Serpina3c (serine (or cysteine) proteinase inhibitor, clade A, member 3C) - Rat Genome Database

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Gene: Serpina3c (serine (or cysteine) proteinase inhibitor, clade A, member 3C) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpina3c
Name: serine (or cysteine) proteinase inhibitor, clade A, member 3C
RGD ID: 2972
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; and positive regulation of apoptotic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: contrapsin-like protease inhibitor; contrapsin-like protease inhibitor 1; CPi-21; GHR-P63; growth hormone-regulated proteinase inhibitor; Kallikrein binding protein (kallistatin); kallikrein-binding protein; kallistatin; Kbp; Klkbp; RATKBP; serine (or cysteine) peptidase inhibitor, clade A, member 3K; Serine protease inhibitor; serine protease inhibitor 2; serine protease inhibitor 2b; serine protease inhibitor A3K; serpin A3K; Serpina3k; SPI-2; SPI-2.3; SPI2; Spin2; Spin2b; thyroid hormone-regulated protein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,007,578 - 129,014,988 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,829,577 - 129,014,971 (-)EnsemblGRCr8
mRatBN7.26123,240,251 - 123,250,219 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,064,804 - 123,250,202 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6123,383,901 - 123,391,296 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,679,195 - 123,686,590 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,043,908 - 123,051,318 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,996,162 - 128,003,433 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,996,165 - 128,003,418 (-)Ensemblrn6Rnor6.0
Rnor_5.06137,206,186 - 137,213,443 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,379,395 - 128,386,799 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,722,835 - 120,730,245 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and analysis of the rat kallikrein-binding protein gene. Chai KX, etal., J Biol Chem 1991 Aug 25;266(24):16029-36.
2. Kallikrein binding protein (KBP) maps to rat chromosome 6 but does not cosegregate with blood pressure in a GH x BN cross. Chen A, etal., Mamm Genome 1997 Sep;8(9):701-3.
3. Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage. Gao G, etal., Diabetologia. 2003 May;46(5):689-98. Epub 2003 May 13.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1694763   PMID:1864837   PMID:2258058   PMID:2398056   PMID:2440672   PMID:3494016   PMID:3778884   PMID:12477932   PMID:15489334   PMID:15638460   PMID:18762777   PMID:20081110  
PMID:20299474   PMID:20351274   PMID:21693707   PMID:22206666   PMID:23129128   PMID:35147994  


Genomics

Variants

.
Variants in Serpina3c
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000013896
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
D6Elh1   No map positions available.


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
6 9 15 57 81 76 51 27 51 5 156 63 1 37 28 46 25

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC062236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO560755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M67496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013896   ⟹   ENSRNOP00000013896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,829,577 - 129,014,971 (-)Ensembl
mRatBN7.2 Ensembl6123,064,804 - 123,250,202 (-)Ensembl
Rnor_6.0 Ensembl6127,996,165 - 128,003,418 (-)Ensembl
RefSeq Acc Id: NM_012657   ⟹   NP_036789
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,007,578 - 129,014,988 (-)NCBI
mRatBN7.26123,242,809 - 123,250,219 (-)NCBI
Rnor_6.06127,996,165 - 128,003,418 (-)NCBI
Rnor_5.06137,206,186 - 137,213,443 (-)NCBI
Celera6120,722,835 - 120,730,245 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240458   ⟹   XP_006240520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,007,578 - 129,014,983 (-)NCBI
mRatBN7.26123,240,251 - 123,250,214 (-)NCBI
Rnor_6.06127,996,162 - 128,003,433 (-)NCBI
Rnor_5.06137,206,186 - 137,213,443 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036789   ⟸   NM_012657
- Peptide Label: precursor
- UniProtKB: Q6P6G8 (UniProtKB/Swiss-Prot),   Q64254 (UniProtKB/Swiss-Prot),   P14281 (UniProtKB/Swiss-Prot),   P05545 (UniProtKB/Swiss-Prot),   A0A0G2JSK1 (UniProtKB/TrEMBL),   A6JEQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240520   ⟸   XM_006240458
- Peptide Label: isoform X1
- UniProtKB: Q6P6G8 (UniProtKB/Swiss-Prot),   Q64254 (UniProtKB/Swiss-Prot),   P14281 (UniProtKB/Swiss-Prot),   P05545 (UniProtKB/Swiss-Prot),   A0A0G2JSK1 (UniProtKB/TrEMBL),   A6JEQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013896   ⟸   ENSRNOT00000013896
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JSK1-F1-model_v2 AlphaFold A0A0G2JSK1 1-416 view protein structure
AF-P05545-F1-model_v2 AlphaFold P05545 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694804
Promoter ID:EPDNEW_R5329
Type:multiple initiation site
Name:Serpina3c_1
Description:serine proteinase inhibitor, clade A, member 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06128,003,419 - 128,003,479EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2972 AgrOrtholog
BioCyc Gene G2FUF-36385 BioCyc
Ensembl Genes ENSRNOG00000010410 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013896 ENTREZGENE
Gene3D-CATH Alpha-1-antitrypsin, domain 1 UniProtKB/Swiss-Prot
  Antithrombin, subunit I, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6888893 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:24794 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72900 IMAGE-MGC_LOAD
NCBI Gene Serpina3c ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR A3C-RELATED UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR, SERPIN UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpina3c PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010410 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP Serpins UniProtKB/Swiss-Prot
TIGR TC218435
UniProt A0A0G2JSK1 ENTREZGENE, UniProtKB/TrEMBL
  A6JEQ6 ENTREZGENE, UniProtKB/TrEMBL
  P05545 ENTREZGENE
  P14281 ENTREZGENE
  Q64254 ENTREZGENE
  Q6P6G8 ENTREZGENE
  SPA3K_RAT UniProtKB/Swiss-Prot
UniProt Secondary P14281 UniProtKB/Swiss-Prot
  Q64254 UniProtKB/Swiss-Prot
  Q6P6G8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-19 Serpina3c  serine (or cysteine) proteinase inhibitor, clade A, member 3C  Serpina3k  serine (or cysteine) peptidase inhibitor, clade A, member 3K  Data merged from RGD:3746 737654 APPROVED
2006-11-30 Serpina3k  serine (or cysteine) peptidase inhibitor, clade A, member 3K  Spin2b  Serine protease inhibitor  Symbol and Name updated 1299863 APPROVED
2003-04-09 Serpina3c  serine (or cysteine) proteinase inhibitor, clade A, member 3C  Klkbp  Kallikrein binding protein (kallistatin)  Symbol and Name updated 629477 APPROVED
2002-06-10 Spin2b  Serine protease inhibitor      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Klkbp  Kallikrein binding protein (kallistatin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in the kidneys of WKY rats as compared to the SHR rats 70854
gene_mapping does not cosegregate with the blood pressure locus on chr6 in the GH x BN cross 70854
gene_regulation expression is induced by sex hormone treatment 70847