Slc22a3 (solute carrier family 22 member 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Slc22a3 (solute carrier family 22 member 3) Rattus norvegicus
Analyze
Symbol: Slc22a3
Name: solute carrier family 22 member 3
RGD ID: 3701
Description: Enables several functions, including dopamine:sodium symporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including histamine transport; monoamine transport; and spermidine transport. Located in apical plasma membrane; endomembrane system; and mitochondrial membrane. Orthologous to human SLC22A3 (solute carrier family 22 member 3); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 1,1'-diethyl-2,2'-cyanine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EMT; extraneuronal monoamine transporter; OCT3; organic cation transporter 3; solute carrier family 22 (extraneuronal monoamine transporter), member 3; solute carrier family 22 (organic cation transporter), member 3; solute carrier family 22, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,783,218 - 50,872,358 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,783,218 - 50,872,353 (+)EnsemblGRCr8
mRatBN7.2148,235,476 - 48,324,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,235,476 - 48,324,612 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,927,055 - 49,016,211 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,912,824 - 55,001,976 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,002,573 - 49,091,712 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,433,079 - 48,521,261 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,433,079 - 48,521,256 (+)Ensemblrn6Rnor6.0
Rnor_5.0151,234,467 - 51,321,364 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,690,158 - 42,781,895 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera144,028,160 - 44,116,659 (+)NCBICelera
RGSC_v3.1142,693,102 - 42,784,835 (+)NCBI
Cytogenetic Map1q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
1,1'-diethyl-2,2'-cyanine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylnicotinamide  (ISO)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[2-(ethylamino)-1-hydroxyethyl]phenol  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
atorvastatin calcium  (ISO)
atropine  (ISO)
Azoxymethane  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-carboline  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clobenpropit  (EXP,ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
desipramine  (EXP,ISO)
dextran sulfate  (ISO)
digoxin  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
diphenhydramine  (ISO)
diquat  (ISO)
dopamine  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethidium  (ISO)
famotidine  (ISO)
flecainide  (ISO)
fluticasone  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glucose  (ISO)
guanidine  (EXP,ISO)
histamine  (EXP,ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
Immepip  (EXP,ISO)
iodide salt  (EXP)
ipratropium  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lidocaine  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
mifepristone  (ISO)
molsidomine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nifedipine  (ISO)
ozone  (ISO)
paclitaxel  (EXP,ISO)
papaverine  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perchlorate  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (EXP,ISO)
phenylephrine  (EXP)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
prazosin  (ISO)
procainamide  (ISO)
progesterone  (EXP,ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
purine-6-thiol  (EXP)
quercetin  (EXP,ISO)
quinidine  (ISO)
quinine  (ISO)
quinolin-8-ol  (ISO)
ranitidine  (ISO)
Salmeterol xinafoate  (ISO)
serotonin  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
spironolactone  (ISO)
sulpiride  (ISO)
synephrine  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraethylammonium  (EXP,ISO)
thioacetamide  (EXP)
Thioperamide  (EXP,ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimazosin  (EXP,ISO)
trimethoprim  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vincaleukoblastine  (ISO)
zearalenone  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Amphoux A, etal., Neuropharmacology. 2006 Jun;50(8):941-52. doi: 10.1016/j.neuropharm.2006.01.005. Epub 2006 Mar 31.
2. Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice. Gasser PJ, etal., Brain Struct Funct. 2017 May;222(4):1913-1928. doi: 10.1007/s00429-016-1315-9. Epub 2016 Sep 22.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Metformin pathways: pharmacokinetics and pharmacodynamics. Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
6. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Grundemann D, etal., Br J Pharmacol. 2002 Nov;137(6):910-8.
7. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. Kekuda R, etal., J Biol Chem 1998 Jun 26;273(26):15971-9.
8. Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway. Lee KR, etal., Drug Metab Pharmacokinet. 2010;25(5):430-41. doi: 10.2133/dmpk.dmpk-10-rg-049. Epub 2010 Sep 30.
9. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Lips KS, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88. Epub 2005 Apr 7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Sala-Rabanal M, etal., Mol Pharm. 2013 Apr 1;10(4):1450-8. doi: 10.1021/mp400024d. Epub 2013 Mar 19.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. Verhey KJ, etal., J Cell Biol. 2001 Mar 5;152(5):959-70.
19. Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. Wu X, etal., J Biol Chem. 1998 Dec 4;273(49):32776-86.
20. Renal tumours in a Tsc1(+)/(-) mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin. Yang J, etal., Eur J Cancer. 2013 Apr;49(6):1479-90. doi: 10.1016/j.ejca.2012.10.027. Epub 2012 Dec 7.
Additional References at PubMed
PMID:10966924   PMID:11390648   PMID:15028779   PMID:16024787   PMID:16061728   PMID:19141712   PMID:20858707   PMID:28543680  


Genomics

Comparative Map Data
Slc22a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,783,218 - 50,872,358 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,783,218 - 50,872,353 (+)EnsemblGRCr8
mRatBN7.2148,235,476 - 48,324,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,235,476 - 48,324,612 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,927,055 - 49,016,211 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,912,824 - 55,001,976 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,002,573 - 49,091,712 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,433,079 - 48,521,261 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,433,079 - 48,521,256 (+)Ensemblrn6Rnor6.0
Rnor_5.0151,234,467 - 51,321,364 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,690,158 - 42,781,895 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera144,028,160 - 44,116,659 (+)NCBICelera
RGSC_v3.1142,693,102 - 42,784,835 (+)NCBI
Cytogenetic Map1q11NCBI
SLC22A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,348,378 - 160,452,577 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,348,373 - 160,452,577 (+)Ensemblhg38GRCh38
GRCh376160,769,410 - 160,873,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,689,415 - 160,796,004 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346160,739,835 - 160,846,425NCBI
Celera6161,420,905 - 161,527,486 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6158,244,012 - 158,348,214 (+)NCBIHuRef
CHM1_16161,032,217 - 161,136,415 (+)NCBICHM1_1
T2T-CHM13v2.06161,598,508 - 161,702,771 (+)NCBIT2T-CHM13v2.0
Slc22a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,638,859 - 12,726,591 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,637,847 - 12,726,591 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381712,419,972 - 12,507,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,418,960 - 12,507,704 (-)Ensemblmm10GRCm38
MGSCv371712,612,838 - 12,700,570 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361712,263,330 - 12,351,062 (-)NCBIMGSCv36mm8
Celera1712,450,734 - 12,539,105 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.52NCBI
Slc22a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,367,333 - 20,476,891 (-)Ensembl
ChiLan1.0NW_00495543920,367,324 - 20,476,891 (-)NCBIChiLan1.0ChiLan1.0
SLC22A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25180,457,233 - 180,561,182 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16178,361,200 - 178,465,143 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,240,390 - 158,344,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,232,539 - 163,351,256 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,247,643 - 163,349,735 (+)EnsemblpanPan2panpan1.1
SLC22A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,407,949 - 49,496,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,407,966 - 49,496,620 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha150,250,859 - 50,339,627 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0149,593,106 - 49,681,894 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,593,126 - 49,681,430 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,475,470 - 49,564,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,347,643 - 49,435,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,962,647 - 50,051,070 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc22a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,441,761 - 144,522,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,693,755 - 11,772,628 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,693,755 - 11,774,380 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,110,074 - 7,207,401 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.117,105,486 - 7,207,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,787,403 - 8,885,452 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,971,305 - 88,076,468 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,971,392 - 88,074,946 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604060,348,130 - 60,452,975 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,399,671 - 2,516,237 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248552,402,096 - 2,516,249 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc22a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12191,160,580 - 191,251,113 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc22a3
904 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:166
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000037369
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
RH132315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,324,258 - 48,324,474 (+)MAPPERmRatBN7.2
Rnor_6.0148,520,903 - 48,521,118NCBIRnor6.0
Rnor_5.0151,234,610 - 51,234,825UniSTSRnor5.0
RGSC_v3.4142,781,537 - 42,781,752UniSTSRGSC3.4
Celera144,116,301 - 44,116,516UniSTS
RH 3.4 Map1586.6UniSTS
Cytogenetic Map1q11UniSTS
AU049521  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8150,851,486 - 50,851,648 (+)Marker Load Pipeline
mRatBN7.2148,303,745 - 48,303,907 (+)MAPPERmRatBN7.2
Rnor_6.0148,500,311 - 48,500,472NCBIRnor6.0
Rnor_5.0151,254,243 - 51,254,404UniSTSRnor5.0
RGSC_v3.4142,760,171 - 42,760,332UniSTSRGSC3.4
Celera144,095,535 - 44,095,696UniSTS
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 113 77 76 45 50 45 6 269 148 11 88 52 92 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000037369   ⟹   ENSRNOP00000029748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,783,218 - 50,872,353 (+)Ensembl
mRatBN7.2 Ensembl148,235,476 - 48,324,612 (+)Ensembl
Rnor_6.0 Ensembl148,433,079 - 48,521,256 (+)Ensembl
RefSeq Acc Id: NM_019230   ⟹   NP_062103
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,783,218 - 50,872,358 (+)NCBI
mRatBN7.2148,235,476 - 48,324,617 (+)NCBI
Rnor_6.0148,433,079 - 48,521,261 (+)NCBI
Rnor_5.0151,234,467 - 51,321,364 (-)NCBI
RGSC_v3.4142,690,158 - 42,781,895 (+)RGD
Celera144,028,160 - 44,116,659 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062103 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40150 (Get FASTA)   NCBI Sequence Viewer  
  EDL83064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029748
  ENSRNOP00000029748.2
GenBank Protein O88446 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062103   ⟸   NM_019230
- UniProtKB: O88446 (UniProtKB/Swiss-Prot),   A6KJX6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029748   ⟸   ENSRNOT00000037369
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88446-F1-model_v2 AlphaFold O88446 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3701 AgrOrtholog
BioCyc Gene G2FUF-61565 BioCyc
Ensembl Genes ENSRNOG00000022946 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037369 ENTREZGENE
  ENSRNOT00000037369.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:29504 UniProtKB/Swiss-Prot
NCBI Gene 29504 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PharmGKB SLC22A3 RGD
PhenoGen Slc22a3 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022946 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC232883
UniProt A6KJX6 ENTREZGENE, UniProtKB/TrEMBL
  O88446 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc22a3  solute carrier family 22 member 3  Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Slc22a3  solute carrier family 22 (extraneuronal monoamine transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc22a3  solute carrier family 22 (extraneuronal monoamine transporter), member 3  Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-24 Slc22a3  solute carrier family 22 (organic cation transporter), member 3  Slc22a3  solute carrier family 22, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc22a3  solute carrier family 22, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression has highest mRNA expression in placenta 70010
gene_regulation transport activity is sensitive to membrane potential 70010