Gabrb2 (gamma-aminobutyric acid type A receptor subunit beta 2) - Rat Genome Database

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Gene: Gabrb2 (gamma-aminobutyric acid type A receptor subunit beta 2) Rattus norvegicus
Analyze
Symbol: Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
RGD ID: 2650
Description: Enables GABA-A receptor activity and monoatomic ion channel activity. Contributes to GABA receptor activity. Involved in GABAergic synaptic transmission; cellular response to histamine; and chloride transmembrane transport. Located in plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2); INTERACTS WITH 17alpha-ethynylestradiol; 2,6-Dimethylphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; gamma-aminobutyric acid (GABA) A receptor, beta 2; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid receptor, subunit beta 2; gamma-aminobutyric acid type A receptor beta 2 subunit; GARB2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81027,438,127 - 27,657,680 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1027,438,238 - 27,655,171 (+)EnsemblGRCr8
mRatBN7.21026,936,592 - 27,156,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,936,551 - 27,151,251 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1031,687,629 - 31,916,745 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01031,176,165 - 31,405,281 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,662,808 - 26,891,915 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,973,694 - 28,193,072 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,973,681 - 28,187,565 (+)Ensemblrn6Rnor6.0
Rnor_5.01027,816,796 - 28,032,603 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41027,602,085 - 27,819,145 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1026,450,647 - 26,662,574 (+)NCBICelera
RGSC_v3.11027,603,057 - 27,820,693 (+)NCBI
Cytogenetic Map10q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-isoborneol  (ISO)
(R)-camphor  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(2-methoxyphenyl)piperazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,6-Dimethylphenol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dibromo-2-(2,4-dibromophenoxy)phenol  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4-ethyl-4-methylpiperidine-2,6-dione  (ISO)
6-Methoxyflavanone  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
acamprosate  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Alphaxolone  (EXP)
ammonium chloride  (EXP)
anthracenes  (EXP)
antirheumatic drug  (ISO)
avermectin  (EXP)
Azoxymethane  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromoform  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
camphor  (ISO)
carbamazepine  (ISO)
carisoprodol  (ISO)
carvone  (ISO)
chlorpyrifos  (EXP,ISO)
cocaine  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazepam  (EXP,ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etomidate  (EXP,ISO)
famotidine  (EXP)
felbamate  (ISO)
fipronil  (ISO)
flurazepam  (ISO)
gaboxadol  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (EXP)
hexachlorophene  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
menthone  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
muscimol  (EXP,ISO)
naltrexone  (ISO)
nickel atom  (ISO)
Niflumic acid  (EXP)
o-cresol  (EXP)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
pentetrazol  (ISO)
pentobarbital  (EXP)
picrotoxin  (EXP,ISO)
picrotoxinin  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
pregnenolone sulfate  (EXP)
propofol  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
tert-Butylbicyclophosphorothionate  (ISO)
theophylline  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topiramate  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vorinostat  (ISO)
zaleplon  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zolpidem  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Identification, Molecular Cloning, and Characterization of a Novel GABAA Receptor-associated Protein, GRIF-1. Beck M, etal., J Biol Chem 2002 Aug 16;277(33):30079-90.
2. Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. Cai X, etal., J Physiol 2002 May 1;540(Pt 3):743-59.
3. Subcellular localization of GABAB receptor subunits in rat globus pallidus. Chen L, etal., J Comp Neurol. 2004 Jun 28;474(3):340-52. doi: 10.1002/cne.20143.
4. Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating. Engblom AC, etal., J Biol Chem 2002 May 17;277(20):17438-47.
5. Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon. Facciolo RM, etal., Exp Brain Res 2002 Feb;142(4):504-11.
6. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. GABAA receptors: structure, function, pharmacology, and related disorders. Ghit A, etal., J Genet Eng Biotechnol. 2021 Aug 21;19(1):123. doi: 10.1186/s43141-021-00224-0.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization. Kuver A and Smith SS, Brain Res Bull. 2016 Jan;120:131-43. doi: 10.1016/j.brainresbull.2015.11.015. Epub 2015 Nov 22.
11. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Ma DQ, etal., Am J Hum Genet. 2005 Sep;77(3):377-88. Epub 2005 Jul 15.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Nusser Z, etal., J Neurosci. 1998 Mar 1;18(5):1693-703.
15. The effect of propofol on actin, ERK-1/2 and GABAA receptor content in neurones. Oscarsson A, etal., Acta Anaesthesiol Scand. 2007 Oct;51(9):1184-9.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry.PG - 241-57 Saha S, etal., Mol Cell Neurosci 2001 Jan;17(1):241-57.
20. Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. Saras A, etal., J Biol Chem. 2008 Apr 18;283(16):10470-5. doi: 10.1074/jbc.M709993200. Epub 2008 Feb 15.
21. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of gamma-aminobutyric acid type A receptors. Sarto-Jackson I, etal., J Biol Chem. 2012 Apr 20;287(17):14201-14. doi: 10.1074/jbc.M111.293175. Epub 2012 Mar 2.
22. Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. Schaerer MT, etal., J Biol Chem. 2001 Jul 13;276(28):26597-604. Epub 2001 May 11.
23. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
24. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. Ymer S, etal., EMBO J 1989 Jun;8(6):1665-70.
25. Structure of a human synaptic GABAA receptor. Zhu S, etal., Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27.
Additional References at PubMed
PMID:11528422   PMID:11850456   PMID:12939268   PMID:14610076   PMID:15158077   PMID:15282269   PMID:15601928   PMID:16754670   PMID:17021187   PMID:17227918   PMID:17317750   PMID:17395622  
PMID:18292428   PMID:18387955   PMID:18643869   PMID:19056867   PMID:19179335   PMID:20007704   PMID:20937799   PMID:21474657   PMID:23205938   PMID:23909897   PMID:24992900   PMID:25489750  
PMID:26179122   PMID:26297893   PMID:27129275   PMID:27382064   PMID:27789573   PMID:29706582   PMID:33958479   PMID:34214584  


Genomics

Comparative Map Data
Gabrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81027,438,127 - 27,657,680 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1027,438,238 - 27,655,171 (+)EnsemblGRCr8
mRatBN7.21026,936,592 - 27,156,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,936,551 - 27,151,251 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1031,687,629 - 31,916,745 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01031,176,165 - 31,405,281 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,662,808 - 26,891,915 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,973,694 - 28,193,072 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,973,681 - 28,187,565 (+)Ensemblrn6Rnor6.0
Rnor_5.01027,816,796 - 28,032,603 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41027,602,085 - 27,819,145 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1026,450,647 - 26,662,574 (+)NCBICelera
RGSC_v3.11027,603,057 - 27,820,693 (+)NCBI
Cytogenetic Map10q21NCBI
GABRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385161,288,436 - 161,548,404 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5161,288,429 - 161,549,044 (-)Ensemblhg38GRCh38
GRCh375160,715,443 - 160,975,410 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365160,648,014 - 160,907,708 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345160,653,448 - 160,907,708NCBI
Celera5156,747,290 - 157,006,998 (-)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5155,807,898 - 156,067,549 (-)NCBIHuRef
CHM1_15160,147,827 - 160,407,563 (-)NCBICHM1_1
T2T-CHM13v2.05161,817,252 - 162,077,933 (-)NCBIT2T-CHM13v2.0
Gabrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391142,310,342 - 42,523,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1142,310,584 - 42,519,855 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381142,419,515 - 42,632,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1142,419,757 - 42,629,028 (+)Ensemblmm10GRCm38
MGSCv371142,233,259 - 42,446,093 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361142,263,180 - 42,472,451 (+)NCBIMGSCv36mm8
Celera1146,252,427 - 46,464,396 (+)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.08NCBI
Gabrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540815,131,909 - 15,363,169 (-)Ensembl
ChiLan1.0NW_00495540815,126,235 - 15,363,169 (-)NCBIChiLan1.0ChiLan1.0
GABRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24156,474,166 - 156,733,420 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15154,613,712 - 154,872,963 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05156,678,750 - 156,937,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15163,373,530 - 163,632,301 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5163,374,346 - 163,632,301 (-)EnsemblpanPan2panpan1.1
GABRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1449,342,527 - 49,579,697 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl449,342,508 - 49,578,092 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha449,230,876 - 49,476,874 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0449,771,687 - 49,919,166 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl449,771,977 - 50,018,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1449,578,711 - 49,828,742 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0449,712,838 - 49,956,441 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0450,235,113 - 50,479,017 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gabrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213103,677,848 - 103,910,350 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365152,127,693 - 2,355,090 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365152,127,107 - 2,359,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1661,984,925 - 62,239,937 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11661,984,923 - 62,240,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21667,212,830 - 67,464,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GABRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12363,636,094 - 63,894,587 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2363,637,109 - 63,893,370 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603413,661,103 - 13,924,348 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473328,022,635 - 28,230,865 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473328,022,632 - 28,236,211 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gabrb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1925,286,309 - 25,493,196 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gabrb2
1318 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000004970
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
U14419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21027,150,634 - 27,150,772 (+)MAPPERmRatBN7.2
Rnor_6.01028,187,566 - 28,187,703NCBIRnor6.0
Rnor_5.01028,027,097 - 28,027,234UniSTSRnor5.0
RGSC_v3.41027,819,343 - 27,819,480UniSTSRGSC3.4
Celera1026,662,772 - 26,662,909UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 8 63 147 61 61 34 27 34 6 196 116 9 130 32 84 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004970   ⟹   ENSRNOP00000004970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1027,438,238 - 27,651,976 (+)Ensembl
mRatBN7.2 Ensembl1026,936,551 - 27,150,437 (+)Ensembl
Rnor_6.0 Ensembl1027,973,681 - 28,187,565 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118632   ⟹   ENSRNOP00000081083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1027,438,238 - 27,655,171 (+)Ensembl
mRatBN7.2 Ensembl1026,936,551 - 27,151,251 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118954   ⟹   ENSRNOP00000091812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1026,937,591 - 27,151,251 (+)Ensembl
RefSeq Acc Id: NM_012957   ⟹   NP_037089
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81027,439,793 - 27,651,976 (+)NCBI
mRatBN7.21026,938,240 - 27,150,437 (+)NCBI
Rnor_6.01027,975,353 - 28,187,368 (+)NCBI
Rnor_5.01027,816,796 - 28,032,603 (+)NCBI
RGSC_v3.41027,602,085 - 27,819,145 (+)RGD
Celera1026,450,647 - 26,662,574 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246127   ⟹   XP_006246189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81027,438,127 - 27,657,680 (+)NCBI
mRatBN7.21026,936,597 - 27,156,141 (+)NCBI
Rnor_6.01027,973,696 - 28,193,072 (+)NCBI
Rnor_5.01027,816,796 - 28,032,603 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767635   ⟹   XP_008765857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81027,438,137 - 27,657,680 (+)NCBI
mRatBN7.21026,936,592 - 27,156,141 (+)NCBI
Rnor_6.01027,973,694 - 28,193,072 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085275   ⟹   XP_038941203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81027,438,602 - 27,657,680 (+)NCBI
mRatBN7.21026,937,313 - 27,156,141 (+)NCBI
RefSeq Acc Id: NP_037089   ⟸   NM_012957
- Peptide Label: precursor
- UniProtKB: P63138 (UniProtKB/Swiss-Prot),   A6HDL9 (UniProtKB/TrEMBL),   A0A8I6AGU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246189   ⟸   XM_006246127
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008765857   ⟸   XM_008767635
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q2J9 (UniProtKB/TrEMBL),   A0A8I6AGU9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004970   ⟸   ENSRNOT00000004970
RefSeq Acc Id: XP_038941203   ⟸   XM_039085275
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000081083   ⟸   ENSRNOT00000118632
Ensembl Acc Id: ENSRNOP00000091812   ⟸   ENSRNOT00000118954
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63138-F1-model_v2 AlphaFold P63138 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2650 AgrOrtholog
BioCyc Gene G2FUF-25470 BioCyc
Ensembl Genes ENSRNOG00000003680 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004970 ENTREZGENE
  ENSRNOT00000118632 ENTREZGENE
  ENSRNOT00000118632.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAb_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:25451 UniProtKB/Swiss-Prot
NCBI Gene 25451 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PharmGKB GABRB2 RGD
PhenoGen Gabrb2 PhenoGen
PRINTS GABAARBETA UniProtKB/Swiss-Prot
  GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003680 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A8I6AGU9 ENTREZGENE
  A0A8L2Q2J9 ENTREZGENE, UniProtKB/TrEMBL
  A6HDL9 ENTREZGENE, UniProtKB/TrEMBL
  GBRB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P15432 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrb2  gamma-aminobutyric acid type A receptor subunit beta 2  Gabrb2  gamma-aminobutyric acid type A receptor beta 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrb2  gamma-aminobutyric acid type A receptor beta 2 subunit  Gabrb2  gamma-aminobutyric acid (GABA) A receptor, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabrb2  gamma-aminobutyric acid (GABA) A receptor, beta 2  Gabrb2  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabrb2  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2    gamma-aminobutyric acid receptor, subunit beta 2  Name updated 1299863 APPROVED
2002-06-10 Gabrb2  Gamma-aminobutyric acid receptor beta 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both cytoplasmic and subsynaptic sites of NTS neurons 625528
gene_expression mRNA expressed in lower amounts in nucleus tractus solitarii and protein expression is seen in many areas of medulla like cuneate, gracile, olivary and spinal trigeminal nuclei 625528
gene_mutations_overexpression G219F mutation in the first transmembrane region slows the time constant (tau) of GABA-A receptor desensitization 727351
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528