Fbln5 (fibulin 5) - Rat Genome Database

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Gene: Fbln5 (fibulin 5) Rattus norvegicus
Analyze
Symbol: Fbln5
Name: fibulin 5
RGD ID: 2594
Description: Predicted to enable integrin binding activity and protein homodimerization activity. Involved in regulation of cell growth. Located in extracellular space. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dance; developmental arteries and neural crest EGF-like protein; embryonic vascular EGF repeat-containing protein; EVEC; FIBL-5; fibulin-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,664,100 - 126,742,847 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6126,664,100 - 126,746,296 (-)EnsemblGRCr8
mRatBN7.26120,899,219 - 120,977,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6120,899,224 - 120,977,755 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6121,049,874 - 121,128,342 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,346,562 - 121,425,038 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,681,448 - 120,759,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,644,797 - 125,723,957 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,644,804 - 125,723,944 (-)Ensemblrn6Rnor6.0
Rnor_5.06134,856,694 - 134,935,853 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46126,018,541 - 126,098,234 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6118,399,373 - 118,476,665 (-)NCBICelera
RGSC_v3.16126,022,288 - 126,102,052 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroxybenzophenone  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (EXP)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fentanyl  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
N-nitrosodiethylamine  (EXP)
naled  (ISO)
nickel dichloride  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (EXP)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
elastic fiber  (IEA,ISO)
extracellular matrix  (IBA,IEA,ISO,ISS)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature. Kowal RC, etal., Circ Res 1999 May 28;84(10):1166-76.
4. Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa. Loeys B, etal., Hum Mol Genet 2002 Sep 1;11(18):2113-8.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. Nakamura T, etal., J Biol Chem 1999 Aug 6;274(32):22476-83.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Yanagisawa H, etal., Nature 2002 Jan 10;415(6868):168-71.
Additional References at PubMed
PMID:11805835   PMID:15489334   PMID:15528465   PMID:17035250   PMID:17607303   PMID:18757743   PMID:19617354   PMID:20007835   PMID:20551380   PMID:20599547   PMID:20942562   PMID:22205540  
PMID:23376485   PMID:23533145   PMID:24006456   PMID:26021746   PMID:26316108   PMID:26399686   PMID:27068509   PMID:28251683   PMID:28755400   PMID:32286390  


Genomics

Comparative Map Data
Fbln5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,664,100 - 126,742,847 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6126,664,100 - 126,746,296 (-)EnsemblGRCr8
mRatBN7.26120,899,219 - 120,977,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6120,899,224 - 120,977,755 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6121,049,874 - 121,128,342 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,346,562 - 121,425,038 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,681,448 - 120,759,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,644,797 - 125,723,957 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,644,804 - 125,723,944 (-)Ensemblrn6Rnor6.0
Rnor_5.06134,856,694 - 134,935,853 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46126,018,541 - 126,098,234 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6118,399,373 - 118,476,665 (-)NCBICelera
RGSC_v3.16126,022,288 - 126,102,052 (-)NCBI
Cytogenetic Map6q32NCBI
FBLN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381491,869,411 - 91,947,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1491,869,410 - 91,948,064 (-)Ensemblhg38GRCh38
GRCh371492,335,755 - 92,414,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361491,405,508 - 91,483,788 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341491,405,508 - 91,483,788NCBI
Celera1472,388,374 - 72,466,655 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1472,516,509 - 72,594,687 (-)NCBIHuRef
CHM1_11492,273,834 - 92,352,362 (-)NCBICHM1_1
T2T-CHM13v2.01486,098,901 - 86,177,154 (-)NCBIT2T-CHM13v2.0
Fbln5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912101,712,820 - 101,785,541 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12101,712,824 - 101,785,314 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812101,746,565 - 101,819,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12101,746,565 - 101,819,055 (-)Ensemblmm10GRCm38
MGSCv3712102,984,775 - 103,057,265 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612102,147,615 - 102,228,101 (-)NCBIMGSCv36mm8
Celera12102,955,562 - 103,028,678 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.29NCBI
Fbln5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,071,410 - 14,145,070 (-)Ensembl
ChiLan1.0NW_00495543814,073,927 - 14,144,644 (-)NCBIChiLan1.0ChiLan1.0
FBLN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,027,865 - 93,106,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,244,375 - 92,323,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,504,240 - 72,583,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11491,848,430 - 91,927,470 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1491,848,430 - 91,927,304 (-)EnsemblpanPan2panpan1.1
FBLN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,162,203 - 1,231,809 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,162,923 - 1,231,719 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha81,181,396 - 1,250,913 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.081,211,329 - 1,280,901 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,211,330 - 1,280,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,149,346 - 1,218,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,105,810 - 1,175,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,226,613 - 1,296,196 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbln5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864013,257,820 - 13,330,662 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733137,207 - 209,473 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936733136,374 - 200,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBLN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7113,423,632 - 113,512,198 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17113,423,629 - 113,526,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,031,698 - 120,120,256 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBLN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12469,626,498 - 69,703,146 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2469,626,339 - 69,703,108 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605356,876,363 - 56,952,959 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbln5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473410,768,751 - 10,843,654 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473410,768,920 - 10,840,740 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbln5
497 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:220
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000007004
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
D6Hmgc5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86126,680,629 - 126,680,793 (+)Marker Load Pipeline
mRatBN7.26120,915,748 - 120,915,912 (+)MAPPERmRatBN7.2
Rnor_6.06125,661,793 - 125,661,956NCBIRnor6.0
Rnor_5.06134,873,689 - 134,873,852UniSTSRnor5.0
Celera6118,415,903 - 118,416,066UniSTS
Cytogenetic Map6q32UniSTS
D6Hmgc15  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86126,680,628 - 126,680,796 (+)Marker Load Pipeline
mRatBN7.26120,915,747 - 120,915,915 (+)MAPPERmRatBN7.2
Rnor_6.06125,661,792 - 125,661,959NCBIRnor6.0
Rnor_5.06134,873,688 - 134,873,855UniSTSRnor5.0
Celera6118,415,902 - 118,416,069UniSTS
Cytogenetic Map6q32UniSTS
RH133848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26120,899,362 - 120,899,564 (+)MAPPERmRatBN7.2
Rnor_6.06125,644,942 - 125,645,143NCBIRnor6.0
Rnor_5.06134,856,838 - 134,857,039UniSTSRnor5.0
RGSC_v3.46126,018,685 - 126,018,886UniSTSRGSC3.4
Celera6118,399,517 - 118,399,718UniSTS
RH 3.4 Map6857.0UniSTS
Cytogenetic Map6q32UniSTS
AU047432  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera6118,425,327 - 118,425,435UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 152 91 90 59 55 59 6 319 155 11 131 81 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000007004   ⟹   ENSRNOP00000007004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6126,664,100 - 126,738,541 (-)Ensembl
mRatBN7.2 Ensembl6120,899,224 - 120,977,755 (-)Ensembl
Rnor_6.0 Ensembl6125,644,804 - 125,723,944 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084815   ⟹   ENSRNOP00000069614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6126,664,100 - 126,746,296 (-)Ensembl
mRatBN7.2 Ensembl6120,899,226 - 120,973,662 (-)Ensembl
Rnor_6.0 Ensembl6125,645,601 - 125,723,732 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111088   ⟹   ENSRNOP00000093087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6126,664,100 - 126,742,215 (-)Ensembl
mRatBN7.2 Ensembl6120,899,237 - 120,977,406 (-)Ensembl
RefSeq Acc Id: NM_019153   ⟹   NP_062026
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,664,100 - 126,742,706 (-)NCBI
mRatBN7.26120,899,219 - 120,977,829 (-)NCBI
Rnor_6.06125,644,798 - 125,723,957 (-)NCBI
Rnor_5.06134,856,694 - 134,935,853 (-)NCBI
RGSC_v3.46126,018,541 - 126,098,234 (-)RGD
Celera6118,399,373 - 118,476,665 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240459   ⟹   XP_006240521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,664,100 - 126,742,466 (-)NCBI
mRatBN7.26120,899,219 - 120,977,406 (-)NCBI
Rnor_6.06125,644,797 - 125,723,685 (-)NCBI
Rnor_5.06134,856,694 - 134,935,853 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063261574   ⟹   XP_063117644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,665,034 - 126,742,847 (-)NCBI
RefSeq Acc Id: NP_062026   ⟸   NM_019153
- Peptide Label: precursor
- UniProtKB: Q9R284 (UniProtKB/Swiss-Prot),   Q9WVH8 (UniProtKB/Swiss-Prot),   A6JEJ1 (UniProtKB/TrEMBL),   A0A8L2R0X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240521   ⟸   XM_006240459
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHX3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069614   ⟸   ENSRNOT00000084815
Ensembl Acc Id: ENSRNOP00000007004   ⟸   ENSRNOT00000007004
Ensembl Acc Id: ENSRNOP00000093087   ⟸   ENSRNOT00000111088
RefSeq Acc Id: XP_063117644   ⟸   XM_063261574
- Peptide Label: isoform X2
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVH8-F1-model_v2 AlphaFold Q9WVH8 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694778
Promoter ID:EPDNEW_R5303
Type:initiation region
Name:Fbln5_1
Description:fibulin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06125,723,863 - 125,723,923EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2594 AgrOrtholog
BioCyc Gene G2FUF-36467 BioCyc
Ensembl Genes ENSRNOG00000050539 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007004 ENTREZGENE
  ENSRNOT00000111088 ENTREZGENE
Gene3D-CATH Laminin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7123752 IMAGE-MGC_LOAD
InterPro cEGF UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Fibulin_C UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Nephronectin_domain UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
KEGG Report rno:29158 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93487 IMAGE-MGC_LOAD
NCBI Gene 29158 ENTREZGENE
PANTHER FIBRILLIN-1 UniProtKB/Swiss-Prot
  PA14 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam cEGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Fibulin_C UniProtKB/Swiss-Prot
PhenoGen Fbln5 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050539 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A8I6AHX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q3P8_RAT UniProtKB/TrEMBL
  A0A8L2R0X2 ENTREZGENE, UniProtKB/TrEMBL
  A6JEJ1 ENTREZGENE, UniProtKB/TrEMBL
  FBLN5_RAT UniProtKB/Swiss-Prot
  Q9R284 ENTREZGENE
  Q9WVH8 ENTREZGENE
UniProt Secondary Q9R284 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fbln5  fibulin 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains Ca2+ binding epidermal growth factor-like repeats 632806
gene_regulation upregulated after vascular injury 632806