1. |
Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension. |
Blumberg FC, etal., Cardiovasc Res. 2002 Jul;55(1):171-7. doi: 10.1016/s0008-6363(02)00318-8.
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2. |
Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury. |
Cao Y, etal., Pflugers Arch. 2019 Apr;471(4):543-555. doi: 10.1007/s00424-018-2229-6. Epub 2018 Nov 9.
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3. |
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. |
Choquet H, etal., Free Radic Biol Med. 2016 Mar;92:100-109. doi: 10.1016/j.freeradbiomed.2016.01.008. Epub 2016 Jan 19.
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4. |
Determination of genetic predisposition to patent ductus arteriosus in preterm infants. |
Dagle JM, etal., Pediatrics. 2009 Apr;123(4):1116-23. doi: 10.1542/peds.2008-0313.
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5. |
Altered expression of inflammation-related genes in human carotid atherosclerotic plaques. |
Di Taranto MD, etal., Atherosclerosis. 2012 Jan;220(1):93-101. doi: 10.1016/j.atherosclerosis.2011.10.022. Epub 2011 Oct 25.
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6. |
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. |
Du X, etal., J Clin Invest. 2006 Apr;116(4):1071-80. doi: 10.1172/JCI23354. Epub 2006 Mar 9.
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7. |
Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells. |
Ebmeyer J, etal., Chem Biol Interact. 2019 Jan 25;298:104-111. doi: 10.1016/j.cbi.2018.11.007. Epub 2018 Nov 19.
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8. |
Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion. |
Fang YC, etal., J Cereb Blood Flow Metab. 2006 Apr;26(4):491-501.
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9. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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10. |
Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. |
Geraci MW, etal., J Clin Invest 1999 Jun;103(11):1509-15.
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11. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
|
12. |
Prostacyclin synthase gene transfer inhibits neointimal formation in rat balloon-injured arteries without bleeding complications. |
Harada M, etal., Cardiovasc Res. 1999 Aug 1;43(2):481-91. doi: 10.1016/s0008-6363(99)00107-8.
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13. |
Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. |
Hiraoka K, etal., Circulation. 2003 Nov 25;108(21):2689-96. doi: 10.1161/01.CIR.0000093275.78676.F4. Epub 2003 Oct 20.
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14. |
Prostacyclin synthase gene transfer inhibits neointimal formation by suppressing PPAR delta expression. |
Imai H, etal., Atherosclerosis. 2007 Dec;195(2):322-32. doi: 10.1016/j.atherosclerosis.2007.01.010. Epub 2007 Feb 14.
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15. |
Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia. |
Ishii M, etal., Atherosclerosis. 2009 Sep;206(1):109-18. doi: 10.1016/j.atherosclerosis.2009.02.023. Epub 2009 Mar 11.
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16. |
Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. |
Ito T, etal., Hypertension. 2007 Sep;50(3):531-6. doi: 10.1161/HYPERTENSIONAHA.107.091348. Epub 2007 Jul 16.
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17. |
Effects of IL-1beta, TNF-alpha, and macrophage migration inhibitory factor on prostacyclin synthesis in rat pulmonary artery smooth muscle cells. |
Itoh A, etal., Respirology. 2003 Dec;8(4):467-72. doi: 10.1046/j.1440-1843.2003.00491.x.
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18. |
Human prostacyclin synthase gene and hypertension : the Suita Study. |
Iwai N, etal., Circulation. 1999 Nov 30;100(22):2231-6. doi: 10.1161/01.cir.100.22.2231.
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19. |
KEGG: Kyoto Encyclopedia of Genes and Genomes |
KEGG
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20. |
Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene. |
Koike H, etal., FASEB J. 2003 Apr;17(6):779-81. doi: 10.1096/fj.02-0754fje. Epub 2003 Feb 5.
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21. |
Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model. |
Leger PL, etal., Stroke. 2016 Dec;47(12):3048-3052. doi: 10.1161/STROKEAHA.116.015095. Epub 2016 Nov 10.
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22. |
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. |
Lemaitre RN, etal., Atherosclerosis. 2009 Jun;204(2):e58-63. Epub 2008 Nov 1.
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23. |
Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. |
Lin H, etal., Circulation. 2002 Apr 23;105(16):1962-9. doi: 10.1161/01.cir.0000015365.49180.05.
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24. |
Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. |
Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
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25. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
|
26. |
Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. |
Myers SI, etal., Prostaglandins Leukot Essent Fatty Acids. 1996 Jun;54(6):403-9. doi: 10.1016/s0952-3278(96)90023-x.
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27. |
Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. |
Nagaya N, etal., Circulation. 2000 Oct 17;102(16):2005-10. doi: 10.1161/01.cir.102.16.2005.
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28. |
Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction. |
Nakayama T, etal., Am Heart J. 2002 May;143(5):797-801. doi: 10.1067/mhj.2002.122171.
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29. |
Association of 5' upstream promoter region of prostacyclin synthase gene variant with cerebral infarction. |
Nakayama T, etal., Am J Hypertens. 2000 Dec;13(12):1263-7. doi: 10.1016/s0895-7061(00)01216-4.
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30. |
Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. |
Nakayama T, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1135-9.
|
31. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
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32. |
Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. |
Numaguchi Y, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):727-33. doi: 10.1161/01.atv.19.3.727.
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33. |
OMIM Disease Annotation Pipeline |
OMIM Disease Annotation Pipeline
|
34. |
17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase. |
Ospina JA, etal., Stroke. 2002 Feb;33(2):600-5. doi: 10.1161/hs0202.102732.
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35. |
Downregulation of PGI2 pathway in Pulmonary Hypertension Group-III patients. |
Ozen G, etal., Prostaglandins Leukot Essent Fatty Acids. 2020 Sep;160:102158. doi: 10.1016/j.plefa.2020.102158. Epub 2020 Jul 5.
|
36. |
KEGG Annotation Import Pipeline |
Pipeline to import KEGG annotations from KEGG into RGD
|
37. |
SMPDB Annotation Import Pipeline |
Pipeline to import SMPDB annotations from SMPDB into RGD
|
38. |
Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. |
Poole EM, etal., Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):502-8. doi: 10.1158/1055-9965.EPI-05-0804.
|
39. |
GOA pipeline |
RGD automated data pipeline
|
40. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
|
41. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
|
42. |
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. |
Russo A, etal., J Oncol. 2018 Nov 8;2018:6301980. doi: 10.1155/2018/6301980. eCollection 2018.
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43. |
Reduced expression of prostacyclin synthase and nitric oxide synthase in subcutaneous arteries of type 2 diabetic patients. |
Safiah Mokhtar S, etal., Tohoku J Exp Med. 2013 Nov;231(3):217-22. doi: 10.1620/tjem.231.217.
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44. |
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. |
Sasaki Y, etal., Sci Rep. 2015 Nov 27;5:17376. doi: 10.1038/srep17376.
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45. |
Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension. |
Schroll S, etal., Scand J Clin Lab Invest. 2008;68(4):270-6. doi: 10.1080/00365510701673375.
|
46. |
PGI2 production by rat blood vessels: diminished prostacyclin formation in veins compared to arteries. |
Skidgel RA and Printz MP, Prostaglandins 1978 Jul;16(1):1-16.
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47. |
Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide. |
Skogastierna C, etal., Heart Vessels. 2011 Nov;26(6):628-36. doi: 10.1007/s00380-010-0097-x. Epub 2011 Jan 7.
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48. |
Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation. |
Soler M, etal., J Infect Dis. 2001 Jan 1;183(1):105-12. doi: 10.1086/317639. Epub 2000 Nov 10.
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49. |
Imidazolineoxyl N-oxide prevents the impairment of vascular contraction caused by interleukin-1beta through several mechanisms. |
Soler M, etal., J Infect Dis. 2003 Sep 15;188(6):927-37. doi: 10.1086/377586. Epub 2003 Sep 4.
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50. |
Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. |
Stearman RS, etal., Am J Respir Crit Care Med. 2014 May 1;189(9):1110-20. doi: 10.1164/rccm.201309-1697OC.
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51. |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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52. |
Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats. |
Suhara H, etal., J Thorac Cardiovasc Surg. 2002 May;123(5):855-61. doi: 10.1067/mtc.2002.118687.
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53. |
Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats. |
Tahara N, etal., Hum Gene Ther. 2004 Dec;15(12):1270-8.
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54. |
Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. |
Tang EH and Vanhoutte PM, Physiol Genomics. 2008 Feb 19;32(3):409-18. doi: 10.1152/physiolgenomics.00136.2007. Epub 2007 Dec 4.
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55. |
Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. |
Todaka T, etal., Stroke. 1999 Feb;30(2):419-26. doi: 10.1161/01.str.30.2.419.
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56. |
Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats. |
Tsai MJ, etal., Oxid Med Cell Longev. 2013;2013:649809. doi: 10.1155/2013/649809. Epub 2013 Apr 3.
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57. |
Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension. |
Wang XJ, etal., JAMA Cardiol. 2020 Jun 1;5(6):677-684. doi: 10.1001/jamacardio.2020.0479.
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58. |
Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. |
Xie X, etal., Clin Chem Lab Med. 2009;47(3):347-52. doi: 10.1515/CCLM.2009.078.
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59. |
[Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China]. |
Xie X, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2008 Jun;29(6):598-603.
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60. |
Assessment of the genetic component of hypertension. |
Yamada Y, etal., Am J Hypertens. 2006 Nov;19(11):1158-65. doi: 10.1016/j.amjhyper.2006.04.010.
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61. |
Interactions among Variants in Eicosanoid Genes Increase Risk of Atherothrombotic Stroke in Chinese Populations. |
Yi X, etal., J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1773-1780. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.005. Epub 2017 May 3.
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62. |
Variants in COX-2, PTGIS, and TBXAS1 Are Associated with Carotid Artery or Intracranial Arterial Stenosis and Neurologic Deterioration in Ischemic Stroke Patients. |
Yi X, etal., J Stroke Cerebrovasc Dis. 2017 May;26(5):1128-1135. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.032. Epub 2017 Jan 17.
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63. |
Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. |
Yi X, etal., PLoS One. 2017 Jul 12;12(7):e0180704. doi: 10.1371/journal.pone.0180704. eCollection 2017.
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64. |
Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits. |
Zhou L, etal., Circulation. 2013 Aug 27;128(9):982-94. doi: 10.1161/CIRCULATIONAHA.113.003139. Epub 2013 Jul 10.
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65. |
Oxymatrine attenuated isoproterenol-induced heart failure in rats via regulation of COX-2/PGI2 pathway. |
Zhou R, etal., Biomed Pharmacother. 2016 Dec;84:1359-1366. doi: 10.1016/j.biopha.2016.10.070. Epub 2016 Oct 29.
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66. |
High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. |
Zou MH, etal., Diabetes. 2002 Jan;51(1):198-203. doi: 10.2337/diabetes.51.1.198.
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