Gad2 (glutamate decarboxylase 2) - Rat Genome Database

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Gene: Gad2 (glutamate decarboxylase 2) Rattus norvegicus
Analyze
Symbol: Gad2
Name: glutamate decarboxylase 2
RGD ID: 2653
Description: Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to brain-derived neurotrophic factor stimulus; and response to dexamethasone. Located in several cellular components, including inhibitory synapse; neuronal cell body; and synaptic vesicle membrane. Is active in GABA-ergic synapse and presynapse. Biomarker of autism spectrum disorder; bipolar disorder; epilepsy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; diabetes mellitus (multiple); drug psychosis; and heroin dependence. Orthologous to human GAD2 (glutamate decarboxylase 2); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; beta-alanine metabolic pathway; butanoate metabolic pathway; INTERACTS WITH (+)-pilocarpine; (aminooxy)acetic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 65 kDa glutamic acid decarboxylase; GAD-65; GAD65; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; glutamic acid decarboxylase 65
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Gad2em24Yyan  
Genetic Models: LE-Gad2em24Yyan
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81789,671,718 - 89,734,246 (+)NCBIGRCr8
mRatBN7.21784,763,630 - 84,826,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,243,822 - 88,306,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,079,214 - 92,141,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,096,016 - 86,158,509 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,171,576 - 89,234,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01790,851,699 - 90,914,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,259,430 - 96,321,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,270,262 - 96,332,686 (+)NCBI
Celera1784,065,137 - 84,127,559 (-)NCBICelera
RH 3.4 Map17841.1RGD
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(aminooxy)acetic acid  (EXP)
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-mercaptopropanoic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminopyridine  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allylglycine  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
chlorpyrifos  (EXP,ISO)
clozapine  (EXP,ISO)
Cyclopamine  (ISO)
dexamethasone  (EXP)
diazepam  (EXP)
diazinon  (ISO)
dichloroacetic acid  (ISO)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenamidone  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
idazoxan  (EXP)
kainic acid  (EXP)
L-glutamic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
malathion  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
Mipafox  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
nicotine  (EXP)
Nonylphenol  (EXP)
olanzapine  (EXP)
oxidopamine  (EXP)
panobinostat  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
pentetrazol  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP,ISO)
pyridoxal 5'-phosphate  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats. Alele PE and Devaud LL, Alcohol Clin Exp Res. 2005 Jun;29(6):1027-34.
2. Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Asada H, etal., Biochem Biophys Res Commun 1996 Dec 24;229(3):891-5.
3. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Bu DF, etal., Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2115-9.
4. Caloric restriction augments brain glutamic acid decarboxylase-65 and -67 expression. Cheng CM, etal., J Neurosci Res. 2004 Jul 15;77(2):270-6. doi: 10.1002/jnr.20144.
5. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. Dirkx R Jr, etal., J Biol Chem. 1995 Feb 3;270(5):2241-6.
6. Two genes encode distinct glutamate decarboxylases. Erlander MG, etal., Neuron 1991 Jul;7(1):91-100.
7. Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9.
8. Heterogeneous neuronal activity in the lateral habenula after short- and long-term cocaine self-administration in rats. Gao P, etal., Eur J Neurosci. 2018 Jan;47(1):83-94. doi: 10.1111/ejn.13780. Epub 2017 Dec 8.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies. Hall TR, etal., Immunology. 2008 Apr;123(4):547-54. Epub 2007 Nov 14.
12. Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes. Kanazawa Y, etal., J Autoimmun. 2009 Mar;32(2):104-9. Epub 2009 Feb 1.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes. Khan MW, etal., Autoimmunity. 2009 Feb;42(2):150-8.
15. Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells. Kobayashi S and Millhorn DE, J Neurochem. 2001 Mar;76(6):1935-48. doi: 10.1046/j.1471-4159.2001.00214.x.
16. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
17. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. Lappalainen J, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):183-92. doi: 10.1002/ajmg.b.30377.
18. Heroin addiction in African Americans: a hypothesis-driven association study. Levran O, etal., Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
19. Increased GAD expression in the striatum after transient cerebral ischemia. Li Y, etal., Mol Cell Neurosci. 2010 Dec;45(4):370-7. doi: 10.1016/j.mcn.2010.07.010. Epub 2010 Jul 24.
20. Construction and functional activity of a recombinant vector expressing rat glutamic acid decarboxylase 65. Liu JS, etal., Neurosci Bull. 2011 Dec;27(6):430-5. doi: 10.1007/s12264-011-1840-8.
21. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
22. Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain. Martin DL, etal., J Neurosci. 1991 Sep;11(9):2725-31.
23. Structural features and regulatory properties of the brain glutamate decarboxylases. Martin DL, etal., Neurochem Int. 2000 Aug-Sep;37(2-3):111-9.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report. Murgia C, etal., Reprod Biol Endocrinol. 2008 Jun 29;6:24.
26. Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha. Namchuk M, etal., J Biol Chem. 1997 Jan 17;272(3):1548-57.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. The components required for amino acid neurotransmitter signaling are present in adipose tissues. Nicolaysen A, etal., J Lipid Res. 2007 Oct;48(10):2123-32. Epub 2007 Jun 28.
29. Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism. Olexová L, etal., Neurosci Lett. 2016 Aug 26;629:9-14. doi: 10.1016/j.neulet.2016.06.035. Epub 2016 Jun 25.
30. Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1). Orban T, etal., Diabetes Care. 2009 Sep 9.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Rat-1 fibroblasts engineered with GAD65 and GAD67 cDNAs in retroviral vectors produce and release GABA. Ruppert C, etal., J Neurochem. 1993 Aug;61(2):768-71. doi: 10.1111/j.1471-4159.1993.tb02186.x.
36. Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophrenia. Schreiber S, etal., World J Biol Psychiatry. 2011 Feb;12(1):57-65. Epub 2011 Jan 20.
37. Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. Shi Y, etal., J Cell Biol. 1994 Mar;124(6):927-34.
38. Influence of progesterone on GAD65 and GAD67 mRNA expression in the dorsolateral striatum and prefrontal cortex of female rats repeatedly treated with cocaine. Souza MF, etal., Braz J Med Biol Res. 2009 Nov;42(11):1068-75. doi: 10.1590/S0100-879X2009001100011.
39. Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures. Sperk G, etal., Hippocampus. 2003;13(7):806-15. doi: 10.1002/hipo.10133.
40. Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. Tao W, etal., Mol Pharmacol. 2015 Jun;87(6):1035-41. doi: 10.1124/mol.115.098186. Epub 2015 Apr 7.
41. Association of polymorphisms in GAD1 and GAD2 genes with methamphetamine dependence. Veerasakul S, etal., Pharmacogenomics. 2017 Jan;18(1):17-22. doi: 10.2217/pgs-2016-0101. Epub 2016 Dec 14.
42. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
43. Prenatal dexamethasone exposure induces anxiety- and depressive-like behavior of male offspring rats through intrauterine programming of the activation of NRG1-ErbB4 signaling in hippocampal PV interneurons. Zhang S, etal., Cell Biol Toxicol. 2023 Jun;39(3):657-678. doi: 10.1007/s10565-021-09621-0. Epub 2021 Jun 29.
Additional References at PubMed
PMID:1321158   PMID:3385490   PMID:10452943   PMID:15479642   PMID:15686475   PMID:15947074   PMID:18230651   PMID:19190758   PMID:19578718   PMID:20232399   PMID:20405034   PMID:21907636  
PMID:21983856   PMID:22194107   PMID:22291989   PMID:22332935   PMID:22427928   PMID:22750123   PMID:23376695   PMID:23500099   PMID:23904086   PMID:23973096   PMID:24275587   PMID:25189404  
PMID:25701657   PMID:27284108   PMID:27702572   PMID:33236473   PMID:34972242   PMID:36587827   PMID:38194067  


Genomics

Comparative Map Data
Gad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81789,671,718 - 89,734,246 (+)NCBIGRCr8
mRatBN7.21784,763,630 - 84,826,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,243,822 - 88,306,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,079,214 - 92,141,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,096,016 - 86,158,509 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,171,576 - 89,234,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01790,851,699 - 90,914,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,259,430 - 96,321,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,270,262 - 96,332,686 (+)NCBI
Celera1784,065,137 - 84,127,559 (-)NCBICelera
RH 3.4 Map17841.1RGD
Cytogenetic Map17q12.3NCBI
GAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381026,216,372 - 26,304,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1026,216,665 - 26,304,558 (+)EnsemblGRCh38hg38GRCh38
GRCh371026,505,301 - 26,593,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361026,545,600 - 26,633,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 341026,545,599 - 26,633,493NCBI
Celera1026,216,982 - 26,305,252 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1026,164,647 - 26,252,919 (+)NCBIHuRef
CHM1_11026,506,137 - 26,594,390 (+)NCBICHM1_1
T2T-CHM13v2.01026,240,884 - 26,329,300 (+)NCBIT2T-CHM13v2.0
Gad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39222,512,262 - 22,583,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl222,512,217 - 22,583,886 (+)EnsemblGRCm39 Ensembl
GRCm38222,621,015 - 22,693,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl222,622,205 - 22,693,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv37222,477,847 - 22,549,397 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36222,473,967 - 22,542,641 (+)NCBIMGSCv36mm8
Celera222,352,193 - 22,424,544 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.15NCBI
Gad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554293,096,453 - 3,169,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554293,092,977 - 3,170,128 (-)NCBIChiLan1.0ChiLan1.0
GAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2838,914,567 - 39,001,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11038,919,890 - 39,007,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01026,392,877 - 26,481,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11026,757,877 - 26,843,647 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1026,759,243 - 26,843,197 (+)Ensemblpanpan1.1panPan2
GAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127,365,708 - 7,450,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27,365,283 - 7,450,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26,118,684 - 6,180,324 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025,562,197 - 5,647,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25,558,766 - 5,648,257 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124,932,241 - 5,017,384 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025,011,639 - 5,096,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025,177,275 - 5,262,494 (-)NCBIUU_Cfam_GSD_1.0
Gad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934425,572,699 - 25,645,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364841,737,520 - 1,810,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364841,737,806 - 1,810,378 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1049,313,647 - 49,390,926 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11049,316,682 - 49,391,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,614,739 - 54,689,368 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1925,906,047 - 25,993,715 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl925,906,103 - 25,995,489 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605131,891,428 - 31,980,135 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gad2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247962,703,614 - 2,771,555 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247962,700,443 - 2,771,757 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gad2
204 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:16
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000024901
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
RH142194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,826,021 - 84,826,148 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,637 - 89,234,763NCBIRnor6.0
Rnor_5.01790,914,760 - 90,914,886UniSTSRnor5.0
RGSC_v3.41796,321,724 - 96,321,850UniSTSRGSC3.4
Celera1784,065,144 - 84,065,270UniSTS
RH 3.4 Map17841.1UniSTS
Cytogenetic Map17q12.3UniSTS
RH138172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,801,020 - 84,801,140 (+)MAPPERmRatBN7.2
Rnor_6.01789,209,638 - 89,209,757NCBIRnor6.0
Rnor_5.01790,889,761 - 90,889,880UniSTSRnor5.0
RGSC_v3.41796,296,724 - 96,296,843UniSTSRGSC3.4
Celera1784,090,167 - 84,090,286UniSTS
RH 3.4 Map17842.8UniSTS
Cytogenetic Map17q12.3UniSTS
RH94411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,826,027 - 84,826,152 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,643 - 89,234,767NCBIRnor6.0
Rnor_5.01790,914,766 - 90,914,890UniSTSRnor5.0
RGSC_v3.41796,321,730 - 96,321,854UniSTSRGSC3.4
Celera1784,065,140 - 84,065,264UniSTS
Cytogenetic Map17q12.3UniSTS
Gad2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,825,894 - 84,826,023 (+)MAPPERmRatBN7.2
Rnor_6.01789,234,510 - 89,234,638NCBIRnor6.0
Rnor_5.01790,914,633 - 90,914,761UniSTSRnor5.0
RGSC_v3.41796,321,597 - 96,321,725UniSTSRGSC3.4
Celera1784,065,269 - 84,065,397UniSTS
Cytogenetic Map17q12.3UniSTS


Genetic Models
This gene Gad2 is modified in the following models/strains:
LE-Gad2em24Yyan    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 19 113 61 59 29 24 29 6 140 61 93 34 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000024901   ⟹   ENSRNOP00000024901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)Ensembl
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)Ensembl
RefSeq Acc Id: NM_012563   ⟹   NP_036695
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81789,671,718 - 89,734,246 (+)NCBI
mRatBN7.21784,763,630 - 84,826,155 (+)NCBI
Rnor_6.01789,171,576 - 89,234,770 (+)NCBI
Rnor_5.01790,851,699 - 90,914,893 (+)NCBI
RGSC_v3.41796,259,430 - 96,321,857 (+)RGD
Celera1784,065,137 - 84,127,559 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036695 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63488 (Get FASTA)   NCBI Sequence Viewer  
  AAC64947 (Get FASTA)   NCBI Sequence Viewer  
  EDL83940 (Get FASTA)   NCBI Sequence Viewer  
  EDL83941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024901.2
  ENSRNOP00055001533
  ENSRNOP00060022394
  ENSRNOP00065003170
GenBank Protein Q05683 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036695   ⟸   NM_012563
- UniProtKB: Q05683 (UniProtKB/Swiss-Prot),   A6KS02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024901   ⟸   ENSRNOT00000024901

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05683-F1-model_v2 AlphaFold Q05683 1-585 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2653 AgrOrtholog
BioCyc Gene G2FUF-8486 BioCyc
BioCyc Pathway GLUDEG-I-PWY [GABA shunt] BioCyc
  PWY0-1305 [L-glutamate degradation IX (via 4-aminobutanoate)] BioCyc
BioCyc Pathway Image GLUDEG-I-PWY BioCyc
  PWY0-1305 BioCyc
Ensembl Genes ENSRNOG00000018200 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055001178 UniProtKB/Swiss-Prot
  ENSRNOG00060016275 UniProtKB/Swiss-Prot
  ENSRNOG00065003157 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024901.5 UniProtKB/Swiss-Prot
  ENSRNOT00055001955 UniProtKB/Swiss-Prot
  ENSRNOT00060027867 UniProtKB/Swiss-Prot
  ENSRNOT00065004444 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type I PLP-dependent aspartate aminotransferase-like (Major domain) UniProtKB/TrEMBL
InterPro PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24380 ENTREZGENE
PANTHER GLUTAMATE DECARBOXYLASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTAMATE DECARBOXYLASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gad2 PhenoGen
PROSITE DDC_GAD_HDC_YDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018200 RatGTEx
  ENSRNOG00055001178 RatGTEx
  ENSRNOG00060016275 RatGTEx
  ENSRNOG00065003157 RatGTEx
Superfamily-SCOP PLP-dependent transferases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KS02 ENTREZGENE, UniProtKB/TrEMBL
  A6KS03_RAT UniProtKB/TrEMBL
  DCE2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-08 Gad2  glutamate decarboxylase 2   Gad2  glutamic acid decarboxylase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gad2  glutamic acid decarboxylase 2    glutamate decarboxylase 2  Name updated 1299863 APPROVED
2002-06-10 Gad2  Glutamate decarboxylase 2 (islet)      Symbol and Name status set to approved 70586 APPROVED