Gpd2 (glycerol-3-phosphate dehydrogenase 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gpd2 (glycerol-3-phosphate dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Gpd2
Name: glycerol-3-phosphate dehydrogenase 2
RGD ID: 2726
Description: Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process and glycerol-3-phosphate shuttle. Predicted to act upstream of or within camera-type eye development and gluconeogenesis. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2); PARTICIPATES IN D-glycericacidemia pathway; electron transport chain pathway; familial lipoprotein lipase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glycerol-3-phosophate dehydrogenase 2 (mitochondrial); glycerol-3-phosphate dehydrogenase 2, mitochondrial; glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; GPDH-M; mtGPDH; mtGPDH gene, promoter region and alternative transcripts
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia11
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,209,432 - 62,346,590 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl362,210,814 - 62,346,593 (+)EnsemblGRCr8
mRatBN7.2341,800,552 - 41,937,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,801,930 - 41,936,901 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx345,140,050 - 45,269,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,724,802 - 53,854,494 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,516,921 - 51,648,631 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,223,892 - 43,359,069 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,255,567 - 43,359,074 (+)Ensemblrn6Rnor6.0
Rnor_5.0348,295,428 - 48,426,568 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4338,980,634 - 39,114,492 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera339,895,025 - 40,025,154 (+)NCBICelera
RGSC_v3.1338,877,005 - 39,010,860 (+)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(aminooxy)acetic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dichloroacetic acid  (ISO)
dihydroxyacetone  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycerol  (ISO)
glycerol 1-phosphate  (ISO)
hydrogen sulfide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
inulin  (ISO)
Iopodic acid  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
methotrexate  (ISO)
Muraglitazar  (EXP)
Nivalenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamoxifen  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetracycline  (ISO)
thapsigargin  (EXP,ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
xylitol  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA. Evidence for EF-hand calcium-binding domains. Brown LJ, etal., J Biol Chem 1994 May 20;269(20):14363-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
5. Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus. Koike G, etal., Genomics 1996 Nov 15;38(1):96-9.
6. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones. Muller S and Seitz HJ, Proc Natl Acad Sci U S A 1994 Oct 25;91(22):10581-5.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells. Tan C, etal., Diabetes. 2002 Oct;51(10):2989-96.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:12093800   PMID:12477932   PMID:12533437   PMID:12865426   PMID:14651853   PMID:15489334   PMID:17886033   PMID:17973206   PMID:18614015   PMID:21296886   PMID:23999537   PMID:25002582  
PMID:29476059  


Genomics

Comparative Map Data
Gpd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,209,432 - 62,346,590 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl362,210,814 - 62,346,593 (+)EnsemblGRCr8
mRatBN7.2341,800,552 - 41,937,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,801,930 - 41,936,901 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx345,140,050 - 45,269,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,724,802 - 53,854,494 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,516,921 - 51,648,631 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,223,892 - 43,359,069 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,255,567 - 43,359,074 (+)Ensemblrn6Rnor6.0
Rnor_5.0348,295,428 - 48,426,568 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4338,980,634 - 39,114,492 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera339,895,025 - 40,025,154 (+)NCBICelera
RGSC_v3.1338,877,005 - 39,010,860 (+)NCBI
Cytogenetic Map3q21NCBI
GPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382156,400,281 - 156,586,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2156,435,290 - 156,613,735 (+)Ensemblhg38GRCh38
GRCh372157,292,064 - 157,442,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362157,000,211 - 157,151,161 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342157,118,427 - 157,265,427NCBI
Celera2150,905,211 - 151,056,180 (+)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2149,177,055 - 149,329,145 (+)NCBIHuRef
CHM1_12157,298,013 - 157,448,944 (+)NCBICHM1_1
T2T-CHM13v2.02156,852,575 - 157,039,187 (+)NCBIT2T-CHM13v2.0
Gpd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39257,127,690 - 57,260,731 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl257,127,647 - 57,260,731 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38257,237,678 - 57,370,719 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl257,237,635 - 57,370,719 (+)Ensemblmm10GRCm38
MGSCv37257,090,089 - 57,223,130 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36257,053,683 - 57,182,998 (+)NCBIMGSCv36mm8
Celera258,979,703 - 59,113,189 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map231.66NCBI
Gpd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,695,435 - 16,802,908 (-)Ensembl
ChiLan1.0NW_00495544916,695,855 - 16,804,184 (-)NCBIChiLan1.0ChiLan1.0
GPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21359,103,098 - 59,254,023 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B59,118,153 - 59,268,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B43,694,744 - 43,845,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B160,938,504 - 161,090,254 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B160,938,514 - 161,117,320 (+)EnsemblpanPan2panpan1.1
GPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,678,749 - 2,780,173 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,681,188 - 2,777,535 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha362,774,808 - 2,917,377 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0362,761,016 - 2,901,673 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,760,786 - 2,901,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,760,613 - 2,903,976 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,820,368 - 2,961,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,860,213 - 3,000,818 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303119,785,975 - 119,930,842 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646921,705,421 - 21,831,745 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646921,705,421 - 21,833,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1563,619,762 - 63,728,633 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11563,592,723 - 63,728,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21570,841,147 - 70,946,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11041,832,772 - 41,984,109 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1041,834,013 - 41,986,423 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040157,577,884 - 157,727,701 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247329,298,156 - 9,447,883 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpd2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1535,117,824 - 35,241,737 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpd2
727 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:32
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000044419
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)35860129171157804Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)35911940270710963Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat

Markers in Region
D3Mgh21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,874,578 - 41,874,764 (+)MAPPERmRatBN7.2
Rnor_6.0343,295,930 - 43,296,111NCBIRnor6.0
Rnor_5.0348,366,676 - 48,366,857UniSTSRnor5.0
RGSC_v3.4339,052,757 - 39,052,938UniSTSRGSC3.4
RGSC_v3.4339,052,756 - 39,052,938RGDRGSC3.4
Celera339,965,027 - 39,965,201UniSTS
RGSC_v3.1338,949,128 - 38,949,310RGD
RH 3.4 Map3545.4RGD
RH 3.4 Map3545.4UniSTS
RH 2.0 Map3290.4RGD
SHRSP x BN Map328.1899RGD
FHH x ACI Map329.3899RGD
Cytogenetic Map3q21-q23UniSTS
D3Chm72  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,874,540 - 41,874,764 (+)MAPPERmRatBN7.2
Rnor_6.0343,295,892 - 43,296,111NCBIRnor6.0
Rnor_5.0348,366,638 - 48,366,857UniSTSRnor5.0
RGSC_v3.4339,052,718 - 39,052,938RGDRGSC3.4
RGSC_v3.4339,052,719 - 39,052,938UniSTSRGSC3.4
Celera339,964,989 - 39,965,201UniSTS
Cytogenetic Map3q21-q23UniSTS
D3Got256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,852,989 - 41,853,127 (+)MAPPERmRatBN7.2
Rnor_6.0343,273,693 - 43,273,830NCBIRnor6.0
Rnor_5.0348,345,464 - 48,345,601UniSTSRnor5.0
RGSC_v3.4339,031,708 - 39,031,845UniSTSRGSC3.4
Celera339,945,177 - 39,945,308UniSTS
Cytogenetic Map3q21-q23UniSTS
BM385025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,833,175 - 41,833,353 (+)MAPPERmRatBN7.2
Rnor_6.0343,253,979 - 43,254,156NCBIRnor6.0
Rnor_5.0348,325,480 - 48,325,657UniSTSRnor5.0
RGSC_v3.4339,010,972 - 39,011,149UniSTSRGSC3.4
Celera339,925,393 - 39,925,570UniSTS
RH 3.4 Map3549.9UniSTS
Cytogenetic Map3q21-q23UniSTS
RH142251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,937,360 - 41,937,556 (+)MAPPERmRatBN7.2
Rnor_6.0343,358,703 - 43,358,898NCBIRnor6.0
Rnor_5.0348,429,411 - 48,429,606UniSTSRnor5.0
RGSC_v3.4339,117,335 - 39,117,530UniSTSRGSC3.4
Celera340,027,997 - 40,028,192UniSTS
RH 3.4 Map3543.5UniSTS
Cytogenetic Map3q21-q23UniSTS
BE109866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,877,173 - 41,877,341 (+)MAPPERmRatBN7.2
Rnor_6.0343,298,521 - 43,298,688NCBIRnor6.0
Rnor_5.0348,369,267 - 48,369,434UniSTSRnor5.0
RGSC_v3.4339,055,348 - 39,055,515UniSTSRGSC3.4
Celera339,967,579 - 39,967,746UniSTS
RH 3.4 Map3544.1UniSTS
Cytogenetic Map3q21-q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF033035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ495842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044419   ⟹   ENSRNOP00000043749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl362,241,069 - 62,343,347 (+)Ensembl
mRatBN7.2 Ensembl341,802,774 - 41,934,517 (+)Ensembl
Rnor_6.0 Ensembl343,255,567 - 43,355,732 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088589   ⟹   ENSRNOP00000071823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl362,241,069 - 62,343,285 (+)Ensembl
mRatBN7.2 Ensembl341,832,160 - 41,934,517 (+)Ensembl
Rnor_6.0 Ensembl343,271,596 - 43,359,074 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090323   ⟹   ENSRNOP00000071643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl362,210,814 - 62,344,442 (+)Ensembl
mRatBN7.2 Ensembl341,872,448 - 41,934,517 (+)Ensembl
Rnor_6.0 Ensembl343,293,185 - 43,355,860 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110582   ⟹   ENSRNOP00000082171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl362,211,634 - 62,346,593 (+)Ensembl
mRatBN7.2 Ensembl341,801,930 - 41,936,901 (+)Ensembl
RefSeq Acc Id: NM_012736   ⟹   NP_036868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,211,653 - 62,343,383 (+)NCBI
mRatBN7.2341,802,774 - 41,934,517 (+)NCBI
Rnor_6.0343,223,927 - 43,355,860 (+)NCBI
Rnor_5.0348,295,428 - 48,426,568 (+)NCBI
RGSC_v3.4338,980,634 - 39,114,492 (+)RGD
Celera339,895,025 - 40,025,154 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104329   ⟹   XP_038960257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,241,010 - 62,346,590 (+)NCBI
mRatBN7.2341,832,127 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_039104330   ⟹   XP_038960258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,240,994 - 62,346,590 (+)NCBI
mRatBN7.2341,832,113 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_039104331   ⟹   XP_038960259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,209,432 - 62,346,590 (+)NCBI
mRatBN7.2341,800,552 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_039104334   ⟹   XP_038960262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,211,576 - 62,346,590 (+)NCBI
mRatBN7.2341,802,686 - 41,937,729 (+)NCBI
RefSeq Acc Id: XM_039104335   ⟹   XP_038960263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,255,648 - 62,346,590 (+)NCBI
mRatBN7.2341,846,827 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_063283137   ⟹   XP_063139207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,243,000 - 62,346,590 (+)NCBI
RefSeq Acc Id: NP_036868   ⟸   NM_012736
- Peptide Label: precursor
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071643   ⟸   ENSRNOT00000090323
Ensembl Acc Id: ENSRNOP00000043749   ⟸   ENSRNOT00000044419
Ensembl Acc Id: ENSRNOP00000071823   ⟸   ENSRNOT00000088589
RefSeq Acc Id: XP_038960259   ⟸   XM_039104331
- Peptide Label: isoform X1
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960262   ⟸   XM_039104334
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUG1 (UniProtKB/TrEMBL),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960258   ⟸   XM_039104330
- Peptide Label: isoform X1
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960257   ⟸   XM_039104329
- Peptide Label: isoform X1
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960263   ⟸   XM_039104335
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K1F9 (UniProtKB/TrEMBL),   F1LNI0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082171   ⟸   ENSRNOT00000110582
RefSeq Acc Id: XP_063139207   ⟸   XM_063283137
- Peptide Label: isoform X1
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35571-F1-model_v2 AlphaFold P35571 1-727 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2726 AgrOrtholog
BioCyc Gene G2FUF-49668 BioCyc
BioCyc Pathway PWY-6118 [glycerol-3-phosphate shuttle] BioCyc
  PWY-6952 [glycerophosphodiester degradation] BioCyc
BioCyc Pathway Image PWY-6118 BioCyc
  PWY-6952 BioCyc
Ensembl Genes ENSRNOG00000033824 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000044419 ENTREZGENE
  ENSRNOT00000088589 ENTREZGENE
  ENSRNOT00000090323 ENTREZGENE
  ENSRNOT00000110582 ENTREZGENE
Gene3D-CATH 1.10.8.870 UniProtKB/Swiss-Prot
  3.50.50.60 UniProtKB/Swiss-Prot
  D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134834 IMAGE-MGC_LOAD
InterPro DAO_C UniProtKB/Swiss-Prot
  DAO_C_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  FAD-dep_OxRdtase UniProtKB/Swiss-Prot
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  G3P_DH_FAD-dep UniProtKB/Swiss-Prot
KEGG Report rno:25062 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93605 IMAGE-MGC_LOAD
NCBI Gene 25062 ENTREZGENE
PANTHER GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11985 UniProtKB/Swiss-Prot
Pfam DAO UniProtKB/Swiss-Prot
  DAO_C UniProtKB/Swiss-Prot
  EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Gpd2 PhenoGen
PRINTS FADG3PDH UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  FAD_G3PDH_1 UniProtKB/Swiss-Prot
  FAD_G3PDH_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033824 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF51905 UniProtKB/Swiss-Prot
TIGR TC221205
UniProt A0A0G2K0Z7_RAT UniProtKB/TrEMBL
  A0A0G2K1F9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUG1 ENTREZGENE, UniProtKB/TrEMBL
  A6JF49_RAT UniProtKB/TrEMBL
  A6JF50_RAT UniProtKB/TrEMBL
  F1LNI0 ENTREZGENE, UniProtKB/TrEMBL
  GPDM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Gpd2  glycerol-3-phosphate dehydrogenase 2  Gpd2  glycerol-3-phosphate dehydrogenase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gpd2  glycerol-3-phosphate dehydrogenase 2, mitochondrial    glycerol-3-phosphate dehydrogenase 2   Name updated 1299863 APPROVED
2002-11-06 Gpd2  glycerol-3-phosphate dehydrogenase 2     Glycerol-3-phosophate dehydrogenase 2 (mitochondrial)  Name updated 625702 APPROVED
2002-06-10 Gpd2  Glycerol-3-phosophate dehydrogenase 2 (mitochondrial)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, heart, muscle, brain, testis, and pancreas 632943
gene_expression expression in liver is induced by thryoid hormone 632943