Tle5 (TLE family member 5, transcriptional modulator) - Rat Genome Database

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Gene: Tle5 (TLE family member 5, transcriptional modulator) Rattus norvegicus
Analyze
Symbol: Tle5
Name: TLE family member 5, transcriptional modulator
RGD ID: 2731
Description: Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of macromolecule biosynthetic process; and positive regulation of anoikis. Predicted to act upstream of or within regulation of DNA-templated transcription; regulation of growth; and skeletal system development. Predicted to be located in nucleus. Orthologous to human TLE5 (TLE family member 5, transcriptional modulator); INTERACTS WITH 17beta-estradiol; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Aes; amino enhancer of split; amino-terminal enhancer of split; Grg; Grg-5; groucho-related protein 5; MGC124620; R-esp1; related to Drosophila groucho; related to Drosophila groucho gene; TLE family member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,794,123 - 8,801,056 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl78,793,796 - 8,801,054 (-)EnsemblGRCr8
mRatBN7.278,143,357 - 8,150,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,143,357 - 8,150,113 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,029,652 - 11,036,443 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,905,315 - 12,912,106 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,772,459 - 10,779,245 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,012,843 - 11,018,156 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,013,681 - 11,018,160 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,180,239 - 11,187,223 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.479,616,545 - 9,621,697 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,334,418 - 6,339,570 (-)NCBICelera
RGSC_v3.179,616,544 - 9,621,684 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer. Okada Y, etal., Cancer Sci. 2017 Apr;108(4):744-752. doi: 10.1111/cas.13187. Epub 2017 Apr 12.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. Schmidt CJ and Sladek TE, J Biol Chem 1993 Dec 5;268(34):25681-6.
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Wang Z, etal., Theranostics. 2021 Mar 4;11(9):4421-4435. doi: 10.7150/thno.53901. eCollection 2021.
Additional References at PubMed
PMID:10322635   PMID:10660609   PMID:11984876   PMID:12050133   PMID:12477932   PMID:15006356   PMID:15489227   PMID:16002402   PMID:19460168   PMID:19796622   PMID:22871113   PMID:22952044  
PMID:27107012  


Genomics

Comparative Map Data
Tle5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,794,123 - 8,801,056 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl78,793,796 - 8,801,054 (-)EnsemblGRCr8
mRatBN7.278,143,357 - 8,150,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,143,357 - 8,150,113 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,029,652 - 11,036,443 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,905,315 - 12,912,106 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,772,459 - 10,779,245 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,012,843 - 11,018,156 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,013,681 - 11,018,160 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,180,239 - 11,187,223 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.479,616,545 - 9,621,697 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,334,418 - 6,339,570 (-)NCBICelera
RGSC_v3.179,616,544 - 9,621,684 (-)NCBI
Cytogenetic Map7q11NCBI
TLE5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,052,910 - 3,062,966 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,052,909 - 3,063,107 (-)Ensemblhg38GRCh38
GRCh37193,052,908 - 3,062,964 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,003,908 - 3,013,964 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34193,003,907 - 3,013,371NCBI
Celera192,987,104 - 2,997,160 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,819,951 - 2,846,898 (-)NCBIHuRef
CHM1_1193,053,022 - 3,063,007 (-)NCBICHM1_1
T2T-CHM13v2.0193,026,363 - 3,036,419 (-)NCBIT2T-CHM13v2.0
Tle5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,395,278 - 81,402,205 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,395,322 - 81,402,196 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381081,559,444 - 81,566,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,559,488 - 81,566,362 (+)Ensemblmm10GRCm38
MGSCv371081,022,305 - 81,029,109 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,962,732 - 80,969,293 (+)NCBIMGSCv36mm8
Celera1082,582,741 - 82,589,545 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tle5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,327,595 - 5,336,715 (+)Ensembl
ChiLan1.0NW_0049554955,328,299 - 5,336,195 (+)NCBIChiLan1.0ChiLan1.0
TLE5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,448,879 - 7,459,190 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,681,720 - 6,692,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,078,933 - 2,089,117 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,029,627 - 3,038,156 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,030,550 - 3,040,375 (-)EnsemblpanPan2panpan1.1
TLE5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2055,914,532 - 55,922,778 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02056,849,569 - 56,857,811 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,803,938 - 56,857,636 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,904,684 - 55,912,933 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,388,895 - 56,397,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,587,646 - 56,595,884 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tle5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,081,073 - 216,088,483 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,746,843 - 1,752,275 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,746,300 - 1,753,727 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLE5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,492,233 - 75,501,542 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1275,492,208 - 75,501,543 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TLE5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,822,814 - 2,832,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660815,749,591 - 5,759,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tle5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,113,044 - 6,121,720 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248286,113,037 - 6,121,951 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tle5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11153,325,108 - 153,331,921 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tle5
16 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH127590  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,143,375 - 8,143,590 (+)MAPPERmRatBN7.2
Rnor_6.0711,012,862 - 11,013,076NCBIRnor6.0
Rnor_5.0711,180,258 - 11,180,472UniSTSRnor5.0
RGSC_v3.479,616,564 - 9,616,778UniSTSRGSC3.4
Celera76,334,437 - 6,334,651UniSTS
Cytogenetic Map7q11UniSTS
RH135261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,145,954 - 8,146,136 (+)MAPPERmRatBN7.2
Rnor_6.0711,015,602 - 11,015,783NCBIRnor6.0
Rnor_5.0711,182,837 - 11,183,018UniSTSRnor5.0
RGSC_v3.479,619,143 - 9,619,324UniSTSRGSC3.4
Celera76,337,016 - 6,337,197UniSTS
RH 3.4 Map716.4UniSTS
Cytogenetic Map7q11UniSTS
RH125487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,143,376 - 8,143,592 (+)MAPPERmRatBN7.2
Rnor_6.0711,012,863 - 11,013,078NCBIRnor6.0
Rnor_5.0711,180,259 - 11,180,474UniSTSRnor5.0
RGSC_v3.479,616,565 - 9,616,780UniSTSRGSC3.4
Celera76,334,438 - 6,334,653UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:532261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,143,385 - 8,143,805 (+)MAPPERmRatBN7.2
Rnor_6.0711,012,872 - 11,013,291NCBIRnor6.0
Rnor_5.0711,180,268 - 11,180,687UniSTSRnor5.0
Celera76,334,447 - 6,334,866UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000092061   ⟹   ENSRNOP00000071178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl78,794,123 - 8,799,506 (-)Ensembl
mRatBN7.2 Ensembl78,143,357 - 8,148,740 (-)Ensembl
Rnor_6.0 Ensembl711,013,681 - 11,018,160 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098364   ⟹   ENSRNOP00000079330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl78,793,796 - 8,800,879 (-)Ensembl
mRatBN7.2 Ensembl78,143,357 - 8,149,184 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100632   ⟹   ENSRNOP00000097044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl78,794,123 - 8,801,054 (-)Ensembl
mRatBN7.2 Ensembl78,143,357 - 8,149,231 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113477   ⟹   ENSRNOP00000092723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl78,794,120 - 8,800,879 (-)Ensembl
mRatBN7.2 Ensembl78,143,357 - 8,150,113 (-)Ensembl
RefSeq Acc Id: NM_019220   ⟹   NP_062093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,794,123 - 8,800,922 (-)NCBI
mRatBN7.278,143,357 - 8,150,156 (-)NCBI
Rnor_6.0711,012,843 - 11,018,156 (-)NCBI
Rnor_5.0711,180,239 - 11,187,223 (-)NCBI
RGSC_v3.479,616,545 - 9,621,697 (-)RGD
Celera76,334,418 - 6,339,570 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078583   ⟹   XP_038934511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,794,330 - 8,801,033 (-)NCBI
mRatBN7.278,143,357 - 8,150,273 (-)NCBI
RefSeq Acc Id: XM_039078584   ⟹   XP_038934512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,794,330 - 8,801,038 (-)NCBI
mRatBN7.278,143,357 - 8,150,279 (-)NCBI
RefSeq Acc Id: XM_039078585   ⟹   XP_038934513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,794,330 - 8,801,048 (-)NCBI
mRatBN7.278,143,357 - 8,150,273 (-)NCBI
RefSeq Acc Id: XM_039078586   ⟹   XP_038934514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,795,604 - 8,801,045 (-)NCBI
mRatBN7.278,144,838 - 8,150,287 (-)NCBI
RefSeq Acc Id: XM_039078587   ⟹   XP_038934515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,796,464 - 8,801,056 (-)NCBI
mRatBN7.278,145,766 - 8,150,295 (-)NCBI
RefSeq Acc Id: NP_062093   ⟸   NM_019220
- UniProtKB: Q3MIF3 (UniProtKB/Swiss-Prot),   P63003 (UniProtKB/Swiss-Prot),   A0A0G2JZT6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071178   ⟸   ENSRNOT00000092061
RefSeq Acc Id: XP_038934512   ⟸   XM_039078584
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ARX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934513   ⟸   XM_039078585
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JZT6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934511   ⟸   XM_039078583
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934514   ⟸   XM_039078586
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038934515   ⟸   XM_039078587
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000097044   ⟸   ENSRNOT00000100632
Ensembl Acc Id: ENSRNOP00000079330   ⟸   ENSRNOT00000098364
Ensembl Acc Id: ENSRNOP00000092723   ⟸   ENSRNOT00000113477
Protein Domains
Groucho/TLE N-terminal Q-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63003-F1-model_v2 AlphaFold P63003 1-197 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694967
Promoter ID:EPDNEW_R5492
Type:single initiation site
Name:Aes_1
Description:amino-terminal enhancer of split
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,018,137 - 11,018,197EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2731 AgrOrtholog
BioCyc Gene G2FUF-35040 BioCyc
Ensembl Genes ENSRNOG00000052025 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000098364 ENTREZGENE
  ENSRNOT00000100632 ENTREZGENE
  ENSRNOT00000113477 ENTREZGENE
  ENSRNOT00000113477.1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7933368 IMAGE-MGC_LOAD
InterPro Groucho/TLE_N UniProtKB/Swiss-Prot
  Groucho_enhance UniProtKB/Swiss-Prot
KEGG Report rno:29466 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124620 IMAGE-MGC_LOAD
NCBI Gene Tle5 ENTREZGENE
PANTHER PTHR10814 UniProtKB/Swiss-Prot
  TRANSDUCIN-LIKE ENHANCER PROTEIN 4 UniProtKB/Swiss-Prot
Pfam TLE_N UniProtKB/Swiss-Prot
PhenoGen Tle5 PhenoGen
RatGTEx ENSRNOG00000052025 RatGTEx
TIGR TC216876
UniProt A0A0G2JZT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G347_RAT UniProtKB/TrEMBL
  P63003 ENTREZGENE
  Q3MIF3 ENTREZGENE
  TLE5_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q06195 UniProtKB/Swiss-Prot
  Q3MIF3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Tle5  TLE family member 5, transcriptional modulator  Aes  amino-terminal enhancer of split  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aes  amino-terminal enhancer of split       Name updated 70584 APPROVED
2001-10-24 Aes  amino-terminal enhancer of split      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state 724707