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Gene: Rabggtb (Rab geranylgeranyltransferase subunit beta) Rattus norvegicus

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Symbol:

Rabggtb

Name:

Rab geranylgeranyltransferase subunit beta

RGD ID:

3530

Description:

Enables several functions, including Rab geranylgeranyltransferase activity; small GTPase binding activity; and zinc ion binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

geranylgeranyl transferase type II subunit beta; geranylgeranyl transferase type-2 subunit beta; GGTase-II-beta; rab geranyl-geranyltransferase subunit beta; Rab geranylgeranyl transferase componenet, subunit beta; RAB geranylgeranyl transferase, b subunit; Rab geranylgeranyltransferase, beta subunit; rab GG transferase beta; rab GGTase beta; type II protein geranyl-geranyltransferase subunit beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RABGGTB (Rab geranylgeranyltransferase subunit beta)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rabggtb (Rab geranylgeranyl transferase, b subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rabggtb (Rab geranylgeranyltransferase subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RABGGTB (Rab geranylgeranyltransferase subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RABGGTB (Rab geranylgeranyltransferase subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rabggtb (Rab geranylgeranyltransferase subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RABGGTB (Rab geranylgeranyltransferase subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RABGGTB (Rab geranylgeranyltransferase subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rabggtb (Rab geranylgeranyltransferase subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Rabggtb (Rab geranylgeranyl transferase, b subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RABGGTB (Rab geranylgeranyltransferase subunit beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rabggtb (Rab geranylgeranyltransferase subunit beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BET2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BET2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	betaggt-II	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ggtb-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rabggtb	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	245,504,586 - 245,510,878 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	245,504,586 - 245,510,774 (-)	Ensembl				GRCr8
mRatBN7.2	2	242,844,758 - 242,850,951 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	242,844,762 - 242,851,050 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	250,667,563 - 250,673,774 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	248,561,386 - 248,567,597 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	243,459,951 - 243,466,163 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	260,110,309 - 260,115,574 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	260,110,309 - 260,115,577 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	278,774,376 - 278,779,641 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	251,852,549 - 251,857,811 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	234,777,191 - 234,782,459 (-)	NCBI		Celera
RGSC_v3.1	2	251,867,151 - 251,872,419 (-)	NCBI
Cytogenetic Map	2	q45	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trimethylbenzene (EXP)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzene (EXP)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chloropicrin (ISO)

chromium(6+) (ISO)

chrysene (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

DDE (ISO)

DDT (ISO)

deguelin (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dimethyl sulfoxide (ISO)

dioxygen (ISO)

diuron (ISO)

dorsomorphin (ISO)

farnesol (ISO)

flavonoids (EXP)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

gold atom (ISO)

gold(0) (ISO)

GSK-J4 (ISO)

GW 4064 (ISO)

ivermectin (ISO)

leflunomide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

oleic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

picoxystrobin (ISO)

pirinixic acid (EXP)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

pyrimidifen (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (EXP)

tamibarotene (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiophenes (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

trovafloxacin (ISO)

uranium atom (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

vitamin K (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum to Golgi vesicle-mediated transport (IBA)

protein geranylgeranylation (IDA,ISO)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

Rab-protein geranylgeranyltransferase complex (IBA,IDA,IEA)

Molecular Function

catalytic activity (IEA)

isoprenoid binding (IDA)

metal ion binding (IEA)

prenyltransferase activity (IEA)

protein binding (IPI,ISO)

protein geranylgeranyltransferase activity (IEA)

protein prenyltransferase activity (IEA)

Rab geranylgeranyltransferase activity (IDA,IEA,ISO)

small GTPase binding (IDA)

transferase activity (IEA)

zinc ion binding (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.	Armstrong SA, etal., J Biol Chem 1993 Jun 5;268(16):12221-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.	Guo Z, etal., Angew Chem Int Ed Engl. 2008;47(20):3747-50. doi: 10.1002/anie.200705795.
5.	Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.	Guo Z, etal., EMBO J. 2008 Sep 17;27(18):2444-56. doi: 10.1038/emboj.2008.164. Epub 2008 Aug 28.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.	Pylypenko O, etal., Mol Cell. 2003 Feb;11(2):483-94.
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10745007	PMID:23114750

Genomics

Comparative Map Data

Rabggtb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	245,504,586 - 245,510,878 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	245,504,586 - 245,510,774 (-)	Ensembl				GRCr8
mRatBN7.2	2	242,844,758 - 242,850,951 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	242,844,762 - 242,851,050 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	250,667,563 - 250,673,774 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	248,561,386 - 248,567,597 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	243,459,951 - 243,466,163 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	260,110,309 - 260,115,574 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	260,110,309 - 260,115,577 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	278,774,376 - 278,779,641 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	251,852,549 - 251,857,811 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	234,777,191 - 234,782,459 (-)	NCBI		Celera
RGSC_v3.1	2	251,867,151 - 251,872,419 (-)	NCBI
Cytogenetic Map	2	q45	NCBI

RABGGTB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	75,786,194 - 75,795,090 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	75,786,188 - 75,795,086 (+)	Ensembl			hg38	GRCh38
GRCh37	1	76,251,879 - 76,260,775 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	76,024,474 - 76,033,352 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	75,963,906 - 75,972,785	NCBI
Celera	1	74,491,796 - 74,500,671 (+)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	74,381,711 - 74,390,606 (+)	NCBI		HuRef
CHM1_1	1	76,367,172 - 76,376,066 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	75,622,856 - 75,631,751 (+)	NCBI		T2T-CHM13v2.0

Rabggtb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	153,612,926 - 153,618,603 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	153,612,924 - 153,618,646 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	153,907,289 - 153,912,966 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	153,907,287 - 153,913,009 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	153,570,253 - 153,575,930 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	153,844,841 - 153,849,445 (-)	NCBI		MGSCv36	mm8
Celera	3	160,370,948 - 160,376,625 (-)	NCBI		Celera
Cytogenetic Map	3	H3	NCBI
cM Map	3	78.76	NCBI

Rabggtb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	17,152,380 - 17,162,310 (-)	Ensembl
ChiLan1.0	NW_004955423	17,155,161 - 17,162,237 (-)	NCBI	ChiLan1.0	ChiLan1.0

RABGGTB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	151,097,980 - 151,106,943 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	150,258,522 - 150,267,454 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	75,001,443 - 75,010,421 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	76,973,158 - 76,982,083 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	76,973,158 - 76,982,083 (+)	Ensembl			panPan2	panpan1.1

RABGGTB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	70,824,822 - 70,834,958 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	70,825,188 - 70,835,238 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	73,489,614 - 73,499,688 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	71,417,955 - 71,428,054 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	71,417,956 - 71,428,066 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	70,913,867 - 70,923,901 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	70,859,305 - 70,869,344 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	71,352,611 - 71,362,696 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rabggtb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	87,302,500 - 87,310,667 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936571	2,812,871 - 2,821,053 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936571	2,812,902 - 2,821,019 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RABGGTB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	137,410,691 - 137,534,233 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	137,525,063 - 137,534,132 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	127,497,462 - 127,506,518 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RABGGTB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	57,398,684 - 57,407,769 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	57,398,327 - 57,407,712 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	60,102,783 - 60,111,881 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rabggtb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624742	21,168,290 - 21,175,923 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Rabggtb
48 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	32
Interacting mature miRNAs:	38
Transcripts:	ENSRNOT00000065997
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat

Markers in Region

RH127932

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	245,504,684 - 245,504,901 (+)	Marker Load Pipeline
mRatBN7.2	2	242,844,856 - 242,845,073 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	260,110,408 - 260,110,624	NCBI	Rnor6.0
Rnor_5.0	2	278,774,475 - 278,774,691	UniSTS	Rnor5.0
RGSC_v3.4	2	251,852,644 - 251,852,860	UniSTS	RGSC3.4
Celera	2	234,777,290 - 234,777,506	UniSTS
RH 3.4 Map	2	1629.8	UniSTS
Cytogenetic Map	2	q45	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010063585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC060536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L10416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S62097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000065997 ⟹ ENSRNOP00000061541

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	245,504,586 - 245,509,890 (-)	Ensembl
mRatBN7.2 Ensembl	2	242,844,762 - 242,850,951 (-)	Ensembl
Rnor_6.0 Ensembl	2	260,110,309 - 260,115,577 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099311 ⟹ ENSRNOP00000086870

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	245,504,588 - 245,510,774 (-)	Ensembl
mRatBN7.2 Ensembl	2	242,844,762 - 242,851,050 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109806 ⟹ ENSRNOP00000096722

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	245,504,586 - 245,510,052 (-)	Ensembl
mRatBN7.2 Ensembl	2	242,844,839 - 242,850,204 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144515 ⟹ ENSRNOP00000101139

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	245,507,937 - 245,509,853 (-)	Ensembl

RefSeq Acc Id:

NM_138708 ⟹ NP_619715

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,504,586 - 245,510,779 (-)	NCBI
mRatBN7.2	2	242,844,758 - 242,850,951 (-)	NCBI
Rnor_6.0	2	260,110,309 - 260,115,574 (-)	NCBI
Rnor_5.0	2	278,774,376 - 278,779,641 (-)	NCBI
RGSC_v3.4	2	251,852,549 - 251,857,811 (-)	RGD
Celera	2	234,777,191 - 234,782,459 (-)	NCBI

Sequence:

show sequence

CGGCACGAGGACATGGGCACACAGCAGAAGGACGTCACCATCAAGTCAGATGCGCCTGACACCC
TGCTGCTCGAGAAGCATGCTGATTATATCGCCTCGTACGGCTCAAAGAAAGATGATTATGAATA
CTGCATGTCCGAATACTTGAGAATGAGCGGCGTCTACTGGGGCCTGACAGTGATGGACCTCATG
GGGCAGCTTCATCGGATGAATAAAGAGGAGATACTGGTGTTTATCAAGTCGTGCCAGCATGAGT
GTGGGGGAGTCAGTGCCAGCATCGGGCACGACCCCCACCTTCTCTACACGCTCAGTGCTGTCCA
GATTCTCACTCTGTATGATAGCATCCATGTAATCAACGTAGACAAAGTGGTAGCCTATGTTCAG
AGTCTACAGAAAGAAGATGGTTCCTTTGCTGGAGACATCTGGGGAGAAATCGATACAAGATTCT
CATTTTGTGCAGTGGCAACTTTGGCTCTCTTGGGCAAACTTGATGCTATTAATGTGGAAAAGGC
CATTGAATTTGTTTTGTCCTGTATGAACTTTGATGGTGGATTTGGGTGCAGACCAGGCTCTGAA
TCTCACGCCGGACAGATCTATTGTTGCACAGGATTCCTGGCCATAACTAGTCAGTTGCATCAAG
TGAACTCCGACCTACTTGGTTGGTGGCTTTGTGAACGACAGTTGCCCTCTGGCGGACTCAATGG
AAGACCCGAGAAGTTACCAGATGTGTGCTATTCCTGGTGGGTGTTGGCCTCCTTAAAGATAATC
GGGAGGCTTCATTGGATTGACAGAGAAAAGCTTCGAAGCTTCATCTTGGCATGTCAAGATGAAG
AGACAGGAGGGTTTGCAGACAGGCCAGGAGACATGGTGGATCCCTTTCACACCTTGTTTGGCAT
TGCTGGATTGTCACTTCTGGGGGAAGAGCAGATCAAGCCTGTCAGCCCTGTCTTTTGCATGCCT
GAAGAAGTGCTACAGAGGGTGAATGTCCAGCCTGAACTAGTGAGCTAGTCCGAGGGGAAGAGCC
TTCGGTGTGCAGTATCAGTTACTGTGGTTATCAAACCCAGAAGTGACTTAATATTTTGTATATC
ATATGTCAATGATAAATTATATAAGTATTGTAAAATAAATGTCATATTTAGATCTTTAGTGTTC
TGAGTACAGTTTCTGTCAATACTGTTTGTTAATGTCTAACAGCAGCAAACTTAAAAAGCTAGTA
TTTAACTGCCATCTCCCTGTGTCCTTTTGACCTGTAACAATGACGGGAAATGATTTCTGTTAAT
AAAGATGATCAAAGTGAGTGAAACTCATGATTTAAATAAAAGATGCATAAAATCGAGCTCGTCC

hide sequence

RefSeq Acc Id:

XM_063281366 ⟹ XP_063137436

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,504,590 - 245,510,878 (-)	NCBI

RefSeq Acc Id:

XM_063281367 ⟹ XP_063137437

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,504,590 - 245,510,783 (-)	NCBI

RefSeq Acc Id:

XM_063281368 ⟹ XP_063137438

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,504,590 - 245,510,777 (-)	NCBI

RefSeq Acc Id:

XM_063281369 ⟹ XP_063137439

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,504,590 - 245,508,022 (-)	NCBI

RefSeq Acc Id:

XR_010063585

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	245,505,544 - 245,510,831 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_619715	(Get FASTA)	NCBI Sequence Viewer
	XP_063137436	(Get FASTA)	NCBI Sequence Viewer
	XP_063137437	(Get FASTA)	NCBI Sequence Viewer
	XP_063137438	(Get FASTA)	NCBI Sequence Viewer
	XP_063137439	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41999	(Get FASTA)	NCBI Sequence Viewer
	AAB27019	(Get FASTA)	NCBI Sequence Viewer
	AAH60536	(Get FASTA)	NCBI Sequence Viewer
	AAH78683	(Get FASTA)	NCBI Sequence Viewer
	EDL82523	(Get FASTA)	NCBI Sequence Viewer
	EDL82524	(Get FASTA)	NCBI Sequence Viewer
	EDL82525	(Get FASTA)	NCBI Sequence Viewer
	EDL82526	(Get FASTA)	NCBI Sequence Viewer
	EDL82527	(Get FASTA)	NCBI Sequence Viewer
	EDL82528	(Get FASTA)	NCBI Sequence Viewer
	EDL82529	(Get FASTA)	NCBI Sequence Viewer
	EDL82530	(Get FASTA)	NCBI Sequence Viewer
	EDL82531	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061541
GenBank Protein	Q08603	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_619715 ⟸ NM_138708

- UniProtKB:

Q08603 (UniProtKB/Swiss-Prot), Q68G48 (UniProtKB/TrEMBL), A6HWN7 (UniProtKB/TrEMBL), A0A8I6GFF2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGTQQKDVTIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGVYWGLTVMDLMGQLH
RMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQK
EDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAG
QIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLH
WIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVL
QRVNVQPELVS

hide sequence

Ensembl Acc Id:

ENSRNOP00000061541 ⟸ ENSRNOT00000065997

Ensembl Acc Id:

ENSRNOP00000086870 ⟸ ENSRNOT00000099311

Ensembl Acc Id:

ENSRNOP00000096722 ⟸ ENSRNOT00000109806

RefSeq Acc Id:	XP_063137436 ⟸ XM_063281366
- Peptide Label:	isoform X1
- UniProtKB:	Q08603 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063137437 ⟸ XM_063281367
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063137438 ⟸ XM_063281368
- Peptide Label:	isoform X3
- UniProtKB:	Q08603 (UniProtKB/Swiss-Prot), A6HWN9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063137439 ⟸ XM_063281369
- Peptide Label:	isoform X4
- UniProtKB:	A6HWP3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000101139 ⟸ ENSRNOT00000144515

Protein Domains

Prenyltransferase alpha-alpha toroid

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q08603-F1-model_v2	AlphaFold	Q08603	1-331	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691831

Promoter ID:

EPDNEW_R2355

Type:

single initiation site

Name:

Rabggtb_1

Description:

Rab geranylgeranyltransferase, beta subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	260,115,586 - 260,115,646	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3530	AgrOrtholog
BioCyc Gene	G2FUF-50774	BioCyc
Ensembl Genes	ENSRNOG00000009992	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000065997	ENTREZGENE
Gene3D-CATH	1.50.10.20	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6918640	IMAGE-MGC_LOAD
	IMAGE:7135106	IMAGE-MGC_LOAD
InterPro	PFTB_repeat	UniProtKB/Swiss-Prot
	PGGT1B-like	UniProtKB/Swiss-Prot
	Ptb1	UniProtKB/Swiss-Prot
	Terpenoid_cyclase/PrenylTrfase	UniProtKB/Swiss-Prot
KEGG Report	rno:25533	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72651	IMAGE-MGC_LOAD
	MGC:93047	IMAGE-MGC_LOAD
NCBI Gene	25533	ENTREZGENE
PANTHER	GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA	UniProtKB/Swiss-Prot
	PTHR11774	UniProtKB/Swiss-Prot
Pfam	Prenyltrans	UniProtKB/Swiss-Prot
PhenoGen	Rabggtb	PhenoGen
RatGTEx	ENSRNOG00000009992	RatGTEx
Superfamily-SCOP	SSF48239	UniProtKB/Swiss-Prot
TIGR	TC217759
UniProt	A0A8I6GFF2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GLQ7_RAT	UniProtKB/TrEMBL
	A0ABK0L7Z1_RAT	UniProtKB/TrEMBL
	A0ABZ3NN91_RAT	UniProtKB/TrEMBL
	A6HWN7	ENTREZGENE, UniProtKB/TrEMBL
	A6HWN8_RAT	UniProtKB/TrEMBL
	A6HWN9	ENTREZGENE, UniProtKB/TrEMBL
	A6HWP2_RAT	UniProtKB/TrEMBL
	A6HWP3	ENTREZGENE, UniProtKB/TrEMBL
	A6HWP4_RAT	UniProtKB/TrEMBL
	A6HWP5_RAT	UniProtKB/TrEMBL
	F1LSM6_RAT	UniProtKB/TrEMBL
	PGTB2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q68G48	ENTREZGENE
	Q6P9Y2_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-04	Rabggtb	Rab geranylgeranyltransferase subunit beta	Rabggtb	Rab geranylgeranyltransferase, beta subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Rabggtb	Rab geranylgeranyltransferase, beta subunit	Rabggtb	RAB geranylgeranyl transferase, b subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Rabggtb	RAB geranylgeranyl transferase, b subunit		Rab geranylgeranyl transferase componenet, subunit beta	Name updated	1299863	APPROVED
2002-06-10	Rabggtb	Rab geranylgeranyl transferase componenet, subunit beta			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	combines with alpha subunit Rabggta to form Component B of the Rab geranylgeranyl transferase, which combines with an additional Component A for enzyme activity	69952

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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