Zfp386 (zinc finger protein 386 (Kruppel-like)) - Rat Genome Database

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Gene: Zfp386 (zinc finger protein 386 (Kruppel-like)) Rattus norvegicus
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Symbol: Zfp386
Name: zinc finger protein 386 (Kruppel-like)
RGD ID: 2985
Description: Enables double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be active in nucleus. Orthologous to human ZNF519 (zinc finger protein 519); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kruppel associated box (KRAB) zinc finger 1; Kzf1; Znf386
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86143,109,563 - 143,124,266 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6143,109,610 - 143,127,027 (+)EnsemblGRCr8
mRatBN7.26136,966,547 - 136,984,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6136,966,586 - 136,983,441 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6140,401,926 - 140,416,581 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06137,026,431 - 137,041,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06137,574,276 - 137,588,931 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06143,901,239 - 143,915,953 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6143,901,280 - 143,917,575 (+)Ensemblrn6Rnor6.0
Rnor_5.06152,840,202 - 152,870,895 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46143,311,722 - 143,326,401 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6134,633,475 - 134,647,999 (+)NCBICelera
RGSC_v3.16143,317,934 - 143,332,580 (+)NCBI
Cytogenetic Map6q33NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis. Bellefroid EJ, etal., Biochim Biophys Acta 1998 Jul 9;1398(3):321-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15522233  


Genomics

Comparative Map Data
Zfp386
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86143,109,563 - 143,124,266 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6143,109,610 - 143,127,027 (+)EnsemblGRCr8
mRatBN7.26136,966,547 - 136,984,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6136,966,586 - 136,983,441 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6140,401,926 - 140,416,581 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06137,026,431 - 137,041,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06137,574,276 - 137,588,931 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06143,901,239 - 143,915,953 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6143,901,280 - 143,917,575 (+)Ensemblrn6Rnor6.0
Rnor_5.06152,840,202 - 152,870,895 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46143,311,722 - 143,326,401 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6134,633,475 - 134,647,999 (+)NCBICelera
RGSC_v3.16143,317,934 - 143,332,580 (+)NCBI
Cytogenetic Map6q33NCBI
ZNF519
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381814,071,121 - 14,132,435 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1814,057,457 - 14,132,490 (-)Ensemblhg38GRCh38
GRCh371814,071,120 - 14,132,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361814,094,724 - 14,122,429 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341814,094,723 - 14,122,429NCBI
Celera1813,958,163 - 14,006,658 (-)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1814,030,183 - 14,086,706 (-)NCBIHuRef
CHM1_11814,075,972 - 14,132,482 (-)NCBICHM1_1
T2T-CHM13v2.01814,233,972 - 14,295,283 (-)NCBIT2T-CHM13v2.0
Zfp386
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,011,334 - 116,026,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12116,011,344 - 116,026,980 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812116,047,714 - 116,063,231 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,047,724 - 116,063,360 (+)Ensemblmm10GRCm38
MGSCv3712117,285,935 - 117,299,065 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612110,248,381 - 110,261,342 (+)NCBIMGSCv36mm8
MGSCv3612116,495,575 - 116,508,405 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1262.59NCBI
ZNF519
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21723,910,579 - 23,971,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,603,175 - 9,634,413 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v018189,977 - 247,868 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1182,407,349 - 2,416,671 (+)NCBIPanPan1.1PanPan1.1panPan2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:89
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000005648
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005648   ⟹   ENSRNOP00000005648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6143,109,655 - 143,124,261 (+)Ensembl
mRatBN7.2 Ensembl6136,974,968 - 136,981,202 (+)Ensembl
Rnor_6.0 Ensembl6143,901,320 - 143,915,944 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091884   ⟹   ENSRNOP00000070717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6143,109,610 - 143,127,027 (+)Ensembl
mRatBN7.2 Ensembl6136,966,586 - 136,983,441 (+)Ensembl
Rnor_6.0 Ensembl6143,901,280 - 143,917,575 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167430   ⟹   ENSRNOP00000106630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6143,109,610 - 143,124,261 (+)Ensembl
RefSeq Acc Id: NM_019620   ⟹   NP_062566
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,109,608 - 143,124,266 (+)NCBI
mRatBN7.26136,966,592 - 136,981,251 (+)NCBI
Rnor_6.06143,901,294 - 143,915,952 (+)NCBI
Rnor_5.06152,840,202 - 152,870,895 (+)NCBI
RGSC_v3.46143,311,722 - 143,326,401 (+)RGD
Celera6134,633,475 - 134,647,999 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111797   ⟹   XP_038967725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,118,135 - 143,124,266 (+)NCBI
mRatBN7.26136,975,121 - 136,984,013 (+)NCBI
RefSeq Acc Id: XM_039111798   ⟹   XP_038967726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,109,563 - 143,124,266 (+)NCBI
mRatBN7.26136,966,547 - 136,979,547 (+)NCBI
RefSeq Acc Id: XM_039111799   ⟹   XP_038967727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,109,563 - 143,122,798 (+)NCBI
mRatBN7.26136,966,547 - 136,979,547 (+)NCBI
RefSeq Acc Id: XM_063261557   ⟹   XP_063117627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,109,918 - 143,124,266 (+)NCBI
RefSeq Acc Id: XM_063261558   ⟹   XP_063117628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,118,135 - 143,124,266 (+)NCBI
RefSeq Acc Id: XR_005505444
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86143,109,563 - 143,122,798 (+)NCBI
mRatBN7.26136,966,547 - 136,979,706 (+)NCBI
RefSeq Acc Id: NP_062566   ⟸   NM_019620
- UniProtKB: Q6AYY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070717   ⟸   ENSRNOT00000091884
Ensembl Acc Id: ENSRNOP00000005648   ⟸   ENSRNOT00000005648
RefSeq Acc Id: XP_038967726   ⟸   XM_039111798
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967727   ⟸   XM_039111799
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038967725   ⟸   XM_039111797
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063117627   ⟸   XM_063261557
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117628   ⟸   XM_063261558
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000106630   ⟸   ENSRNOT00000167430
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAL7-F1-model_v2 AlphaFold F1MAL7 1-590 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694907
Promoter ID:EPDNEW_R5429
Type:initiation region
Name:Zfp386_1
Description:zinc finger protein 386 (Kruppel-like)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06143,901,361 - 143,901,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2985 AgrOrtholog
BioCyc Gene G2FUF-35517 BioCyc
Ensembl Genes ENSRNOG00000004268 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005648.9 UniProtKB/TrEMBL
  ENSRNOT00000091884 ENTREZGENE
  ENSRNOT00000091884.3 UniProtKB/TrEMBL
  ENSRNOT00000167430.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115131 IMAGE-MGC_LOAD
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Zinc_finger UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:25165 UniProtKB/TrEMBL
MGC_CLONE MGC:93475 IMAGE-MGC_LOAD
NCBI Gene 25165 ENTREZGENE
PANTHER FI01424P UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER AND SCAN DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 833-RELATED UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp386 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004268 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2JYM8_RAT UniProtKB/TrEMBL
  A0ABK0LW64_RAT UniProtKB/TrEMBL
  F1MAL7_RAT UniProtKB/TrEMBL
  Q6AYY1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-14 Zfp386  zinc finger protein 386 (Kruppel-like)  Znf386  zinc finger protein 386 (Kruppel-like)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Znf386  zinc finger protein 386 (Kruppel-like)  Kzf1  Kruppel associated box (KRAB) zinc finger 1  Symbol and Name updated 625702 APPROVED
2002-06-10 Kzf1  Kruppel associated box (KRAB) zinc finger 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed specifically in germ cells in the testis 633130