Pmch (pro-melanin-concentrating hormone) - Rat Genome Database

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Gene: Pmch (pro-melanin-concentrating hormone) Rattus norvegicus
Analyze
Symbol: Pmch
Name: pro-melanin-concentrating hormone
RGD ID: 3358
Description: Enables type 1 melanin-concentrating hormone receptor binding activity. Involved in several processes, including lactation; modulation of chemical synaptic transmission; and positive regulation of circadian sleep/wake cycle, REM sleep. Located in extracellular space. Biomarker of obesity and sleeping sickness. Orthologous to several human genes including PMCH (pro-melanin concentrating hormone); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pro-MCH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pmchm1Hubr  
Genetic Models: WI-Pmchm1Hubr
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,399,404 - 24,400,720 (+)NCBIGRCr8
mRatBN7.2722,511,934 - 22,513,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,511,934 - 22,513,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,506,585 - 24,507,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,669,288 - 26,670,604 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,446,310 - 26,447,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,655,206 - 28,656,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,654,733 - 28,657,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,764,993 - 28,766,309 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,778,133 - 24,779,449 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,798,403 - 24,799,720 (+)NCBI
Celera719,682,044 - 19,683,360 (+)NCBICelera
RH 3.4 Map7118.65RGD
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PmchRatInsulin Resistance  IDA 1642484 RGD 
PmchRatobesity  IEP 1624360associated with Hyperphagia and protein:increased expression:hypothalamusRGD 
PmchRatobesity  ISOPmch (Mus musculus)1642486associated with HyperphagiaRGD 
PmchRatsleeping sickness  IEP 405650615 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PmchRatobesity  ISOPMCH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12355323

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PmchRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PMCH mRNACTDPMID:15977195
PmchRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PMCH mRNACTDPMID:15093705
PmchRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of PMCH mRNACTDPMID:15977195
PmchRat2-deoxy-D-glucose increases expressionEXP 6480464Deoxyglucose results in increased expression of PMCH mRNACTDPMID:10683841
PmchRataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of PMCH mRNACTDPMID:23630614
PmchRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PMCH mRNACTDPMID:16483693
PmchRatarachidonyl-2'-chloroethylamide multiple interactionsEXP 6480464arachidonyl-2-chloroethylamide promotes the reaction [[Water deficiency co-treated with Sodium Chloride and Dietary deficiency] results in increased expression of PMCH mRNA]CTDPMID:26468265
PmchRatarachidonyl-2'-chloroethylamide increases expressionEXP 6480464arachidonyl-2-chloroethylamide results in increased expression of PMCH mRNACTDPMID:26468265
PmchRatarsenite(3-) increases expressionISOPmch (Mus musculus)6480464arsenite results in increased expression of PMCH mRNACTDPMID:33053406
PmchRatbenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of PMCH mRNACTDPMID:21839799
PmchRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PMCH mRNACTDPMID:25181051
PmchRatbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of PMCH mRNACTDPMID:34947998
PmchRatbisphenol A decreases expressionISOPmch (Mus musculus)6480464bisphenol A results in decreased expression of PMCH mRNACTDPMID:29165653
PmchRatcalcidiol increases expressionEXP 6480464Calcifediol deficiency results in increased expression of PMCH mRNACTDPMID:17293106
PmchRatcalcitonin decreases expressionEXP 6480464salmon calcitonin results in decreased expression of PMCH mRNACTDPMID:12686383
PmchRatcalcitriol decreases expressionISOPMCH (Homo sapiens)6480464Calcitriol results in decreased expression of PMCH mRNACTDPMID:21592394
PmchRatcalcitriol multiple interactionsISOPMCH (Homo sapiens)6480464[Testosterone co-treated with Calcitriol] results in decreased expression of PMCH mRNACTDPMID:21592394
PmchRatcandesartan decreases expressionEXP 6480464candesartan results in decreased expression of PMCH mRNACTDPMID:21287150
PmchRatcypermethrin decreases expressionISOPmch (Mus musculus)6480464cypermethrin results in decreased expression of PMCH mRNACTDPMID:29020013
PmchRatdiprotium oxide multiple interactionsEXP 6480464[Water deficiency co-treated with Sodium Chloride more ...CTDPMID:26468265

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PmchRatchemical synaptic transmission involved_inIEAInterPro:IPR0054561600115GO_REF:0000002InterProGO_REF:0000002
PmchRatdrinking behavior  IDA 1642491 RGD 
PmchRatfeeding behavior  IDA 1642487 RGD 
PmchRatfeeding behavior involved_inIEAUniProtKB:P56942 and ensembl:ENSMUSP000000443521600115GO_REF:0000107EnsemblGO_REF:0000107
PmchRatfeeding behavior involved_inISSUniProtKB:P569421600115GO_REF:0000024UniProtGO_REF:0000024
PmchRatfeeding behavior involved_inISOPmch (Mus musculus)1624291 PMID:11867747RGDPMID:11867747
PmchRatlactation  IEP 1642485 RGD 
PmchRatlearning or memory  TAS 729531 RGD 
PmchRatnegative regulation of blood pressure  IDA 1642492 RGD 
PmchRatnegative regulation of synaptic transmission, dopaminergic  IDA 1642493 RGD 
PmchRatnegative regulation of synaptic transmission, dopaminergic involved_inIBAPANTHER:PTN002636265 and Pmch (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
PmchRatneuropeptide signaling pathway involved_inIEAUniProtKB-KW:KW-05271600115GO_REF:0000043UniProtGO_REF:0000043
PmchRatpositive regulation of circadian sleep/wake cycle, REM sleep  IDA 1642489 RGD 
PmchRatpositive regulation of cytosolic calcium ion concentration  IDA 1624363 RGD 
PmchRatregulation of heart rate  IDA 1642492 RGD 
PmchRatregulation of neuronal synaptic plasticity  IMP 729531 RGD 
PmchRatsignal transduction involved_inIEAGO:00303541600115GO_REF:0000108GOCGO_REF:0000108
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PmchRatextracellular space  IDA 1642488 RGD 
PmchRatnucleus located_inIEAUniProtKB:P56942 and ensembl:ENSMUSP000000443521600115GO_REF:0000107EnsemblGO_REF:0000107
PmchRatnucleus located_inISOPmch (Mus musculus)1624291 PMID:8724342RGDPMID:8724342
PmchRatsynapse located_inIEAGO:00072681600115GO_REF:0000108GOCGO_REF:0000108

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PmchRatmelanin-concentrating hormone activity enablesIEAInterPro:IPR0054561600115GO_REF:0000002InterProGO_REF:0000002
PmchRattype 1 melanin-concentrating hormone receptor binding  IDA 1642494 RGD 
PmchRattype 1 melanin-concentrating hormone receptor binding enablesIBAPANTHER:PTN002636265 and Pmch (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033


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#
Reference Title
Reference Citation
1. The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat. Chaffer CL and Morris MJ, Endocrinology 2002 Jan;143(1):191-7.
2. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Chambers J, etal., Nature. 1999 Jul 15;400(6741):261-5.
3. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Della-Zuana O, etal., Int J Obes Relat Metab Disord. 2002 Oct;26(10):1289-95.
4. The regulation of alcohol intake by melanin-concentrating hormone in rats. Duncan EA, etal., Pharmacol Biochem Behav. 2006 Dec;85(4):728-35. Epub 2006 Dec 22.
5. Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats. Elliott JC, etal., Brain Res Mol Brain Res. 2004 Sep 28;128(2):150-9.
6. Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin. Garcia MC, etal., FASEB J 2003 Aug;17(11):1392-400.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone. Gomori A, etal., Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E583-8. Epub 2002 Nov 26.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Lembo PM, etal., Nat Cell Biol. 1999 Sep;1(5):267-71.
12. Cardiovascular effects of melanin-concentrating hormone. Messina MM and Overton JM, Regul Pept. 2007 Mar 1;139(1-3):23-30. Epub 2006 Oct 11.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Pmch expression during early development is critical for normal energy homeostasis. Mul JD, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E477-88. doi: 10.1152/ajpendo.00154.2009. Epub 2009 Nov 24.
15. Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive. Mul JD, etal., PLoS One. 2013;8(3):e60214. doi: 10.1371/journal.pone.0060214. Epub 2013 Mar 26.
16. The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Nahon JL, etal., Endocrinology 1989 Oct;125(4):2056-65.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Alterations of orexinergic and melanin-concentrating hormone neurons in experimental sleeping sickness. Palomba M, etal., Neuroscience. 2015 Apr 2;290:185-95. doi: 10.1016/j.neuroscience.2014.12.066. Epub 2015 Jan 13.
19. Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Pereira-da-Silva M, etal., Endocrinology. 2003 Nov;144(11):4831-40. Epub 2003 Jul 24.
20. Melanin-concentrating hormone induces insulin resistance through a mechanism independent of body weight gain. Pereira-da-Silva M, etal., J Endocrinol. 2005 Jul;186(1):193-201.
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PMID:1327720   PMID:2759038   PMID:7617126   PMID:7647772   PMID:7783849   PMID:8593803   PMID:8724342   PMID:9700748   PMID:9809645   PMID:10037747   PMID:11867747   PMID:12706266  
PMID:12832098   PMID:15044362   PMID:15567347   PMID:17016031   PMID:17151950   PMID:17683785   PMID:17884195   PMID:17924541   PMID:17989139   PMID:19101033   PMID:19188611   PMID:21103352  
PMID:21530599   PMID:21925200   PMID:22209364   PMID:22967922   PMID:23123302   PMID:23531605   PMID:24676683   PMID:24780894   PMID:24893251   PMID:25084113   PMID:26456505   PMID:27845162  
PMID:28867197   PMID:31034718   PMID:31664021   PMID:31917877   PMID:36565982  



Pmch
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,399,404 - 24,400,720 (+)NCBIGRCr8
mRatBN7.2722,511,934 - 22,513,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,511,934 - 22,513,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,506,585 - 24,507,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,669,288 - 26,670,604 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,446,310 - 26,447,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,655,206 - 28,656,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,654,733 - 28,657,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,764,993 - 28,766,309 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,778,133 - 24,779,449 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,798,403 - 24,799,720 (+)NCBI
Celera719,682,044 - 19,683,360 (+)NCBICelera
RH 3.4 Map7118.65RGD
Cytogenetic Map7q13NCBI
PMCH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812102,196,459 - 102,197,833 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12102,196,459 - 102,197,833 (-)EnsemblGRCh38hg38GRCh38
GRCh3712102,590,237 - 102,591,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,114,367 - 101,115,744 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412101,092,705 - 101,094,069NCBI
Celera12102,254,196 - 102,255,573 (-)NCBICelera
Cytogenetic Map12q23.2NCBI
HuRef1299,649,705 - 99,651,082 (-)NCBIHuRef
CHM1_112102,556,902 - 102,558,279 (-)NCBICHM1_1
T2T-CHM13v2.012102,157,595 - 102,158,969 (-)NCBIT2T-CHM13v2.0
Pmch
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391087,926,934 - 87,928,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1087,926,934 - 87,928,237 (+)EnsemblGRCm39 Ensembl
GRCm381088,091,072 - 88,092,374 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1088,091,072 - 88,092,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371087,553,817 - 87,555,119 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361087,520,874 - 87,522,172 (+)NCBIMGSCv36mm8
Celera1090,075,720 - 90,077,022 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.7NCBI
Pmch
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540537,356,755 - 37,360,695 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,357,468 - 37,360,695 (-)NCBIChiLan1.0ChiLan1.0
PMCH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210110,269,790 - 110,271,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112110,266,188 - 110,267,581 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01299,783,925 - 99,785,292 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112103,181,777 - 103,183,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12103,181,497 - 103,182,616 (-)Ensemblpanpan1.1panPan2
PMCH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11541,036,428 - 41,037,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1541,036,428 - 41,037,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1541,404,422 - 41,405,547 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01541,690,821 - 41,691,974 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1541,690,821 - 41,691,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11540,958,046 - 40,959,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01541,054,180 - 41,055,305 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01541,328,497 - 41,329,622 (-)NCBIUU_Cfam_GSD_1.0
Pmch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494518,937,096 - 18,938,482 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649211,947,489 - 11,948,896 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649211,947,489 - 11,948,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMCH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl582,018,915 - 82,020,266 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1582,018,915 - 82,020,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2585,944,967 - 85,946,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PMCH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11197,436,682 - 97,438,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037147,566,730 - 147,568,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmch
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247506,109,284 - 6,111,547 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247506,109,542 - 6,110,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pmch
6 total Variants

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:110
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000006174
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat

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RH94549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,513,064 - 22,513,234 (+)MAPPERmRatBN7.2
Rnor_6.0728,656,337 - 28,656,506NCBIRnor6.0
Rnor_5.0728,766,124 - 28,766,293UniSTSRnor5.0
RGSC_v3.4724,779,264 - 24,779,433UniSTSRGSC3.4
Celera719,683,175 - 19,683,344UniSTS
RH 3.4 Map7118.65UniSTS
Cytogenetic Map7q13UniSTS
RH137732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,513,056 - 22,513,235 (+)MAPPERmRatBN7.2
Rnor_6.0728,656,329 - 28,656,507NCBIRnor6.0
Rnor_5.0728,766,116 - 28,766,294UniSTSRnor5.0
RGSC_v3.4724,779,256 - 24,779,434UniSTSRGSC3.4
Celera719,683,167 - 19,683,345UniSTS
RH 3.4 Map7120.2UniSTS
Cytogenetic Map7q13UniSTS


This gene Pmch is modified in the following models/strains:
WI-Pmchm1Hubr    




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 1 81 21 19 5 14 5 4 32 19 73 2 24 14



Ensembl Acc Id: ENSRNOT00000006174   ⟹   ENSRNOP00000006174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl728,654,733 - 28,657,522 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095213   ⟹   ENSRNOP00000091581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl722,511,934 - 22,513,250 (+)Ensembl
RefSeq Acc Id: NM_012625   ⟹   NP_036757
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,399,404 - 24,400,720 (+)NCBI
mRatBN7.2722,511,934 - 22,513,250 (+)NCBI
Rnor_6.0728,655,206 - 28,656,522 (+)NCBI
Rnor_5.0728,764,993 - 28,766,309 (+)NCBI
RGSC_v3.4724,778,133 - 24,779,449 (+)RGD
Celera719,682,044 - 19,683,360 (+)RGD
Sequence:
Protein RefSeqs NP_036757 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41580 (Get FASTA)   NCBI Sequence Viewer  
  AAA41581 (Get FASTA)   NCBI Sequence Viewer  
  EDM17019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091581.1
GenBank Protein P14200 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036757   ⟸   NM_012625
- Peptide Label: precursor
- UniProtKB: P14200 (UniProtKB/Swiss-Prot),   A0A8I6ABX9 (UniProtKB/TrEMBL),   A6IFM9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006174   ⟸   ENSRNOT00000006174
Ensembl Acc Id: ENSRNOP00000091581   ⟸   ENSRNOT00000095213

Name Modeler Protein Id AA Range Protein Structure
AF-P14200-F1-model_v2 AlphaFold P14200 1-165 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 18 of 18 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34521 BioCyc
Ensembl Genes ENSRNOG00000004632 Ensembl
  ENSRNOG00000066777 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095213.1 UniProtKB/TrEMBL
InterPro Prepro-melanin_conc_hormone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24659 UniProtKB/Swiss-Prot
NCBI Gene 24659 ENTREZGENE
PANTHER PRO-MCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pro-MCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pmch PhenoGen
PRINTS PROMCHFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004632 RatGTEx
  ENSRNOG00000066777 RatGTEx
TIGR TC220489
UniProt A0A8I6ABX9 ENTREZGENE, UniProtKB/TrEMBL
  A6IFM9 ENTREZGENE, UniProtKB/TrEMBL
  MCH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 18 of 18 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pmch  Pro-melanin-concentrating hormone      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease disruption of the gene in mice results in a lean phenotype as a result of hypophagia and increased metabolic rate, whereas overexpression causes obesity and insulin-resistant 628540
gene_expression found in the brain lateral hypothalamic area 70437
gene_expression expressed in the lateral hypothalamus and zona incerta of the central nervous system 628540
gene_process regulates appetite 70437
gene_process activates Y1 receptor which in turn mediates Npy 70437
gene_process may play a role in retrograde facilitation on the inhibitory avoidance 729531
gene_process plays a role in regulation of feeding behavior 628540
gene_protein the mature product is a 19-amino acid cyclic peptide 628540