Cyp4b1 (cytochrome P450, family 4, subfamily b, polypeptide 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cyp4b1 (cytochrome P450, family 4, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp4b1
Name: cytochrome P450, family 4, subfamily b, polypeptide 1
RGD ID: 2480
Description: Enables heterocyclic compound binding activity. Involved in biphenyl metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP4B1 (cytochrome P450 family 4 subfamily B member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIVB1; cytochrome P450 4B1; cytochrome P450 isozyme 5; cytochrome P450 L-2; Cytochrome P450 subfamily IVB polypeptide 1; Cytochrome P450 subfamily IVB polypeptide 1 see also D5M4Rp1; cytochrome P450, subfamily 4B, polypeptide 1; Cytochrome P450, subfamily IVB, polypeptide 1; P450 L-2; P450-isozyme 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,375,807 - 134,413,635 (-)NCBIGRCr8
mRatBN7.25129,139,019 - 129,176,860 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,139,038 - 129,156,348 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,749,529 - 131,766,903 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,504,409 - 133,521,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,526,563 - 133,543,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,508,728 - 134,526,103 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,508,730 - 134,526,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,299,551 - 138,316,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,917,327 - 135,934,636 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,922,552 - 135,939,862 (-)NCBI
Celera5127,676,727 - 127,694,036 (-)NCBICelera
RH 3.4 Map5823.3RGD
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-naphthylamine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-Dichlorobenzidine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylbenzyl alcohol  (EXP)
3-methylcholanthrene  (EXP)
3-methyleneindolenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-Ipomeanol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dodecanoic acid  (ISO)
elemental selenium  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
glycidol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
ketoconazole  (EXP)
kojic acid  (EXP,ISO)
levofloxacin  (EXP)
m-tolualdehyde  (EXP)
m-xylene  (EXP)
methimazole  (EXP)
mifepristone  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nevirapine  (EXP)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
ritonavir  (EXP)
rotenone  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
tamoxifen  (ISO)
terephthalic acid  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB. Gasser R and Philpot RM, Mol Pharmacol 1989 May;35(5):617-25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family. Hardwick JP, etal., J Biol Chem 1987 Jan 15;262(2):801-10.
5. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. Imaoka S, etal., Biochem Pharmacol. 1997 Sep 15;54(6):677-83.
6. Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction. Imaoka S, etal., Cancer Lett 2001 May 26;166(2):119-23.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. Kimura S, etal., DNA 1989 Sep;8(7):503-16.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. CYP4B1 activates 4-ipomeanol in rat lung. Verschoyle RD, etal., Toxicol Appl Pharmacol. 1993 Dec;123(2):193-8.
Additional References at PubMed
PMID:2229008   PMID:15489334   PMID:16788951  


Genomics

Comparative Map Data
Cyp4b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,375,807 - 134,413,635 (-)NCBIGRCr8
mRatBN7.25129,139,019 - 129,176,860 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,139,038 - 129,156,348 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,749,529 - 131,766,903 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,504,409 - 133,521,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,526,563 - 133,543,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,508,728 - 134,526,103 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,508,730 - 134,526,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,299,551 - 138,316,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,917,327 - 135,934,636 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,922,552 - 135,939,862 (-)NCBI
Celera5127,676,727 - 127,694,036 (-)NCBICelera
RH 3.4 Map5823.3RGD
Cytogenetic Map5q35NCBI
CYP4B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,799,046 - 46,819,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,757,838 - 46,819,413 (+)EnsemblGRCh38hg38GRCh38
GRCh37147,264,718 - 47,285,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,037,257 - 47,057,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 34146,976,761 - 46,997,105NCBI
Celera145,552,027 - 45,572,396 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,380,284 - 45,400,633 (+)NCBIHuRef
CHM1_1147,381,383 - 47,401,714 (+)NCBICHM1_1
T2T-CHM13v2.0146,676,425 - 46,696,812 (+)NCBIT2T-CHM13v2.0
Cyp4b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,481,895 - 115,504,918 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,481,922 - 115,504,920 (-)EnsemblGRCm39 Ensembl
GRCm384115,624,698 - 115,647,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,624,725 - 115,647,723 (-)EnsemblGRCm38mm10GRCm38
MGSCv374115,297,333 - 115,320,310 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,122,660 - 115,145,637 (-)NCBIMGSCv36mm8
Celera4114,360,727 - 114,383,719 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.06NCBI
LOC102012414
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,378,980 - 11,556,544 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,539,467 - 11,556,519 (-)NCBIChiLan1.0ChiLan1.0
CYP4B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,984,908 - 180,003,684 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,126,616 - 179,145,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,107,787 - 46,127,162 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,462,178 - 47,481,502 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,462,178 - 47,481,502 (+)Ensemblpanpan1.1panPan2
CYP4B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,676,631 - 13,694,483 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1513,676,371 - 13,694,705 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1513,796,940 - 13,814,798 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01513,826,980 - 13,844,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,826,737 - 13,844,877 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,628,060 - 13,645,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,696,377 - 13,714,240 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,765,891 - 13,783,754 (-)NCBIUU_Cfam_GSD_1.0
LOC101955242
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,881,092 - 61,957,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,767,371 - 27,782,008 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,705,874 - 27,782,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP4B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6164,718,444 - 164,737,552 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16164,718,393 - 164,737,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,210,031 - 152,229,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP4B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12085,997,796 - 86,018,649 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2085,996,269 - 86,018,055 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603330,987,875 - 31,007,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101725929
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,663,940 - 2,684,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249062,664,057 - 2,683,527 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp4b1
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:129
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000012681, ENSRNOT00000013321, ENSRNOT00000045571
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat

Markers in Region
D5M4Rp1   No map positions available.
D5Rat200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,140,953 - 129,141,153 (+)MAPPERmRatBN7.2
Rnor_6.05134,510,644 - 134,510,843NCBIRnor6.0
Rnor_5.05138,301,467 - 138,301,666UniSTSRnor5.0
RGSC_v3.45135,919,242 - 135,919,442RGDRGSC3.4
RGSC_v3.45135,919,243 - 135,919,442UniSTSRGSC3.4
RGSC_v3.15135,924,370 - 135,924,698RGD
Celera5127,678,643 - 127,678,842UniSTS
SHRSP x BN Map568.3499RGD
SHRSP x BN Map568.3499UniSTS
Cytogenetic Map5q36UniSTS
RH142421  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map5823.3UniSTS
Cytogenetic Map5q36UniSTS
RH137159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,139,100 - 129,139,251 (+)MAPPERmRatBN7.2
Rnor_6.05134,508,791 - 134,508,941NCBIRnor6.0
Rnor_5.05138,299,614 - 138,299,764UniSTSRnor5.0
RGSC_v3.45135,917,390 - 135,917,540UniSTSRGSC3.4
Celera5127,676,790 - 127,676,940UniSTS
RH 3.4 Map5837.8UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 12 9 2 2 2 2 23 8 11
Low 1 31 48 39 17 39 8 9 18 12 26 8
Below cutoff 32 6

Sequence


RefSeq Acc Id: ENSRNOT00000013321   ⟹   ENSRNOP00000013321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5129,139,038 - 129,156,348 (-)Ensembl
Rnor_6.0 Ensembl5134,508,730 - 134,526,089 (-)Ensembl
RefSeq Acc Id: NM_016999   ⟹   NP_058695
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,375,807 - 134,393,116 (-)NCBI
mRatBN7.25129,139,038 - 129,156,348 (-)NCBI
Rnor_6.05134,508,728 - 134,526,037 (-)NCBI
Rnor_5.05138,299,551 - 138,316,860 (-)NCBI
RGSC_v3.45135,917,327 - 135,934,636 (-)RGD
Celera5127,676,727 - 127,694,036 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109255   ⟹   XP_038965183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,375,818 - 134,413,635 (-)NCBI
mRatBN7.25129,139,019 - 129,176,860 (-)NCBI
RefSeq Acc Id: XR_001837834
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,376,306 - 134,393,158 (-)NCBI
mRatBN7.25129,139,537 - 129,156,386 (-)NCBI
Rnor_6.05134,509,279 - 134,526,103 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058695   ⟸   NM_016999
- UniProtKB: P15129 (UniProtKB/Swiss-Prot),   A6JZ44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013321   ⟸   ENSRNOT00000013321
RefSeq Acc Id: XP_038965183   ⟸   XM_039109255
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15129-F1-model_v2 AlphaFold P15129 1-511 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693922
Promoter ID:EPDNEW_R4447
Type:single initiation site
Name:Cyp4b1_1
Description:cytochrome P450, family 4, subfamily b, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05134,526,065 - 134,526,125EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2480 AgrOrtholog
BioCyc Gene G2FUF-40281 BioCyc
Ensembl Genes ENSRNOG00000055078 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055031661 UniProtKB/Swiss-Prot
  ENSRNOG00060029816 UniProtKB/Swiss-Prot
  ENSRNOG00065015786 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013321 ENTREZGENE
  ENSRNOT00000013321.7 UniProtKB/Swiss-Prot
  ENSRNOT00055054814 UniProtKB/Swiss-Prot
  ENSRNOT00060051785 UniProtKB/Swiss-Prot
  ENSRNOT00065026221 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100197 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91453 IMAGE-MGC_LOAD
NCBI Gene 24307 ENTREZGENE
PANTHER CYTOCHROME P450 4B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp4b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055078 RatGTEx
  ENSRNOG00055031661 RatGTEx
  ENSRNOG00060029816 RatGTEx
  ENSRNOG00065015786 RatGTEx
Superfamily-SCOP Cytochrome P450 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JZ44 ENTREZGENE, UniProtKB/TrEMBL
  CP4B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp4b1  cytochrome P450, family 4, subfamily b, polypeptide 1    cytochrome P450, subfamily 4B, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp4b1  cytochrome P450, subfamily 4B, polypeptide 1    Cytochrome P450, subfamily IVB, polypeptide 1  Name updated 625702 APPROVED
2002-06-10 Cyp4b1  Cytochrome P450, subfamily IVB, polypeptide 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is induced by androgens 729927