233,829,246 - 233,844,950 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sqle
137 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:114
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000012883
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH130198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2790,883,363 - 90,883,574 (+)MAPPERmRatBN7.2
Rnor_6.0799,624,551 - 99,624,761NCBIRnor6.0
Rnor_5.07100,211,716 - 100,211,926UniSTSRnor5.0
RGSC_v3.4796,111,520 - 96,111,730UniSTSRGSC3.4
Celera787,646,034 - 87,646,244UniSTS
RH 3.4 Map7651.28UniSTS
Cytogenetic Map7q33UniSTS
RH133886  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2790,868,435 - 90,868,624 (+)MAPPERmRatBN7.2
Rnor_6.0799,609,623 - 99,609,811NCBIRnor6.0
Rnor_5.07100,196,788 - 100,196,976UniSTSRnor5.0
RGSC_v3.4796,096,591 - 96,096,779UniSTSRGSC3.4
Celera787,631,106 - 87,631,294UniSTS
Cytogenetic Map7q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012883   ⟹   ENSRNOP00000012883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl792,757,409 - 92,773,050 (+)Ensembl
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)Ensembl
Rnor_6.0 Ensembl799,609,191 - 99,624,732 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101449   ⟹   ENSRNOP00000094097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl792,757,409 - 92,773,050 (+)Ensembl
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)Ensembl
RefSeq Acc Id: NM_017136   ⟹   NP_058832
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8792,758,175 - 92,773,049 (+)NCBI
mRatBN7.2790,868,742 - 90,883,616 (+)NCBI
Rnor_6.0799,609,929 - 99,624,803 (+)NCBI
Rnor_5.07100,197,094 - 100,211,968 (+)NCBI
RGSC_v3.4796,096,897 - 96,111,772 (+)RGD
Celera787,631,412 - 87,646,286 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058832 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97330 (Get FASTA)   NCBI Sequence Viewer  
  AAN61971 (Get FASTA)   NCBI Sequence Viewer  
  BAA07141 (Get FASTA)   NCBI Sequence Viewer  
  EDM16202 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012883
  ENSRNOP00000012883.2
GenBank Protein P52020 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058832   ⟸   NM_017136
- UniProtKB: Q4V8L3 (UniProtKB/Swiss-Prot),   P52020 (UniProtKB/Swiss-Prot),   A6HRM0 (UniProtKB/TrEMBL),   A0A8I6AKW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012883   ⟸   ENSRNOT00000012883
Ensembl Acc Id: ENSRNOP00000094097   ⟸   ENSRNOT00000101449
Protein Domains
FAD-binding   Squalene epoxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52020-F1-model_v2 AlphaFold P52020 1-573 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695356
Promoter ID:EPDNEW_R5881
Type:initiation region
Name:Sqle_1
Description:squalene epoxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0799,609,189 - 99,609,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3755 AgrOrtholog
BioCyc Gene G2FUF-33291 BioCyc
BioCyc Pathway PWY-5670 [epoxysqualene biosynthesis] BioCyc
BioCyc Pathway Image PWY-5670 BioCyc
Ensembl Genes ENSRNOG00000009550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012883 ENTREZGENE
  ENSRNOT00000012883.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7460860 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  Squalene_epoxidase UniProtKB/Swiss-Prot
  Squalene_monox UniProtKB/Swiss-Prot
KEGG Report rno:29230 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114336 IMAGE-MGC_LOAD
NCBI Gene 29230 ENTREZGENE
PANTHER PTHR10835 UniProtKB/Swiss-Prot
  SQUALENE MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam PF08491 UniProtKB/Swiss-Prot
PhenoGen Sqle PhenoGen
PRINTS RNGMNOXGNASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009550 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot
TIGR TC204824
UniProt A0A8I6AKW2 ENTREZGENE, UniProtKB/TrEMBL
  A6HRM0 ENTREZGENE, UniProtKB/TrEMBL
  ERG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8L3 ENTREZGENE
UniProt Secondary Q4V8L3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Sqle  squalene epoxidase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains one transmembrane domain and one consensus FAD binding domain 70024
gene_protein putative protein contains 573 aa residues and has mass of 63.9 kDa 70024