Igfbp5 (insulin-like growth factor binding protein 5) - Rat Genome Database

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Gene: Igfbp5 (insulin-like growth factor binding protein 5) Rattus norvegicus
Analyze
Symbol: Igfbp5
Name: insulin-like growth factor binding protein 5
RGD ID: 2876
Description: Enables insulin-like growth factor binding activity. Involved in intracellular signal transduction. Predicted to be located in cytoplasm; extracellular region; and nucleus. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Biomarker of congenital diaphragmatic hernia. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,10-phenanthroline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IBP-5; IGF-binding protein 5; IGF-BP5; IGFBP-5; insulin-like growth factor-binding protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,901,605 - 81,914,187 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl981,897,616 - 81,914,390 (-)EnsemblGRCr8
mRatBN7.2974,452,371 - 74,464,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,448,382 - 74,465,156 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx982,907,194 - 82,919,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0988,036,079 - 88,048,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0986,422,859 - 86,435,462 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0980,154,230 - 80,166,813 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)Ensemblrn6Rnor6.0
Rnor_5.0979,924,622 - 79,937,205 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4972,003,637 - 72,016,263 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera972,045,541 - 72,058,122 (-)NCBICelera
RGSC_v3.1972,150,618 - 72,163,245 (-)NCBI
RH 3.4 Map9679.1RGD
Cytogenetic Map9q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aluminium trifluoride  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzamidine  (EXP)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
flavonoids  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nitrofen  (EXP)
Nonylphenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmethanesulfonyl fluoride  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
Thiorphan  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): role for protein kinase-C in the pre- and posttranslational modulation of IGFBP-4 and IGFBP-5. Chamoun D, etal., Biol Reprod 2002 Sep;67(3):1003-12.
2. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
3. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Fischer F, etal., Clin Endocrinol (Oxf). 2004 Nov;61(5):595-602.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland. Gonzalez-Parra S, etal., Horm Res 2002;57(1-2):10-4.
7. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Pilewski JM, etal., Am J Pathol. 2005 Feb;166(2):399-407.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Downregulation of insulin-like growth factor binding protein 3 and 5 in nitrofen-induced pulmonary hypoplasia. Ruttenstock E, etal., Pediatr Surg Int. 2010 Jan;26(1):59-63. doi: 10.1007/s00383-009-2509-5.
16. Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. Shimasaki S, etal., J Biol Chem 1991 Jun 5;266(16):10646-53.
17. Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent. Spangenburg EE, etal., Am J Physiol Endocrinol Metab 2003 Feb;284(2):E340-50.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Cloning of the rat insulin- like growth factor binding protein-5 gene and DNA sequence analysis of its promoter region. Zhu X, etal., Biochem Biophys Res Commun 1993 Feb 15;190(3):1045-52.
Additional References at PubMed
PMID:7559606   PMID:9497324   PMID:10766744   PMID:12477932   PMID:12626499   PMID:14566968   PMID:15010534   PMID:15589207   PMID:15700281   PMID:15845624   PMID:16024235   PMID:16204335  
PMID:16311053   PMID:16339387   PMID:16672690   PMID:16675541   PMID:17255210   PMID:18762576   PMID:19208758   PMID:19236847   PMID:19864299   PMID:19897600   PMID:20167606   PMID:21598309  
PMID:23417767   PMID:25127757   PMID:25230843   PMID:28077319   PMID:29016699   PMID:31310371   PMID:31926246   PMID:33035436   PMID:35821045  


Genomics

Comparative Map Data
Igfbp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,901,605 - 81,914,187 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl981,897,616 - 81,914,390 (-)EnsemblGRCr8
mRatBN7.2974,452,371 - 74,464,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,448,382 - 74,465,156 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx982,907,194 - 82,919,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0988,036,079 - 88,048,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0986,422,859 - 86,435,462 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0980,154,230 - 80,166,813 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)Ensemblrn6Rnor6.0
Rnor_5.0979,924,622 - 79,937,205 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4972,003,637 - 72,016,263 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera972,045,541 - 72,058,122 (-)NCBICelera
RGSC_v3.1972,150,618 - 72,163,245 (-)NCBI
RH 3.4 Map9679.1RGD
Cytogenetic Map9q33NCBI
IGFBP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,672,105 - 216,695,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,672,105 - 216,695,549 (-)Ensemblhg38GRCh38
GRCh372217,536,828 - 217,560,272 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,245,073 - 217,268,516 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342217,362,334 - 217,385,777NCBI
Celera2211,304,716 - 211,328,161 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2209,391,205 - 209,414,636 (-)NCBIHuRef
CHM1_12217,543,006 - 217,566,425 (-)NCBICHM1_1
T2T-CHM13v2.02217,154,530 - 217,177,979 (-)NCBIT2T-CHM13v2.0
Igfbp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,897,224 - 72,914,024 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,897,091 - 72,914,043 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38172,858,065 - 72,874,865 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,857,932 - 72,874,884 (-)Ensemblmm10GRCm38
MGSCv37172,904,639 - 72,921,439 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36172,791,272 - 72,808,072 (-)NCBIMGSCv36mm8
Celera173,426,251 - 73,443,205 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.94NCBI
Igfbp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,530,110 - 16,550,733 (+)Ensembl
ChiLan1.0NW_00495545316,530,110 - 16,550,733 (+)NCBIChiLan1.0ChiLan1.0
IGFBP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213119,300,448 - 119,324,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B119,315,416 - 119,339,017 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,932,983 - 103,956,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,534,967 - 222,558,432 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B222,534,967 - 222,558,432 (-)EnsemblpanPan2panpan1.1
IGFBP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,575,265 - 23,596,970 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,579,841 - 23,596,870 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3724,403,819 - 24,425,502 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03723,603,056 - 23,624,922 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,603,193 - 23,624,698 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,486,557 - 23,508,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03723,439,644 - 23,461,314 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03723,458,321 - 23,480,088 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igfbp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,959,265 - 171,978,245 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936586647,493 - 666,621 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936586647,553 - 666,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,857,625 - 118,878,120 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115118,861,816 - 118,877,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,682,267 - 131,684,608 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110102,510,939 - 102,531,710 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10102,510,897 - 102,531,724 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604096,877,547 - 96,898,347 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248238,434,635 - 8,454,747 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248238,434,614 - 8,454,879 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Igfbp5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14146,373,051 - 146,390,057 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Igfbp5
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:611
Count of miRNA genes:263
Interacting mature miRNAs:364
Transcripts:ENSRNOT00000023530
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
D9Wox32  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0979,937,995 - 79,938,109NCBIRnor5.0
RGSC_v3.4972,017,507 - 72,017,728UniSTSRGSC3.4
Cytogenetic Map9q33UniSTS
RH127562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,448,393 - 74,448,601 (+)MAPPERmRatBN7.2
Rnor_6.0980,150,253 - 80,150,460NCBIRnor6.0
Rnor_5.0979,920,645 - 79,920,852UniSTSRnor5.0
RGSC_v3.4971,999,660 - 71,999,867UniSTSRGSC3.4
Celera972,041,564 - 72,041,771UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS
RH94791  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,464,690 - 74,464,989 (+)MAPPERmRatBN7.2
Rnor_6.0980,166,551 - 80,166,849NCBIRnor6.0
Rnor_5.0979,936,943 - 79,937,241UniSTSRnor5.0
RGSC_v3.4972,016,001 - 72,016,299UniSTSRGSC3.4
Celera972,057,860 - 72,058,158UniSTS
RH 3.4 Map9679.1UniSTS
Cytogenetic Map9q33UniSTS
AA963598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,448,392 - 74,448,603 (+)MAPPERmRatBN7.2
Rnor_6.0980,150,252 - 80,150,462NCBIRnor6.0
Rnor_5.0979,920,644 - 79,920,854UniSTSRnor5.0
RGSC_v3.4971,999,659 - 71,999,869UniSTSRGSC3.4
Celera972,041,563 - 72,041,773UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS
Igfbp5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,452,653 - 74,453,508 (+)MAPPERmRatBN7.2
Rnor_6.0980,154,513 - 80,155,367NCBIRnor6.0
Rnor_5.0979,924,905 - 79,925,759UniSTSRnor5.0
RGSC_v3.4972,003,920 - 72,004,774UniSTSRGSC3.4
Celera972,045,824 - 72,046,678UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 155 91 90 59 37 59 6 301 137 11 134 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000023530   ⟹   ENSRNOP00000023530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl981,897,616 - 81,914,390 (-)Ensembl
mRatBN7.2 Ensembl974,448,382 - 74,465,156 (-)Ensembl
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079493   ⟹   ENSRNOP00000069640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl980,154,230 - 80,166,807 (-)Ensembl
RefSeq Acc Id: NM_012817   ⟹   NP_036949
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8981,901,605 - 81,914,187 (-)NCBI
mRatBN7.2974,452,371 - 74,464,953 (-)NCBI
Rnor_6.0980,154,230 - 80,166,813 (-)NCBI
Rnor_5.0979,924,622 - 79,937,205 (-)NCBI
RGSC_v3.4972,003,637 - 72,016,263 (-)RGD
Celera972,045,541 - 72,058,122 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53533 (Get FASTA)   NCBI Sequence Viewer  
  AAN87105 (Get FASTA)   NCBI Sequence Viewer  
  EDL75317 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023530
  ENSRNOP00000023530.3
GenBank Protein P24594 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036949   ⟸   NM_012817
- Peptide Label: precursor
- UniProtKB: P24594 (UniProtKB/Swiss-Prot),   A6JVR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069640   ⟸   ENSRNOT00000079493
Ensembl Acc Id: ENSRNOP00000023530   ⟸   ENSRNOT00000023530
Protein Domains
IGFBP N-terminal   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24594-F1-model_v2 AlphaFold P24594 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696740
Promoter ID:EPDNEW_R7265
Type:single initiation site
Name:Igfbp5_1
Description:insulin-like growth factor binding protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0980,167,035 - 80,167,095EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2876 AgrOrtholog
BioCyc Gene G2FUF-27190 BioCyc
Ensembl Genes ENSRNOG00000017206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023530 ENTREZGENE
  ENSRNOT00000023530.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.20 UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110383 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-5 UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report rno:25285 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93594 IMAGE-MGC_LOAD
NCBI Gene 25285 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR11551:SF4 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Igfbp5 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot
  IGFBPFAMILY5 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017206 RatGTEx
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
TIGR TC217713
UniProt A6JVR0 ENTREZGENE, UniProtKB/TrEMBL
  IBP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Igfbp5  insulin-like growth factor binding protein 5    insulin-like growth factor-binding protein 5  Name updated 1299863 APPROVED
2002-06-10 Igfbp5  insulin-like growth factor-binding protein 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in soleus muscle 729113
gene_regulation expression is decreased in soleus muscle by aging 729113