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Gene: Ggt5 (gamma-glutamyltransferase 5) Rattus norvegicus

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Symbol:

Ggt5 (Ensembl: AABR07044631.2)

Name:

gamma-glutamyltransferase 5

RGD ID:

2684

Description:

Predicted to enable glutathione hydrolase activity; leukotriene-C(4) hydrolase; and peptidyltransferase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; glutathione catabolic process; and proteolysis. Predicted to act upstream of or within lymphocyte migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5); PARTICIPATES IN arachidonic acid metabolic pathway; cyanoamino acid metabolic pathway; glutathione metabolic pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

gamma-glutamyl leukotrienase; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyltransferase-like activity 1; gamma-glutamyltranspeptidase 5; GGL; GGT 5; GGT-rel; Ggta1; Ggtla1; glutathione hydrolase 5; glutathione hydrolase 5 proenzyme; leukotriene-C4 hydrolase; MGC93485

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GGT5 (gamma-glutamyltransferase 5)	HGNC	HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Ggt5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ggt5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GGT5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GGT5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ggt5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GGT5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ggt5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ggt5 (gamma-glutamyltransferase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GGT1 (gamma-glutamyltransferase 1)	HGNC	OrthoDB
Homo sapiens (human):	GGTLC1 (gamma-glutamyltransferase light chain 1)	HGNC	OrthoDB
Homo sapiens (human):	GGTLC2 (gamma-glutamyltransferase light chain 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	GGT5 (gamma-glutamyltransferase 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ggt5 (gamma-glutamyltransferase 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ggt5b (gamma-glutamyltransferase 5b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ggt5a (gamma-glutamyltransferase 5a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1492	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1492	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ECM38	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ECM38	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y7A9A.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG17636	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C53D5.5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG4829	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ggt-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ggt5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ggt5	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	13,042,694 - 13,070,960 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	13,042,696 - 13,070,892 (-)	Ensembl				GRCr8
mRatBN7.2	20	13,043,255 - 13,071,523 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	13,043,257 - 13,071,450 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	13,749,839 - 13,778,030 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	13,110,786 - 13,138,974 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	13,583,284 - 13,611,483 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	20	13,363,585 - 13,391,748 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	20	14,359,445 - 14,387,613 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	20	14,362,579 - 14,390,751 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	20	13,372,394 - 13,400,562 (-)	NCBI		F344_StmMcwi
Rnor_6.0	20	13,988,444 - 14,001,296 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	19	62,302,144 - 62,302,579 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	20	16,178,488 - 16,191,069 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	20	14,531,284 - 14,557,667 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Lung Neoplasms (IEP,ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

beclomethasone (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cobalt dichloride (ISO)

copper(II) chloride (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

fluticasone (ISO)

genistein (ISO)

inulin (ISO)

isobutyl nitrite (EXP)

isoprenaline (ISO)

lead diacetate (ISO)

leukotriene C4 (ISO)

maleic acid (ISO)

methapyrilene (ISO)

methoxyacetic acid (EXP)

methylparaben (ISO)

N-methyl-4-phenylpyridinium (EXP)

ochratoxin A (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

progesterone (ISO)

Ptaquiloside (ISO)

sodium arsenite (ISO)

Tesaglitazar (EXP)

thiram (ISO)

topotecan (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid metabolic process (ISO)

fatty acid metabolic process (ISO)

glutathione biosynthetic process (IEA)

glutathione catabolic process (IBA,IEA,ISO,ISS)

glutathione metabolic process (IEA)

inflammatory response (IBA,ISO)

leukotriene biosynthetic process (IEA)

leukotriene D4 biosynthetic process (IBA,ISO,ISS)

lymphocyte migration (ISO)

proteolysis (IEA,ISO)

response to oxidative stress (TAS)

response to stress (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

acyltransferase activity (IEA)

glutathione hydrolase activity (IBA,IEA,ISO)

hydrolase activity (IEA)

leukotriene C4 gamma-glutamyl transferase activity (IEA)

leukotriene-C(4) hydrolase activity (IBA,IEA,ISO,ISS)

peptidase activity (IEA)

peptidyltransferase activity (ISO,ISS)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

arachidonic acid metabolic pathway (IEA)

cyanoamino acid metabolic pathway (IEA)

glutathione metabolic pathway (IEA)

taurine and hypotaurine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells.	Potdar PD, etal., Am J Physiol 1997 Nov;273(5 Pt 1):L1082-9.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:1676842	PMID:9774450	PMID:12163373	PMID:12477932	PMID:21447318

Genomics

Comparative Map Data

Ggt5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	13,042,694 - 13,070,960 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	13,042,696 - 13,070,892 (-)	Ensembl				GRCr8
mRatBN7.2	20	13,043,255 - 13,071,523 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	13,043,257 - 13,071,450 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	13,749,839 - 13,778,030 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	13,110,786 - 13,138,974 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	13,583,284 - 13,611,483 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	20	13,363,585 - 13,391,748 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	20	14,359,445 - 14,387,613 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	20	14,362,579 - 14,390,751 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	20	13,372,394 - 13,400,562 (-)	NCBI		F344_StmMcwi
Rnor_6.0	20	13,988,444 - 14,001,296 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	19	62,302,144 - 62,302,579 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	20	16,178,488 - 16,191,069 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	20	14,531,284 - 14,557,667 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

GGT5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	24,219,654 - 24,245,142 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	24,218,000 - 24,245,748 (-)	Ensembl			hg38	GRCh38
GRCh37	22	24,615,622 - 24,641,110 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	22,945,622 - 22,971,110 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	22,940,192 - 22,965,582	NCBI
Celera	22	8,416,020 - 8,441,502 (-)	NCBI		Celera
Cytogenetic Map	22	q11.23	NCBI
HuRef	22	7,564,739 - 7,590,237 (-)	NCBI		HuRef
CHM1_1	22	24,574,371 - 24,599,750 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	24,681,268 - 24,706,753 (-)	NCBI		T2T-CHM13v2.0

Ggt5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	75,425,161 - 75,453,034 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	75,425,174 - 75,453,034 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	75,589,327 - 75,617,200 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	75,589,340 - 75,617,200 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	75,052,126 - 75,079,713 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	75,033,097 - 75,060,684 (+)	NCBI		MGSCv36	mm8
Celera	10	76,634,075 - 76,661,662 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	38.55	NCBI

Ggt5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	8,102,499 - 8,125,966 (+)	Ensembl
ChiLan1.0	NW_004955455	8,101,251 - 8,125,597 (+)	NCBI	ChiLan1.0	ChiLan1.0

GGT5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	34,004,643 - 34,033,738 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	36,738,366 - 36,767,475 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	5,025,740 - 5,053,074 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	23,110,461 - 23,125,629 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	23,110,780 - 23,125,632 (-)	Ensembl			panPan2	panpan1.1

GGT5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	28,316,022 - 28,343,928 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	28,317,989 - 28,343,611 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	27,390,911 - 27,419,099 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	29,720,313 - 29,748,512 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	29,721,943 - 29,750,656 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	27,804,270 - 27,832,467 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	27,421,067 - 27,449,253 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	28,411,249 - 28,439,354 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ggt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	141,916,314 - 141,959,384 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	794,889 - 837,736 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	794,876 - 837,748 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GGT5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	49,640,586 - 49,663,003 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	49,638,184 - 49,663,007 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,080,650 - 53,104,965 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Ggt5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	10,051,553 - 10,071,983 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	10,050,765 - 10,072,255 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ggt5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	11,829,780 - 11,855,917 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ggt5
284 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8043920	29865039	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8043920	15089182	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
7	1	18	48	67	133	95	11	43	31	32	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U76252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000093720 ⟹ ENSRNOP00000076334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	13,042,696 - 13,070,892 (-)	Ensembl
mRatBN7.2 Ensembl	20	13,043,257 - 13,071,450 (-)	Ensembl

RefSeq Acc Id:

NM_019235 ⟹ NP_062108

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	13,042,694 - 13,070,892 (-)	NCBI
mRatBN7.2	20	13,043,255 - 13,071,450 (-)	NCBI
Dahl_SR_JrHsd	20	13,363,585 - 13,391,748 (-)	NCBI
Lyon_Normotensive	20	14,359,445 - 14,387,613 (-)	NCBI
Lyon_Hypertensive	20	14,362,579 - 14,390,751 (-)	NCBI
F344_StmMcwi	20	13,372,394 - 13,400,562 (-)	NCBI
Rnor_6.0	20	13,988,444 - 14,001,296 (-)	NCBI
Rnor_5.0	20	16,178,488 - 16,191,069 (-)	NCBI
Rnor_5.0	19	62,302,144 - 62,302,579 (-)	NCBI
Celera	20	14,531,284 - 14,557,667 (-)	NCBI

Sequence:

show sequence

GAAGCAGTGGAGGAGGTAGCAACAGTCTGGCTGGCCAGCTTCCCGGTTGCTCCTCCGTAACCTG
CCTGGCTACCTATCTGTAAGCCTGTCCGTTATCCTTCCTATCCAGTTGTCTGATCTGTGCAACT
GTCTCTTGCTGGACCCATCGATCTTTCCCATCTGTCCAATCGCCTGAGTTCACCCTTCATCTGG
CAGTCAGTTTGTCCCTCTGTCTGCCCACTGCCCTGTGTGTCCAGCTGCCTCTCTCCCTGGACCA
CTGAGCCATGGCATGGGGCCATAGGACCACAGTCTGCCTGGTCCTGCTGGGTGTGAGTCTGGGT
CTGGCCATCATTGTGCTGGCTGTGGTCCTTCCTCATCACCAAGCCTCTTGCCGTCCCGATGCCT
TCACTCGTGCTGCCGTAGCTGCTGATTCTAAGATCTGCTCAGATATTGGACGAGTCATCCTCCA
GCAGCAGGGCTCACCTGTGGACGCCGCCATTGCTGCCCTCATCTGTACCGGTGTTGTTAACCCT
CAGAGCATGGGCCTGGGCGGAGGGGTCGTCTTCACCATCTACAATGCATCTACAGGGAAGGTGG
AGGTCATCAATGCTCGGGAGACAGTGCCAGCCAGCCATGACCAGAGACTGCTAGACCAGTGTAC
AAATGCCCTGCCACTGTGCACAGGGGCCCAGTGGATCGGGGTTCCTGGTGAGCTCCGCGGCTAT
GCTGAGGCGCACCGCCGATACGGCCGCCTGCCTTGGGCTCAGCTTTTCCAGCCCACCATTGCCC
TGCTCCGAGAGGGTTTCCGTGTGCCCCCTATCCTCAGTCAGTTCCTCAACACCAGCTTCCTGCA
GCCCTGCTTGAATTCATCAACCCTGAGACAGCTCTTCTTCAATGGGACAGAAACCTTGAGATCT
CAGGACCCACTCCCATGGCCTGCGCTGGCCAACACCTTGGAGACTGTGGCTAAGGAGGGTGCAG
AGGTCTTATACACCGGAAAGCTGGGACAAACGCTGGTGGAAGACATTGCCTGGCAAGGAAGCCA
GCTGACGGTTCAGGACTTGGCTGCCTTCCGGCCGAAAGTGGTGGAACCCCTGGAGATGGCCCTA
GGAAACTATACCCTGTACTCTCCACCGCCGCCGGCAGGGGGCGCTATTCTTAGCTTCATTCTCA
ACGTGCTGAAAGGGTTCAACTTCTCTGCAGAGACGGTGGCCGGGCCTGAAGGGAAGGTGAACAT
GTACCACCACCTTGTAGAGGCTCTCAAGTTCGCAGTAGGGCAGAGGTGGCGGCTATGGGACCCC
TACAGCCACCCAGGGATACAGAACATCTCCCAGGACCTTCTCCGGGAGACTCTAGCCCAGCACA
TCCGCCAGCAGATTGATGGCCGTGGTGACCACCAGCTCAGCCATTACAACCTGTCCGGGGTCAG
GGGCAACAGCATGGGCACGTCTCATGTGTCTGTGTTGGGAGAAGACGGCAGCGCTGTGGCAGCC
ACCAGCACCATCAACACACCCTTTGGAGCGATGGTGTACTCCCCACGGACAGGCATCCTCCTCA
ACAACGAGCTACTAGACTTATGCTGGAGACACAAGCCAGGTTCAACGGTCACCCCTCCCCCTGT
TCCAGGTGAGCAGCCACCATCATCCATGGTACCCTCCATCTTGATCAACGAAGTCCAGGGGTCG
AAGCTGGTGATCGGTGGGGCTGGTGGGGAGCTTATCATCTCTGCTGTGACCCAGGCTATCGTGA
ATAAGCTGTGGCTTGGCTTTAGCCTGACAGACGCCATCGCAGCGCCCATCCTACATGTGAATAG
CAAGGGCCACGTGGAATATGAGCCCAAGTTTAACCAGGAGGTTCGGAAGGGGCTACAGGACCGA
GGCCAGAGCCAGAGCCAGAGCCAGAGGCCGGTTTTCCTGAATTCGGTCCAGGCTGTGTTTCAGG
AAGGGCCCTGTGTCTATGCAGCATCTGACCTGAGGAAGGCTGGAAAGGCTTCAGGATACTAAGA
CAGCTCTGCCCAGGGCTAGGATCTGGCCCACTGTGAGTCCTGTGCCTGACATGGATGATGCTGT
ACGTCTAAATACTCCAGGACCCGGATCCCTTGCTCTGAGACCTACCTGGGACCAAAAGAACAGG
GATCAGCCCAGCCGATGAATGAATGAAGAGGGAAGGATTGACTTGTCCCTGGTCCCGTCCCAAC
ACCTCCTGTGGCCCTGCCCTGTTTCTTCTAGCCTTGCCCTCCCTGGCCTCATGCTCACACTCCA
AATGGTGTACCTCCCAGTCCACAGTGTGAACTGATTTAGTGGTTCTAAGCAGTTAAAGGGACCC
TCGGATAGTTCCCAGTGATATGCAACACACCACAGACTCCTACGGTCCTTCATGACTTGCCATC
GGGGCCAAGAGATGAGCCAGGCTTCACAAGGCTCAGCGGACAGGGGCAAGCACACCGCCCACGT
CTACTCTGCTCCTGCTACAATATCTCTTCCGGGGGTTTCGCAATGTGTCTGCTCCCCCCACCCT
CTGTCTTGCCTGCTGGTGGGAAGACAGGAGTGTGGCTTGTAGTACTTATGTTTTGCTCCACTCA
GGAAAAGGTTGGATAAAGCAGAGCTCGGTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039098626 ⟹ XP_038954554

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	13,046,412 - 13,070,960 (-)	NCBI
mRatBN7.2	20	13,046,654 - 13,071,523 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_062108	(Get FASTA)	NCBI Sequence Viewer
	XP_038954554	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC23546	(Get FASTA)	NCBI Sequence Viewer
	AAH87018	(Get FASTA)	NCBI Sequence Viewer
	EDL97198	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076334
	ENSRNOP00000076334.2
GenBank Protein	Q9QWE9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062108 ⟸ NM_019235

- UniProtKB:

Q9QWE9 (UniProtKB/Swiss-Prot), Q5PQV0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAWGHRTTVCLVLLGVSLGLAIIVLAVVLPHHQASCRPDAFTRAAVAADSKICSDIGRVILQQQ
GSPVDAAIAALICTGVVNPQSMGLGGGVVFTIYNASTGKVEVINARETVPASHDQRLLDQCTNA
LPLCTGAQWIGVPGELRGYAEAHRRYGRLPWAQLFQPTIALLREGFRVPPILSQFLNTSFLQPC
LNSSTLRQLFFNGTETLRSQDPLPWPALANTLETVAKEGAEVLYTGKLGQTLVEDIAWQGSQLT
VQDLAAFRPKVVEPLEMALGNYTLYSPPPPAGGAILSFILNVLKGFNFSAETVAGPEGKVNMYH
HLVEALKFAVGQRWRLWDPYSHPGIQNISQDLLRETLAQHIRQQIDGRGDHQLSHYNLSGVRGN
SMGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGILLNNELLDLCWRHKPGSTVTPPPVPG
EQPPSSMVPSILINEVQGSKLVIGGAGGELIISAVTQAIVNKLWLGFSLTDAIAAPILHVNSKG
HVEYEPKFNQEVRKGLQDRGQSQSQSQRPVFLNSVQAVFQEGPCVYAASDLRKAGKASGY

hide sequence

RefSeq Acc Id:	XP_038954554 ⟸ XM_039098626
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000076334 ⟸ ENSRNOT00000093720

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QWE9-F1-model_v2	AlphaFold	Q9QWE9	1-572	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2684	AgrOrtholog
BioCyc Gene	G2FUF-4152	BioCyc
Ensembl Genes	ENSRNOG00000062276	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000093720	ENTREZGENE
	ENSRNOT00000093720.2	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.246.130	UniProtKB/Swiss-Prot
	3.60.20.40	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7191011	IMAGE-MGC_LOAD
InterPro	GGT_CS	UniProtKB/Swiss-Prot
	GGT_lsub_C	UniProtKB/Swiss-Prot
	GGT_peptidase	UniProtKB/Swiss-Prot
	GGT_ssub	UniProtKB/Swiss-Prot
	Ntn_hydrolases_N	UniProtKB/Swiss-Prot
KEGG Report	rno:29566	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93485	IMAGE-MGC_LOAD
NCBI Gene	29566	ENTREZGENE
PANTHER	GAMMA-GLUTAMYLTRANSFERASE 5	UniProtKB/Swiss-Prot
	PUTATIVE GLUTATHIONE HYDROLASE LIGHT CHAIN	UniProtKB/Swiss-Prot
Pfam	G_glu_transpept	UniProtKB/Swiss-Prot
PhenoGen	Ggt5	PhenoGen
PRINTS	GGTRANSPTASE	UniProtKB/Swiss-Prot
PROSITE	G_GLU_TRANSPEPTIDASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000062276	RatGTEx
Superfamily-SCOP	SSF56235	UniProtKB/Swiss-Prot
UniProt	A0A1W2Q6M5_RAT	UniProtKB/TrEMBL
	GGT5_RAT	UniProtKB/Swiss-Prot
	Q5PQV0	ENTREZGENE
	Q9QWE9	ENTREZGENE
UniProt Secondary	Q5PQV0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-31	Ggt5	gamma-glutamyltransferase 5	Ggtla1	gamma-glutamyltransferase-like activity 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Ggtla1	gamma-glutamyltransferase-like activity 1			Name updated	70584	APPROVED
2002-02-27	Ggtla1	gamma-glutamyltransferase-like activity 1			Symbol updated	70292	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in rat tracheal epithelial cultured cells	69846
gene_function	protein cleaves the gamma-glutamyl peptide bond of glutathione	69846
gene_transcript	2.6 Kb cDNA which is 79% identical to human	69846

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)