Slc19a1 (solute carrier family 19 member 1) - Rat Genome Database

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Gene: Slc19a1 (solute carrier family 19 member 1) Rattus norvegicus
Analyze
Symbol: Slc19a1
Name: solute carrier family 19 member 1
RGD ID: 3695
Description: Enables folate:monoatomic anion antiporter activity; folic acid binding activity; and methotrexate transmembrane transporter activity. Involved in several processes, including female pregnancy; methotrexate transport; and xenobiotic transmembrane transport. Located in basolateral plasma membrane and brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cleft lip; dextro-looped transposition of the great arteries; immunodeficiency 114; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: folate transporter 1; methotrexate carrier 1; methotrexate carrier 2; methotrexate carrier 5; methotrexate carrier 6; MGC93506; MTX-1; MTX1; plasma membrane folate antiporter SLC19A1; reduced folate carrier 1; reduced folate transporter; RFC-1; RFC1; solute carrier family 19 (folate transporter), member 1; solute carrier family 19 (sodium/hydrogen exchanger) member 1; solute carrier family 19 (sodium/hydrogen exchanger), member 1; solute carrier family 19, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82011,583,928 - 11,601,959 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2011,583,929 - 11,601,488 (-)EnsemblGRCr8
mRatBN7.22011,584,410 - 11,602,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,584,411 - 11,601,972 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2012,280,810 - 12,298,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02011,641,794 - 11,659,406 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,113,554 - 12,131,164 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,334,675 - 12,354,517 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,334,676 - 12,352,377 (-)Ensemblrn6Rnor6.0
Rnor_5.02014,497,058 - 14,515,221 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,984,283 - 12,001,865 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2013,083,139 - 13,100,721 (-)NCBICelera
RGSC_v3.12011,984,510 - 12,001,518 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5,6,7,8-tetrahydrofolic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methyltetrahydrofolic acid  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ARV-825  (ISO)
atenolol  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromosulfophthalein  (EXP)
bumetanide  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
chlorpromazine  (EXP)
cholate  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dihydrofolic acid  (EXP)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ICI D1694  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
monocrotaline  (ISO)
nicotine  (ISO)
okadaic acid  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
taurocholic acid  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trimetrexate  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IBA,IDA,IEA,ISO)
basolateral plasma membrane  (IBA,IDA,IEA,ISO)
brush border membrane  (IDA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
2. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Bukhari FJ, etal., Nephrol Dial Transplant. 2011 Jul;26(7):2137-44. doi: 10.1093/ndt/gfq675. Epub 2010 Dec 13.
3. The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue. Chiusolo P, etal., Cancer Chemother Pharmacol. 2012 Mar;69(3):691-6. doi: 10.1007/s00280-011-1751-4. Epub 2011 Oct 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects. Gong D, etal., Clin Chem Lab Med. 2012 Feb 4;50(8):1455-61. doi: 10.1515/cclm-2011-0759.
7. The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier. Halwachs S, etal., Mol Pharmacol. 2011 Oct;80(4):621-9. doi: 10.1124/mol.111.072421. Epub 2011 Jul 7.
8. Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway. Halwachs S, etal., Toxicol Appl Pharmacol. 2010 Jul;246(1-2):100-6. doi: 10.1016/j.taap.2010.04.020. Epub 2010 May 6.
9. Low folate transport across intestinal basolateral surface is associated with down-regulation of reduced folate carrier in in vivo model of folate malabsorption. Hamid A, etal., IUBMB Life. 2009 Mar;61(3):236-43. doi: 10.1002/iub.153.
10. Subcellular localization and distribution of the reduced folate carrier in normal rat tissues. Hinken M, etal., Eur J Histochem. 2011 Jan 27;55(1):e3. doi: 10.4081/ejh.2011.e3.
11. Cloning and functional characterization of the bile acid-sensitive methotrexate carrier from rat liver cells. Honscha W, etal., Hepatology. 2000 Jun;31(6):1296-304. doi: 10.1053/jhep.2000.7478.
12. Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate. Hosoya K, etal., Drug Metab Pharmacokinet. 2008;23(4):285-92. doi: 10.2133/dmpk.23.285.
13. Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization. Kneuer C, etal., Am J Physiol Renal Physiol 2004 Mar;286(3):F564-71. Epub 2003 Nov 11.
14. Rat reduced-folate carrier-1 is localized basolaterally in MDCK kidney epithelial cells and contributes to the secretory transport of methotrexate and fluoresceinated methotrexate. Kneuer C, etal., Cell Tissue Res. 2005 Jun;320(3):517-24. Epub 2005 Apr 22.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India. Mirgal D, etal., Trans R Soc Trop Med Hyg. 2016 May;110(5):294-8. doi: 10.1093/trstmh/trw026.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. Rajgopal A, etal., Am J Physiol Cell Physiol 2001 Nov;281(5):C1579-86.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only. Vieira AR, etal., Braz J Med Biol Res. 2008 Aug;41(8):689-93.
23. Mechanism of intestinal folate transport during folate deficiency in rodent model. Wani NA, etal., Indian J Med Res. 2012 Nov;136(5):758-65.
24. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
25. Placental folate transport during pregnancy. Yasuda S, etal., Biosci Biotechnol Biochem. 2008 Sep;72(9):2277-84. Epub 2008 Sep 7.
Additional References at PubMed
PMID:9111015   PMID:9748272   PMID:10787414   PMID:12477932   PMID:14609557   PMID:15385270   PMID:16040340   PMID:16495369   PMID:16753822   PMID:21069807   PMID:21861943   PMID:22163044  
PMID:22554803   PMID:26990146   PMID:28885847   PMID:31126740   PMID:31511694   PMID:32521439   PMID:35850595  


Genomics

Comparative Map Data
Slc19a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82011,583,928 - 11,601,959 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2011,583,929 - 11,601,488 (-)EnsemblGRCr8
mRatBN7.22011,584,410 - 11,602,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,584,411 - 11,601,972 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2012,280,810 - 12,298,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02011,641,794 - 11,659,406 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,113,554 - 12,131,164 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,334,675 - 12,354,517 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,334,676 - 12,352,377 (-)Ensemblrn6Rnor6.0
Rnor_5.02014,497,058 - 14,515,221 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,984,283 - 12,001,865 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2013,083,139 - 13,100,721 (-)NCBICelera
RGSC_v3.12011,984,510 - 12,001,518 (-)NCBI
Cytogenetic Map20p12NCBI
SLC19A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382145,502,517 - 45,563,025 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2145,493,572 - 45,573,564 (-)Ensemblhg38GRCh38
GRCh372146,932,461 - 46,982,939 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362145,759,057 - 45,786,779 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342145,759,056 - 45,786,779NCBI
Celera2132,045,498 - 32,073,224 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2132,311,090 - 32,338,803 (-)NCBIHuRef
CHM1_12146,495,459 - 46,523,222 (-)NCBICHM1_1
T2T-CHM13v2.02143,870,718 - 43,932,046 (-)NCBIT2T-CHM13v2.0
Slc19a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391076,868,103 - 76,886,266 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1076,868,075 - 76,896,836 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381077,032,269 - 77,050,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,032,241 - 77,061,002 (+)Ensemblmm10GRCm38
MGSCv371076,496,004 - 76,513,171 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361076,476,975 - 76,494,142 (+)NCBIMGSCv36mm8
Celera1078,077,259 - 78,094,426 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Slc19a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540742,132,165 - 42,141,992 (-)Ensembl
ChiLan1.0NW_00495540742,132,216 - 42,154,252 (-)NCBIChiLan1.0ChiLan1.0
SLC19A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22241,591,647 - 41,638,681 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12136,460,180 - 36,507,367 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02131,836,774 - 31,883,829 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12145,108,537 - 45,155,049 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2145,090,595 - 45,134,752 (-)EnsemblpanPan2panpan1.1
SLC19A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,958,332 - 38,971,091 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3138,967,013 - 38,971,094 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3138,186,973 - 38,207,074 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03138,595,425 - 38,615,689 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3138,593,432 - 38,614,546 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13138,459,144 - 38,479,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03138,418,853 - 38,439,175 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,937,728 - 38,958,024 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc19a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497138,283,370 - 38,301,406 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936778829,550 - 848,833 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936778823,376 - 846,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC19A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,986,098 - 208,007,675 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113207,986,094 - 208,007,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213218,089,574 - 218,114,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC19A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,188,171 - 89,232,081 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,188,733 - 89,209,281 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605417,449,163 - 17,496,448 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc19a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,794,024 - 30,811,944 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474530,793,114 - 30,811,944 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc19a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v118373,242 - 386,651 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc19a1
88 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:178
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000044212, ENSRNOT00000065236
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
U32469  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,584,773 - 11,584,965 (+)MAPPERmRatBN7.2
Rnor_6.02012,335,039 - 12,335,230NCBIRnor6.0
Rnor_5.02014,497,422 - 14,497,613UniSTSRnor5.0
RGSC_v3.42011,984,647 - 11,984,838UniSTSRGSC3.4
Celera2013,083,503 - 13,083,694UniSTS
Cytogenetic Map20p12UniSTS
RH129841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,584,442 - 11,584,605 (+)MAPPERmRatBN7.2
Rnor_6.02012,334,708 - 12,334,870NCBIRnor6.0
Rnor_5.02014,497,091 - 14,497,253UniSTSRnor5.0
RGSC_v3.42011,984,316 - 11,984,478UniSTSRGSC3.4
Celera2013,083,172 - 13,083,334UniSTS
RH 3.4 Map20177.0UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001035232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF099009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF099010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF173642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY756273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044212   ⟹   ENSRNOP00000041562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2011,583,929 - 11,601,488 (-)Ensembl
mRatBN7.2 Ensembl2011,584,411 - 11,601,972 (-)Ensembl
Rnor_6.0 Ensembl2012,334,676 - 12,352,377 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065236   ⟹   ENSRNOP00000060579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2011,583,929 - 11,600,945 (-)Ensembl
mRatBN7.2 Ensembl2011,584,411 - 11,601,429 (-)Ensembl
Rnor_6.0 Ensembl2012,334,676 - 12,351,813 (-)Ensembl
RefSeq Acc Id: NM_001035232   ⟹   NP_001030309
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,583,928 - 11,601,509 (-)NCBI
mRatBN7.22011,584,410 - 11,601,993 (-)NCBI
Rnor_6.02012,334,675 - 12,352,377 (-)NCBI
Rnor_5.02014,497,058 - 14,515,221 (-)NCBI
RGSC_v3.42011,984,283 - 12,001,865 (-)RGD
Celera2013,083,139 - 13,100,721 (-)RGD
Sequence:
RefSeq Acc Id: NM_017299   ⟹   NP_058995
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,583,928 - 11,600,936 (-)NCBI
mRatBN7.22011,584,410 - 11,601,420 (-)NCBI
Rnor_6.02012,334,675 - 12,351,804 (-)NCBI
Rnor_5.02014,497,058 - 14,515,221 (-)NCBI
RGSC_v3.42011,984,283 - 12,001,865 (-)RGD
Celera2013,083,139 - 13,100,148 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098630   ⟹   XP_038954558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,583,928 - 11,600,955 (-)NCBI
mRatBN7.22011,584,410 - 11,601,470 (-)NCBI
RefSeq Acc Id: XM_039098631   ⟹   XP_038954559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,583,928 - 11,601,931 (-)NCBI
mRatBN7.22011,584,410 - 11,602,402 (-)NCBI
RefSeq Acc Id: XM_039098632   ⟹   XP_038954560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,583,928 - 11,600,977 (-)NCBI
mRatBN7.22011,584,410 - 11,601,471 (-)NCBI
RefSeq Acc Id: XM_039098633   ⟹   XP_038954561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,583,928 - 11,601,959 (-)NCBI
mRatBN7.22011,584,410 - 11,602,429 (-)NCBI
RefSeq Acc Id: XM_039098634   ⟹   XP_038954562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,588,951 - 11,600,906 (-)NCBI
mRatBN7.22011,589,433 - 11,601,487 (-)NCBI
RefSeq Acc Id: NP_001030309   ⟸   NM_001035232
- UniProtKB: Q62866 (UniProtKB/Swiss-Prot),   D3ZQS7 (UniProtKB/Swiss-Prot),   Q9QUM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_058995   ⟸   NM_017299
- UniProtKB: Q62866 (UniProtKB/Swiss-Prot),   D3ZQS7 (UniProtKB/Swiss-Prot),   Q9QUM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060579   ⟸   ENSRNOT00000065236
Ensembl Acc Id: ENSRNOP00000041562   ⟸   ENSRNOT00000044212
RefSeq Acc Id: XP_038954561   ⟸   XM_039098633
- Peptide Label: isoform X1
- UniProtKB: Q62866 (UniProtKB/Swiss-Prot),   D3ZQS7 (UniProtKB/Swiss-Prot),   Q9QUM8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954559   ⟸   XM_039098631
- Peptide Label: isoform X1
- UniProtKB: Q62866 (UniProtKB/Swiss-Prot),   D3ZQS7 (UniProtKB/Swiss-Prot),   Q9QUM8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954560   ⟸   XM_039098632
- Peptide Label: isoform X1
- UniProtKB: Q62866 (UniProtKB/Swiss-Prot),   D3ZQS7 (UniProtKB/Swiss-Prot),   Q9QUM8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954558   ⟸   XM_039098630
- Peptide Label: isoform X1
- UniProtKB: Q62866 (UniProtKB/Swiss-Prot),   D3ZQS7 (UniProtKB/Swiss-Prot),   Q9QUM8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954562   ⟸   XM_039098634
- Peptide Label: isoform X2
- UniProtKB: A6JKA5 (UniProtKB/TrEMBL),   Q9QYB9 (UniProtKB/TrEMBL),   Q5UD30 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62866-F1-model_v2 AlphaFold Q62866 1-512 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701510
Promoter ID:EPDNEW_R12034
Type:initiation region
Name:Slc19a1_1
Description:solute carrier family 19 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12035  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02012,351,761 - 12,351,821EPDNEW
RGD ID:13701511
Promoter ID:EPDNEW_R12035
Type:initiation region
Name:Slc19a1_2
Description:solute carrier family 19 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12034  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02012,352,357 - 12,352,417EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3695 AgrOrtholog
BioCyc Gene G2FUF-4209 BioCyc
Ensembl Genes ENSRNOG00000001232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065236 ENTREZGENE
  ENSRNOT00000065236.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193913 IMAGE-MGC_LOAD
InterPro Folate_carrier UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  RFC UniProtKB/Swiss-Prot
KEGG Report rno:29723 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93506 IMAGE-MGC_LOAD
NCBI Gene 29723 ENTREZGENE
PANTHER PTHR10686 UniProtKB/Swiss-Prot
  PTHR10686:SF12 UniProtKB/Swiss-Prot
Pfam Folate_carrier UniProtKB/Swiss-Prot
PharmGKB SLC19A1 RGD
PhenoGen Slc19a1 PhenoGen
PIRSF Folate_carrier UniProtKB/Swiss-Prot
  Folate_transporter_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001232 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A6JKA5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQS7 ENTREZGENE
  Q5UD30 ENTREZGENE, UniProtKB/TrEMBL
  Q5UD31_RAT UniProtKB/TrEMBL
  Q5UD32_RAT UniProtKB/TrEMBL
  Q62866 ENTREZGENE
  Q9QUM8 ENTREZGENE
  Q9QYB9 ENTREZGENE
  S19A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary D3ZQS7 UniProtKB/Swiss-Prot
  Q9QUM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc19a1  solute carrier family 19 member 1  Slc19a1  solute carrier family 19 (folate transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc19a1  solute carrier family 19 (folate transporter), member 1  Slc19a1  solute carrier family 19 (sodium/hydrogen exchanger), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-24 Slc19a1  solute carrier family 19 (sodium/hydrogen exchanger), member 1  Slc19a1  solute carrier family 19, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc19a1  solute carrier family 19, member 1      Name updated 70584 APPROVED