Pygb (glycogen phosphorylase B) - Rat Genome Database

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Gene: Pygb (glycogen phosphorylase B) Rattus norvegicus
Analyze
Symbol: Pygb
Name: glycogen phosphorylase B
RGD ID: 3460
Description: Enables carbohydrate binding activity; glycogen phosphorylase activity; and identical protein binding activity. Involved in glycogen catabolic process. Located in axon. Orthologous to human PYGB (glycogen phosphorylase B); PARTICIPATES IN glycogen degradation pathway; insulin signaling pathway; starch and sucrose metabolic pathway; INTERACTS WITH 2,5-hexanedione; 3-chloropropane-1,2-diol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: brain; brain glycogen phosphorylase; glycogen phosphorylase, brain form; GLYPHOA; phosphorylase, glycogen; phosphorylase, glycogen; brain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,072,141 - 160,118,930 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3160,072,115 - 160,123,961 (+)EnsemblGRCr8
mRatBN7.23139,611,724 - 139,658,521 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,611,749 - 139,663,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3143,507,801 - 143,554,693 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,091,537 - 152,138,438 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03149,840,091 - 149,886,995 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,581,063 - 146,629,504 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,582,752 - 146,634,535 (+)Ensemblrn6Rnor6.0
Rnor_5.03152,941,739 - 152,988,417 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43141,421,421 - 141,468,094 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3138,373,554 - 138,420,266 (+)NCBICelera
RGSC_v3.13141,327,094 - 141,373,658 (+)NCBI
RH 3.4 Map31196.32RGD
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
baicalein  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
cadmium dichloride  (EXP)
calcidiol  (EXP)
cantharidin  (ISO)
capecitabine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
diethyldithiocarbamic acid  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
plumbagin  (EXP)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium nitrate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toxaphene  (EXP)
trametinib  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IDA)
cytoplasm  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors. Birch AM, etal., Bioorg Med Chem Lett. 2007 Jan 15;17(2):394-9. Epub 2006 Oct 19.
2. Structural relationships among regulated and unregulated phosphorylases. Buchbinder JL, etal., Annu Rev Biophys Biomol Struct. 2001;30:191-209.
3. Studies on the expression and evolution of the glycogen phosphorylase gene family in the rat. Crerar MM, etal., Genome 1988 Aug;30(4):582-90.
4. Idazoxan activates rat forebrain glycogen phosphorylase in vivo: a histochemical study. Fara-On M, etal., Brain Res. 2005 Oct 12;1059(1):83-92. Epub 2005 Oct 13.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Comparative analysis of species-independent, isozyme-specific amino-acid substitutions in mammalian muscle, brain and liver glycogen phosphorylases. Hudson JW, etal., Biochim Biophys Acta 1993 Jul 10;1164(2):197-208.
8. Glycogen phosphorylase: control by phosphorylation and allosteric effectors. Johnson LN FASEB J. 1992 Mar;6(6):2274-82.
9. Histochemical mapping of the substrate for brain-stimulation reward with glycogen phosphorylase. Konkle AT, etal., J Neurosci Methods. 1999 Nov 15;93(2):111-9.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Glycogen synthesis in the astrocyte: from glycogenin to proglycogen to glycogen. Lomako J, etal., FASEB J. 1993 Nov;7(14):1386-93.
12. Glycogen phosphorylase isoenzymes from hepatoma 3924A and from a non-tumorigenic liver cell line. Comparison with the liver and brain enzymes. Mayer D, etal., Biochem J. 1992 Mar 15;282 ( Pt 3):665-73.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Glycogen phosphorylase isozymes and energy metabolism in the rat peripheral nervous system--an immunocytochemical study. Pfeiffer-Guglielmi B, etal., Brain Res. 2007 Mar 9;1136(1):20-7. Epub 2006 Dec 20.
15. Isozyme pattern of glycogen phosphorylase in the rat nervous system and rat astroglia-rich primary cultures: electrophoretic and polymerase chain reaction studies. Pfeiffer-Guglielmi B, etal., Neurochem Res. 2000 Nov;25(11):1485-91.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10638593   PMID:12477932   PMID:16229987   PMID:16879805   PMID:17442042   PMID:19292454   PMID:19946888   PMID:21700703   PMID:22206666   PMID:22871113   PMID:23533145  
PMID:25931508   PMID:26316108   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Pygb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,072,141 - 160,118,930 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3160,072,115 - 160,123,961 (+)EnsemblGRCr8
mRatBN7.23139,611,724 - 139,658,521 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,611,749 - 139,663,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3143,507,801 - 143,554,693 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,091,537 - 152,138,438 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03149,840,091 - 149,886,995 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,581,063 - 146,629,504 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,582,752 - 146,634,535 (+)Ensemblrn6Rnor6.0
Rnor_5.03152,941,739 - 152,988,417 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43141,421,421 - 141,468,094 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3138,373,554 - 138,420,266 (+)NCBICelera
RGSC_v3.13141,327,094 - 141,373,658 (+)NCBI
RH 3.4 Map31196.32RGD
Cytogenetic Map3q41NCBI
PYGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382025,248,085 - 25,298,012 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2025,248,030 - 25,298,014 (+)Ensemblhg38GRCh38
GRCh372025,228,721 - 25,278,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362025,176,706 - 25,226,648 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342025,176,705 - 25,226,648NCBI
Celera2025,302,440 - 25,352,386 (+)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2025,186,079 - 25,235,994 (+)NCBIHuRef
CHM1_12025,229,585 - 25,279,528 (+)NCBICHM1_1
T2T-CHM13v2.02025,313,131 - 25,363,101 (+)NCBIT2T-CHM13v2.0
Pygb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392150,628,716 - 150,673,668 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2150,628,655 - 150,673,678 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382150,786,796 - 150,831,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2150,786,735 - 150,831,758 (+)Ensemblmm10GRCm38
MGSCv372150,612,532 - 150,657,484 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362150,478,237 - 150,523,189 (+)NCBIMGSCv36mm8
Celera2152,019,819 - 152,065,130 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.74NCBI
Pygb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,254,204 - 31,283,651 (+)Ensembl
ChiLan1.0NW_00495541531,254,240 - 31,283,651 (+)NCBIChiLan1.0ChiLan1.0
PYGB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22126,121,781 - 26,173,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12026,118,634 - 26,170,623 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02025,191,066 - 25,242,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12025,607,895 - 25,648,066 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2025,593,589 - 25,648,066 (+)EnsemblpanPan2panpan1.1
PYGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,440,826 - 1,494,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,420,052 - 1,496,245 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha231,470,378 - 1,524,112 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0231,681,167 - 1,734,965 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,681,075 - 1,735,315 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1231,521,968 - 1,575,698 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0231,646,573 - 1,700,313 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,613,910 - 1,667,799 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pygb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640147,113,119 - 147,155,398 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936620532,634 - 575,916 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936620533,574 - 575,893 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYGB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,940,452 - 30,995,691 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11730,940,457 - 30,995,688 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103247035
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660787,750,872 - 7,807,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pygb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624939270,652 - 302,608 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624939273,448 - 302,604 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pygb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15130,494,177 - 130,543,505 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pygb
427 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:297
Count of miRNA genes:206
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000010157
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH127518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23139,658,253 - 139,658,442 (+)MAPPERmRatBN7.2
Rnor_6.03146,629,237 - 146,629,425NCBIRnor6.0
Rnor_5.03152,988,150 - 152,988,338UniSTSRnor5.0
RGSC_v3.43141,467,827 - 141,468,015UniSTSRGSC3.4
Celera3138,419,999 - 138,420,187UniSTS
RH 3.4 Map31192.91UniSTS
Cytogenetic Map3q41UniSTS
RH94711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23139,657,832 - 139,657,942 (+)MAPPERmRatBN7.2
Rnor_6.03146,628,816 - 146,628,925NCBIRnor6.0
Rnor_5.03152,987,729 - 152,987,838UniSTSRnor5.0
RGSC_v3.43141,467,406 - 141,467,515UniSTSRGSC3.4
Celera3138,419,578 - 138,419,687UniSTS
RH 3.4 Map31196.32UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010157   ⟹   ENSRNOP00000010158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,072,185 - 160,123,961 (+)Ensembl
mRatBN7.2 Ensembl3139,611,768 - 139,663,552 (+)Ensembl
Rnor_6.0 Ensembl3146,582,752 - 146,634,535 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100727   ⟹   ENSRNOP00000084107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,072,151 - 160,118,927 (+)Ensembl
mRatBN7.2 Ensembl3139,611,760 - 139,658,175 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111537   ⟹   ENSRNOP00000093697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,072,115 - 160,122,420 (+)Ensembl
mRatBN7.2 Ensembl3139,611,749 - 139,663,553 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151221   ⟹   ENSRNOP00000107540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,072,115 - 160,117,588 (+)Ensembl
RefSeq Acc Id: NM_013188   ⟹   NP_037320
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83160,072,141 - 160,118,930 (+)NCBI
mRatBN7.23139,611,724 - 139,658,521 (+)NCBI
Rnor_6.03146,582,708 - 146,629,504 (+)NCBI
Rnor_5.03152,941,739 - 152,988,417 (+)NCBI
RGSC_v3.43141,421,421 - 141,468,094 (+)RGD
Celera3138,373,554 - 138,420,266 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037320 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40815 (Get FASTA)   NCBI Sequence Viewer  
  AAA41252 (Get FASTA)   NCBI Sequence Viewer  
  AAI66475 (Get FASTA)   NCBI Sequence Viewer  
  EDL86138 (Get FASTA)   NCBI Sequence Viewer  
  EDL86139 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084107
GenBank Protein P53534 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037320   ⟸   NM_013188
- UniProtKB: P53534 (UniProtKB/Swiss-Prot),   A6KHG6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010158   ⟸   ENSRNOT00000010157
Ensembl Acc Id: ENSRNOP00000084107   ⟸   ENSRNOT00000100727
Ensembl Acc Id: ENSRNOP00000093697   ⟸   ENSRNOT00000111537
Ensembl Acc Id: ENSRNOP00000107540   ⟸   ENSRNOT00000151221

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53534-F1-model_v2 AlphaFold P53534 1-838 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692518
Promoter ID:EPDNEW_R3043
Type:initiation region
Name:Pygb_1
Description:glycogen phosphorylase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03146,582,733 - 146,582,793EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3460 AgrOrtholog
BioCyc Gene G2FUF-47337 BioCyc
BioCyc Pathway PWY-5941 [glycogen degradation II] BioCyc
BioCyc Pathway Image PWY-5941 BioCyc
Ensembl Genes ENSRNOG00000007583 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000100727 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9100353 IMAGE-MGC_LOAD
InterPro Glycg_phsphrylas UniProtKB/Swiss-Prot
  Glyco_trans_35 UniProtKB/Swiss-Prot
  Pyridoxal_P_attach_site UniProtKB/Swiss-Prot
KEGG Report rno:25739 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187917 IMAGE-MGC_LOAD
NCBI Gene 25739 ENTREZGENE
PANTHER GLYCOGEN PHOSPHORYLASE, BRAIN FORM UniProtKB/Swiss-Prot
  PTHR11468 UniProtKB/Swiss-Prot
Pfam Phosphorylase UniProtKB/Swiss-Prot
PhenoGen Pygb PhenoGen
PIRSF Pprylas_GlgP UniProtKB/Swiss-Prot
PROSITE PHOSPHORYLASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007583 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A0A8I6G9W3_RAT UniProtKB/TrEMBL
  A0A8I6GKE5_RAT UniProtKB/TrEMBL
  A0ABK0LP55_RAT UniProtKB/TrEMBL
  A6KHG6 ENTREZGENE, UniProtKB/TrEMBL
  A6KHG7_RAT UniProtKB/TrEMBL
  G3V6Y6_RAT UniProtKB/TrEMBL
  P53534 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-18 Pygb  glycogen phosphorylase B  Pygb  phosphorylase, glycogen; brain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Pygb  phosphorylase, glycogen; brain  Pygb  brain glycogen phosphorylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pygb  Brain glycogen phosphorylase      Symbol and Name status set to approved 70586 APPROVED