Cyp2d2 (cytochrome P450, family 2, subfamily d, polypeptide 2) - Rat Genome Database

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Gene: Cyp2d2 (cytochrome P450, family 2, subfamily d, polypeptide 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2d2
Name: cytochrome P450, family 2, subfamily d, polypeptide 2
RGD ID: 2471
Description: Enables monooxygenase activity. Involved in female pregnancy; response to genistein; and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 1,2-dichlorobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyp2d26; CYPIID26; cytochrome P450 2D26; cytochrome P450, family 2, subfamily d, polypeptide 26; Cytochrome P450, subfamily IID2; cytochrome P450-CMF2; cytochrome P450-DB2; debrisoquine 4-hydroxylase; P450-CMF2; P450-DB2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,815,212 - 115,819,281 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,815,212 - 115,819,281 (-)EnsemblGRCr8
mRatBN7.27113,935,138 - 113,939,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,935,138 - 113,939,209 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7115,690,180 - 115,694,258 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,914,310 - 117,918,388 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,883,760 - 117,887,838 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,651,827 - 123,655,896 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,651,827 - 123,655,896 (-)Ensemblrn6Rnor6.0
Rnor_5.07123,636,789 - 123,640,858 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,796,210 - 120,800,279 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7110,250,322 - 110,254,396 (-)NCBICelera
RGSC_v3.17120,830,439 - 120,834,509 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes. Bogacz A, etal., Ginekol Pol. 2014 May;85(5):348-53. doi: 10.17772/gp/1741.
2. Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Dickmann LJ, etal., Biochem Pharmacol. 2008 Apr 15;75(8):1677-87. Epub 2008 Feb 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon. Gilbert EA, etal., J Neural Transm 2003 Oct;110(10):1091-101.
5. Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. Gonzalez FJ, etal., DNA 1987 Apr;6(2):149-61.
6. Metabolic activity of cytochrome p450 isoforms in hepatocytes cryopreserved with wheat protein extract. Grondin M, etal., Drug Metab Dispos. 2008 Oct;36(10):2121-9. Epub 2008 Jul 10.
7. Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily. Ishida N, etal., Biochem Biophys Res Commun 1988 Oct 31;156(2):681-8.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats. Masubuchi Y, etal., Arch Toxicol. 2006 Jun;80(6):347-53. Epub 2006 Feb 17.
10. The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site. Matsunaga E, etal., J Mol Evol 1990 Feb;30(2):155-69.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity. Wan J, etal., Arch Biochem Biophys 1997 Dec 15;348(2):383-90.
Additional References at PubMed
PMID:2819073   PMID:15474473   PMID:15489334   PMID:18191824   PMID:22162298   PMID:29415952   PMID:39063146  


Genomics

Variants

.
Variants in Cyp2d2
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000012413
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87115,818,345 - 115,818,616 (+)Marker Load Pipeline
mRatBN7.27113,938,271 - 113,938,544 (+)MAPPERmRatBN7.2
Rnor_6.07123,654,961 - 123,655,231NCBIRnor6.0
Rnor_5.07123,639,923 - 123,640,193UniSTSRnor5.0
RGSC_v3.47120,799,343 - 120,799,614RGDRGSC3.4
RGSC_v3.47120,799,344 - 120,799,614UniSTSRGSC3.4
Celera7110,253,456 - 110,253,731UniSTS
RGSC_v3.17120,833,573 - 120,833,844RGD
RH 3.4 Map7902.1UniSTS
RH 3.4 Map7902.1RGD
RH 2.0 Map7680.4RGD
Cytogenetic Map7q34UniSTS
BE110228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,934,793 - 113,934,959 (+)MAPPERmRatBN7.2
Rnor_6.07123,651,483 - 123,651,648NCBIRnor6.0
Rnor_5.07123,636,445 - 123,636,610UniSTSRnor5.0
RGSC_v3.47120,795,866 - 120,796,031UniSTSRGSC3.4
Celera7110,249,978 - 110,250,143UniSTS
RH 3.4 Map7895.5UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 36 121 91 90 59 85 59 6 307 143 1 100 81 69 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000012413   ⟹   ENSRNOP00000012413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,815,212 - 115,819,281 (-)Ensembl
mRatBN7.2 Ensembl7113,935,138 - 113,939,209 (-)Ensembl
Rnor_6.0 Ensembl7123,651,827 - 123,655,896 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082473   ⟹   ENSRNOP00000070699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,815,212 - 115,819,181 (-)Ensembl
mRatBN7.2 Ensembl7113,935,138 - 113,939,109 (-)Ensembl
RefSeq Acc Id: NM_012730   ⟹   NP_036862
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,815,212 - 115,819,281 (-)NCBI
mRatBN7.27113,935,138 - 113,939,209 (-)NCBI
Rnor_6.07123,651,827 - 123,655,896 (-)NCBI
Rnor_5.07123,636,789 - 123,640,858 (-)NCBI
RGSC_v3.47120,796,210 - 120,800,279 (-)RGD
Celera7110,250,322 - 110,254,396 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036862 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41049 (Get FASTA)   NCBI Sequence Viewer  
  AAA41055 (Get FASTA)   NCBI Sequence Viewer  
  AAH78897 (Get FASTA)   NCBI Sequence Viewer  
  BAA23123 (Get FASTA)   NCBI Sequence Viewer  
  CAA36269 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012413
  ENSRNOP00000012413.3
GenBank Protein P10634 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036862   ⟸   NM_012730
- UniProtKB: P10634 (UniProtKB/Swiss-Prot),   A6HT76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012413   ⟸   ENSRNOT00000012413
Ensembl Acc Id: ENSRNOP00000070699   ⟸   ENSRNOT00000082473

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10634-F1-model_v2 AlphaFold P10634 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695540
Promoter ID:EPDNEW_R6064
Type:multiple initiation site
Name:Cyp2d2_1
Description:cytochrome P450, family 2, subfamily d, polypeptide 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07123,655,867 - 123,655,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2471 AgrOrtholog
BioCyc Gene G2FUF-32618 BioCyc
Ensembl Genes ENSRNOG00000008988 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012413 ENTREZGENE
  ENSRNOT00000012413.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109496 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2D-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:25053 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93631 IMAGE-MGC_LOAD
NCBI Gene 25053 ENTREZGENE
PANTHER CYTOCHROME P450 2D26 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2d2 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2D UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008988 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC230168
UniProt A0A0G2JYL2_RAT UniProtKB/TrEMBL
  A6HT76 ENTREZGENE, UniProtKB/TrEMBL
  CP2DQ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp2d2  cytochrome P450, family 2, subfamily d, polypeptide 2  Cyp2d26  cytochrome P450, family 2, subfamily d, polypeptide 26  Name updated 1299863 APPROVED
2004-09-10 Cyp2d26  cytochrome P450, family 2, subfamily d, polypeptide 26  Cyp2d2  Cytochrome P450, subfamily IID2  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cyp2d2  Cytochrome P450, subfamily IID2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a conserved heme binding region 727679
gene_transcript gene contains nine exons 727761