Cryge (crystallin, gamma E) - Rat Genome Database

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Gene: Cryge (crystallin, gamma E) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cryge
Name: crystallin, gamma E
RGD ID: 2423
Description: Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D); INTERACTS WITH acrylamide; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cryg5; Crystallin, gamma polypeptide 5; gamma-2; gamma-crystallin 3-1; gamma-crystallin D-like; gamma-crystallin E; gamma-E-crystallin; Len; LOC100363730
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,923,661 - 73,926,258 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl973,923,661 - 73,927,011 (-)EnsemblGRCr8
mRatBN7.2966,429,924 - 66,432,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,429,924 - 66,433,274 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx974,943,162 - 74,945,759 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,078,465 - 80,081,062 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,486,894 - 78,489,491 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,764,317 - 71,767,045 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4963,698,609 - 63,701,230 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera963,827,782 - 63,828,162 (-)NCBICelera
RGSC_v3.1963,845,590 - 63,848,212 (-)NCBI
RH 3.4 Map9577.2RGD
Cytogenetic Map9q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Strict co-linearity of genetic and protein folding domains in an intragenically duplicated rat lens gamma-crystallin gene. Moormann RJ, etal., J Mol Biol 1983 Dec 25;171(4):353-68.
6. Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene. Moormann RJ, etal., Proc Natl Acad Sci U S A 1982 Nov;79(22):6876-80.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Differential synthesis of crystallins in the developing rat eye lens. Voorter CE, etal., Exp Eye Res. 1990 Apr;50(4):429-37.
Additional References at PubMed
PMID:2777080   PMID:3562235   PMID:9367641   PMID:26385181  


Genomics

Variants

.
Variants in Cryge
24 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH94588  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,429,637 - 66,429,737 (+)MAPPERmRatBN7.2
Rnor_6.0971,764,032 - 71,764,131NCBIRnor6.0
Rnor_5.0970,804,150 - 70,804,249UniSTSRnor5.0
RGSC_v3.4963,698,323 - 63,698,422UniSTSRGSC3.4
RH 3.4 Map9577.2UniSTS
Cytogenetic Map9q32UniSTS
Crygf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,429,952 - 66,430,118 (+)MAPPERmRatBN7.2
Rnor_6.0971,764,347 - 71,764,512NCBIRnor6.0
Rnor_5.0970,803,769 - 70,803,934UniSTSRnor5.0
RGSC_v3.4963,698,638 - 63,698,803UniSTSRGSC3.4
Cytogenetic Map9q32UniSTS
UniSTS:463202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2967,448,568 - 67,450,216 (+)MAPPERmRatBN7.2
Rnor_6.0972,933,608 - 72,935,255NCBIRnor6.0
Rnor_5.0974,363,661 - 74,365,308UniSTSRnor5.0
RGSC_v3.4964,679,915 - 64,681,562UniSTSRGSC3.4
Celera964,941,525 - 64,943,172UniSTS
Cytogenetic Map9q32UniSTS
Cryge  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2967,448,641 - 67,450,187 (+)MAPPERmRatBN7.2
Rnor_6.0972,933,681 - 72,935,226NCBIRnor6.0
Rnor_5.0974,363,690 - 74,365,235UniSTSRnor5.0
RGSC_v3.4964,679,988 - 64,681,533UniSTSRGSC3.4
Celera964,941,598 - 64,943,143UniSTS
Cytogenetic Map9q32UniSTS


Expression

RNA-SEQ Expression

circulatory system
ectoderm
mesenchyme
mesoderm
nervous system
sensory system
visual system
7 5 7 7 5 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000064562   ⟹   ENSRNOP00000060248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl973,923,661 - 73,927,011 (-)Ensembl
mRatBN7.2 Ensembl966,429,924 - 66,433,274 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106108   ⟹   ENSRNOP00000093789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl973,923,661 - 73,926,216 (-)Ensembl
mRatBN7.2 Ensembl966,429,924 - 66,432,479 (-)Ensembl
RefSeq Acc Id: NM_173289   ⟹   NP_775411
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,923,661 - 73,926,258 (-)NCBI
mRatBN7.2966,429,924 - 66,432,521 (-)NCBI
RGSC_v3.4963,698,609 - 63,701,230 (-)RGD
Celera963,827,782 - 63,828,162 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_775411 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40985 (Get FASTA)   NCBI Sequence Viewer  
  AAA40987 (Get FASTA)   NCBI Sequence Viewer  
  CAA25073 (Get FASTA)   NCBI Sequence Viewer  
  CAA25074 (Get FASTA)   NCBI Sequence Viewer  
  P02528 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775411   ⟸   NM_173289
- UniProtKB: P02528 (UniProtKB/Swiss-Prot),   D3ZR45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060248   ⟸   ENSRNOT00000064562
Ensembl Acc Id: ENSRNOP00000093789   ⟸   ENSRNOT00000106108
Protein Domains
Beta/gamma crystallin 'Greek key'

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02528-F1-model_v2 AlphaFold P02528 1-174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2423 AgrOrtholog
BioCyc Gene G2FUF-27308 BioCyc
Ensembl Genes ENSRNOG00000014790 Ensembl
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot
InterPro Beta/Gamma-Crystallin UniProtKB/Swiss-Prot
  Beta/gamma_crystallin UniProtKB/Swiss-Prot
  G_crystallin-like UniProtKB/Swiss-Prot
KEGG Report rno:24279 UniProtKB/Swiss-Prot
NCBI Gene 24279 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot
  GAMMA-CRYSTALLIN E-RELATED UniProtKB/Swiss-Prot
Pfam Crystall UniProtKB/Swiss-Prot
PhenoGen Cryge PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014790 RatGTEx
SMART XTALbg UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot
UniProt A0A8I6AKQ5_RAT UniProtKB/TrEMBL
  CRGE_RAT UniProtKB/Swiss-Prot
  D3ZR45 ENTREZGENE, UniProtKB/TrEMBL
  P02528 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Cryge  crystallin, gamma E  LOC100363730  gamma-crystallin D-like  Data merged from RGD:2322421 737654 PROVISIONAL
2010-05-06 LOC100363730  gamma-crystallin D-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Cryge  crystallin, gamma E    Crystallin, gamma polypeptide 5  Name updated 625702 APPROVED
2002-06-10 Cryge  Crystallin, gamma polypeptide 5      Symbol and Name status set to approved 70586 APPROVED