Mstn (myostatin) - Rat Genome Database

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Gene: Mstn (myostatin) Rattus norvegicus
Analyze
Symbol: Mstn
Name: myostatin
RGD ID: 3115
Description: Predicted to enable several functions, including cytokine activity; heparin binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hypoxia; negative regulation of skeletal muscle tissue growth; and skeletal muscle atrophy. Located in extracellular space. Used to study amyotrophic lateral sclerosis. Biomarker of congestive heart failure; hypothyroidism; muscular atrophy; peripheral vascular disease; and uremia. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GDF-8; Gdf8; growth differentiation factor 8; growth/differentiation factor 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mstnem2Mcwi ; Mstnem3Mcwi ; Mstnem1Mcwi ; Mstnem1Cqin
Genetic Models: SD-Mstnem1Cqin ; SS-Mstnem2Mcwi ; SS-Mstnem1Mcwi-/- ; SS-Mstnem3Mcwi-/- ; SS-Mstnem1Mcwi ; SS-Mstnem3Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,944,513 - 55,950,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl955,944,513 - 55,950,913 (-)EnsemblGRCr8
mRatBN7.2948,452,533 - 48,458,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx956,995,653 - 57,000,498 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,118,483 - 62,123,328 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,414,473 - 60,419,318 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)Ensemblrn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera946,124,738 - 46,129,565 (-)NCBICelera
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to dexamethasone stimulus  (ISO)
cellular response to hypoxia  (IEP)
muscle cell cellular homeostasis  (IEA,ISO)
myoblast migration involved in skeletal muscle regeneration  (IEA,ISO,ISS)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of kinase activity  (ISO)
negative regulation of muscle hypertrophy  (IMP)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of myoblast proliferation  (ISS)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of satellite cell differentiation  (ISS)
negative regulation of skeletal muscle satellite cell proliferation  (ISS)
negative regulation of skeletal muscle tissue growth  (IEA,IMP,ISO)
ovulation cycle process  (IEP)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of lamellipodium assembly  (IEA,ISO,ISS)
positive regulation of macrophage chemotaxis  (IEA,ISO,ISS)
response to electrical stimulus  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to glucocorticoid  (IEA,IEP)
response to gravity  (IEP)
response to ketone  (IEA)
response to muscle activity  (IEP)
response to testosterone  (IEP)
skeletal muscle atrophy  (IEP)
skeletal muscle satellite cell differentiation  (IEA,ISO)
skeletal muscle tissue development  (IBA)
skeletal muscle tissue regeneration  (IEA,IEP,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,ISO)

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Myostatin expression in age and denervation-induced skeletal muscle atrophy. Baumann AP, etal., J Musculoskelet Neuronal Interact. 2003 Mar;3(1):8-16.
2. Hypothyroidism is associated with increased myostatin expression in rats. Carneiro I, etal., J Endocrinol Invest. 2008 Sep;31(9):773-8.
3. Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Ciarmela P, etal., Endocrinology. 2009 Feb;150(2):906-14. Epub 2008 Oct 9.
4. Muscle myostatin signalling is enhanced in experimental cancer cachexia. Costelli P, etal., Eur J Clin Invest. 2008 Jul;38(7):531-8.
5. Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Dasarathy S, etal., Am J Physiol Gastrointest Liver Physiol 2004 Jul 15;.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Establishment and phenotypic analysis of an Mstn knockout rat. Gu H, etal., Biochem Biophys Res Commun. 2016 Aug 12;477(1):115-22. doi: 10.1016/j.bbrc.2016.06.030. Epub 2016 Jun 8.
9. Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis. Holzbaur EL, etal., Neurobiol Dis. 2006 Sep;23(3):697-707. Epub 2006 Jul 11.
10. Role of serum myostatin during the lactation period. Hosoyama T, etal., J Reprod Dev. 2006 Aug;52(4):469-78. Epub 2006 Mar 31.
11. Long term adrenal insufficiency induces skeletal muscle atrophy and increases the serum levels of active form myostatin in rat serum. Hosoyama T, etal., Zoolog Sci. 2005 Feb;22(2):229-36.
12. Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats. Kawada S and Ishii N, Eur J Appl Physiol. 2009 Jan 6.
13. Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. Lalani R, etal., J Endocrinol. 2000 Dec;167(3):417-28.
14. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Lang CH, etal., Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E916-26. Epub 2004 Jan 28.
15. Regulation of myostatin by glucocorticoids after thermal injury. Lang CH, etal., FASEB J. 2001 Aug;15(10):1807-9.
16. Muscle and nerve responses after different intervals of electrical stimulation sessions on denervated rat muscle. Lima SC, etal., Am J Phys Med Rehabil. 2009 Feb;88(2):126-35.
17. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Ma K, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E363-71. Epub 2003 Apr 29.
18. Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. Magee TR, etal., J Gene Med. 2006 Sep;8(9):1171-81.
19. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Magga J, etal., Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.
20. Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat. Matsakas A, etal., Acta Physiol Scand. 2005 Mar;183(3):299-307.
21. Double muscling in cattle due to mutations in the myostatin gene. McPherron AC and Lee SJ, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12457-61.
22. Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats. Mendias CL, etal., J Physiol. 2015 Apr 15;593(8):2037-52. doi: 10.1113/jphysiol.2014.287144. Epub 2015 Feb 25.
23. Myostatin levels in regenerating rat muscles and in myogenic cell cultures. Mendler L, etal., J Muscle Res Cell Motil. 2000;21(6):551-63.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Spatiotemporal expression of decorin and myostatin during rat skeletal muscle development. Nishimura T, etal., Biochem Biophys Res Commun. 2007 Oct 5;361(4):896-902. Epub 2007 Jul 30.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Muscle expressions of MGF, IGF-IEa, and myostatin in intact and hypophysectomized rats: effects of rhGH and testosterone alone or combined. Rigamonti AE, etal., Horm Metab Res. 2009 Jan;41(1):23-9. Epub 2008 Oct 7.
34. The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression. Salehian B, etal., Metabolism. 2006 Sep;55(9):1239-47.
35. Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure. Shyu KG, etal., Eur J Clin Invest. 2006 Oct;36(10):713-9.
36. Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. Sun DF, etal., Kidney Int. 2006 Jun 28.
37. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
Additional References at PubMed
PMID:9139826   PMID:11459935   PMID:11877467   PMID:12595574   PMID:14517293   PMID:15215484   PMID:16182246   PMID:16450055   PMID:16873457   PMID:16941139   PMID:17395701   PMID:17959844  
PMID:18089396   PMID:18286185   PMID:18422491   PMID:18801898   PMID:19218333   PMID:19357233   PMID:19406121   PMID:19591015   PMID:19644449   PMID:19736304   PMID:19903098   PMID:19959771  
PMID:20002838   PMID:20007454   PMID:20103742   PMID:20191313   PMID:20396675   PMID:20677217   PMID:20801187   PMID:20884321   PMID:21390326   PMID:21539891   PMID:22033906   PMID:22244812  
PMID:22332899   PMID:22464481   PMID:22684687   PMID:22696074   PMID:22854904   PMID:23255067   PMID:23752591   PMID:23829672   PMID:23844238   PMID:24076600   PMID:25575785   PMID:25960249  
PMID:26151859   PMID:26205544   PMID:26342801   PMID:26927339   PMID:27128567   PMID:27625211   PMID:28257634   PMID:28533206   PMID:28539643   PMID:29330193   PMID:30366029   PMID:31054482  
PMID:32173683   PMID:34453705   PMID:34576046   PMID:35758824   PMID:39093510  


Genomics

Comparative Map Data
Mstn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,944,513 - 55,950,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl955,944,513 - 55,950,913 (-)EnsemblGRCr8
mRatBN7.2948,452,533 - 48,458,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx956,995,653 - 57,000,498 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,118,483 - 62,123,328 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,414,473 - 60,419,318 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)Ensemblrn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera946,124,738 - 46,129,565 (-)NCBICelera
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Cytogenetic Map9q22NCBI
MSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,055,700 - 190,062,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,055,700 - 190,062,729 (-)Ensemblhg38GRCh38
GRCh372190,920,426 - 190,927,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,628,671 - 190,635,700 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342190,745,932 - 190,752,961NCBI
Celera2184,515,357 - 184,522,386 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,780,433 - 182,787,462 (-)NCBIHuRef
CHM1_12190,926,378 - 190,933,407 (-)NCBICHM1_1
T2T-CHM13v2.02190,545,060 - 190,552,089 (-)NCBIT2T-CHM13v2.0
Mstn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,100,799 - 53,107,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,100,799 - 53,107,238 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38153,061,640 - 53,068,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,061,640 - 53,068,079 (+)Ensemblmm10GRCm38
MGSCv37153,118,507 - 53,124,923 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36153,006,208 - 53,012,624 (+)NCBIMGSCv36mm8
Celera153,601,512 - 53,607,928 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Mstn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,914,482 - 8,923,465 (+)Ensembl
ChiLan1.0NW_0049554038,914,505 - 8,921,190 (+)NCBIChiLan1.0ChiLan1.0
MSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,751,094 - 92,761,026 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,765,891 - 92,773,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,364,927 - 77,452,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,283,903 - 195,290,922 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B195,283,903 - 195,290,922 (-)EnsemblpanPan2panpan1.1
MSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137729,172 - 734,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37729,172 - 734,362 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha371,685,007 - 1,690,090 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.037623,197 - 628,235 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37621,860 - 628,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137633,617 - 638,697 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037601,655 - 606,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037629,871 - 634,951 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mstn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,842,726 - 148,849,304 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,988,718 - 7,996,971 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,988,879 - 7,996,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,620,270 - 94,628,545 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11594,623,526 - 94,628,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,734,309 - 105,739,223 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,564,816 - 75,570,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,565,152 - 75,570,528 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040123,900,932 - 123,908,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mstn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,892,938 - 5,899,473 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248545,893,051 - 5,899,380 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mstn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14122,200,328 - 122,206,691 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mstn
59 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:149
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000038093
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
GDF8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,454,110 - 48,454,300 (+)MAPPERmRatBN7.2
Rnor_6.0953,311,106 - 53,311,295NCBIRnor6.0
Rnor_5.0952,977,500 - 52,977,689UniSTSRnor5.0
RGSC_v3.4945,426,960 - 45,427,149UniSTSRGSC3.4
Celera946,124,867 - 46,125,056UniSTS
Cytogenetic Map9q22UniSTS


Genetic Models
This gene Mstn is modified in the following models/strains:
SD-Mstnem1Cqin     SS-Mstnem2Mcwi     SS-Mstnem1Mcwi-/-     SS-Mstnem3Mcwi-/-     SS-Mstnem1Mcwi     SS-Mstnem3Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 11 64 116 31 40 12 25 12 6 192 107 8 104 55 47 28 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000038093   ⟹   ENSRNOP00000038159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl955,944,513 - 55,950,913 (-)Ensembl
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)Ensembl
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)Ensembl
RefSeq Acc Id: NM_019151   ⟹   NP_062024
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,944,513 - 55,950,913 (-)NCBI
mRatBN7.2948,452,533 - 48,458,933 (-)NCBI
Rnor_6.0953,310,977 - 53,315,804 (-)NCBI
Rnor_5.0952,977,371 - 52,982,198 (-)NCBI
RGSC_v3.4945,426,831 - 45,431,658 (-)RGD
Celera946,124,738 - 46,129,565 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062024 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB86691 (Get FASTA)   NCBI Sequence Viewer  
  EDL99109 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038159
  ENSRNOP00000038159.1
GenBank Protein O35312 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062024   ⟸   NM_019151
- Peptide Label: precursor
- UniProtKB: O35312 (UniProtKB/Swiss-Prot),   A6INV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038159   ⟸   ENSRNOT00000038093
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35312-F1-model_v2 AlphaFold O35312 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3115 AgrOrtholog
BioCyc Gene G2FUF-27623 BioCyc
Ensembl Genes ENSRNOG00000021294 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038093 ENTREZGENE
  ENSRNOT00000038093.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:29152 UniProtKB/Swiss-Prot
NCBI Gene 29152 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  PTHR11848:SF150 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Mstn PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021294 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A6INV1 ENTREZGENE, UniProtKB/TrEMBL
  GDF8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Mstn  myostatin  Gdf8  growth differentiation factor 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gdf8  growth differentiation factor 8       Name updated 70584 APPROVED
2002-02-27 Gdf8  growth differentiation factor 8      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may contribute to cirrhosis-associated skeletal muscle atrophy by causing impairment of satellite cell proliferation 1302208
gene_function positive regulator of satellite cell function 1302208
gene_mutations_overexpression overexpression leads to skeletal muscle atrophy 1302208
gene_physical_interaction binds to receptor activinR2b 1302208