Cyb5r3 (cytochrome b5 reductase 3) - Rat Genome Database

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Gene: Cyb5r3 (cytochrome b5 reductase 3) Rattus norvegicus
Analyze
Symbol: Cyb5r3
Name: cytochrome b5 reductase 3
RGD ID: 2502
Description: Enables cytochrome-b5 reductase activity, acting on NAD(P)H and nucleotide binding activity. Predicted to be involved in nitric oxide biosynthetic process. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R3 (cytochrome b5 reductase 3); PARTICIPATES IN amino sugar metabolic pathway; nucleotide sugar metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B5R; Dia1; Diaphorase (NADH) (cytochrome b-5 reductase); diaphorase 1; diaphorase-1; NADH-cytochrome b5 reductase 3; Nadhcb5; RNNADHCB5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,186,729 - 116,204,290 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7116,186,729 - 116,204,306 (-)EnsemblGRCr8
mRatBN7.27114,306,686 - 114,324,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,306,685 - 114,324,298 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7116,061,829 - 116,079,400 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,286,246 - 118,303,784 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,255,692 - 118,273,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,024,003 - 124,041,564 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,023,995 - 124,041,594 (-)Ensemblrn6Rnor6.0
Rnor_5.07124,006,942 - 124,024,503 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47121,187,821 - 121,205,382 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7110,620,903 - 110,638,468 (-)NCBICelera
RGSC_v3.17121,222,050 - 121,239,612 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzamidoxime  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bezafibrate  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP)
eugenol  (EXP)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furfural  (ISO)
genistein  (ISO)
glafenine  (EXP)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydroxylamine  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
kojic acid  (EXP)
L-methionine  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP)
quinidine  (EXP)
resveratrol  (ISO)
ritonavir  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sulfamethoxazole hydroxylamine  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A case of methemoglobinemia type II due to NADH-cytochrome b5 reductase deficiency: determination of the molecular basis. Aalfs CM, etal., Hum Mutat 2000;16(1):18-22.
2. High-level expression in Escherichia coli of the soluble, catalytic domain of rat hepatic cytochrome b5 reductase. Barber MJ and Quinn GB, Protein Expr Purif. 1996 Aug;8(1):41-7. doi: 10.1006/prep.1996.0072.
3. The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent. Bewley MC, etal., Biochemistry. 2001 Nov 13;40(45):13574-82. doi: 10.1021/bi0106336.
4. The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site. Bewley MC, etal., Biochemistry. 2003 Nov 18;42(45):13145-51.
5. Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women. Blanke KL, etal., Cancer Causes Control. 2014 Nov;25(11):1513-21. doi: 10.1007/s10552-014-0454-7. Epub 2014 Sep 16.
6. A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes. Borgese N, etal., J Cell Biol. 1996 Dec;135(6 Pt 1):1501-13. doi: 10.1083/jcb.135.6.1501.
7. Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands. Davis CA, etal., Arch Biochem Biophys 2002 Apr 1;400(1):63-75.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
12. Molecular basis of recessive congenital methemoglobinemia, types I and II: Exon skipping and three novel missense mutations in the NADH-cytochrome b5 reductase (diaphorase 1) gene. Kugler W, etal., Hum Mutat. 2001 Apr;17(4):348.
13. Molecular basis of two novel mutations found in type I methemoglobinemia. Lorenzo FR 5th, etal., Blood Cells Mol Dis. 2011 Apr 15;46(4):277-81. doi: 10.1016/j.bcmd.2011.01.005. Epub 2011 Feb 24.
14. NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer. Lund RR, etal., Mol Cell Proteomics. 2015 Nov;14(11):2988-99. doi: 10.1074/mcp.M115.050385. Epub 2015 Sep 8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons. Mota Vieira L, etal., Eur J Biochem 1994 Mar 15;220(3):729-37.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. A single mRNA, transcribed from an alternative, erythroid-specific, promoter, codes for two non-myristylated forms of NADH-cytochrome b5 reductase. Pietrini G, etal., J Cell Biol 1992 Jun;117(5):975-86.
20. Two transcripts encode rat cytochrome b5 reductase. Pietrini G, etal., Proc Natl Acad Sci U S A 1988 Oct;85(19):7246-50.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. Molecular cloning of a cDNA encoding rat NADH-cytochrome b5 reductase and the corresponding gene. Zenno S, etal., J Biochem (Tokyo) 1990 Jun;107(6):810-6.
Additional References at PubMed
PMID:2498303   PMID:12865426   PMID:14741744   PMID:15489334   PMID:19946888   PMID:20833797   PMID:20861021   PMID:23376485   PMID:24945955   PMID:25850901   PMID:29706024   PMID:34800366  


Genomics

Comparative Map Data
Cyb5r3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,186,729 - 116,204,290 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7116,186,729 - 116,204,306 (-)EnsemblGRCr8
mRatBN7.27114,306,686 - 114,324,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,306,685 - 114,324,298 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7116,061,829 - 116,079,400 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,286,246 - 118,303,784 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,255,692 - 118,273,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,024,003 - 124,041,564 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,023,995 - 124,041,594 (-)Ensemblrn6Rnor6.0
Rnor_5.07124,006,942 - 124,024,503 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47121,187,821 - 121,205,382 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7110,620,903 - 110,638,468 (-)NCBICelera
RGSC_v3.17121,222,050 - 121,239,612 (-)NCBI
Cytogenetic Map7q34NCBI
CYB5R3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,617,840 - 42,649,392 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2242,615,730 - 42,720,870 (-)Ensemblhg38GRCh38
GRCh372243,013,846 - 43,045,398 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,344,763 - 41,375,349 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342241,339,318 - 41,367,516NCBI
Celera2226,924,326 - 26,955,882 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,974,473 - 26,005,949 (-)NCBIHuRef
CHM1_12242,972,995 - 43,004,519 (-)NCBICHM1_1
T2T-CHM13v2.02243,098,710 - 43,130,267 (-)NCBIT2T-CHM13v2.0
Cyb5r3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,037,696 - 83,060,641 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,037,695 - 83,056,793 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381583,153,495 - 83,176,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,153,494 - 83,172,592 (-)Ensemblmm10GRCm38
MGSCv371582,983,931 - 83,002,638 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361582,981,267 - 82,999,974 (-)NCBIMGSCv36mm8
Celera1585,286,802 - 85,305,568 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
LOC102012303
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541327,969,949 - 27,979,909 (-)Ensembl
ChiLan1.0NW_00495541327,971,140 - 27,979,905 (-)NCBIChiLan1.0ChiLan1.0
LOC100982559
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,453,476 - 52,484,518 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,145,984 - 55,177,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,513,724 - 23,544,746 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12241,666,548 - 41,694,104 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2241,666,548 - 41,694,104 (-)EnsemblpanPan2panpan1.1
CYB5R3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,829,898 - 22,848,284 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,819,221 - 22,848,284 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1022,756,034 - 22,783,841 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01023,565,239 - 23,592,996 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,565,191 - 23,595,635 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,282,809 - 23,310,756 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,602,619 - 23,630,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,777,463 - 23,805,206 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101962805
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,411,149 - 6,427,796 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936718549,938 - 564,195 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936718552,369 - 564,195 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYB5R3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,146,276 - 6,170,212 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.156,146,230 - 6,170,209 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,604,124 - 3,628,138 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYB5R3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,172,513 - 25,191,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045100,266,413 - 100,298,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101718541
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247526,182,129 - 6,198,400 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247526,182,156 - 6,198,395 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116914394
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11252,575,716 - 252,597,835 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyb5r3
98 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:648
Count of miRNA genes:243
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000012878, ENSRNOT00000064700
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27114,321,734 - 114,321,932 (+)MAPPERmRatBN7.2
Rnor_6.07124,039,052 - 124,039,249NCBIRnor6.0
Rnor_5.07124,021,991 - 124,022,188UniSTSRnor5.0
RGSC_v3.47121,202,870 - 121,203,067UniSTSRGSC3.4
Celera7110,635,956 - 110,636,153UniSTS
Cytogenetic Map7q34UniSTS
RH137308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27114,306,856 - 114,307,051 (+)MAPPERmRatBN7.2
Rnor_6.07124,024,174 - 124,024,368NCBIRnor6.0
Rnor_5.07124,007,113 - 124,007,307UniSTSRnor5.0
RGSC_v3.47121,187,992 - 121,188,186UniSTSRGSC3.4
Celera7110,621,074 - 110,621,268UniSTS
RH 3.4 Map7903.0UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064700   ⟹   ENSRNOP00000061381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,186,729 - 116,204,306 (-)Ensembl
mRatBN7.2 Ensembl7114,306,687 - 114,324,298 (-)Ensembl
Rnor_6.0 Ensembl7124,023,995 - 124,041,594 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102247   ⟹   ENSRNOP00000077900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,187,678 - 116,204,306 (-)Ensembl
mRatBN7.2 Ensembl7114,306,686 - 114,324,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111302   ⟹   ENSRNOP00000082175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,186,729 - 116,198,538 (-)Ensembl
mRatBN7.2 Ensembl7114,306,686 - 114,322,571 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118499   ⟹   ENSRNOP00000076621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,186,729 - 116,198,082 (-)Ensembl
mRatBN7.2 Ensembl7114,306,685 - 114,324,262 (-)Ensembl
RefSeq Acc Id: NM_138877   ⟹   NP_620232
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,186,729 - 116,204,290 (-)NCBI
mRatBN7.27114,306,686 - 114,324,247 (-)NCBI
Rnor_6.07124,024,003 - 124,041,564 (-)NCBI
Rnor_5.07124,006,942 - 124,024,503 (-)NCBI
RGSC_v3.47121,187,821 - 121,205,382 (-)RGD
Celera7110,620,903 - 110,638,468 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242065   ⟹   XP_006242127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,186,729 - 116,202,619 (-)NCBI
mRatBN7.27114,306,686 - 114,322,577 (-)NCBI
Rnor_6.07124,024,003 - 124,039,895 (-)NCBI
Rnor_5.07124,006,942 - 124,024,503 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078438   ⟹   XP_038934366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,186,729 - 116,202,309 (-)NCBI
mRatBN7.27114,306,695 - 114,322,267 (-)NCBI
RefSeq Acc Id: NP_620232   ⟸   NM_138877
- UniProtKB: Q64569 (UniProtKB/Swiss-Prot),   Q64720 (UniProtKB/Swiss-Prot),   P20070 (UniProtKB/Swiss-Prot),   A6HT85 (UniProtKB/TrEMBL),   A0A8L2QWB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242127   ⟸   XM_006242065
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QWB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061381   ⟸   ENSRNOT00000064700
RefSeq Acc Id: XP_038934366   ⟸   XM_039078438
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QWB9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082175   ⟸   ENSRNOT00000111302
Ensembl Acc Id: ENSRNOP00000077900   ⟸   ENSRNOT00000102247
Ensembl Acc Id: ENSRNOP00000076621   ⟸   ENSRNOT00000118499
Protein Domains
FAD-binding FR-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20070-F1-model_v2 AlphaFold P20070 1-301 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695544
Promoter ID:EPDNEW_R6069
Type:initiation region
Name:Cyb5r3_1
Description:cytochrome b5 reductase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07124,041,574 - 124,041,634EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2502 AgrOrtholog
BioCyc Gene G2FUF-32607 BioCyc
Ensembl Genes ENSRNOG00000009592 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064700 ENTREZGENE
  ENSRNOT00000102247.1 UniProtKB/Swiss-Prot
  ENSRNOT00000111302 ENTREZGENE
  ENSRNOT00000111302.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.80 UniProtKB/Swiss-Prot
  Translation factors UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599255 IMAGE-MGC_LOAD
InterPro CBR-like UniProtKB/Swiss-Prot
  Cbr1-like_FAD-bd_dom UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report rno:25035 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72299 IMAGE-MGC_LOAD
NCBI Gene 25035 ENTREZGENE
PANTHER NADH-CYTOCHROME B5 REDUCTASE 3 UniProtKB/Swiss-Prot
  PTHR19370 UniProtKB/Swiss-Prot
Pfam FAD_binding_6 UniProtKB/Swiss-Prot
  NAD_binding_1 UniProtKB/Swiss-Prot
PharmGKB CYB5R3 RGD
PhenoGen Cyb5r3 PhenoGen
PRINTS CYTB5RDTASE UniProtKB/Swiss-Prot
  FPNCR UniProtKB/Swiss-Prot
PROSITE FAD_FR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009592 RatGTEx
Superfamily-SCOP SSF52343 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt A0A8I5Y5E9_RAT UniProtKB/TrEMBL
  A0A8L2QWB9 ENTREZGENE, UniProtKB/TrEMBL
  A6HT85 ENTREZGENE, UniProtKB/TrEMBL
  NB5R3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64569 ENTREZGENE
  Q64720 ENTREZGENE
UniProt Secondary Q64569 UniProtKB/Swiss-Prot
  Q64720 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Cyb5r3  cytochrome b5 reductase 3  Dia1  diaphorase 1  Symbol and Name updated 1299863 APPROVED
2002-11-06 Dia1  diaphorase 1    Diaphorase (NADH) (cytochrome b-5 reductase)  Name updated 625702 APPROVED
2002-06-10 Dia1  Diaphorase (NADH) (cytochrome b-5 reductase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency of the human homolog causes recessive congenital methemoglobinemia types I and II 728833