Gys2 (glycogen synthase 2) - Rat Genome Database

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Gene: Gys2 (glycogen synthase 2) Rattus norvegicus
Analyze
Symbol: Gys2
Name: glycogen synthase 2
RGD ID: 2773
Description: Enables D-glucose binding activity and alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in glycogen biosynthetic process and response to glucose. Located in cortical actin cytoskeleton and cytosol. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2); PARTICIPATES IN glycogen biosynthetic pathway; glycogen metabolic pathway; congenital sucrase-isomaltase deficiency pathway; INTERACTS WITH 1-benzylpiperazine; 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycogen [starch] synthase, liver; Glycogen synthase 2 (liver); GLYSN
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,096,063 - 177,137,236 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4177,096,063 - 177,137,236 (-)EnsemblGRCr8
mRatBN7.24175,365,054 - 175,406,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,365,054 - 175,406,228 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4181,659,898 - 181,701,068 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,444,169 - 177,485,337 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,064,732 - 176,105,904 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,638,632 - 176,679,805 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,638,629 - 176,679,815 (-)Ensemblrn6Rnor6.0
Rnor_5.04240,856,037 - 240,896,372 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44179,984,036 - 180,018,819 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4163,897,690 - 163,941,472 (-)NCBICelera
RGSC_v3.14180,229,159 - 180,263,943 (-)NCBI
RH 3.4 Map41028.6RGD
Cytogenetic Map4q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-benzylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (EXP,ISO)
dichlorvos  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
glycidol  (EXP)
inulin  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methylarsonite  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nicotinamide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B1  (ISO)
propiconazole  (ISO)
resveratrol  (EXP)
sevoflurane  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetracycline  (EXP)
titanium dioxide  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell cortex  (IDA)
cortical actin cytoskeleton  (IDA)
cytoplasm  (IBA,IDA)
cytoskeleton  (IDA)
cytosol  (IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The primary structure of rat liver glycogen synthase deduced by cDNA cloning. Absence of phosphorylation sites 1a and 1b. Bai G, etal., J Biol Chem 1990 May 15;265(14):7843-8.
2. Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes. Carabaza A, etal., FEBS Lett. 1992 Jan 20;296(2):211-4.
3. Glycogen synthase: towards a minimum catalytic unit? Cid E, etal., FEBS Lett. 2002 Sep 25;528(1-3):5-11.
4. Glucose induces the translocation of glycogen synthase to the cell cortex in rat hepatocytes. Fernandez-Novell JM, etal., Biochem J. 1997 Jan 1;321 ( Pt 1):227-31.
5. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
6. Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes. Garcia-Rocha M, etal., Biochem J. 2001 Jul 1;357(Pt 1):17-24.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Glycogen synthesis by rat hepatocytes. Katz J, etal., Biochem J. 1979 May 15;180(2):389-402.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
16. Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0. Orho M, etal., J Clin Invest. 1998 Aug 1;102(3):507-15.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Effects of the specific cAMP antagonist, (Rp)-adenosine cyclic 3',5'-phosphorothioate, on the cAMP-dependent protein kinase-induced activity of hepatic glycogen phosphorylase and glycogen synthase. Rothermel JD, etal., J Biol Chem. 1984 Dec 25;259(24):15294-300.
23. Glycogen-binding protein components of rat tissues. Satoh K and Sato K, Biochem Biophys Res Commun. 1980 Sep 16;96(1):28-33.
24. Comparative characterization of human and rat liver glycogen synthase. Westphal SA and Nuttall FQ, Arch Biochem Biophys. 1992 Feb 1;292(2):479-86.
Additional References at PubMed
PMID:1898724   PMID:12519761   PMID:17200418   PMID:17880910   PMID:19124463   PMID:20841354  


Genomics

Comparative Map Data
Gys2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,096,063 - 177,137,236 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4177,096,063 - 177,137,236 (-)EnsemblGRCr8
mRatBN7.24175,365,054 - 175,406,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,365,054 - 175,406,228 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4181,659,898 - 181,701,068 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,444,169 - 177,485,337 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,064,732 - 176,105,904 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,638,632 - 176,679,805 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,638,629 - 176,679,815 (-)Ensemblrn6Rnor6.0
Rnor_5.04240,856,037 - 240,896,372 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44179,984,036 - 180,018,819 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4163,897,690 - 163,941,472 (-)NCBICelera
RGSC_v3.14180,229,159 - 180,263,943 (-)NCBI
RH 3.4 Map41028.6RGD
Cytogenetic Map4q44NCBI
GYS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,532,577 - 21,604,847 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,536,107 - 21,604,917 (-)Ensemblhg38GRCh38
GRCh371221,689,041 - 21,757,781 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,580,390 - 21,649,048 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341221,580,391 - 21,648,821NCBI
Celera1226,844,519 - 26,913,106 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,463,128 - 21,531,710 (-)NCBIHuRef
CHM1_11221,654,730 - 21,723,356 (-)NCBICHM1_1
T2T-CHM13v2.01221,415,082 - 21,483,766 (-)NCBIT2T-CHM13v2.0
Gys2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,368,339 - 142,418,856 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,368,339 - 142,418,835 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386142,422,612 - 142,473,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,422,613 - 142,473,109 (-)Ensemblmm10GRCm38
MGSCv376142,371,133 - 142,421,629 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366142,379,835 - 142,430,174 (-)NCBIMGSCv36mm8
MGSCv366142,999,467 - 143,049,414 (-)NCBIMGSCv36mm8
Celera6145,483,115 - 145,534,322 (-)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.04NCBI
Gys2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,178,983 - 17,240,213 (-)Ensembl
ChiLan1.0NW_00495541317,182,342 - 17,240,180 (-)NCBIChiLan1.0ChiLan1.0
GYS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21075,197,392 - 75,266,040 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11275,193,790 - 75,262,438 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,693,285 - 64,761,855 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,297,131 - 67,365,773 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,297,131 - 67,365,773 (+)EnsemblpanPan2panpan1.1
GYS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,509,833 - 25,558,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,509,655 - 25,558,844 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2720,792,441 - 20,848,094 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02725,732,712 - 25,788,382 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,732,517 - 25,788,145 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,531,505 - 25,581,297 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,554,947 - 25,604,305 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02720,968,756 - 21,018,506 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gys2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,333,228 - 87,395,940 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365485,256,437 - 5,309,758 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365485,256,185 - 5,309,758 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GYS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,862,863 - 51,917,757 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1551,862,952 - 51,915,153 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,129,103 - 55,191,552 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GYS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,400,582 - 21,464,438 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,398,869 - 21,463,277 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606913,681,409 - 13,742,874 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gys2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,090,563 - 17,143,493 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475217,090,741 - 17,145,823 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gys2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16172,350 - 214,986 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gys2
234 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:35
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000066553
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4176806581181925369Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
RH133339  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84177,096,216 - 177,096,937 (+)Marker Load Pipeline
mRatBN7.24175,365,207 - 175,365,928 (+)MAPPERmRatBN7.2
Rnor_6.04176,638,786 - 176,639,506NCBIRnor6.0
Rnor_5.04240,856,190 - 240,856,910UniSTSRnor5.0
Rnor_5.04240,852,611 - 240,853,331UniSTSRnor5.0
RGSC_v3.44179,984,189 - 179,984,909UniSTSRGSC3.4
Celera4163,897,844 - 163,898,564UniSTS
RH 3.4 Map41043.4UniSTS
Cytogenetic Map4q44UniSTS
RH142415  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84177,096,215 - 177,096,940 (+)Marker Load Pipeline
mRatBN7.24175,365,206 - 175,365,931 (+)MAPPERmRatBN7.2
Rnor_6.04176,638,785 - 176,639,509NCBIRnor6.0
Rnor_5.04240,856,189 - 240,856,913UniSTSRnor5.0
Rnor_5.04240,852,610 - 240,853,334UniSTSRnor5.0
RGSC_v3.44179,984,188 - 179,984,912UniSTSRGSC3.4
Celera4163,897,843 - 163,898,567UniSTS
RH 3.4 Map41028.6UniSTS
Cytogenetic Map4q44UniSTS
Gys2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,392,871 - 175,392,943 (+)MAPPERmRatBN7.2
Rnor_6.04176,666,449 - 176,666,520NCBIRnor6.0
Rnor_5.04240,883,602 - 240,883,673UniSTSRnor5.0
RGSC_v3.44180,005,218 - 180,005,289UniSTSRGSC3.4
Celera4163,928,075 - 163,928,146UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 8 54 109 91 89 59 26 59 6 241 108 8 84 60 74 30 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000090122   ⟹   ENSRNOP00000074743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4177,096,063 - 177,137,236 (-)Ensembl
mRatBN7.2 Ensembl4175,365,054 - 175,406,228 (-)Ensembl
Rnor_6.0 Ensembl4176,638,629 - 176,679,815 (-)Ensembl
RefSeq Acc Id: NM_013089   ⟹   NP_037221
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,096,063 - 177,137,236 (-)NCBI
mRatBN7.24175,365,054 - 175,406,228 (-)NCBI
Rnor_6.04176,638,632 - 176,679,805 (-)NCBI
Rnor_5.04240,856,037 - 240,896,372 (-)NCBI
RGSC_v3.44179,984,036 - 180,018,819 (-)RGD
Celera4163,897,690 - 163,941,472 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037221 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41255 (Get FASTA)   NCBI Sequence Viewer  
  AAK16592 (Get FASTA)   NCBI Sequence Viewer  
  EDM01496 (Get FASTA)   NCBI Sequence Viewer  
  EDM01497 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074743
GenBank Protein P17625 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037221   ⟸   NM_013089
- UniProtKB: Q99MF8 (UniProtKB/Swiss-Prot),   P17625 (UniProtKB/Swiss-Prot),   D4A5K9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074743   ⟸   ENSRNOT00000090122

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17625-F1-model_v2 AlphaFold P17625 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693488
Promoter ID:EPDNEW_R4012
Type:initiation region
Name:Gys2_2
Description:glycogen synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4013  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,679,650 - 176,679,710EPDNEW
RGD ID:13693489
Promoter ID:EPDNEW_R4013
Type:initiation region
Name:Gys2_1
Description:glycogen synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4012  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,679,803 - 176,679,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2773 AgrOrtholog
BioCyc Gene G2FUF-42492 BioCyc
Ensembl Genes ENSRNOG00000059753 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090122 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro Glycogen_synth UniProtKB/Swiss-Prot
NCBI Gene 25623 ENTREZGENE
PANTHER GLYCOGEN [STARCH] SYNTHASE, LIVER UniProtKB/Swiss-Prot
  PTHR10176 UniProtKB/Swiss-Prot
Pfam Glycogen_syn UniProtKB/Swiss-Prot
PhenoGen Gys2 PhenoGen
RatGTEx ENSRNOG00000059753 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A6IMU2_RAT UniProtKB/TrEMBL
  A6IMU3_RAT UniProtKB/TrEMBL
  D4A5K9 ENTREZGENE, UniProtKB/TrEMBL
  GYS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99MF8 ENTREZGENE
UniProt Secondary Q99MF8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gys2  Glycogen synthase 2 (liver)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 703 amino acids; 80.5 kDa 728434