Gucy1b2 (guanylate cyclase 1 soluble subunit beta 2) - Rat Genome Database

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Gene: Gucy1b2 (guanylate cyclase 1 soluble subunit beta 2) Rattus norvegicus
Analyze
Symbol: Gucy1b2
Name: guanylate cyclase 1 soluble subunit beta 2
RGD ID: 2770
Description: Enables nitric oxide binding activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytosol. Predicted to be part of guanylate cyclase complex, soluble. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GCS-beta-2; guanylate cyclase 1 soluble beta 2; guanylate cyclase 1, soluble, beta 2; Guanylate cyclase soluble beta 2 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit beta-2; guanylate cyclase, soluble, beta 2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); Gucy1b2a; Gucy1b2b; SGC; soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81540,774,907 - 40,845,463 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1540,774,906 - 40,845,463 (-)EnsemblGRCr8
mRatBN7.21536,589,501 - 36,669,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,598,883 - 36,669,441 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1538,483,209 - 38,545,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01539,633,844 - 39,696,424 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,067,533 - 38,130,118 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01545,479,662 - 45,550,285 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,479,658 - 45,550,285 (-)Ensemblrn6Rnor6.0
Rnor_5.01549,255,071 - 49,325,713 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41541,620,373 - 41,668,802 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1536,296,636 - 36,358,650 (-)NCBICelera
RGSC_v3.11541,636,072 - 41,684,502 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat. Azam M, etal., Hypertension 1998 Jul;32(1):149-54.
2. The beta 2 subunit of nitric oxide-sensitive guanylyl cyclase is developmentally regulated in rat kidney. Behrends S, etal., Naunyn Schmiedebergs Arch Pharmacol 2001 Dec;364(6):573-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Nitric oxide activates the beta 2 subunit of soluble guanylyl cyclase in the absence of a second subunit. Koglin M, etal., J Biol Chem 2001 Aug 17;276(33):30737-43. Epub 2001 Jun 13.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.
11. A new form of guanylyl cyclase is preferentially expressed in rat kidney. Yuen PS, etal., Biochemistry 1990 Dec 11;29(49):10872-8.
Additional References at PubMed
PMID:20623   PMID:1298938   PMID:14687925   PMID:15652699   PMID:16331987  


Genomics

Comparative Map Data
Gucy1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81540,774,907 - 40,845,463 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1540,774,906 - 40,845,463 (-)EnsemblGRCr8
mRatBN7.21536,589,501 - 36,669,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,598,883 - 36,669,441 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1538,483,209 - 38,545,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01539,633,844 - 39,696,424 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,067,533 - 38,130,118 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01545,479,662 - 45,550,285 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,479,658 - 45,550,285 (-)Ensemblrn6Rnor6.0
Rnor_5.01549,255,071 - 49,325,713 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41541,620,373 - 41,668,802 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1536,296,636 - 36,358,650 (-)NCBICelera
RGSC_v3.11541,636,072 - 41,684,502 (-)NCBI
Cytogenetic Map15p12NCBI
GUCY1B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381350,994,511 - 51,066,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,006,991 - 51,062,894 (-)Ensemblhg38GRCh38
GRCh38.p14 Ensembl1350,994,505 - 51,080,862 (-)Ensemblhg38GRCh38
GRCh371351,568,647 - 51,640,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,466,770 - 50,538,143 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341350,466,648 - 50,538,143NCBI
Celera1332,617,656 - 32,689,305 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1332,357,567 - 32,429,119 (-)NCBIHuRef
CHM1_11351,535,852 - 51,607,823 (-)NCBICHM1_1
T2T-CHM13v2.01350,209,471 - 50,281,130 (-)NCBIT2T-CHM13v2.0
Gucy1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,610,384 - 62,693,745 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,630,125 - 62,693,738 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381462,372,935 - 62,456,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,392,676 - 62,456,289 (-)Ensemblmm10GRCm38
MGSCv371463,011,513 - 63,075,126 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361461,346,786 - 61,410,399 (-)NCBIMGSCv36mm8
Celera1460,167,130 - 60,218,922 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.21NCBI
LOC485435
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122912,345 - 922,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22944,177 - 948,277 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.022893,270 - 897,370 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.122814,253 - 818,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022863,454 - 867,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022881,784 - 885,883 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100625149
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11116,772,313 - 16,811,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Gucy1b2
450 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:36
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000012948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 6 38 141 91 90 59 79 59 6 297 145 11 119 74 64 31 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB058888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB109451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB114835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF352566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY004153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012948   ⟹   ENSRNOP00000012948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1540,782,893 - 40,845,463 (-)Ensembl
mRatBN7.2 Ensembl1536,606,870 - 36,669,441 (-)Ensembl
Rnor_6.0 Ensembl1545,487,645 - 45,550,285 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081912   ⟹   ENSRNOP00000071659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1540,774,906 - 40,819,831 (-)Ensembl
mRatBN7.2 Ensembl1536,598,883 - 36,643,807 (-)Ensembl
Rnor_6.0 Ensembl1545,479,658 - 45,524,582 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087678   ⟹   ENSRNOP00000073161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1540,782,893 - 40,840,491 (-)Ensembl
mRatBN7.2 Ensembl1536,606,870 - 36,664,889 (-)Ensembl
Rnor_6.0 Ensembl1545,487,573 - 45,545,875 (-)Ensembl
RefSeq Acc Id: NM_001270711   ⟹   NP_001257640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81540,782,877 - 40,845,463 (-)NCBI
mRatBN7.21536,606,854 - 36,669,441 (-)NCBI
Rnor_6.01545,487,629 - 45,550,285 (-)NCBI
Rnor_5.01549,255,071 - 49,325,713 (-)NCBI
Celera1536,296,636 - 36,358,650 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012770   ⟹   NP_036902
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81540,782,877 - 40,831,307 (-)NCBI
mRatBN7.21536,606,854 - 36,655,285 (-)NCBI
Rnor_6.01545,487,629 - 45,536,058 (-)NCBI
Rnor_5.01549,255,071 - 49,325,713 (-)NCBI
RGSC_v3.41541,620,373 - 41,668,802 (-)RGD
Celera1536,296,636 - 36,345,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770741   ⟹   XP_008768963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81540,774,907 - 40,840,576 (-)NCBI
mRatBN7.21536,598,884 - 36,655,498 (-)NCBI
Rnor_6.01545,479,662 - 45,545,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063273993   ⟹   XP_063130063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81540,782,869 - 40,840,922 (-)NCBI
RefSeq Acc Id: NP_036902   ⟸   NM_012770
- Peptide Label: isoform 2
- UniProtKB: F1M7R3 (UniProtKB/TrEMBL),   Q80WY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257640   ⟸   NM_001270711
- Peptide Label: isoform 1
- UniProtKB: A0A0G2QC51 (UniProtKB/TrEMBL),   Q91XJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768963   ⟸   XM_008770741
- Peptide Label: isoform X2
- UniProtKB: Q91XJ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073161   ⟸   ENSRNOT00000087678
Ensembl Acc Id: ENSRNOP00000071659   ⟸   ENSRNOT00000081912
Ensembl Acc Id: ENSRNOP00000012948   ⟸   ENSRNOT00000012948
RefSeq Acc Id: XP_063130063   ⟸   XM_063273993
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4T2 (UniProtKB/TrEMBL),   Q91XJ7 (UniProtKB/TrEMBL)
Protein Domains
Guanylate cyclase   Haem NO binding associated   Heme NO-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22717-F1-model_v2 AlphaFold P22717 1-682 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2770 AgrOrtholog
BioCyc Gene G2FUF-13462 BioCyc
Ensembl Genes ENSRNOG00000009440 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012948 ENTREZGENE
  ENSRNOT00000081912 ENTREZGENE
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot
  3.30.70.1230 UniProtKB/Swiss-Prot
  3.90.1520.10 UniProtKB/Swiss-Prot
  6.10.250.780 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  H-NOX_domain_sf UniProtKB/Swiss-Prot
  Heme_NO-bd UniProtKB/Swiss-Prot
  HNOB_dom_associated UniProtKB/Swiss-Prot
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
KEGG Report rno:25206 UniProtKB/Swiss-Prot
NCBI Gene 25206 ENTREZGENE
PANTHER GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 UniProtKB/Swiss-Prot
  GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 UniProtKB/Swiss-Prot
Pfam Guanylate_cyc UniProtKB/Swiss-Prot
  HNOB UniProtKB/Swiss-Prot
  HNOBA UniProtKB/Swiss-Prot
PhenoGen Gucy1b2 PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009440 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111126 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
UniProt A0A0G2K4T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2QC51 ENTREZGENE, UniProtKB/TrEMBL
  A6K6D0_RAT UniProtKB/TrEMBL
  A6K6D4_RAT UniProtKB/TrEMBL
  A6K6D5_RAT UniProtKB/TrEMBL
  F1M7R3 ENTREZGENE
  GCYB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80WX7_RAT UniProtKB/TrEMBL
  Q80WY0 ENTREZGENE, UniProtKB/TrEMBL
  Q91XJ7 ENTREZGENE, UniProtKB/TrEMBL
  Q920Q1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Gucy1b2  guanylate cyclase 1 soluble subunit beta 2  Gucy1b2  guanylate cyclase 1, soluble, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gucy1b2  guanylate cyclase 1, soluble, beta 2    guanylate cyclase, soluble, beta 2  Name updated 1299863 APPROVED
2003-04-09 Gucy1b2  guanylate cyclase, soluble, beta 2    guanylate cyclase 1, soluble, beta 2  Name updated 629478 APPROVED
2002-06-10 Gucy1b2  guanylate cyclase 1, soluble, beta 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation 61495
gene_expression expressed at higher levels in kidney and liver than Gucy1b1 61495
gene_process maybe involved in the regulation of blood pressure 61495
gene_process may control salt-sensitive hypertension 61495