Mdh1 (malate dehydrogenase 1) - Rat Genome Database

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Gene: Mdh1 (malate dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Mdh1
Name: malate dehydrogenase 1
RGD ID: 3072
Description: Enables L-malate dehydrogenase (NAD+) activity and NAD binding activity. Involved in NAD+ metabolic process; malate metabolic process; and oxaloacetate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 88. Orthologous to human MDH1 (malate dehydrogenase 1); PARTICIPATES IN Leigh disease pathway; nicotinamide adenine dinucleotide metabolic pathway; primary hyperoxaluria type 2 pathway; INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: aromatic alpha-keto acid reductase; cytosolic malate dehydrogenase; KAR; malate dehydrogenase 1, NAD (soluble); malate dehydrogenase soluble; malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal; malate dehydrogenase, soluble; Malate dehydrogenase-like enzyme; Mdhl; MDL1; Mor2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81499,831,934 - 99,847,227 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1499,831,615 - 99,847,232 (-)EnsemblGRCr8
mRatBN7.21495,630,625 - 95,645,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1495,630,306 - 95,645,925 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1499,982,791 - 99,997,990 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014101,223,133 - 101,238,332 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01497,696,668 - 97,711,868 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014106,378,349 - 106,393,642 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14106,378,942 - 106,393,670 (-)Ensemblrn6Rnor6.0
Rnor_5.014106,449,337 - 106,463,995 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414102,259,130 - 102,273,788 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1494,639,971 - 94,655,156 (-)NCBICelera
RGSC_v3.114102,278,343 - 102,292,999 (-)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
8-Br-cAMP  (ISO)
9H-xanthine  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium trinitrate  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
D-glucose  (EXP,ISO)
deoxycholic acid  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
dinophysistoxin 1  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (EXP)
leflunomide  (EXP)
malic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menthofuran  (EXP)
methimazole  (EXP)
miconazole  (ISO)
monosodium L-glutamate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nitrates  (ISO)
obeticholic acid  (ISO)
oxaloacetic acid  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
potassium chloride  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
T-2 toxin  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Glutamine and ornithine alpha-ketoglutarate supplementation on malate dehydrogenases expression in hepatectomized rats. Guimarães Filho A, etal., Acta Cir Bras. 2014 Jun;29(6):365-70.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Receptor-mediated endocytosis of lactate dehydrogenase M4 by liver macrophages: a mechanism for elimination of enzymes from plasma. Evidence for competition by creatine kinase MM, adenylate kinase, malate, and alcohol dehydrogenase. Smit MJ, etal., J Biol Chem 1987 Sep 25;262(27):13020-6.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells. Tan C, etal., Diabetes. 2002 Oct;51(10):2989-96.
14. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
15. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:3312200   PMID:10075524   PMID:11726686   PMID:14760703   PMID:15489334   PMID:16854843   PMID:17634366   PMID:18614015   PMID:19056867   PMID:22664934   PMID:22871113   PMID:23376485  
PMID:23533145   PMID:24625528   PMID:25340584   PMID:26316108   PMID:36755387  


Genomics

Comparative Map Data
Mdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81499,831,934 - 99,847,227 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1499,831,615 - 99,847,232 (-)EnsemblGRCr8
mRatBN7.21495,630,625 - 95,645,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1495,630,306 - 95,645,925 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1499,982,791 - 99,997,990 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014101,223,133 - 101,238,332 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01497,696,668 - 97,711,868 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014106,378,349 - 106,393,642 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14106,378,942 - 106,393,670 (-)Ensemblrn6Rnor6.0
Rnor_5.014106,449,337 - 106,463,995 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414102,259,130 - 102,273,788 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1494,639,971 - 94,655,156 (-)NCBICelera
RGSC_v3.114102,278,343 - 102,292,999 (-)NCBI
Cytogenetic Map14q22NCBI
MDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38263,588,963 - 63,607,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl263,588,557 - 63,607,273 (+)Ensemblhg38GRCh38
GRCh37263,816,097 - 63,834,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36263,669,626 - 63,687,832 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34263,727,772 - 63,745,979NCBI
Celera263,661,163 - 63,679,336 (+)NCBICelera
Cytogenetic Map2p15NCBI
HuRef263,556,773 - 63,575,326 (+)NCBIHuRef
CHM1_1263,745,880 - 63,764,431 (+)NCBICHM1_1
T2T-CHM13v2.0263,596,617 - 63,614,818 (+)NCBIT2T-CHM13v2.0
Mdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391121,506,692 - 21,521,934 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1121,506,692 - 21,522,367 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381121,556,692 - 21,571,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1121,556,692 - 21,572,367 (-)Ensemblmm10GRCm38
MGSCv371121,456,695 - 21,471,937 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361121,456,790 - 21,471,832 (-)NCBIMGSCv36mm8
Celera1123,704,959 - 23,720,201 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1113.89NCBI
Mdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542420,706,058 - 20,723,493 (-)Ensembl
ChiLan1.0NW_00495542420,707,765 - 20,723,493 (-)NCBIChiLan1.0ChiLan1.0
MDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21262,789,858 - 62,808,152 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A62,793,808 - 62,812,102 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A63,658,933 - 63,677,257 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A64,785,132 - 64,803,631 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A64,785,132 - 64,803,631 (+)EnsemblpanPan2panpan1.1
MDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11063,316,818 - 63,334,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1063,316,831 - 63,361,735 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1063,205,783 - 63,223,532 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01064,325,732 - 64,343,477 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1064,325,748 - 64,393,190 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11064,008,394 - 64,026,100 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01064,316,618 - 64,334,341 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01064,609,207 - 64,626,872 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629219,984,379 - 20,000,470 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364918,570,472 - 8,587,686 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364918,570,472 - 8,586,914 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl378,244,999 - 78,268,600 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1378,247,229 - 78,263,085 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2382,274,663 - 82,280,460 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11443,406,502 - 43,425,525 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1443,406,499 - 43,425,095 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604568,435,625 - 68,454,293 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247629,881,950 - 9,901,372 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247629,884,521 - 9,900,593 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mdh1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11189,663,414 - 89,679,121 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mdh1
98 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:108
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000011429
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582201Sffal2Serum free fatty acids level QTL 240.0002blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)1496755448100078267Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1486271332100078267Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat

Markers in Region
Mor2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81499,834,287 - 99,834,757 (+)Marker Load Pipeline
mRatBN7.21495,632,978 - 95,633,448 (+)MAPPERmRatBN7.2
Rnor_6.014106,380,703 - 106,381,172NCBIRnor6.0
Rnor_5.014106,451,095 - 106,451,564UniSTSRnor5.0
RGSC_v3.414102,260,888 - 102,261,357UniSTSRGSC3.4
Celera1494,642,325 - 94,642,794UniSTS
Cytogenetic Map14q22UniSTS
RH134361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21495,631,476 - 95,632,931 (+)MAPPERmRatBN7.2
Rnor_6.014106,379,201 - 106,380,655NCBIRnor6.0
Rnor_5.014106,449,593 - 106,451,047UniSTSRnor5.0
RGSC_v3.414102,259,386 - 102,260,840UniSTSRGSC3.4
Celera1494,640,823 - 94,642,277UniSTS
Cytogenetic Map14q22UniSTS
BE120360  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21495,630,523 - 95,630,634 (+)MAPPERmRatBN7.2
Rnor_6.014106,378,248 - 106,378,358NCBIRnor6.0
Rnor_5.014106,448,640 - 106,448,750UniSTSRnor5.0
RGSC_v3.414102,258,433 - 102,258,543UniSTSRGSC3.4
Celera1494,639,870 - 94,639,980UniSTS
RH 3.4 Map14755.8UniSTS
Cytogenetic Map14q22UniSTS
D2S1567E  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81499,832,825 - 99,833,527 (+)Marker Load Pipeline
mRatBN7.21495,631,516 - 95,632,217 (+)MAPPERmRatBN7.2
Rnor_6.014106,379,241 - 106,379,941NCBIRnor6.0
Rnor_5.014106,449,633 - 106,450,333UniSTSRnor5.0
RGSC_v3.414102,259,426 - 102,260,126UniSTSRGSC3.4
Celera1494,640,863 - 94,641,563UniSTS
Cytogenetic Map14q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001316877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF075574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF093773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM055335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM081843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM085125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM086546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM108375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN799180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000011429   ⟹   ENSRNOP00000011429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1499,831,615 - 99,847,232 (-)Ensembl
mRatBN7.2 Ensembl1495,630,306 - 95,645,925 (-)Ensembl
Rnor_6.0 Ensembl14106,378,942 - 106,393,670 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094321   ⟹   ENSRNOP00000088696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1499,831,615 - 99,842,218 (-)Ensembl
mRatBN7.2 Ensembl1495,630,306 - 95,640,911 (-)Ensembl
RefSeq Acc Id: NM_001316877   ⟹   NP_001303806
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81499,831,934 - 99,847,227 (-)NCBI
mRatBN7.21495,630,625 - 95,645,920 (-)NCBI
Rnor_6.014106,378,349 - 106,393,642 (-)NCBI
Celera1494,639,971 - 94,655,156 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033235   ⟹   NP_150238
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81499,831,934 - 99,847,227 (-)NCBI
mRatBN7.21495,630,625 - 95,645,920 (-)NCBI
Rnor_6.014106,378,349 - 106,393,642 (-)NCBI
Rnor_5.014106,449,337 - 106,463,995 (-)NCBI
RGSC_v3.414102,259,130 - 102,273,788 (-)RGD
Celera1494,639,971 - 94,655,156 (-)NCBI
Sequence:
RefSeq Acc Id: NP_150238   ⟸   NM_033235
- Peptide Label: isoform Mdh1
- UniProtKB: O88585 (UniProtKB/Swiss-Prot),   Q6PCV2 (UniProtKB/Swiss-Prot),   O88989 (UniProtKB/Swiss-Prot),   A6JQ40 (UniProtKB/TrEMBL),   A0A8I6A721 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303806   ⟸   NM_001316877
- Peptide Label: isoform Mdh1x
- UniProtKB: A0A8I6A721 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011429   ⟸   ENSRNOT00000011429
Ensembl Acc Id: ENSRNOP00000088696   ⟸   ENSRNOT00000094321
Protein Domains
Lactate/malate dehydrogenase C-terminal   Lactate/malate dehydrogenase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88989-F1-model_v2 AlphaFold O88989 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699515
Promoter ID:EPDNEW_R10039
Type:initiation region
Name:Mdh1_1
Description:malate dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014106,393,647 - 106,393,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3072 AgrOrtholog
BioCyc Gene G2FUF-14828 BioCyc
BioCyc Pathway MALATE-ASPARTATE-SHUTTLE-PWY [malate/L-aspartate shuttle pathway] BioCyc
  PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image MALATE-ASPARTATE-SHUTTLE-PWY BioCyc
  PWY-5690 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000008103 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011429 ENTREZGENE
  ENSRNOT00000011429.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921518 IMAGE-MGC_LOAD
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot
  Lactate/malate_DH_C UniProtKB/Swiss-Prot
  Lactate/malate_DH_N UniProtKB/Swiss-Prot
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot
  Malate_DH_AS UniProtKB/Swiss-Prot
  Malate_DH_NAD-dep_euk UniProtKB/Swiss-Prot
  Malate_DH_type2 UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24551 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72755 IMAGE-MGC_LOAD
NCBI Gene 24551 ENTREZGENE
PANTHER PTHR23382 UniProtKB/Swiss-Prot
Pfam Ldh_1_C UniProtKB/Swiss-Prot
  Ldh_1_N UniProtKB/Swiss-Prot
PhenoGen Mdh1 PhenoGen
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot
PROSITE MDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008103 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
  SSF56327 UniProtKB/Swiss-Prot
UniProt A0A8I6A721 ENTREZGENE, UniProtKB/TrEMBL
  A6JQ40 ENTREZGENE, UniProtKB/TrEMBL
  A6JQ41_RAT UniProtKB/TrEMBL
  MDHC_RAT UniProtKB/Swiss-Prot
  O88585 ENTREZGENE
  O88989 ENTREZGENE
  Q6PCV2 ENTREZGENE
UniProt Secondary O88585 UniProtKB/Swiss-Prot
  Q6PCV2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Mdh1  malate dehydrogenase 1  Mdh1  malate dehydrogenase 1, NAD (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mdh1  malate dehydrogenase 1, NAD (soluble)    malate dehydrogenase 1  Name updated 1299863 APPROVED
2003-05-19 Mdh1  malate dehydrogenase 1  Mor2  malate dehydrogenase, soluble  Data merged from RGD:619720 629477 PROVISIONAL
2003-04-09 Mdh1  malate dehydrogenase 1  Mdhl  Malate dehydrogenase-like enzyme  Symbol and Name updated 629477 APPROVED
2002-08-07 Mor2  malate dehydrogenase, soluble      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Mdhl  Malate dehydrogenase-like enzyme      Symbol and Name status set to approved 70586 APPROVED