Sparc (secreted protein acidic and cysteine rich) - Rat Genome Database

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Gene: Sparc (secreted protein acidic and cysteine rich) Rattus norvegicus
Analyze
Symbol: Sparc
Name: secreted protein acidic and cysteine rich
RGD ID: 3742
Description: Enables calcium ion binding activity. Involved in several processes, including response to L-ascorbic acid; response to lead ion; and response to lipopolysaccharide. Located in extracellular space and vesicle. Is active in glutamatergic synapse. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basement-membrane protein 40; BM-40; ON; osteonectin; Secreted acidic cystein-rich glycoprotein (osteonectin); secreted acidic cysteine rich glycoprotein; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Vetf2 Vetf10
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,017,065 - 40,038,816 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1040,017,075 - 40,039,268 (-)EnsemblGRCr8
mRatBN7.21039,516,394 - 39,538,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1044,200,679 - 44,221,761 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,690,774 - 43,711,860 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,194,463 - 39,215,539 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)Ensemblrn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1038,848,158 - 38,869,906 (-)NCBICelera
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
RH 3.4 Map10414.6RGD
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-camphor  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
Abemaciclib  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ampullosporin  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
Azoxymethane  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (EXP)
camphor  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
Ethoxyacetic acid  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gallocatechin  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-Oryzanol (TN)  (EXP)
genistein  (EXP)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
magnesium atom  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
notoginsenoside R1  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
poly(vinylpyrrolidone)  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (EXP)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Trapidil  (EXP)
triacsin C  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. SPARC from olfactory ensheathing cells stimulates Schwann cells to promote neurite outgrowth and enhances spinal cord repair. Au E, etal., J Neurosci. 2007 Jul 4;27(27):7208-21.
2. Secreted protein, acidic and rich in cysteine (SPARC) and thrombospondin in the developing follicle and corpus luteum of the rat. Bagavandoss P, etal., J Histochem Cytochem. 1998 Sep;46(9):1043-49.
3. Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer. Brown TJ, etal., Gynecol Oncol. 1999 Oct;75(1):25-33.
4. Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats. Camino AM, etal., J Gene Med. 2008 Sep;10(9):993-1004.
5. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Chang W, etal., Endocrinology. 2002 Apr;143(4):1467-74.
6. Purification of a calcium binding protein (rat SPARC) from primary Sertoli cell-enriched culture medium. Cheng CY Biochem Biophys Res Commun. 1990 Mar 30;167(3):1393-9.
7. Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Cheng D, etal., Mol Cell Proteomics. 2006 Jun;5(6):1158-70. doi: 10.1074/mcp.D500009-MCP200. Epub 2006 Feb 28.
8. Coordinate gene expression during neonatal rat heart development. A possible role for the myocyte in extracellular matrix biogenesis and capillary angiogenesis. Engelmann GL Cardiovasc Res. 1993 Sep;27(9):1598-605.
9. Regulation of selenoprotein P mRNA expression in comparison with metallothionein and osteonectin mRNAs following cadmium and dexamethasone administration. Fujii M, etal., Kobe J Med Sci. 1997 Feb;43(1):13-23.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. SPARC gene expression is reduced in early diabetes-related kidney growth. Gilbert RE, etal., Kidney Int. 1995 Oct;48(4):1216-25.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
14. Osteonectin gene expression in fibrotic liver. Inagaki H, etal., Life Sci. 1996;58(11):927-34.
15. Gene expression and immunohistochemical localization of osteonectin in association with early bone formation in the developing mandible. Ishigaki R, etal., Histochem J. 2002 Jan-Feb;34(1-2):57-66.
16. SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy. Jandeleit-Dahm K, etal., Microvasc Res. 2000 Jan;59(1):61-71.
17. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
18. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
19. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
20. Spatially and temporally different expression of osteonectin and osteopontin in the infarct zone of experimentally induced myocardial infarction in rats. Komatsubara I, etal., Cardiovasc Pathol. 2003 Jul-Aug;12(4):186-94.
21. Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Kucukdereli H, etal., Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9. doi: 10.1073/pnas.1104977108. Epub 2011 Jul 25.
22. Microgravity signal ensnarls cell adhesion, cytoskeleton, and matrix proteins of rat osteoblasts: osteopontin, CD44, osteonectin, and alpha-tubulin. Kumei Y, etal., Ann N Y Acad Sci. 2006 Dec;1090:311-7.
23. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
24. Regional differences in expression of osteonectin mRNA after administration of cadmium to rats. Lee MJ, etal., Arch Toxicol 1995;69(9):590-5.
25. Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity. Li J, etal., Am J Physiol Endocrinol Metab 2002 Jun;282(6):E1334-41.
26. Osteonectin RNA and collagen alpha1(I) RNA in the developing rat maxilla. Liao H, etal., Eur J Oral Sci 1998 Jan;106 Suppl 1:418-23.
27. Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N'-nitro-N-nitrosoguanidine. Maeng HY, etal., Jpn J Cancer Res. 2002 Sep;93(9):960-7.
28. SPARC/osteonectin mRNA is induced in blood vessels following injury to the adult rat cerebral cortex. Mendis DB, etal., Neurochem Res. 1998 Aug;23(8):1117-23.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Expression of mRNA encoding extracellular matrix glycoproteins SPARC and SC1 is temporally and spatially regulated in the developing cochlea of the rat inner ear. Mothe AJ and Brown IR, Hear Res. 2001 May;155(1-2):161-74.
31. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. Nimphius W, etal., Virchows Arch. 2007 Feb;450(2):179-85.
34. Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray. Onyia JE, etal., J Cell Biochem. 2005 May 15;95(2):403-18.
35. SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro. Pichler RH, etal., Am J Pathol. 1996 Apr;148(4):1153-67.
36. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Pichler RH, etal., Kidney Int. 1996 Dec;50(6):1978-89.
37. Expression of SPARC (secreted protein, acidic and rich in cysteine) in healing intestinal anastomoses and short bowel syndrome in rats. Puolakkainen P, etal., Dig Dis Sci. 1999 Aug;44(8):1554-64.
38. Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization. Reed MJ, etal., J Histochem Cytochem. 1993 Oct;41(10):1467-77.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma. Rodriguez-Jimenez FJ, etal., Oncol Rep. 2007 Jun;17(6):1301-7.
42. Normalization of the ovarian cancer microenvironment by SPARC. Said N, etal., Mol Cancer Res. 2007 Oct;5(10):1015-30.
43. SPARC expression in primary human renal cell carcinoma: upregulation of SPARC in sarcomatoid renal carcinoma. Sakai N, etal., Hum Pathol. 2001 Oct;32(10):1064-70.
44. Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8 cells. Sauk JJ, etal., Toxicol Appl Pharmacol. 1992 Oct;116(2):240-7.
45. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. Socha MJ, etal., Am J Pathol. 2007 Oct;171(4):1104-12. Epub 2007 Aug 23.
46. Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Sova P, etal., Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):114-23.
47. SPARC participates in the branching morphogenesis of developing fetal rat lung. Strandjord TP, etal., Am J Respir Cell Mol Biol. 1995 Sep;13(3):279-87.
48. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
49. Impaired expression of noncollagenous bone matrix protein mRNAs during fracture healing in ascorbic acid-deficient rats. Sugimoto M, etal., J Bone Miner Res. 1998 Feb;13(2):271-8.
50. The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. Tartare-Deckert S, etal., J Biol Chem. 2001 Jun 22;276(25):22231-7. Epub 2001 Apr 9.
51. Effects of parathyroid hormone on bone formation in a rat model for chronic alcohol abuse. Turner RT, etal., Alcohol Clin Exp Res. 2001 May;25(5):667-71.
52. Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat. Walpen S, etal., J Am Soc Nephrol. 2000 Mar;11(3):468-76.
53. Analysis of the gene expression of SPARC and its prognostic value for bladder cancer. Yamanaka M, etal., J Urol. 2001 Dec;166(6):2495-9.
Additional References at PubMed
PMID:1737102   PMID:3400777   PMID:3427055   PMID:7034958   PMID:7848824   PMID:8906420   PMID:9501084   PMID:10559001   PMID:11856645   PMID:12867428   PMID:14505356   PMID:15389586  
PMID:16093428   PMID:16443258   PMID:17299058   PMID:18757743   PMID:19285050   PMID:19837135   PMID:22289652   PMID:22306863   PMID:22876197   PMID:22880013   PMID:23910024   PMID:24006456  
PMID:24245505   PMID:25340873   PMID:26110898   PMID:26420865   PMID:27068509   PMID:27339669   PMID:28499910   PMID:30424792   PMID:30560317   PMID:34876214   PMID:36241137  


Genomics

Comparative Map Data
Sparc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,017,065 - 40,038,816 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1040,017,075 - 40,039,268 (-)EnsemblGRCr8
mRatBN7.21039,516,394 - 39,538,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1044,200,679 - 44,221,761 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,690,774 - 43,711,860 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,194,463 - 39,215,539 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)Ensemblrn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1038,848,158 - 38,869,906 (-)NCBICelera
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
RH 3.4 Map10414.6RGD
Cytogenetic Map10q22NCBI
SPARC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,661,096 - 151,686,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,661,096 - 151,687,352 (-)Ensemblhg38GRCh38
GRCh375151,040,657 - 151,066,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,021,201 - 151,046,710 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345151,021,203 - 151,046,710NCBI
Celera5147,122,406 - 147,147,929 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,186,043 - 146,212,010 (-)NCBIHuRef
CHM1_15150,473,070 - 150,499,042 (-)NCBICHM1_1
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBIT2T-CHM13v2.0
Sparc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,284,985 - 55,310,906 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,285,326 - 55,314,009 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381155,394,159 - 55,420,080 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,394,500 - 55,423,183 (-)Ensemblmm10GRCm38
MGSCv371155,208,003 - 55,233,582 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361155,237,924 - 55,263,289 (-)NCBIMGSCv36mm8
Celera1159,982,920 - 59,995,424 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1133.04NCBI
Sparc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,099,003 - 6,122,459 (-)Ensembl
ChiLan1.0NW_0049554086,100,123 - 6,122,460 (-)NCBIChiLan1.0ChiLan1.0
SPARC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,892,751 - 146,917,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15145,032,296 - 145,057,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05147,087,903 - 147,112,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15153,091,160 - 153,115,745 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,090,181 - 153,115,750 (-)EnsemblpanPan2panpan1.1
SPARC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,659,541 - 57,682,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,659,650 - 57,681,711 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha457,479,010 - 57,501,597 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0458,102,077 - 58,124,747 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,101,302 - 58,124,748 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,918,069 - 57,940,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,016,600 - 58,039,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,519,992 - 58,542,658 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sparc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,576,762 - 112,597,465 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651511,025,724 - 11,046,849 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651511,026,156 - 11,046,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPARC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,357,586 - 71,381,161 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11671,368,164 - 71,380,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,576,864 - 77,584,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPARC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,224,003 - 54,248,869 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,222,838 - 54,238,006 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603423,456,066 - 23,481,034 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sparc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,338,284 - 37,369,804 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473337,348,993 - 37,369,804 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sparc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1937,815,104 - 37,837,029 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sparc
248 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:175
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000017486
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128632  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81040,017,215 - 40,017,404 (+)Marker Load Pipeline
mRatBN7.21039,516,544 - 39,516,733 (+)MAPPERmRatBN7.2
Rnor_6.01040,742,541 - 40,742,729NCBIRnor6.0
Rnor_5.01040,573,661 - 40,573,849UniSTSRnor5.0
RGSC_v3.41040,809,881 - 40,810,069UniSTSRGSC3.4
Celera1038,848,309 - 38,848,497UniSTS
RH 3.4 Map10408.7UniSTS
Cytogenetic Map10q22UniSTS
RH94599  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,516,435 - 39,516,593 (+)MAPPERmRatBN7.2
Rnor_6.01040,742,432 - 40,742,589NCBIRnor6.0
Rnor_5.01040,573,552 - 40,573,709UniSTSRnor5.0
RGSC_v3.41040,809,772 - 40,809,929UniSTSRGSC3.4
Celera1038,848,200 - 38,848,357UniSTS
RH 3.4 Map10414.6UniSTS
Cytogenetic Map10q22UniSTS
RH140308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,516,913 - 39,517,093 (+)MAPPERmRatBN7.2
Rnor_6.01040,742,910 - 40,743,089NCBIRnor6.0
Rnor_5.01040,574,030 - 40,574,209UniSTSRnor5.0
RGSC_v3.41040,810,250 - 40,810,429UniSTSRGSC3.4
Celera1038,848,678 - 38,848,857UniSTS
RH 3.4 Map10408.0UniSTS
Cytogenetic Map10q22UniSTS
PMC151926P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,517,071 - 39,518,238 (+)MAPPERmRatBN7.2
Rnor_6.01040,743,068 - 40,744,234NCBIRnor6.0
Rnor_5.01040,574,188 - 40,575,354UniSTSRnor5.0
RGSC_v3.41040,810,408 - 40,811,574UniSTSRGSC3.4
Celera1038,848,836 - 38,850,002UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017486   ⟹   ENSRNOP00000017486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1040,017,075 - 40,038,831 (-)Ensembl
mRatBN7.2 Ensembl1039,516,416 - 39,538,242 (-)Ensembl
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098312   ⟹   ENSRNOP00000094410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1040,017,075 - 40,039,268 (-)Ensembl
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099801   ⟹   ENSRNOP00000083269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,516,406 - 39,526,241 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115607   ⟹   ENSRNOP00000093140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1040,018,651 - 40,029,337 (-)Ensembl
mRatBN7.2 Ensembl1039,517,585 - 39,538,180 (-)Ensembl
RefSeq Acc Id: NM_012656   ⟹   NP_036788
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,017,065 - 40,038,816 (-)NCBI
mRatBN7.21039,516,394 - 39,538,149 (-)NCBI
Rnor_6.01040,742,390 - 40,764,141 (-)NCBI
Rnor_5.01040,573,510 - 40,595,261 (-)NCBI
RGSC_v3.41040,809,730 - 40,831,481 (-)RGD
Celera1038,848,158 - 38,869,906 (-)RGD
Sequence:
RefSeq Acc Id: NP_036788   ⟸   NM_012656
- Peptide Label: precursor
- UniProtKB: O08953 (UniProtKB/Swiss-Prot),   Q6GSZ4 (UniProtKB/Swiss-Prot),   P16975 (UniProtKB/Swiss-Prot),   A6HEL9 (UniProtKB/TrEMBL),   A0A8I6ALJ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017486   ⟸   ENSRNOT00000017486
Ensembl Acc Id: ENSRNOP00000094410   ⟸   ENSRNOT00000098312
Ensembl Acc Id: ENSRNOP00000083269   ⟸   ENSRNOT00000099801
Ensembl Acc Id: ENSRNOP00000093140   ⟸   ENSRNOT00000115607
Protein Domains
EF-hand   Follistatin-like   Kazal-like   SPARC/Testican calcium-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16975-F1-model_v2 AlphaFold P16975 1-301 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697202
Promoter ID:EPDNEW_R7726
Type:initiation region
Name:Sparc_1
Description:secreted protein acidic and cysteine rich
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01040,764,175 - 40,764,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3742 AgrOrtholog
BioCyc Gene G2FUF-25080 BioCyc
Ensembl Genes ENSRNOG00000012840 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017486 ENTREZGENE
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621666 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  Fol_N UniProtKB/Swiss-Prot
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot
  Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Osteonectin_CS UniProtKB/Swiss-Prot
  SPARC UniProtKB/Swiss-Prot
  SPARC/Testican_Ca-bd-dom UniProtKB/Swiss-Prot
KEGG Report rno:24791 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72514 IMAGE-MGC_LOAD
NCBI Gene 24791 ENTREZGENE
PANTHER PTHR13866:SF6 UniProtKB/Swiss-Prot
  SPARC OSTEONECTIN UniProtKB/Swiss-Prot
Pfam FOLN UniProtKB/Swiss-Prot
  Kazal_1 UniProtKB/Swiss-Prot
  SPARC_Ca_bdg UniProtKB/Swiss-Prot
PhenoGen Sparc PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
  OSTEONECTIN_1 UniProtKB/Swiss-Prot
  OSTEONECTIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012840 RatGTEx
SMART FOLN UniProtKB/Swiss-Prot
  KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF100895 UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I6ALJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK51_RAT UniProtKB/TrEMBL
  A0A8L2Q9I7_RAT UniProtKB/TrEMBL
  A6HEL9 ENTREZGENE, UniProtKB/TrEMBL
  A6HEM4_RAT UniProtKB/TrEMBL
  O08953 ENTREZGENE
  P16975 ENTREZGENE
  Q6GSZ4 ENTREZGENE
  SPRC_RAT UniProtKB/Swiss-Prot
UniProt Secondary O08953 UniProtKB/Swiss-Prot
  Q6GSZ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Sparc  secreted protein acidic and cysteine rich  Sparc  secreted protein, acidic, cysteine-rich (osteonectin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sparc  secreted protein, acidic, cysteine-rich (osteonectin)  Sparc  secreted acidic cysteine rich glycoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sparc  Secreted acidic cystein-rich glycoprotein (osteonectin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is increased 2.2 fold in SHR compared with WKY rats 1357414
gene_expression mRNA expressed in osteoblasts, odontoblasts, and fibroblasts during development 730043
gene_regulation expression increases at the onset of high-fat-diet obesity 625747