Npr3 (natriuretic peptide receptor 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Npr3 (natriuretic peptide receptor 3) Rattus norvegicus
Analyze
Symbol: Npr3
Name: natriuretic peptide receptor 3
RGD ID: 3196
Description: Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of pancreatic juice secretion; and positive regulation of relaxation of smooth muscle. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3); PARTICIPATES IN C-type natriuretic peptide signaling pathway; natriuretic peptide signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ANP-C; ANP-CR; ANPR-C; ANPRC; atrial natriuretic peptide C-type receptor; atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide clearence receptor 3; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); NPR-C; NPRC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,592,557 - 62,660,497 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl262,597,668 - 62,660,066 (-)EnsemblGRCr8
mRatBN7.2260,865,483 - 60,933,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,870,594 - 60,932,955 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx268,000,358 - 68,061,538 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0266,121,915 - 66,183,093 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0261,123,277 - 61,184,447 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0261,883,946 - 61,950,291 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,888,950 - 61,949,926 (-)Ensemblrn6Rnor6.0
Rnor_5.0282,740,513 - 82,806,584 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4261,278,264 - 61,341,460 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera257,760,666 - 57,821,249 (+)NCBICelera
RGSC_v3.1261,206,496 - 61,269,693 (-)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chlormequat chloride  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (EXP)
dimethylselenide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethylparaben  (ISO)
flavonoids  (EXP)
flusilazole  (EXP)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Guanylin  (ISO)
icariin  (ISO)
ketoconazole  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctanoic acid  (EXP)
peroxynitrous acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium atom  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trametinib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein. Anand-Srivastava MB, etal., J Biol Chem. 1996 Aug 9;271(32):19324-9.
2. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. Bordicchia M, etal., J Clin Invest. 2012 Mar;122(3):1022-36. doi: 10.1172/JCI59701. Epub 2012 Feb 6.
3. Modulation of ANP-C receptor signaling by endothelin-1 in A-10 smooth muscle cells. Boumati M, etal., Arch Biochem Biophys 2002 May 15;401(2):178-86.
4. A single residue determines the distinct pharmacology of rat and human natriuretic peptide receptor-C. Engel AM, etal., J Biol Chem 1994 Jun 24;269(25):17005-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Hobbs A, etal., Circulation. 2004 Sep 7;110(10):1231-5. Epub 2004 Aug 30.
8. Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3). Jaubert J, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10278-83.
9. Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide. Khambata RS, etal., Br J Pharmacol. 2011 Sep;164(2b):584-97. doi: 10.1111/j.1476-5381.2011.01400.x.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells. Mouawad R, etal., Mol Pharmacol. 2004 Apr;65(4):917-24.
12. G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor. Murthy KS, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):C1409-16.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Oliver PM, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5.
15. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. Pitzalis MV, etal., J Hypertens. 2003 Aug;21(8):1491-6.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Downregulation of the atrial natriuretic peptide/natriuretic peptide receptor-C system in the early stages of diabetic retinopathy in the rat. Rollin R, etal., Mol Vis. 2005 Mar 18;11:216-24.
20. Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors. Sabbatini ME, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G929-37. Epub 2003 Jun 26.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alphaT3-1 and LbetaT2 gonadotroph cells. Thompson IR, etal., J Endocrinol. 2009 Nov;203(2):215-29. doi: 10.1677/JOE-09-0189. Epub 2009 Aug 7.
23. Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells. Trachte GJ Endocrinology 2003 Jan;144(1):94-100.
24. Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Villar IC, etal., Cardiovasc Res. 2007 Jun 1;74(3):515-25. Epub 2007 Mar 3.
25. Identification of the G protein-activating sequence of the single-transmembrane natriuretic peptide receptor C (NPR-C). Zhou H and Murthy KS, Am J Physiol Cell Physiol. 2003 May;284(5):C1255-61.
Additional References at PubMed
PMID:1660465   PMID:7554122   PMID:10377427   PMID:14599710   PMID:15911073   PMID:16712979   PMID:16870210   PMID:17702953   PMID:17951249   PMID:18162186   PMID:18778744   PMID:19187227  
PMID:19252090   PMID:19878700   PMID:19969282   PMID:20304036   PMID:20564198   PMID:21723350   PMID:22131352   PMID:23376485   PMID:23533145   PMID:24155894   PMID:24189506   PMID:25736855  
PMID:27108789   PMID:27494651   PMID:29417337   PMID:33849828   PMID:36243172   PMID:37857164  


Genomics

Comparative Map Data
Npr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,592,557 - 62,660,497 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl262,597,668 - 62,660,066 (-)EnsemblGRCr8
mRatBN7.2260,865,483 - 60,933,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,870,594 - 60,932,955 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx268,000,358 - 68,061,538 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0266,121,915 - 66,183,093 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0261,123,277 - 61,184,447 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0261,883,946 - 61,950,291 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,888,950 - 61,949,926 (-)Ensemblrn6Rnor6.0
Rnor_5.0282,740,513 - 82,806,584 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4261,278,264 - 61,341,460 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera257,760,666 - 57,821,249 (+)NCBICelera
RGSC_v3.1261,206,496 - 61,269,693 (-)NCBI
Cytogenetic Map2q16NCBI
NPR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38532,690,872 - 32,791,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl532,689,070 - 32,791,724 (+)Ensemblhg38GRCh38
GRCh37532,690,978 - 32,791,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36532,747,422 - 32,823,013 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34532,747,421 - 32,823,009NCBI
Celera532,593,318 - 32,668,888 (+)NCBICelera
Cytogenetic Map5p13.3NCBI
HuRef532,678,571 - 32,759,879 (+)NCBIHuRef
CHM1_1532,712,833 - 32,793,931 (+)NCBICHM1_1
T2T-CHM13v2.0532,804,528 - 32,905,709 (+)NCBIT2T-CHM13v2.0
Npr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391511,839,982 - 11,907,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1511,839,982 - 11,907,373 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381511,839,896 - 11,907,837 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1511,839,896 - 11,907,287 (-)Ensemblmm10GRCm38
MGSCv371511,769,651 - 11,835,429 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361511,784,621 - 11,850,399 (-)NCBIMGSCv36mm8
Celera1511,624,844 - 11,690,388 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.83NCBI
Npr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542618,491,350 - 18,553,743 (+)Ensembl
ChiLan1.0NW_00495542618,491,350 - 18,559,299 (+)NCBIChiLan1.0ChiLan1.0
NPR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2477,504,441 - 77,588,838 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1575,658,072 - 75,742,227 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0577,542,200 - 77,621,983 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1582,921,035 - 83,004,964 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl582,926,409 - 83,004,964 (-)EnsemblpanPan2panpan1.1
NPR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1474,794,553 - 74,863,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl474,799,857 - 74,862,969 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha474,429,055 - 74,497,877 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0475,311,739 - 75,380,568 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl475,311,746 - 75,380,475 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1475,049,009 - 75,118,047 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0475,177,562 - 75,246,355 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0475,708,336 - 75,777,195 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213223,211,508 - 223,281,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365188,093,561 - 8,158,868 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365188,093,111 - 8,158,862 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1618,842,039 - 18,929,805 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11618,841,540 - 18,929,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NPR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1431,984,712 - 32,062,593 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl431,986,217 - 32,062,199 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607122,244,880 - 22,328,902 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475921,829,336 - 21,904,405 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475921,826,271 - 21,904,928 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Npr3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13169,162,879 - 169,223,328 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npr3
410 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:70
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000025966
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
PMC17879P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8262,658,708 - 62,659,289 (+)Marker Load Pipeline
mRatBN7.2260,931,634 - 60,932,217 (+)MAPPERmRatBN7.2
Rnor_6.0261,949,650 - 61,950,232NCBIRnor6.0
Rnor_5.0282,740,551 - 82,741,133UniSTSRnor5.0
RGSC_v3.4261,341,404 - 61,341,986UniSTSRGSC3.4
Celera257,760,140 - 57,760,722UniSTS
Cytogenetic Map2q16UniSTS
RH130055  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2260,889,134 - 60,889,352 (+)MAPPERmRatBN7.2
mRatBN7.21610,074,951 - 10,075,169 (+)MAPPERmRatBN7.2
Rnor_6.01611,108,549 - 11,108,766NCBIRnor6.0
Rnor_6.0261,907,585 - 61,907,802NCBIRnor6.0
Rnor_5.0169,434,028 - 9,434,245UniSTSRnor5.0
Rnor_5.0282,783,104 - 82,783,321UniSTSRnor5.0
RGSC_v3.4261,297,441 - 61,297,658UniSTSRGSC3.4
RGSC_v3.41610,409,488 - 10,409,705UniSTSRGSC3.4
Celera165,142,569 - 5,142,786UniSTS
Celera257,802,577 - 57,802,794UniSTS
RH 3.4 Map1698.1UniSTS
Cytogenetic Map2q16UniSTS
Cytogenetic Map16p15UniSTS
PMC22098P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2260,930,929 - 60,931,451 (+)MAPPERmRatBN7.2
Rnor_6.0261,948,945 - 61,949,466NCBIRnor6.0
Rnor_5.0282,741,317 - 82,741,838UniSTSRnor5.0
RGSC_v3.4261,340,699 - 61,341,220UniSTSRGSC3.4
Celera257,760,906 - 57,761,427UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 152 91 90 59 36 59 6 300 136 11 131 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000025966   ⟹   ENSRNOP00000025966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,597,668 - 62,658,765 (-)Ensembl
mRatBN7.2 Ensembl260,870,594 - 60,931,691 (-)Ensembl
Rnor_6.0 Ensembl261,888,950 - 61,949,926 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116101   ⟹   ENSRNOP00000079490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,597,708 - 62,660,066 (-)Ensembl
mRatBN7.2 Ensembl260,870,634 - 60,932,955 (-)Ensembl
RefSeq Acc Id: NM_012868   ⟹   NP_037000
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,597,668 - 62,658,765 (-)NCBI
mRatBN7.2260,870,594 - 60,931,691 (-)NCBI
Rnor_6.0261,889,053 - 61,949,706 (-)NCBI
Rnor_5.0282,740,513 - 82,806,584 (+)NCBI
RGSC_v3.4261,278,264 - 61,341,460 (-)RGD
Celera257,760,666 - 57,821,249 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232045   ⟹   XP_006232107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,592,557 - 62,659,732 (-)NCBI
mRatBN7.2260,865,483 - 60,932,662 (-)NCBI
Rnor_6.0261,883,946 - 61,950,291 (-)NCBI
Rnor_5.0282,740,513 - 82,806,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101782   ⟹   XP_038957710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,592,557 - 62,660,497 (-)NCBI
mRatBN7.2260,865,483 - 60,933,432 (-)NCBI
RefSeq Acc Id: NP_037000   ⟸   NM_012868
- Peptide Label: precursor
- UniProtKB: Q64156 (UniProtKB/Swiss-Prot),   P41740 (UniProtKB/Swiss-Prot),   A6KJR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232107   ⟸   XM_006232045
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QFC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025966   ⟸   ENSRNOT00000025966
RefSeq Acc Id: XP_038957710   ⟸   XM_039101782
- Peptide Label: isoform X2
- UniProtKB: A6KJR3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079490   ⟸   ENSRNOT00000116101
Protein Domains
Receptor ligand binding region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41740-F1-model_v2 AlphaFold P41740 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691192
Promoter ID:EPDNEW_R1716
Type:single initiation site
Name:Npr3_1
Description:natriuretic peptide receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0261,949,881 - 61,949,941EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3196 AgrOrtholog
BioCyc Gene G2FUF-54054 BioCyc
Ensembl Genes ENSRNOG00000019184 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025966 ENTREZGENE
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  ANP_Clearance_Receptor UniProtKB/Swiss-Prot
  ANPR/GUC UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:25339 UniProtKB/Swiss-Prot
NCBI Gene 25339 ENTREZGENE
PANTHER ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 UniProtKB/Swiss-Prot
  NATRIURETIC PEPTIDE RECEPTOR 3-RELATED UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
PhenoGen Npr3 PhenoGen
PRINTS NATPEPTIDER UniProtKB/Swiss-Prot
PROSITE ANF_RECEPTORS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019184 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
TIGR TC232480
UniProt A0A8I6G3D8_RAT UniProtKB/TrEMBL
  A0A8L2QFC4 ENTREZGENE, UniProtKB/TrEMBL
  A6KJR1 ENTREZGENE, UniProtKB/TrEMBL
  A6KJR2_RAT UniProtKB/TrEMBL
  A6KJR3 ENTREZGENE, UniProtKB/TrEMBL
  ANPRC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64156 ENTREZGENE
UniProt Secondary Q64156 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-07 Npr3  natriuretic peptide receptor 3  Npr3  natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Npr3  natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)  Npr3  natriuretic peptide receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Npr3  natriuretic peptide receptor 3      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates the attenuation of protein kinase C activity 727487
gene_regulation downregulated by endothelin-1 in A-10 smooth muscle cells 729225