Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) Rattus norvegicus
Analyze
Symbol: Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
RGD ID: 3310
Description: Enables 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be active in cytosol. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4); PARTICIPATES IN fructose and mannose metabolic pathway; glycolysis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ASE testis-type isozyme; LOC100911725; PFK/FBPase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,522,371 - 118,565,478 (+)NCBIGRCr8
mRatBN7.28109,643,558 - 109,687,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,643,937 - 109,685,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,262,543 - 115,300,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,461,728 - 113,499,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,304,523 - 111,342,518 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,733,347 - 117,776,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,737,117 - 117,775,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,085,098 - 117,128,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,012,543 - 114,050,534 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,031,997 - 114,069,989 (+)NCBI
Celera8108,939,193 - 108,977,086 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diethyl malate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
gentamycin  (EXP)
hydralazine  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenate  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider MH, etal., Biochem J. 2004 Aug 1;381(Pt 3):561-79.
9. Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase. Sakata J, etal., J Biol Chem 1991 Aug 25;266(24):15764-70.
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2837207   PMID:8805587   PMID:9464277   PMID:9890980   PMID:10095107   PMID:15896703   PMID:19595670   PMID:28235572  


Genomics

Comparative Map Data
Pfkfb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,522,371 - 118,565,478 (+)NCBIGRCr8
mRatBN7.28109,643,558 - 109,687,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,643,937 - 109,685,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,262,543 - 115,300,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,461,728 - 113,499,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,304,523 - 111,342,518 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,733,347 - 117,776,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,737,117 - 117,775,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,085,098 - 117,128,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,012,543 - 114,050,534 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,031,997 - 114,069,989 (+)NCBI
Celera8108,939,193 - 108,977,086 (+)NCBICelera
Cytogenetic Map8q32NCBI
PFKFB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,517,684 - 48,563,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,517,684 - 48,562,015 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,555,117 - 48,598,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,530,121 - 48,569,231 (-)NCBINCBI36Build 36hg18NCBI36
Build 34348,530,122 - 48,569,231NCBI
Celera348,510,977 - 48,550,079 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,613,565 - 48,652,666 (-)NCBIHuRef
CHM1_1348,507,387 - 48,546,534 (-)NCBICHM1_1
T2T-CHM13v2.0348,546,648 - 48,592,093 (-)NCBIT2T-CHM13v2.0
Pfkfb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,817,336 - 108,861,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,820,846 - 108,861,296 (+)EnsemblGRCm39 Ensembl
GRCm389108,988,272 - 109,032,236 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,991,778 - 109,032,228 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,893,947 - 108,934,739 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,848,901 - 108,889,603 (+)NCBIMGSCv36mm8
Celera9108,549,891 - 108,591,002 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
Pfkfb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532606,643 - 644,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955532606,597 - 644,238 (-)NCBIChiLan1.0ChiLan1.0
PFKFB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,491,191 - 48,533,286 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,497,153 - 48,538,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,439,542 - 48,479,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,521,541 - 49,560,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,521,550 - 49,560,711 (-)Ensemblpanpan1.1panPan2
PFKFB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,556,548 - 40,587,036 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,556,790 - 40,585,652 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,470,623 - 40,504,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,038,756 - 41,072,657 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,038,813 - 41,072,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,276,197 - 40,310,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,680,959 - 40,715,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,961,893 - 40,995,823 (+)NCBIUU_Cfam_GSD_1.0
Pfkfb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,543,590 - 63,585,774 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529303,843 - 342,935 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529304,090 - 346,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,212,552 - 31,259,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,212,553 - 31,259,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,457,005 - 34,504,235 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,920,252 - 9,962,243 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,919,764 - 9,957,543 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,123,631 - 157,165,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247302,519,678 - 2,563,059 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247302,519,661 - 2,566,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pfkfb4
237 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000028039
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU404101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU404102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU404103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028039   ⟹   ENSRNOP00000028039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,647,686 - 109,685,634 (+)Ensembl
Rnor_6.0 Ensembl8117,737,117 - 117,775,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000037662   ⟹   ENSRNOP00000033343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8118,402,930 - 118,414,603 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066305   ⟹   ENSRNOP00000061383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8118,392,773 - 118,414,603 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090164   ⟹   ENSRNOP00000074158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,643,937 - 109,685,634 (+)Ensembl
Rnor_6.0 Ensembl8117,737,387 - 117,775,386 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091573   ⟹   ENSRNOP00000075289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,648,036 - 109,685,532 (+)Ensembl
Rnor_6.0 Ensembl8117,737,467 - 117,775,051 (+)Ensembl
RefSeq Acc Id: NM_019333   ⟹   NP_062206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,166 - 118,564,112 (+)NCBI
mRatBN7.28109,647,686 - 109,685,634 (+)NCBI
Rnor_6.08117,737,117 - 117,775,153 (+)NCBI
Rnor_5.08117,085,098 - 117,128,270 (+)NCBI
RGSC_v3.48114,012,543 - 114,050,534 (+)RGD
Celera8108,939,193 - 108,977,086 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243840   ⟹   XP_006243902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,522,371 - 118,565,478 (+)NCBI
mRatBN7.28109,643,891 - 109,687,006 (+)NCBI
Rnor_6.08117,733,347 - 117,776,525 (+)NCBI
Rnor_5.08117,085,098 - 117,128,270 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766563   ⟹   XP_008764785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,565,478 (+)NCBI
mRatBN7.28109,647,036 - 109,687,006 (+)NCBI
Rnor_6.08117,737,106 - 117,776,525 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082017   ⟹   XP_038937945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,542,411 - 118,565,478 (+)NCBI
mRatBN7.28109,663,925 - 109,687,006 (+)NCBI
RefSeq Acc Id: XM_039082018   ⟹   XP_038937946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,545,202 (+)NCBI
mRatBN7.28109,646,937 - 109,666,724 (+)NCBI
RefSeq Acc Id: XM_039082019   ⟹   XP_038937947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,544,734 (+)NCBI
mRatBN7.28109,646,973 - 109,666,248 (+)NCBI
RefSeq Acc Id: XM_063266037   ⟹   XP_063122107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,469 - 118,565,478 (+)NCBI
RefSeq Acc Id: XM_063266038   ⟹   XP_063122108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,469 - 118,565,478 (+)NCBI
RefSeq Acc Id: XM_063266039   ⟹   XP_063122109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,582 - 118,565,478 (+)NCBI
RefSeq Acc Id: XM_063266040   ⟹   XP_063122110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,543,000 - 118,565,478 (+)NCBI
RefSeq Acc Id: XR_005487907
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,545,848 (+)NCBI
mRatBN7.28109,646,991 - 109,667,369 (+)NCBI
RefSeq Acc Id: XR_010054021
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,563,779 (+)NCBI
RefSeq Acc Id: XR_010054022
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,522,371 - 118,545,848 (+)NCBI
RefSeq Acc Id: NP_062206   ⟸   NM_019333
- UniProtKB: P25114 (UniProtKB/Swiss-Prot),   A6I399 (UniProtKB/TrEMBL),   B0ZTI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243902   ⟸   XM_006243840
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R9R3 (UniProtKB/TrEMBL),   B0ZTI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764785   ⟸   XM_008766563
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038937946   ⟸   XM_039082018
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038937947   ⟸   XM_039082019
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038937945   ⟸   XM_039082017
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000074158   ⟸   ENSRNOT00000090164
Ensembl Acc Id: ENSRNOP00000075289   ⟸   ENSRNOT00000091573
Ensembl Acc Id: ENSRNOP00000028039   ⟸   ENSRNOT00000028039
Ensembl Acc Id: ENSRNOP00000033343   ⟸   ENSRNOT00000037662
Ensembl Acc Id: ENSRNOP00000061383   ⟸   ENSRNOT00000066305
RefSeq Acc Id: XP_063122107   ⟸   XM_063266037
- Peptide Label: isoform X3
- UniProtKB: B0ZTI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122108   ⟸   XM_063266038
- Peptide Label: isoform X3
- UniProtKB: B0ZTI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122109   ⟸   XM_063266039
- Peptide Label: isoform X3
- UniProtKB: B0ZTI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122110   ⟸   XM_063266040
- Peptide Label: isoform X5
Protein Domains
6-phosphofructo-2-kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FKL9-F1-model_v2 AlphaFold F7FKL9 1-330 view protein structure
AF-P25114-F1-model_v2 AlphaFold P25114 1-469 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696327
Promoter ID:EPDNEW_R6843
Type:single initiation site
Name:Pfkfb4_1
Description:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,737,444 - 117,737,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3310 AgrOrtholog
BioCyc Gene G2FUF-29099 BioCyc
BioCyc Pathway PWY66-423 [fructose 2,6-bisphosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY66-423 BioCyc
Ensembl Genes ENSRNOG00000020656 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000048130 Ensembl
  ENSRNOG00055007209 UniProtKB/Swiss-Prot
  ENSRNOG00060017864 UniProtKB/Swiss-Prot
  ENSRNOG00065006921 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028039.5 UniProtKB/Swiss-Prot
  ENSRNOT00000090164.2 UniProtKB/TrEMBL
  ENSRNOT00000091573.2 UniProtKB/TrEMBL
  ENSRNOT00055011984 UniProtKB/Swiss-Prot
  ENSRNOT00060030716 UniProtKB/Swiss-Prot
  ENSRNOT00065010840 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6Phosfructo_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54283 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54283 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 6PF2K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Phos_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pfkfb4 PhenoGen
PIRSF 6PFK_2-Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020656 RatGTEx
  ENSRNOG00000048130 RatGTEx
  ENSRNOG00055007209 RatGTEx
  ENSRNOG00060017864 RatGTEx
  ENSRNOG00065006921 RatGTEx
SMART PGAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC212530
UniProt A0A8L2R9R3 ENTREZGENE, UniProtKB/TrEMBL
  A6I399 ENTREZGENE, UniProtKB/TrEMBL
  B0ZTH8_RAT UniProtKB/TrEMBL
  B0ZTH9_RAT UniProtKB/TrEMBL
  B0ZTI0 ENTREZGENE, UniProtKB/TrEMBL
  F264_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pfkfb4  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4  LOC100911725  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like  Data merged from RGD:6491338 737654 PROVISIONAL
2012-07-05 LOC100911725  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pfkfb4  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4      Name updated 70584 APPROVED