Ephx1 (epoxide hydrolase 1) - Rat Genome Database

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Gene: Ephx1 (epoxide hydrolase 1) Rattus norvegicus
Analyze
Symbol: Ephx1
Name: epoxide hydrolase 1
RGD ID: 2557
Description: Enables cis-stilbene-oxide hydrolase activity and enzyme binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Located in intracellular membrane-bounded organelle and membrane. Biomarker of aflatoxins-related hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1); PARTICIPATES IN carbamazepine pharmacokinetics pathway; phenytoin pharmacodynamics pathway; bile acid transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: epoxide hydratase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase; Epoxide hydrolase 1 (microsomal xenobiotic hydrolase); epoxide hydrolase 1, microsomal; epoxide hydrolase 1, microsomal (xenobiotic); liver microsomal xenobiotic epoxide hydrolase; mEH; MEH8; microsomal epoxide hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81395,246,079 - 95,275,852 (-)NCBIGRCr8
mRatBN7.21392,714,315 - 92,744,105 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,714,315 - 92,790,235 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1395,219,628 - 95,249,435 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,619,561 - 96,649,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,794,258 - 93,824,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01399,271,390 - 99,300,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013104,268,704 - 104,297,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,722,973 - 96,752,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,912,126 - 96,925,415 (-)NCBI
Celera1392,256,740 - 92,285,424 (-)NCBICelera
RH 3.4 Map13631.9RGD
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Ephx1Ratacute lymphoblastic leukemia susceptibilityISOEPHX1 (Homo sapiens)11252110DNA:missense mutation and haplotype:exon:p.Y113H (human)RGD 
Ephx1Ratacute lymphoblastic leukemia no_associationISOEPHX1 (Homo sapiens)11252110DNA:missense mutation and haplotype:exon:p.H139R (human)RGD 
Ephx1Ratacute lymphoblastic leukemia no_associationISOEPHX1 (Homo sapiens)11252114DNA:SNPs:exon:rs1051740 and rs2234922 (human)RGD 
Ephx1Ratacute lymphoblastic leukemia susceptibilityISOEPHX1 (Homo sapiens)11252111 RGD 
Ephx1Ratacute lymphoblastic leukemia susceptibilityISOEPHX1 (Homo sapiens)11252113DNA:polymorphisms:exonRGD 
Ephx1Ratacute myeloid leukemia no_associationISOEPHX1 (Homo sapiens)11252115DNA:polymorphismRGD 
Ephx1Ratacute myeloid leukemia no_associationISOEPHX1 (Homo sapiens)11252114DNA:SNPs:exon:rs1051740 and rs2234922 (human)RGD 
Ephx1Ratacute myeloid leukemia  ISOEPHX1 (Homo sapiens)11252119DNA:missense mutations:exon:p.Y113H and p.H139R (human)RGD 
Ephx1Rataflatoxins-related hepatocellular carcinoma  IEP 152998935associated with estrogen excess more ...RGD 
Ephx1RatAlzheimer's disease  ISOEPHX1 (Homo sapiens)5688388protein:increased expression:hippocampusRGD 
Ephx1Ratanemia treatmentISOEPHX1 (Homo sapiens)11097078associated with Ovarian NeoplasmsRGD 
Ephx1Rataplastic anemia disease_progressionISOEPHX1 (Homo sapiens)11252120DNA:SNPs:exon:p.Y113H (rs1051740), p.H139R (rs2234922) (human)RGD 
Ephx1Rataplastic anemia susceptibilityISOEPHX1 (Homo sapiens)11252118DNA:missense mutation:exon:p.H139R (human)RGD 
Ephx1Ratasbestosis susceptibilityISOEPHX1 (Homo sapiens)4889408DNA:SNP:exon:p.Y113H (rs1051740) (human)RGD 
Ephx1Ratasthma susceptibilityISOEPHX1 (Homo sapiens)4889407DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human)RGD 
Ephx1Ratbone disease  ISOEPHX1 (Homo sapiens)11252112associated with Multiple Myeloma and DNA:SNPRGD 
Ephx1Ratchronic obstructive pulmonary disease no_associationISOEPHX1 (Homo sapiens)4889123DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human)RGD 
Ephx1Ratchronic obstructive pulmonary disease  ISOEPHX1 (Homo sapiens)1601065DNA:polymorphismRGD 
Ephx1Ratchronic obstructive pulmonary disease no_associationISOEPHX1 (Homo sapiens)4889122DNA:SNPs: :multiple (human)RGD 
Ephx1Ratchronic obstructive pulmonary disease no_associationISOEPHX1 (Homo sapiens)4889120DNA:SNP:exon:p.H139R (rs2234922) (human)RGD 
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Ephx1Ratcystic fibrosis  ISOEPHX1 (Homo sapiens)8554872ClinVar Annotator: match by term: MucoviscidosisClinVarPMID:12704386 more ...
Ephx1RatFamilial Hypercholanemia 1  ISOEPHX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypercholanemia and familial 1ClinVarPMID:25326635 and PMID:25741868
Ephx1Ratgastrointestinal stromal tumor  ISOEPHX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Ephx1Ratlipodystrophy  ISOEPHX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary lipodystrophyClinVarPMID:25741868 and PMID:34342583
Ephx1Ratneutropenia  ISOEPHX1 (Homo sapiens)8554872ClinVar Annotator: match by term: NeutropeniaClinVar 
Ephx1Ratparathyroid carcinoma  ISOEPHX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
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Ephx1RatAbnormalities, Drug-Induced  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2336087
Ephx1RatAcute Lung Injury  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26840748
Ephx1Ratacute lymphoblastic leukemia  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21983886
Ephx1Ratacute myeloid leukemia  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29605894
Ephx1Ratamphetamine abuse  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19598248
Ephx1RatAnimal Mammary Neoplasms  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Ephx1Ratautism spectrum disorder  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Ephx1Ratcarcinoma  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Ephx1RatChemical and Drug Induced Liver Injury  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25226513
Ephx1Ratchronic obstructive pulmonary disease  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9288046
Ephx1RatExperimental Mammary Neoplasms  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Ephx1RatFamilial Hypercholanemia  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12878321
Ephx1RatFever  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:31422080
Ephx1Rathepatocellular carcinoma  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7892276
Ephx1RatLung Neoplasms  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17114358 and PMID:17311802
Ephx1Ratlymphoma  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11406608
Ephx1Ratmalignant mesothelioma  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16697254
Ephx1RatMicronuclei, Chromosome-Defective  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22156006
Ephx1Ratmultiple myeloma  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16949155
Ephx1RatMyocardial Ischemia  ISOEPHX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29298899
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Ephx1Rat(1->4)-beta-D-glucan multiple interactionsISOEphx1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of EPHX1 mRNACTDPMID:36331819
Ephx1Rat(2,4,5-trichlorophenoxy)acetic acid increases activityISOEphx1 (Mus musculus)64804642 more ...CTDPMID:3032197
Ephx1Rat(9R,10S)-9,10-epoxy-9,10-dihydrophenanthrene increases metabolic processingISOEphx1 (Mus musculus)6480464EPHX1 protein mutant form results in increased metabolism of 9 more ...CTDPMID:26838043
Ephx1Rat(S)-mandelic acid multiple interactionsISOEPHX1 (Homo sapiens)6480464EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]CTDPMID:25562543
Ephx1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of EPHX1 mRNACTDPMID:17984292
Ephx1Rat1,1-dichloroethene increases expressionISOEphx1 (Mus musculus)6480464vinylidene chloride results in increased expression of EPHX1 mRNACTDPMID:26682919
Ephx1Rat1,2-dibromoethane decreases expressionISOEphx1 (Mus musculus)6480464Ethylene Dibromide results in decreased expression of EPHX1 mRNACTDPMID:17311802
Ephx1Rat1,2-dihydronaphthalene-1,2-diol multiple interactionsISOEphx1 (Mus musculus)6480464[EPHX1 protein results in increased metabolism of naphthalene] which results in increased chemical synthesis of 1 more ...CTDPMID:18363382 and PMID:26840748
Ephx1Rat1,2-dimethylhydrazine increases expressionISOEphx1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of EPHX1 mRNACTDPMID:22206623
Ephx1Rat1,3,5-trimethylbenzene increases expressionISOEPHX1 (Homo sapiens)6480464mesitylene results in increased expression of EPHX1 mRNACTDPMID:33269480
Ephx1Rat1,4-dioxane increases expressionISOEphx1 (Mus musculus)64804641 and 4-dioxane results in increased expression of EPHX1 mRNACTDPMID:33693819
Ephx1Rat1-benzofuran increases expressionISOEphx1 (Mus musculus)6480464benzofuran results in increased expression of EPHX1 mRNACTDPMID:17311802
Ephx1Rat1-benzofuran affects expressionISOEphx1 (Mus musculus)6480464benzofuran affects the expression of EPHX1 mRNACTDPMID:17114358
Ephx1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of EPHX1 mRNACTDPMID:30723492
Ephx1Rat1-nitropropane decreases expressionEXP 64804641-nitropropane results in decreased expression of EPHX1 mRNACTDPMID:17070881
Ephx1Rat17alpha-ethynylestradiol affects expressionISOEphx1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of EPHX1 mRNACTDPMID:17555576
Ephx1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of EPHX1 mRNACTDPMID:16926038
Ephx1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of EPHX1 mRNACTDPMID:16174780 and PMID:29097150
Ephx1Rat17alpha-ethynylestradiol multiple interactionsISOEphx1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EPHX1 mRNACTDPMID:17942748
Ephx1Rat17alpha-ethynylestradiol decreases expressionISOEphx1 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of EPHX1 mRNACTDPMID:16174780

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Biological Process
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Ephx1Ratarachidonate metabolic process involved_inISSUniProtKB:P070991600115GO_REF:0000024UniProtGO_REF:0000024
Ephx1Ratarachidonate metabolic process involved_inIBAPANTHER:PTN002728981 and UniProtKB:P070991600115GO_REF:0000033GO_CentralGO_REF:0000033
Ephx1Ratarachidonate metabolic process involved_inISOEPHX1 (Homo sapiens)1624291 PMID:24958911RGDPMID:24958911
Ephx1Ratcatabolic process involved_inIEAUniProtKB-KW:KW-00581600115GO_REF:0000043UniProtGO_REF:0000043
Ephx1Ratcellular response to glucocorticoid stimulus  IEP 4889422 RGD 
Ephx1Ratdiol biosynthetic process  IDA 11252156 RGD 
Ephx1Ratepoxide metabolic process involved_inIDA 13210555PMID:9854022UniProt 
Ephx1Ratepoxide metabolic process involved_inIBAPANTHER:PTN001856032 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ephx1Ratepoxide metabolic process involved_inISOEPHX1 (Homo sapiens)1624291 PMID:22798687RGDPMID:22798687
Ephx1Rathydrocarbon catabolic process acts_upstream_of_or_withinISOEphx1 (Mus musculus)1624291MGI:2137236 PMID:10446164RGDPMID:10446164
Ephx1Rathydrocarbon catabolic process acts_upstream_of_or_withinIEAUniProtKB:Q9D379 and ensembl:ENSMUSP000000475511600115GO_REF:0000107EnsemblGO_REF:0000107
Ephx1Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Ephx1Ratliver development  IEP 4889418 RGD 
Ephx1Ratresponse to toxic substance involved_inIEAUniProtKB-KW:KW-02161600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Ephx1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Ephx1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Ephx1Ratendoplasmic reticulum membrane located_inIEAUniRule:UR0003967961600115GO_REF:0000104UniProtGO_REF:0000104
Ephx1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-04921600115GO_REF:0000043UniProtGO_REF:0000043
Ephx1Ratintracellular membrane-bounded organelle located_inIDA 13210555PMID:9854022UniProt 
Ephx1Ratintracellular membrane-bounded organelle located_inIDA 13210525PMID:22798687UniProt 
Ephx1Ratintracellular membrane-bounded organelle located_inIDA 13210535PMID:9245728UniProt 
Ephx1Ratmembrane located_inIDA 13210535PMID:9245728UniProt 
Ephx1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ephx1Ratmembrane located_inIDA 13210555PMID:9854022UniProt 
Ephx1Ratmembrane located_inIDA 13210525PMID:22798687UniProt 
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Molecular Function
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Ephx1Ratcatalytic activity enablesIEAInterPro:IPR0006391600115GO_REF:0000002InterProGO_REF:0000002
Ephx1Ratcis-stilbene-oxide hydrolase activity enablesIEAEC:3.3.2.91600115GO_REF:0000003UniProtGO_REF:0000003
Ephx1Ratcis-stilbene-oxide hydrolase activity enablesISOEPHX1 (Homo sapiens)1624291 PMID:24958911RGDPMID:24958911
Ephx1Ratcis-stilbene-oxide hydrolase activity enablesIMP 13210555PMID:9854022UniProt 
Ephx1Ratcis-stilbene-oxide hydrolase activity enablesISSUniProtKB:P070991600115GO_REF:0000024UniProtGO_REF:0000024
Ephx1Ratcis-stilbene-oxide hydrolase activity enablesIEAUniRule:UR0003967961600115GO_REF:0000104UniProtGO_REF:0000104
Ephx1Ratcis-stilbene-oxide hydrolase activity enablesIEARHEA:239001600115GO_REF:0000116RHEAGO_REF:0000116
Ephx1Ratenzyme binding  IPICyp1a1 (Rattus norvegicus)2306634 RGD 
Ephx1Ratepoxide hydrolase activity  IDA 4889412 RGD 
Ephx1Ratepoxide hydrolase activity enablesIBAFB:FBgn0010053 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ephx1Ratepoxide hydrolase activity enablesIMP 13210555PMID:9854022UniProt 
Ephx1Ratepoxide hydrolase activity enablesISOEPHX1 (Homo sapiens)1624291 PMID:22798687 and PMID:24958911RGDPMID:22798687 and PMID:24958911
Ephx1Ratepoxide hydrolase activity  IDA 11252123 RGD 
Ephx1Ratether hydrolase activity enablesIEAInterPro:IPR0162921600115GO_REF:0000002InterProGO_REF:0000002
Ephx1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Ephx1Ratoxysterol binding enablesISOEphx1 (Mus musculus)1624291 PMID:34799735RGDPMID:34799735
Ephx1Ratoxysterol binding enablesIEAUniProtKB:Q9D379 and ensembl:ENSMUSP000000475511600115GO_REF:0000107EnsemblGO_REF:0000107
Ephx1Ratoxysterol binding enablesISSUniProtKB:Q9D3791600115GO_REF:0000024UniProtGO_REF:0000024
Ephx1Ratprotein binding enablesISOEPHX1 (Homo sapiens)1624291UniProtKB:P13569 more ...RGDPMID:32814053 more ...
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Imported Annotations - SMPDB

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Ephx1Ratcarbamazepine pharmacokinetics pathway  ISOEPHX1 (Homo sapiens)10402751 SMPDBSMP:00634
Ephx1Ratphenytoin pharmacodynamics pathway  ISOEPHX1 (Homo sapiens)10402751 SMPDBSMP:00327

Imported Annotations - KEGG (archival)

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Ephx1Ratbile acid transport pathway  IEA 6907045 KEGGrno:04976
Ephx1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980

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Reference Title
Reference Citation
1. GSTM1 and mEPHX polymorphisms in Parkinson's disease and age of onset. Ahmadi A, etal., Biochem Biophys Res Commun. 2000 Mar 24;269(3):676-80.
2. Bladder cancer SNP panel predicts susceptibility and survival. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
3. Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate. Arand M, etal., Biochem J. 1999 Jan 1;337 ( Pt 1):37-43.
4. Expression of rat microsomal epoxide hydrolase in Escherichia coli. Identification of a histidyl residue essential for catalysis. Bell PA and Kasper CB, J Biol Chem. 1993 Jul 5;268(19):14011-7.
5. Glucocorticoid repression and basal regulation of the epoxide hydrolase promoter. Bell PA, etal., Arch Biochem Biophys. 1990 Jun;279(2):363-9.
6. Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). Bonaventure A, etal., Cancer Causes Control. 2012 Feb;23(2):329-45. doi: 10.1007/s10552-011-9882-9. Epub 2011 Dec 27.
7. Genetic susceptibility for emphysematous changes of the lung in Japanese. Budhi A, etal., Int J Mol Med. 2003 Mar;11(3):321-9.
8. Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. Chang HS, etal., Nutr Res. 2010 Jun;30(6):435-40.
9. Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Chappell S, etal., Eur Respir J. 2008 Oct;32(4):931-7. Epub 2008 Jul 9.
10. Association of glutathione S-transferase, EPHX, and p53 codon 72 gene polymorphisms with adult acute myeloid leukemia. Chauhan PS, etal., DNA Cell Biol. 2011 Jan;30(1):39-46. doi: 10.1089/dna.2010.1092. Epub 2010 Aug 23.
11. High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia. Chauhan PS, etal., Environ Mol Mutagen. 2012 Oct;53(8):619-30. doi: 10.1002/em.21723. Epub 2012 Aug 29.
12. Epoxide hydratase: sex specific expression and rate-limiting role in DMBA metabolism. Christou M, etal., Carcinogenesis. 1989 Oct;10(10):1883-90.
13. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. Decker M, etal., J Lipid Res. 2012 Oct;53(10):2038-45. doi: 10.1194/jlr.M024448. Epub 2012 Jul 12.
14. Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma. Durie BG, etal., Leukemia. 2009 Oct;23(10):1913-9. doi: 10.1038/leu.2009.129. Epub 2009 Aug 6.
15. Structure and organization of the microsomal xenobiotic epoxide hydrolase gene. Falany CN, etal., J Biol Chem 1987 Apr 25;262(12):5924-30.
16. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Farin FM, etal., Pharmacogenetics. 2001 Nov;11(8):703-8.
17. Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells. Friedberg T, etal., Carcinogenesis. 1994 Feb;15(2):171-5.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. Gold LS, etal., Cancer Epidemiol. 2009 Oct;33(3-4):276-80. doi: 10.1016/j.canep.2009.08.005. Epub 2009 Sep 6.
1 to 20 of 70 rows
PMID:10446164   PMID:15047867   PMID:15489334   PMID:20396348   PMID:22061827   PMID:24958911   PMID:28736260  



Ephx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81395,246,079 - 95,275,852 (-)NCBIGRCr8
mRatBN7.21392,714,315 - 92,744,105 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,714,315 - 92,790,235 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1395,219,628 - 95,249,435 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,619,561 - 96,649,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,794,258 - 93,824,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01399,271,390 - 99,300,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013104,268,704 - 104,297,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,722,973 - 96,752,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,912,126 - 96,925,415 (-)NCBI
Celera1392,256,740 - 92,285,424 (-)NCBICelera
RH 3.4 Map13631.9RGD
Cytogenetic Map13q26NCBI
EPHX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,810,124 - 225,845,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1225,810,124 - 225,845,563 (+)EnsemblGRCh38hg38GRCh38
GRCh371225,997,826 - 226,033,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,079,599 - 224,099,884 (+)NCBINCBI36Build 36hg18NCBI36
Build 341222,319,710 - 222,339,996NCBI
Celera1199,188,853 - 199,224,327 (+)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1196,515,661 - 196,550,964 (+)NCBIHuRef
CHM1_11227,270,121 - 227,305,585 (+)NCBICHM1_1
T2T-CHM13v2.01224,998,070 - 225,033,336 (+)NCBIT2T-CHM13v2.0
Ephx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,817,121 - 180,845,134 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,803,775 - 180,848,469 (-)EnsemblGRCm39 Ensembl
GRCm381180,989,556 - 181,017,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,976,210 - 181,020,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,919,687 - 182,947,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,826,231 - 182,854,170 (-)NCBIMGSCv36mm8
Celera1188,055,356 - 188,083,565 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.48NCBI
Ephx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955520116,363 - 128,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955520116,363 - 142,983 (-)NCBIChiLan1.0ChiLan1.0
EPHX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,692,322 - 23,727,663 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,640,786 - 23,675,962 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01201,271,366 - 201,306,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11206,272,866 - 206,307,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,272,866 - 206,307,581 (+)Ensemblpanpan1.1panPan2
EPHX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,964,319 - 39,004,902 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,964,338 - 38,999,238 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,446,530 - 38,481,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,798,288 - 38,833,289 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,798,291 - 38,833,208 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1738,638,072 - 38,673,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,646,207 - 38,681,169 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,915,983 - 38,950,983 (-)NCBIUU_Cfam_GSD_1.0
Ephx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934452,094,468 - 52,163,372 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365262,614,059 - 2,653,286 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365262,589,254 - 2,652,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,751,881 - 13,773,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11013,757,489 - 13,773,071 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,016,584 - 16,054,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,924,396 - 3,960,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,924,606 - 3,945,535 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660553,930,701 - 3,966,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ephx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248356,162,111 - 6,168,714 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248356,161,930 - 6,181,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ephx1
260 total Variants

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000004780
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 14 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat

1 to 10 of 14 rows
Ephx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,716,681 - 92,716,790 (+)MAPPERmRatBN7.2
Rnor_6.01399,273,757 - 99,273,865NCBIRnor6.0
Rnor_5.013104,271,071 - 104,271,179UniSTSRnor5.0
RGSC_v3.41396,725,337 - 96,725,445UniSTSRGSC3.4
Celera1392,259,107 - 92,259,215UniSTS
Cytogenetic Map13q26UniSTS
RH94562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,714,240 - 92,714,327 (+)MAPPERmRatBN7.2
mRatBN7.21392,790,387 - 92,790,474 (+)MAPPERmRatBN7.2
Rnor_6.01399,346,749 - 99,346,835NCBIRnor6.0
Rnor_6.01399,271,316 - 99,271,402NCBIRnor6.0
Rnor_5.013104,343,786 - 104,343,872UniSTSRnor5.0
Rnor_5.013104,268,630 - 104,268,716UniSTSRnor5.0
RGSC_v3.41396,722,896 - 96,722,982UniSTSRGSC3.4
RGSC_v3.41396,799,199 - 96,799,285UniSTSRGSC3.4
Celera1392,331,667 - 92,331,753UniSTS
Celera1392,256,666 - 92,256,752UniSTS
RH 3.4 Map13631.9UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:142997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21392,716,681 - 92,716,791 (+)MAPPERmRatBN7.2
Rnor_6.01399,273,757 - 99,273,866NCBIRnor6.0
Rnor_5.013104,271,071 - 104,271,180UniSTSRnor5.0
RGSC_v3.41396,725,337 - 96,725,446UniSTSRGSC3.4
Celera1392,259,107 - 92,259,216UniSTS
Cytogenetic Map13q26UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000004780   ⟹   ENSRNOP00000004780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,319 - 92,790,235 (-)Ensembl
Rnor_6.0 Ensembl1399,271,390 - 99,287,887 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000029787   ⟹   ENSRNOP00000034917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,316 - 92,744,054 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085279   ⟹   ENSRNOP00000074206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,315 - 92,727,979 (-)Ensembl
Rnor_6.0 Ensembl1399,271,366 - 99,300,579 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109605   ⟹   ENSRNOP00000080132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,714,315 - 92,725,978 (-)Ensembl
RefSeq Acc Id: NM_001034090   ⟹   NP_001029262
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,246,079 - 95,275,852 (-)NCBI
mRatBN7.21392,714,318 - 92,744,105 (-)NCBI
Rnor_6.01399,271,390 - 99,300,580 (-)NCBI
Rnor_5.013104,268,704 - 104,297,617 (-)NCBI
RGSC_v3.41396,722,973 - 96,752,940 (-)RGD
Celera1392,256,740 - 92,285,424 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012844   ⟹   NP_036976
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,246,079 - 95,263,117 (-)NCBI
mRatBN7.21392,714,318 - 92,731,364 (-)NCBI
Rnor_6.01399,271,390 - 99,287,887 (-)NCBI
Rnor_5.013104,268,704 - 104,297,617 (-)NCBI
RGSC_v3.41396,722,973 - 96,752,940 (-)RGD
Celera1392,256,740 - 92,272,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090378   ⟹   XP_038946306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,246,079 - 95,263,682 (-)NCBI
mRatBN7.21392,714,315 - 92,731,911 (-)NCBI
RefSeq Acc Id: NP_001029262   ⟸   NM_001034090
- UniProtKB: P07687 (UniProtKB/Swiss-Prot),   A6JGI7 (UniProtKB/TrEMBL),   A0A8L2R8K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_036976   ⟸   NM_012844
- UniProtKB: P07687 (UniProtKB/Swiss-Prot),   A6JGI7 (UniProtKB/TrEMBL),   A0A8L2R8K5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074206   ⟸   ENSRNOT00000085279
Ensembl Acc Id: ENSRNOP00000004780   ⟸   ENSRNOT00000004780
RefSeq Acc Id: XP_038946306   ⟸   XM_039090378
- Peptide Label: isoform X1
- UniProtKB: P07687 (UniProtKB/Swiss-Prot),   A6JGI7 (UniProtKB/TrEMBL),   A0A8L2R8K5 (UniProtKB/TrEMBL)
AB hydrolase-1   Epoxide hydrolase N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-F1LTS8-F1-model_v2 AlphaFold F1LTS8 1-453 view protein structure
AF-P07687-F1-model_v2 AlphaFold P07687 1-455 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699065
Promoter ID:EPDNEW_R9590
Type:multiple initiation site
Name:Ephx1_2
Description:epoxide hydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9591  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01399,287,887 - 99,287,947EPDNEW
RGD ID:13699066
Promoter ID:EPDNEW_R9591
Type:initiation region
Name:Ephx1_1
Description:epoxide hydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9590  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01399,300,536 - 99,300,596EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17106 BioCyc
Ensembl Genes ENSRNOG00000003515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004780 ENTREZGENE
  ENSRNOT00000004780.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889368 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Epox_hydrolase-like UniProtKB/Swiss-Prot
  Epoxide_hydro_N UniProtKB/Swiss-Prot
  Epoxide_hydrolase UniProtKB/Swiss-Prot
KEGG Report rno:25315 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72921 IMAGE-MGC_LOAD
NCBI Gene 25315 ENTREZGENE
PANTHER EPOXIDE HYDROLASE 1 UniProtKB/Swiss-Prot
  EPOXIDE HYDROLASE 1-RELATED UniProtKB/Swiss-Prot
Pfam EHN UniProtKB/Swiss-Prot
PharmGKB EPHX1 RGD
PhenoGen Ephx1 PhenoGen
PIRSF Epoxide_hydrolase UniProtKB/Swiss-Prot
PRINTS EPOXHYDRLASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003515 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A8I5ZSE7_RAT UniProtKB/TrEMBL
  A0A8L2R8K5 ENTREZGENE, UniProtKB/TrEMBL
  A6JGI6_RAT UniProtKB/TrEMBL
  A6JGI7 ENTREZGENE, UniProtKB/TrEMBL
  A6JGI8_RAT UniProtKB/TrEMBL
  A6JGI9_RAT UniProtKB/TrEMBL
  A6JGJ0_RAT UniProtKB/TrEMBL
  F1LTS8_RAT UniProtKB/TrEMBL
  HYEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Ephx1  epoxide hydrolase 1  Ephx1  epoxide hydrolase 1, microsomal (xenobiotic)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Ephx1  epoxide hydrolase 1, microsomal (xenobiotic)  Ephx1  epoxide hydrolase 1, microsomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ephx1  epoxide hydrolase 1, microsomal    epoxide hydrolase 1  Name updated 1299863 APPROVED
2002-11-06 Ephx1  epoxide hydrolase 1    Epoxide hydrolase 1 (microsomal xenobiotic hydrolase)  Name updated 625702 APPROVED
2002-06-10 Ephx1  Epoxide hydrolase 1 (microsomal xenobiotic hydrolase)      Symbol and Name status set to approved 70586 APPROVED