Dbh (dopamine beta-hydroxylase) - Rat Genome Database

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Gene: Dbh (dopamine beta-hydroxylase) Rattus norvegicus
Analyze
Symbol: Dbh
Name: dopamine beta-hydroxylase
RGD ID: 2489
Description: Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular response to manganese ion; cellular response to nicotine; and norepinephrine biosynthetic process. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; depressive disorder; hypertension; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH 2,4-D; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dopamine beta hydroxylase; Dopamine beta hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-monooxygenase; DOPBHY
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,886,313 - 30,903,313 (+)NCBIGRCr8
mRatBN7.2310,488,260 - 10,505,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,488,260 - 10,505,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,554,214 - 13,571,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,139,613 - 22,156,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,394,908 - 20,411,896 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,709,236 - 5,731,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,073,477 - 11,095,363 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,052,706 - 6,069,826 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,053,005 - 6,070,129 (+)NCBI
Celera35,285,082 - 5,302,054 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
2,4-D  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aluminium hydroxide  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromocriptine  (ISO)
bupropion  (ISO)
C60 fullerene  (EXP)
chlorpyrifos  (EXP)
citalopram  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
cyanazine  (EXP)
D-mannitol  (ISO)
desipramine  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
dieldrin  (EXP)
disulfiram  (ISO)
dobutamine  (ISO)
dopamine  (EXP,ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
Fusaric acid  (EXP)
hydrogen sulfide  (ISO)
lamotrigine  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyllycaconitine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
nimodipine  (EXP)
paracetamol  (ISO)
Pargyline  (ISO)
paroxetine  (ISO)
procymidone  (EXP)
reboxetine  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
serotonin  (ISO)
sertraline  (ISO)
simazine  (EXP)
tamoxifen  (EXP)
taurine  (ISO)
testosterone  (EXP)
thimerosal  (ISO)
triazines  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function
copper ion binding  (IBA,IEA,IMP,ISO,ISS)
dopamine beta-monooxygenase activity  (IBA,IDA,IEA,IMP,ISO,TAS)
L-ascorbic acid binding  (IEA)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley rats. Bianco LE, etal., J Neurochem. 2008 Jul;106(1):205-15. Epub 2008 Jul 1.
2. Hypoxia inducible factor (HIF)-2 alpha is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. Brown ST, etal., J Neurochem. 2009 Jul;110(2):622-30. Epub 2009 May 8.
3. Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup. Buller KM, etal., Pediatr Res. 2008 Apr;63(4):364-9.
4. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. Chen Y, etal., Am J Hypertens. 2011 Jan;24(1):24-32. Epub 2010 Sep 2.
5. Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
6. Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., Liver Int. 2010 Apr;30(4):593-602. Epub 2009 Nov 30.
7. Synaptic release of dopamine in the subthalamic nucleus. Cragg SJ, etal., Eur J Neurosci. 2004 Oct;20(7):1788-802.
8. Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. Dina OA, etal., Eur J Neurosci. 2008 Sep;28(6):1180-90. Epub 2008 Sep 9.
9. Effect of age on angiotensin II-mediated downregulation of adrenomedullary catecholamine biosynthetic enzymes. Erdos B, etal., Exp Gerontol. 2008 Aug;43(8):806-9. Epub 2008 Apr 27.
10. Association between a 19 bp deletion polymorphism at the dopamine beta-hydroxylase (DBH) locus and migraine with aura. Fernandez F, etal., J Neurol Sci. 2006 Dec 21;251(1-2):118-23. Epub 2006 Nov 7.
11. The DBH -1021 C/T polymorphism is not associated with alcoholism but possibly with patients' exposure to life events. Freire MT, etal., J Neural Transm. 2005 Sep;112(9):1269-74.
12. Noradrenergic innervation of hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in rats. Fuzesi T, etal., Brain Res. 2009 Oct 19;1294:38-44. Epub 2009 Aug 6.
13. Development of rat tibia innervation: colocalization of autonomic nerve fiber markers with growth-associated protein 43. Gajda M, etal., Cells Tissues Organs. 2010;191(6):489-99. Epub 2010 Jan 14.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Effect of immobilization stress on gene expression of catecholamine biosynthetic enzymes in heart auricles of socially isolated rats. Gavrilovic L, etal., Braz J Med Biol Res. 2009 Dec;42(12):1185-90. Epub 2009 Nov 6.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Estradiol prevents ozone-induced increases in brain lipid peroxidation and impaired social recognition memory in female rats. Guevara-Guzman R, etal., Neuroscience. 2009 Mar 31;159(3):940-50. Epub 2009 Jan 31.
18. A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease. Healy DG, etal., Ann Neurol 2004 Mar;55(3):443-6.
19. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Inouye KE, etal., Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.
20. Autophagy generates retrogradely transported organelles: a hypothesis. Kaasinen SK, etal., Int J Dev Neurosci. 2008 Oct;26(6):625-34. Epub 2008 Apr 7.
21. Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells. Kim Y, etal., Nutr Res Pract. 2010 Aug;4(4):270-5. Epub 2010 Aug 31.
22. Degeneration of the locus ceruleus noradrenergic neurons in the stress-induced depression of rats. Kitayama IT, etal., Ann N Y Acad Sci. 2008 Dec;1148:95-8.
23. DBH*444G/A polymorphism of the dopamine-beta-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms. Kohnke MD, etal., J Neural Transm. 2006 Jul;113(7):869-76. Epub 2005 Oct 27.
24. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
25. The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme. Lamouroux A, etal., EMBO J 1987 Dec 20;6(13):3931-7.
26. Simultaneous silencing of Npy and Dbh expression in hindbrain A1/C1 catecholamine cells suppresses glucoprivic feeding. Li AJ, etal., J Neurosci. 2009 Jan 7;29(1):280-7.
27. Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome. Marques Pereira P, etal., J Neurochem. 2008 Dec;107(5):1325-34. Epub 2008 Sep 24.
28. Rat dopamine beta-hydroxylase: molecular cloning and characterization of the cDNA and regulation of the mRNA by reserpine. McMahon A, etal., J Neurosci Res 1990 Mar;25(3):395-404.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Gene expression of catecholamine synthesizing enzymes in A5 cell group and modulation of tyrosine hydroxylase mRNA by immobilization stress. Micutkova L, etal., Endocr Regul 2001 Dec;35(4):195-200.
31. Physiological and morphological properties of, and effect of substance P on, neurons in the A7 catecholamine cell group in rats. Min MY, etal., Neuroscience. 2008 Jun 2;153(4):1020-33. Epub 2008 Mar 19.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Copper deficiency in rodents alters dopamine beta-mono-oxygenase activity, mRNA and protein level. Nelson KT and Prohaska JR, Br J Nutr. 2009 Jul;102(1):18-28. Epub 2008 Dec 15.
34. Noradrenergic nuclei that receive sensory input during mating and project to the ventromedial hypothalamus play a role in mating-induced pseudopregnancy in the female rat. Northrop LE, etal., J Neuroendocrinol. 2010 Oct;22(10):1061-71. doi: 10.1111/j.1365-2826.2010.02049.x.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Angiotensinergic and noradrenergic neurons in the rat and human heart. Patil J, etal., Regul Pept. 2011 Feb 25;167(1):31-41. Epub 2010 Dec 9.
37. Ethanol consumption increases rat stress hormones and adrenomedullary gene expression. Patterson-Buckendahl P, etal., Alcohol. 2005 Nov;37(3):157-66.
38. Ultrastructural evidence for selective noradrenergic innervation of CNS vagal projections to the fundus of the rat. Pearson RJ, etal., Auton Neurosci. 2007 Oct 30;136(1-2):31-42. Epub 2007 Jun 14.
39. The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid. Petrovic N, etal., Physiol Res. 2001;50(3):289-97.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
42. Social hierarchy affects gene expression for catecholamine biosynthetic enzymes in rat adrenal glands. Pohorecky LA, etal., Neuroendocrinology. 2004;80(1):42-51. Epub 2004 Sep 2.
43. Noradrenergic neurons of the area postrema mediate amylin's hypophagic action. Potes CS, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R623-31. Epub 2010 Jun 16.
44. Copper deficiency alters rat dopamine beta-monooxygenase mRNA and activity. Prohaska JR and Brokate B, J Nutr. 1999 Dec;129(12):2147-53.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension. Sato T, etal., J Mol Neurosci. 2011 Feb;43(2):193-9. Epub 2010 Jul 2.
49. Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus. Serova L, etal., Neuroendocrinology 2002 Mar;75(3):193-200.
50. Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study. Smith KM, etal., Am J Med Genet B Neuropsychiatr Genet 2003 May 15;119(1):77-85.
51. Effects of repeated maprotiline and fluoxetine treatment on gene expression of catecholamine synthesizing enzymes in adrenal medulla of unstressed and stressed rats. Spasojevic N, etal., Auton Autacoid Pharmacol. 2010 Oct;30(4):213-7. doi: 10.1111/j.1474-8673.2010.00458.x. Epub 2010 Jul 5.
52. Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress. Swoap SJ, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R108-13. Epub 2003 Sep 11.
53. Expression levels of mRNAs for catecholamine biosynthetic enzymes as markers of acute response to contusion stress during the early postmortem period. Takahashi S Tohoku J Exp Med. 2008 Nov;216(3):239-48.
54. Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge. Temel S, etal., Endocrinology 2002 Oct;143(10):3974-83.
55. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
56. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Thomas SA and Palmiter RD, Nature. 1997 May 1;387(6628):94-7. doi: 10.1038/387094a0.
57. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
58. Characterization of the expression pattern of adrenergic receptors in rat taste buds. Zhang Y, etal., Neuroscience. 2010 Sep 1;169(3):1421-37. Epub 2010 May 15.
Additional References at PubMed
PMID:7715704   PMID:7961964   PMID:8889548   PMID:9189272   PMID:9393852   PMID:9603211   PMID:10051631   PMID:10777779   PMID:11805341   PMID:12370425   PMID:12959968   PMID:15066288  
PMID:15231500   PMID:15849236   PMID:16033425   PMID:16100957   PMID:16614076   PMID:19112418   PMID:19482560   PMID:21062376   PMID:21488089   PMID:21763404   PMID:21777029   PMID:22546625  
PMID:23160224   PMID:27148966   PMID:27152332   PMID:27959576   PMID:28473232   PMID:28726094  


Genomics

Comparative Map Data
Dbh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,886,313 - 30,903,313 (+)NCBIGRCr8
mRatBN7.2310,488,260 - 10,505,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,488,260 - 10,505,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,554,214 - 13,571,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,139,613 - 22,156,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,394,908 - 20,411,896 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,709,236 - 5,731,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,073,477 - 11,095,363 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,052,706 - 6,069,826 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,053,005 - 6,070,129 (+)NCBI
Celera35,285,082 - 5,302,054 (+)NCBICelera
Cytogenetic Map3p12NCBI
DBH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,636,363 - 133,659,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,636,363 - 133,659,329 (+)EnsemblGRCh38hg38GRCh38
GRCh379136,501,485 - 136,524,451 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,491,306 - 135,514,287 (+)NCBINCBI36Build 36hg18NCBI36
Build 349133,531,038 - 133,554,020NCBI
Celera9107,048,360 - 107,071,346 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9106,002,148 - 106,025,141 (+)NCBIHuRef
CHM1_19136,651,448 - 136,674,425 (+)NCBICHM1_1
T2T-CHM13v2.09145,852,365 - 145,875,347 (+)NCBIT2T-CHM13v2.0
Dbh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,055,519 - 27,073,216 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,055,245 - 27,073,212 (+)EnsemblGRCm39 Ensembl
GRCm38227,165,507 - 27,183,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,165,233 - 27,183,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv37227,021,027 - 27,038,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,987,242 - 27,004,928 (+)NCBIMGSCv36mm8
Celera226,868,411 - 26,886,118 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.29NCBI
Dbh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,918,286 - 2,932,247 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,918,085 - 2,932,481 (+)NCBIChiLan1.0ChiLan1.0
DBH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,692,146 - 5,715,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,694,480 - 5,717,385 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,761,504 - 104,784,445 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,371,818 - 133,394,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,371,821 - 133,393,697 (+)Ensemblpanpan1.1panPan2
DBH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,004,806 - 50,024,130 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,004,806 - 50,024,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,285,838 - 49,305,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,879,184 - 50,898,677 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,879,184 - 50,898,677 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,640,508 - 49,659,973 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,982,444 - 50,001,971 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,060,855 - 50,080,372 (+)NCBIUU_Cfam_GSD_1.0
Dbh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,048,835 - 200,073,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,301,802 - 3,320,643 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,302,014 - 3,326,233 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,204,175 - 273,225,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,204,407 - 273,225,562 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,178,237 - 307,199,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.13NCBI
DBH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,474,041 - 4,498,942 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,474,958 - 4,498,910 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058490,145 - 515,071 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dbh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,015,474 - 2,029,939 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247602,016,066 - 2,030,240 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dbh
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:170
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000061201, ENSRNOT00000070887
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
RH135117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,504,894 - 10,505,087 (+)MAPPERmRatBN7.2
Rnor_6.035,731,545 - 5,731,737NCBIRnor6.0
Rnor_5.0311,095,013 - 11,095,205UniSTSRnor5.0
RGSC_v3.436,069,476 - 6,069,668UniSTSRGSC3.4
Celera35,301,704 - 5,301,896UniSTS
RH 3.4 Map319.3UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 49 97 60 59 28 25 28 4 155 92 79 20 42 31

Sequence


Ensembl Acc Id: ENSRNOT00000061201   ⟹   ENSRNOP00000057915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,488,260 - 10,505,248 (+)Ensembl
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000070887   ⟹   ENSRNOP00000065474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl35,709,242 - 5,731,511 (+)Ensembl
RefSeq Acc Id: NM_013158   ⟹   NP_037290
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,886,328 - 30,903,313 (+)NCBI
mRatBN7.2310,488,260 - 10,505,245 (+)NCBI
Rnor_6.035,709,236 - 5,731,895 (+)NCBI
Rnor_5.0311,073,477 - 11,095,363 (+)NCBI
RGSC_v3.436,052,706 - 6,069,826 (+)RGD
Celera35,285,082 - 5,302,054 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283164   ⟹   XP_063139234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,886,313 - 30,892,243 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037290 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139234 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93440 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057915.1
GenBank Protein Q05754 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037290   ⟸   NM_013158
- UniProtKB: Q05754 (UniProtKB/Swiss-Prot),   G3V9S4 (UniProtKB/TrEMBL),   A6JTK7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065474   ⟸   ENSRNOT00000070887
Ensembl Acc Id: ENSRNOP00000057915   ⟸   ENSRNOT00000061201
RefSeq Acc Id: XP_063139234   ⟸   XM_063283164
- Peptide Label: isoform X1
Protein Domains
DOMON

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05754-F1-model_v2 AlphaFold Q05754 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2489 AgrOrtholog
BioCyc Gene G2FUF-50305 BioCyc
BioCyc Pathway PWY66-301 [catecholamine biosynthesis] BioCyc
BioCyc Pathway Image PWY66-301 BioCyc
Ensembl Genes ENSRNOG00000006641 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061201.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cu2_ascorb_mOase-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_ascorb_mOase_CS-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_ascorb_mOase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_ascorb_mOase_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_monoox_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOH_DOMON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOMON_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHM/PNGase_F_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tbh/DBH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25699 UniProtKB/Swiss-Prot
NCBI Gene 25699 ENTREZGENE
PANTHER DOPAMINE BETA-HYDROXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10157 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cu2_monoox_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_monooxygen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOMON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dbh PhenoGen
PRINTS DBMONOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CU2_MONOOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOMON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006641 RatGTEx
SMART DoH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49742 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC222723
UniProt A6JTK7 ENTREZGENE, UniProtKB/TrEMBL
  DOPO_RAT UniProtKB/Swiss-Prot
  G3V9S4 ENTREZGENE, UniProtKB/TrEMBL
  Q05754 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Dbh  dopamine beta-hydroxylase  Dbh  dopamine beta-hydroxylase (dopamine beta-monooxygenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Dbh  dopamine beta-hydroxylase (dopamine beta-monooxygenase)  Dbh  dopamine beta hydroxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dbh  dopamine beta hydroxylase    Dopamine beta hydroxylase (dopamine beta-monooxygenase)  Name updated 625702 APPROVED
2002-06-10 Dbh  Dopamine beta hydroxylase (dopamine beta-monooxygenase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression basal levels of mRNA is expressed by norepinephrine (NE) and epinephrine neurons,expression is higher in young animals during the steroid induced surge 628385
gene_process regulates norepinephrine synthesis 628385
gene_regulation expression is regulated by estrogens 727567
gene_regulation gene expression is stimulated by estrogen 727567